Project name: tRE LACCASE

Chain sequence(s)	A: AIGPVTDLTISNADVTPDGFTRAAVVANGVFPGPLITGNKGDNFQINVIDNLTNATMLKTTTIHWHGLFQHGTNWADGPAFVNQCPIASGNSFLYDFTVPDQAGTFWYHSHLSTQYCDGLRGPLVVYDPSDPYASMYDVDDDTTVITLSDWYHTAAKLGPAFPPNADSVLINGLGRFAGGNASDLAVITVEQNKRYRFRLVSLSCDPNFTFSIDGHNMTIIEVDGVNHEPLEVDSIQIFASQRYSFVLNATQSVDNYWIRAIPNTGTIDTTGGLNSAILRYSGADIVDPTANATTSVIPLVETDLVPLDSPAAPGDPVVGGVDLAMNLDFSFNGTNFFINNETLIPPTVPVLLQILSGAQSASDLLPTGSVYTLPLNSTIELSFPITTVNGVTNAPGAPHPFHLHGHAFSVVRSAGSSDYNYVNPVRRDTVSTGNPGDNVTIRFTTDNAGPWFLHCHIDFHLEAGFAIVFAEDTPDTASVNPVPTAWSDLCPTYDALDPSDH
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -1.9693
• Maximal score value: 2.0269
• Average score: -0.1368
• Total score value: -68.668

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	0.1327
2	I	A	0.3907
3	G	A	0.1421
4	P	A	0.2112
5	V	A	1.6976
6	T	A	0.1370
7	D	A	-1.0357
8	L	A	0.0000
9	T	A	-0.0331
10	I	A	0.0000
11	S	A	-0.1336
12	N	A	-0.2348
13	A	A	-0.3448
14	D	A	-1.7358
15	V	A	-0.1233
16	T	A	-0.0462
17	P	A	-0.0421
18	D	A	0.0000
19	G	A	0.0448
20	F	A	0.7620
21	T	A	0.0669
22	R	A	0.0000
23	A	A	-0.2877
24	A	A	0.0000
25	V	A	0.0000
26	V	A	0.0000
27	A	A	0.0000
28	N	A	-0.5248
29	G	A	-0.1970
30	V	A	1.7327
31	F	A	0.5239
32	P	A	0.0337
33	G	A	0.0000
34	P	A	-0.0338
35	L	A	0.0000
36	I	A	0.0000
37	T	A	-0.0122
38	G	A	0.0000
39	N	A	-0.9668
40	K	A	-1.0510
41	G	A	-0.6661
42	D	A	-0.6056
43	N	A	-0.7419
44	F	A	0.0000
45	Q	A	-0.2007
46	I	A	0.0000
47	N	A	-0.3327
48	V	A	0.0000
49	I	A	0.4140
50	D	A	0.0000
51	N	A	-0.9459
52	L	A	0.0000
53	T	A	-0.1519
54	N	A	-0.4499
55	A	A	-0.0266
56	T	A	-0.0278
57	M	A	0.0000
58	L	A	0.1486
59	K	A	-0.2344
60	T	A	0.0000
61	T	A	0.0000
62	T	A	0.0000
63	I	A	0.0000
64	H	A	0.0000
65	W	A	0.0000
66	H	A	0.0000
67	G	A	-0.0528
68	L	A	0.0000
69	F	A	0.3389
70	Q	A	0.0000
71	H	A	-0.6122
72	G	A	-0.2087
73	T	A	-0.0266
74	N	A	0.0000
75	W	A	0.0000
76	A	A	0.0000
77	D	A	0.0000
78	G	A	0.0000
79	P	A	0.0000
80	A	A	0.0000
81	F	A	0.2544
82	V	A	0.0000
83	N	A	0.0000
84	Q	A	0.0000
85	C	A	0.0000
86	P	A	0.0000
87	I	A	0.0000
88	A	A	0.0000
89	S	A	-0.1687
90	G	A	-0.6731
91	N	A	-1.1556
92	S	A	-0.2935
93	F	A	0.0000
94	L	A	0.6169
