Project name: 9cfc4c29917e8b2

Chain sequence(s)	A: REIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYT
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7333
• Maximal score value: 3.5209
• Average score: -0.7364
• Total score value: -139.1809

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
511	R	A	-2.3893
512	E	A	-1.5388
513	I	A	1.4331
514	P	A	1.1556
515	L	A	1.7161
516	K	A	0.0444
517	V	A	1.6525
518	L	A	2.5653
519	V	A	2.2807
520	K	A	0.7470
521	A	A	2.0049
522	V	A	3.2344
523	L	A	3.1338
524	F	A	3.5209
525	A	A	2.3281
526	C	A	1.6809
527	M	A	1.6991
528	L	A	1.7641
529	M	A	0.4269
530	R	A	-1.6291
531	K	A	-1.8268
532	T	A	-0.9251
533	M	A	-1.0870
534	A	A	-1.3101
535	S	A	-1.1496
536	R	A	-0.9333
537	V	A	-0.6248
538	R	A	-2.0576
539	V	A	0.0000
540	T	A	0.0000
541	I	A	0.0000
542	L	A	0.0000
543	F	A	0.0000
544	A	A	0.0000
545	T	A	-1.5926
546	E	A	-2.3453
547	T	A	-1.4534
548	G	A	-1.4450
549	K	A	-1.8069
550	S	A	0.0000
551	E	A	-1.0780
552	A	A	-0.4901
553	L	A	0.0000
554	A	A	0.0000
555	W	A	0.4619
556	D	A	-0.2343
557	L	A	0.0000
558	G	A	-0.2623
559	A	A	-0.0861
560	L	A	0.0000
561	F	A	0.0000
562	S	A	-0.4681
563	C	A	-0.0527
564	A	A	-0.4337
565	F	A	0.0000
566	N	A	-1.3805
567	P	A	-1.2639
568	K	A	-1.7670
569	V	A	-0.4254
570	V	A	-0.5184
571	C	A	-0.7118
572	M	A	0.0000
573	D	A	-2.5101
574	K	A	-2.4999
575	Y	A	0.0000
576	R	A	-2.1750
577	L	A	-1.1351
578	S	A	-1.0504
579	C	A	-1.0874
580	L	A	0.0000
581	E	A	-2.2389
582	E	A	-2.8334
583	E	A	0.0000
584	R	A	-2.3298
585	L	A	0.0000
586	L	A	0.0000
587	L	A	0.0000
588	V	A	0.0000
589	V	A	0.0000
590	T	A	0.0000
591	S	A	-0.9566
592	T	A	-0.9439
593	F	A	-1.0057
594	G	A	-1.4498
595	N	A	-2.1744
596	G	A	-2.0938
597	D	A	-2.8119
598	C	A	-2.2553
599	P	A	0.0000
600	G	A	-2.1685
601	N	A	-2.5890
602	G	A	0.0000
603	E	A	-3.7333
604	K	A	-3.6857
605	L	A	0.0000
606	K	A	-2.8390
607	K	A	-2.1565
608	S	A	-1.2552
609	L	A	0.0000
610	F	A	0.1358
611	M	A	0.4083
612	L	A	-0.4708
613	K	A	-2.1627
614	E	A	-2.8782
615	L	A	0.0000
616	N	A	-2.5259
617	N	A	-2.5233
618	K	A	-2.4741
619	F	A	0.0000
620	R	A	-1.7049
621	Y	A	0.0000
622	A	A	0.0000
623	V	A	0.0000
624	F	A	0.0000
625	G	A	0.0000
626	L	A	0.0000
627	G	A	-0.3716
628	S	A	-0.0514
629	S	A	0.3180
630	M	A	1.3346
631	Y	A	0.9929
632	P	A	-0.3733
633	R	A	-1.8051
634	F	A	-0.3147
635	C	A	0.0000
636	A	A	-1.4351
637	F	A	0.0000
638	A	A	0.0000
639	H	A	-1.6967
640	D	A	-2.1765
641	I	A	0.0000
642	D	A	0.0000
643	Q	A	-2.1436
644	K	A	-1.6508
645	L	A	0.0000
646	S	A	-1.5784
647	H	A	-1.9224
648	L	A	0.0000
649	G	A	-1.7311
650	A	A	0.0000
651	S	A	-1.2567
652	Q	A	-1.1832
653	L	A	-0.5869
654	T	A	0.0000
655	P	A	-0.5319
656	M	A	-0.5213
657	G	A	-0.5849
658	E	A	-1.2726
659	G	A	0.0000
660	D	A	-1.2166
661	E	A	-1.6234
662	L	A	0.4185
663	S	A	-0.6573
664	G	A	-1.4150
665	Q	A	0.0000
666	E	A	-2.6448
667	D	A	-2.5619
668	A	A	-1.7598
669	F	A	0.0000
670	R	A	-1.4105
671	S	A	-1.2204
672	W	A	0.0000
673	A	A	0.0000
674	V	A	-0.6402
675	Q	A	-1.3364
676	T	A	0.0000
677	F	A	0.0000
678	K	A	-2.2789
679	A	A	-1.6656
680	A	A	0.0000
681	C	A	0.0000
682	E	A	-3.1517
683	T	A	-1.4817
684	F	A	-1.5118
685	D	A	-2.8423
686	V	A	-2.5842
687	R	A	-3.1273
688	G	A	-2.6153
689	K	A	-3.4478
690	Q	A	-2.9405
691	H	A	-2.2898
692	I	A	-1.5574
693	Q	A	-1.6058
694	I	A	-0.5486
695	P	A	-0.8255
696	K	A	-1.4973
697	L	A	-0.4134
698	Y	A	0.0000
699	T	A	-0.5738