Project name: mAb2

Chain sequence(s)	H: QVQLVESGGGVVQPGRSLRLSCAASGFTFSDFGMHWVRQAPGKGLEWVALITYDGGYKIYSDSVKGRFTISRDNSKNTLFLQMNSLRAEDTAVYYCARIGGQTDYWGQGTLVTVSS; L: SALTQPTSVSGSPGQSITISCTGTSSDVGAYNYVSWYQQHPGKVPKLMIYDVSDRPSGVSNRFSGSKSGNTASLTISGLQAEDEADYYCSSYTRSTTLVIFGGGTKLTVLGQP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.4986
• Maximal score value: 1.5668
• Average score: -0.6348
• Total score value: -145.3578

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	S	L	-0.1638
4	A	L	-0.2038
5	L	L	0.0000
6	T	L	-0.3043
7	Q	L	0.0000
8	P	L	-0.4432
9	T	L	-0.6002
10	S	L	-0.6462
11	V	L	-0.4322
12	S	L	-0.2356
13	G	L	-0.5084
14	S	L	-0.7570
15	P	L	-1.1834
16	G	L	-1.4744
17	Q	L	-1.7764
18	S	L	-1.1683
19	I	L	0.0000
20	T	L	-0.1494
21	I	L	0.0000
22	S	L	-0.2564
23	C	L	0.0000
24	T	L	-0.5248
25	G	L	-0.4956
26	T	L	-0.6088
27	S	L	-0.7585
28	S	L	-0.7818
29	D	L	0.0000
30	V	L	0.0000
30A	G	L	-0.9198
30B	A	L	-0.5063
30C	Y	L	-0.3611
31	N	L	-1.0702
32	Y	L	-0.0825
33	V	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	H	L	-1.5489
40	P	L	-1.2506
41	G	L	-1.5451
42	K	L	-2.2066
43	V	L	-0.9275
44	P	L	0.0000
45	K	L	-1.1624
46	L	L	0.0000
47	M	L	0.0000
48	I	L	0.0000
49	Y	L	-1.3571
50	D	L	-1.8666
51	V	L	-1.2937
52	S	L	-1.6611
53	D	L	-2.3727
54	R	L	-2.4467
55	P	L	-1.1633
56	S	L	-0.8500
57	G	L	-0.8341
58	V	L	-0.9481
59	S	L	-1.1403
60	N	L	-1.7939
61	R	L	-1.2437
62	F	L	0.0000
63	S	L	-1.1033
64	G	L	-0.9601
65	S	L	-0.9923
66	K	L	-1.0940
67	S	L	-0.9205
68	G	L	-1.1222
69	N	L	-1.1989
70	T	L	-0.8630
71	A	L	0.0000
72	S	L	-0.3618
73	L	L	0.0000
74	T	L	-0.3167
75	I	L	0.0000
76	S	L	-1.1857
77	G	L	-1.2285
78	L	L	0.0000
79	Q	L	-1.8493
80	A	L	-1.6158
81	E	L	-2.3741
82	D	L	0.0000
83	E	L	-1.8130
84	A	L	0.0000
85	D	L	-1.0637
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	S	L	0.0000
90	S	L	0.0000
91	Y	L	0.0885
92	T	L	-0.5853
93	R	L	-1.7976
94	S	L	-1.1368
95	T	L	-0.8424
95A	T	L	-0.6766
95B	L	L	-0.1991
96	V	L	0.0000
97	I	L	0.2027
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.9841
101	G	L	-0.9781
102	T	L	0.0000
103	K	L	-1.4523
104	L	L	0.0000
105	T	L	-0.6891
106	V	L	0.0000
107	L	L	0.2567
108	G	L	-0.6167
109	Q	L	-1.2461
110	P	L	-0.7967
1	Q	H	-1.4016
2	V	H	-0.5444
3	Q	H	-0.9217
4	L	H	0.0000
5	V	H	0.5833
6	E	H	0.0000
7	S	H	-0.2372
8	G	H	-0.7812
9	G	H	0.1306
10	G	H	1.0325
11	V	H	1.5668
12	V	H	-0.1707
13	Q	H	-1.3729
14	P	H	-1.8867
15	G	H	-2.1088
16	R	H	-2.4871
17	S	H	-2.0527
18	L	H	-1.2919
19	R	H	-2.2439
20	L	H	0.0000
21	S	H	-0.4693
22	C	H	0.0000
23	A	H	-0.1954
24	A	H	-0.5560
25	S	H	-0.6720
26	G	H	-0.8981
27	F	H	-0.5346
28	T	H	-0.6047
29	F	H	0.0000
30	S	H	-1.1718
31	D	H	-1.6228
32	F	H	-0.5270
33	G	H	-0.2623
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	-0.4893
39	Q	H	-0.7982
40	A	H	-1.1242
41	P	H	-0.8801
42	G	H	-1.5281
43	K	H	-2.3006
44	G	H	-1.5548
45	L	H	0.0000
46	E	H	-1.1616
47	W	H	0.0000
48	V	H	0.0000
49	A	H	0.0000
50	L	H	0.0000
51	I	H	0.0000
52	T	H	0.0155
52A	Y	H	-0.1468
53	D	H	-1.5482
54	G	H	-0.7235
55	G	H	-0.3721
56	Y	H	0.7112
57	K	H	0.2112
58	I	H	0.0251
59	Y	H	-0.7087
60	S	H	0.0000
61	D	H	-2.3145
62	S	H	-1.5145
63	V	H	0.0000
64	K	H	-2.2326
65	G	H	-1.6305
66	R	H	-1.4186
67	F	H	0.0000
68	T	H	-0.9693
69	I	H	0.0000
70	S	H	-0.5169
71	R	H	-1.0373
72	D	H	-1.7164
73	N	H	-1.9234
74	S	H	-1.5954
75	K	H	-2.3838
76	N	H	-1.7989
77	T	H	-1.0108
78	L	H	0.0000
79	F	H	-0.5642
80	L	H	0.0000
81	Q	H	-1.6553
82	M	H	0.0000
82A	N	H	-1.9514
82B	S	H	-1.7209
82C	L	H	0.0000
83	R	H	-2.4986
84	A	H	-1.6374
85	E	H	-2.2164
86	D	H	0.0000
87	T	H	-0.3733
88	A	H	0.0000
89	V	H	0.6741
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	-0.1156
95	I	H	0.0000
96	G	H	-0.7551
97	G	H	-0.5966
98	Q	H	-0.4913
99	T	H	0.0000
101	D	H	-0.3000
102	Y	H	0.4668
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.1127
106	G	H	0.0000
107	T	H	0.4510
108	L	H	1.4401
109	V	H	0.0000
110	T	H	0.5039
111	V	H	0.0000
112	S	H	-0.7427
113	S	H	-0.4838