95	Y	A	0.0000
96	D	A	-0.7179
97	F	A	0.0000
98	T	A	-0.1499
99	V	A	0.0000
100	P	A	-0.6525
101	D	A	-1.8611
102	Q	A	-0.4592
103	A	A	-0.0182
104	G	A	0.0000
105	T	A	0.0000
106	F	A	0.0000
107	W	A	0.0000
108	Y	A	0.0000
109	H	A	0.0000
110	S	A	0.0000
111	H	A	0.0000
112	L	A	0.1354
113	S	A	-0.0471
114	T	A	0.0000
115	Q	A	0.0000
116	Y	A	0.0000
117	C	A	0.0000
118	D	A	0.0000
119	G	A	0.0000
120	L	A	0.0000
121	R	A	0.0000
122	G	A	0.0000
123	P	A	0.0000
124	L	A	0.0000
125	V	A	0.0000
126	V	A	0.0000
127	Y	A	0.0879
128	D	A	-0.2473
129	P	A	-0.3340
130	S	A	-0.2956
131	D	A	-0.3023
132	P	A	-0.2663
133	Y	A	0.0903
134	A	A	0.0409
135	S	A	-0.1732
136	M	A	0.1542
137	Y	A	-0.2663
138	D	A	-1.8150
139	V	A	-0.0912
140	D	A	-0.4262
141	D	A	-1.2838
142	D	A	-1.9693
143	T	A	-0.4018
144	T	A	0.0000
145	V	A	0.0000
146	I	A	0.0000
147	T	A	0.0000
148	L	A	0.0000
149	S	A	0.0000
150	D	A	0.0000
151	W	A	0.0000
152	Y	A	0.0000
153	H	A	-0.1714
154	T	A	-0.0950
155	A	A	-0.0039
156	A	A	-0.2048
157	K	A	-0.8405
158	L	A	1.3174
159	G	A	0.1069
160	P	A	-0.2724
161	A	A	0.0989
162	F	A	0.5844
163	P	A	0.0326
164	P	A	-0.3746
165	N	A	-0.6995
166	A	A	-0.3097
167	D	A	-1.0839
168	S	A	0.0000
169	V	A	0.0000
170	L	A	0.0000
171	I	A	0.0000
172	N	A	-0.4731
173	G	A	0.0000
174	L	A	0.4945
175	G	A	0.0000
176	R	A	-0.1783
177	F	A	0.2510
178	A	A	0.0282
179	G	A	-0.4856
180	G	A	-0.4532
181	N	A	-1.2930
182	A	A	-0.1954
183	S	A	-0.4464
184	D	A	-1.8133
185	L	A	0.0000
186	A	A	0.0000
187	V	A	1.3521
188	I	A	0.0000
189	T	A	-0.0709
190	V	A	0.0000
191	E	A	-0.8377
192	Q	A	-1.4822
193	N	A	-1.6040
194	K	A	-1.1456
195	R	A	-1.4514
196	Y	A	0.0000
197	R	A	0.0000
198	F	A	0.0000
199	R	A	0.0000
200	L	A	0.0000
201	V	A	0.0000
202	S	A	0.0000
203	L	A	0.0000
204	S	A	0.0000
205	C	A	0.0000
206	D	A	-0.3108
207	P	A	0.0000
208	N	A	0.0000
209	F	A	0.0000
210	T	A	-0.1058
211	F	A	0.0000
212	S	A	-0.0377
213	I	A	0.0000
214	D	A	0.0000
215	G	A	-0.4663
216	H	A	0.0000
217	N	A	-1.2730
218	M	A	0.0000
219	T	A	-0.0088
220	I	A	0.0000
221	I	A	0.0000
222	E	A	0.0000
223	V	A	0.0000
224	D	A	0.0000
225	G	A	0.0000
226	V	A	0.2319
227	N	A	-0.3465
228	H	A	0.0000
229	E	A	-1.3989
230	P	A	-0.3516
231	L	A	-0.1583
232	E	A	-1.7826
233	V	A	0.0000
234	D	A	-0.3096
235	S	A	0.0000
236	I	A	0.0000
237	Q	A	-0.6245
238	I	A	0.0000
239	F	A	0.0000
240	A	A	0.0000
241	S	A	0.0000
242	Q	A	0.0000
243	R	A	0.0000
244	Y	A	0.0000
245	S	A	0.0000
246	F	A	0.0000
247	V	A	0.0000
248	L	A	0.0000
249	N	A	-0.9767
250	A	A	0.0000
251	T	A	-0.2115
252	Q	A	-0.8369
253	S	A	-0.1709
254	V	A	0.7420
255	D	A	-1.1296
256	N	A	0.0000
257	Y	A	0.0000
258	W	A	0.1150
259	I	A	0.0000
260	R	A	0.0000
261	A	A	0.0000
262	I	A	0.2779
263	P	A	0.0000
264	N	A	-1.2786
265	T	A	-0.3265
266	G	A	-0.3884
267	T	A	0.2346
268	I	A	1.7441
269	D	A	-1.1019
270	T	A	-0.2908
271	T	A	-0.1596
272	G	A	-0.4882
273	G	A	-0.1055
274	L	A	0.1484
275	N	A	0.0000
276	S	A	0.0000
277	A	A	0.0000
278	I	A	0.0000
279	L	A	0.0000
280	R	A	0.0000
281	Y	A	0.0000
282	S	A	-0.2287
283	G	A	-0.4913
284	A	A	-0.3999
285	D	A	-1.4173
286	I	A	1.8720
287	V	A	1.0949
288	D	A	-1.5920
289	P	A	0.0000
290	T	A	-0.0684
291	A	A	-0.2312
292	N	A	-1.2637
293	A	A	-0.2100
294	T	A	-0.0771
295	T	A	-0.1077
296	S	A	0.1806
297	V	A	2.0032
298	I	A	1.6919
299	P	A	0.0954
300	L	A	0.0000
301	V	A	1.0943
302	E	A	-0.0508
303	T	A	-0.4199
304	D	A	-1.7982
305	L	A	0.0000
306	V	A	0.4745
307	P	A	0.0000
308	L	A	0.0974
309	D	A	-1.7189
310	S	A	-0.5546
311	P	A	-0.2011
312	A	A	0.1839
313	A	A	0.0000
314	P	A	-0.0790
315	G	A	-0.4595
316	D	A	-1.8593
317	P	A	-0.2453
318	V	A	1.9663
319	V	A	2.0269
320	G	A	0.0003
321	G	A	0.0956
322	V	A	-0.1012
323	D	A	-1.6441
324	L	A	0.2039
325	A	A	0.1814
326	M	A	-0.0549
327	N	A	-1.1820
328	L	A	0.0000
329	D	A	-1.8203
330	F	A	0.0000
331	S	A	-0.0421
332	F	A	0.3101
333	N	A	-1.2560
334	G	A	-0.7120
335	T	A	-0.1997
336	N	A	-0.2378
337	F	A	0.0000
338	F	A	0.3254
339	I	A	0.0000
340	N	A	-0.7214
341	N	A	-1.4901
342	E	A	-1.1083
343	T	A	-0.1313
344	L	A	0.0000
345	I	A	1.9743
346	P	A	0.1352
347	P	A	0.0000
348	T	A	0.1002
349	V	A	0.8967
350	P	A	0.0000
351	V	A	0.0000
352	L	A	0.0000
353	L	A	0.4092
354	Q	A	0.0000
355	I	A	0.0000
356	L	A	0.4180
357	S	A	-0.2252
358	G	A	-0.5052
359	A	A	-0.2866
360	Q	A	-1.1438
361	S	A	-0.3111
362	A	A	-0.0356
363	S	A	-0.5315
364	D	A	-1.8278
365	L	A	0.0000
366	L	A	1.1709
367	P	A	0.2969
368	T	A	0.0108
369	G	A	-0.3064
370	S	A	0.0000
371	V	A	0.0000
372	Y	A	0.2496
373	T	A	0.0168
374	L	A	0.0000
375	P	A	0.0913
376	L	A	0.9480
377	N	A	-1.0399
378	S	A	0.0000
379	T	A	-0.2073
380	I	A	0.0000
381	E	A	0.0000
382	L	A	0.0000
383	S	A	-0.1509
384	F	A	0.0000
385	P	A	-0.1493
386	I	A	0.0000
387	T	A	-0.0520
388	T	A	0.1113
389	V	A	0.7799
390	N	A	-1.1792
391	G	A	-0.3786
392	V	A	1.6833
393	T	A	0.2546
394	N	A	-0.1506
395	A	A	0.0000
396	P	A	-0.2419
397	G	A	-0.4915
398	A	A	-0.0768
399	P	A	-0.0321
400	H	A	0.0000
401	P	A	0.0000
402	F	A	0.0000
403	H	A	0.0000
404	L	A	0.0000
405	H	A	0.0000
406	G	A	0.0000
407	H	A	0.0000
408	A	A	0.0092
409	F	A	0.0000
410	S	A	0.0000
411	V	A	0.0000
412	V	A	0.0000
413	R	A	0.0000
414	S	A	0.0000
415	A	A	-0.0759
416	G	A	-0.4724
417	S	A	-0.1713
418	S	A	-0.5663
419	D	A	-1.7622
420	Y	A	0.0028
421	N	A	-0.1160
422	Y	A	0.4221
423	V	A	1.7022
424	N	A	-0.2392
425	P	A	0.0000
426	V	A	0.0000
427	R	A	-0.2520
428	R	A	0.0000
429	D	A	0.0000
430	T	A	0.0000
431	V	A	0.0000
432	S	A	0.0000
433	T	A	0.0000
434	G	A	0.0000
435	N	A	-1.2902
436	P	A	-0.4138
437	G	A	-0.5181
438	D	A	-0.4101
439	N	A	-0.7726
440	V	A	0.0000
441	T	A	0.0000
442	I	A	0.0000
443	R	A	0.0000
444	F	A	0.0000
445	T	A	-0.0257
446	T	A	0.0000
447	D	A	-1.7894
448	N	A	0.0000
449	A	A	0.0061
450	G	A	0.0000
451	P	A	0.0000
452	W	A	0.0000
453	F	A	0.0000
454	L	A	0.0000
455	H	A	0.0000
456	C	A	0.0000
457	H	A	0.0000
458	I	A	0.0000
459	D	A	0.0000
460	F	A	0.0000
461	H	A	0.0000
462	L	A	-0.0270
463	E	A	-1.0696
464	A	A	0.0000
465	G	A	0.0000
466	F	A	0.0000
467	A	A	0.0000
468	I	A	0.0000
469	V	A	0.0000
470	F	A	0.0000
471	A	A	0.0000
472	E	A	0.0000
473	D	A	0.0000
474	T	A	0.0000
475	P	A	-0.4559
476	D	A	-1.1163
477	T	A	0.0000
478	A	A	-0.0046
479	S	A	-0.0500
480	V	A	0.8395
481	N	A	0.0000
482	P	A	-0.1408
483	V	A	0.5559
484	P	A	0.0107
485	T	A	-0.0822
486	A	A	0.0135
487	W	A	0.0000
488	S	A	-0.4800
489	D	A	-1.8157
490	L	A	0.0000
491	C	A	0.0377
492	P	A	-0.2427
493	T	A	-0.0661
494	Y	A	0.0000
495	D	A	-1.7787
496	A	A	-0.2062
497	L	A	0.0269
498	D	A	-1.7731
499	P	A	-0.6647
500	S	A	-0.5000
501	D	A	-1.4175
502	H	A	-0.6107