Project name: 9d73ea3b04fdc39

Chain sequence(s)	A: NLQLVSELKNPSGSCSVDVSAMFWEGCKEPCCIITACEDVVSLWKALDAWQWEKLYTWHFAEVPVLQIVPVPDVYNLVCCVALGNLEIREIRALFCSEKQVLLKSGNIKAVLGLTKRRLVSSSGTLSDQQVEVMTFAGGGKENQFLMPPEETILTFAEVQGMQEALLGTTIMNNIVIWNLKTGQLLKKMHIDDSYQASVCHKAYSEMGLLFIVLSHPVFQLIVINPKTTLSVGVMLYCLPPGQAGRFLEGDVKDHAAAILTSGTIAIWDLLLGQCTALLPPVSDQHWSFVKWSGTDSHLLAGQKDGNIFVYHYS; X: LGPISLNWFEELSS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3593
• Maximal score value: 2.4013
• Average score: -0.4384
• Total score value: -142.9253

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
854	N	A	-1.3859
855	L	A	-0.6313
856	Q	A	-0.8603
857	L	A	0.7103
858	V	A	0.7266
859	S	A	0.0000
860	E	A	-0.5297
861	L	A	0.0000
862	K	A	-2.4621
863	N	A	0.0000
864	P	A	-1.4747
865	S	A	-1.0831
866	G	A	-0.9841
867	S	A	-1.0824
868	C	A	-1.0581
869	S	A	0.0000
870	V	A	-0.3276
871	D	A	0.0000
872	V	A	0.0000
873	S	A	0.0000
874	A	A	-0.2241
875	M	A	-0.3482
876	F	A	-1.0093
877	W	A	0.0000
878	E	A	-2.4747
881	G	A	-1.2971
882	C	A	-1.1629
883	K	A	-2.3893
884	E	A	-2.0237
885	P	A	-1.1390
886	C	A	0.0000
887	I	A	0.0000
888	I	A	0.0000
889	T	A	0.0000
890	A	A	0.0000
891	C	A	0.0000
892	E	A	-1.6490
893	D	A	-1.7143
894	V	A	-0.9292
895	V	A	0.0000
896	S	A	0.0000
897	L	A	0.0000
898	W	A	0.0000
899	K	A	-1.1023
900	A	A	-0.3598
901	L	A	0.2993
902	D	A	-0.1564
903	A	A	0.4151
904	W	A	1.0673
905	Q	A	-0.3729
906	W	A	-1.0229
907	E	A	-2.1094
908	K	A	-1.7550
909	L	A	-0.2920
910	Y	A	0.0559
911	T	A	-0.3698
912	W	A	0.0000
913	H	A	-1.5704
914	F	A	0.0000
915	A	A	-1.3297
916	E	A	-2.0606
917	V	A	-1.4775
918	P	A	-1.3053
919	V	A	0.0000
920	L	A	-0.4168
921	Q	A	-0.2803
922	I	A	0.0000
923	V	A	0.0000
924	P	A	-0.3239
925	V	A	-0.4838
926	P	A	-1.0478
927	D	A	-1.5530
928	V	A	0.0000
929	Y	A	-0.7679
930	N	A	-0.9178
931	L	A	0.0000
932	V	A	0.0000
933	C	A	0.0000
934	V	A	0.0000
935	A	A	0.0000
936	L	A	0.0000
937	G	A	0.0000
938	N	A	-1.4192
939	L	A	-0.0795
940	E	A	-2.0781
941	I	A	-1.8849
942	R	A	-2.5783
943	E	A	0.0000
944	I	A	0.0000
945	R	A	0.3148
946	A	A	0.0000
947	L	A	0.0000
948	F	A	-0.0221
949	C	A	-0.1860
955	S	A	-0.5692
956	E	A	-1.2774
957	K	A	-1.8175
958	Q	A	-0.5734
959	V	A	0.7901
960	L	A	1.2157
961	L	A	0.4468
962	K	A	-0.4149
963	S	A	-1.0359
964	G	A	-1.8780
965	N	A	-2.4712
966	I	A	0.0000
967	K	A	-1.7172
968	A	A	0.0000
969	V	A	0.2746
970	L	A	0.4074
971	G	A	0.0000
972	L	A	0.0000
973	T	A	-1.5329
974	K	A	-2.2277
975	R	A	-1.5411
976	R	A	-1.2468
977	L	A	0.0000
978	V	A	0.0000
979	S	A	0.0000
980	S	A	0.0000
981	S	A	-1.1854
982	G	A	-1.1851
983	T	A	-0.2488
984	L	A	0.2664
985	S	A	-0.7637
986	D	A	-1.7130
987	Q	A	0.0000
988	Q	A	-0.7766
989	V	A	0.0000
990	E	A	-0.4467
991	V	A	0.0000
992	M	A	0.0000
993	T	A	-2.1253
994	F	A	0.0000
995	A	A	-1.2675
998	G	A	-1.0604
999	G	A	-1.4654
1000	G	A	-1.9171
1001	K	A	-3.1737
1002	E	A	-3.3593
1003	N	A	-2.3529
1004	Q	A	-1.4237
1005	F	A	0.3145
1006	L	A	0.0000
1007	M	A	0.6557
1008	P	A	-0.0328
1009	P	A	-0.3051
1010	E	A	-0.3684
1011	E	A	0.0000
1012	T	A	0.0000
1013	I	A	0.0000
1014	L	A	1.1476
1015	T	A	0.6678
1016	F	A	0.0000
1017	A	A	0.0000
1018	E	A	-0.9696
1019	V	A	0.0000
1020	Q	A	-2.2037
1021	G	A	-1.5950
1022	M	A	-1.3681
1023	Q	A	-1.9279
1024	E	A	-1.7603
1025	A	A	0.0000
1026	L	A	0.0000
1027	L	A	0.0000
1028	G	A	0.0000
1029	T	A	0.0000
1030	T	A	0.0000
1031	I	A	2.3443
1032	M	A	1.0998
1033	N	A	-0.0794
1034	N	A	0.0000
1035	I	A	0.0000
1036	V	A	0.0000
1037	I	A	0.0000
1038	W	A	0.0000
1039	N	A	0.0000
1040	L	A	0.0000
1041	K	A	-2.2383
1042	T	A	-0.9935
1043	G	A	0.0000
1044	Q	A	-0.3287
1045	L	A	0.0497
1046	L	A	-0.3637
1047	K	A	-0.9264
1048	K	A	-1.3813
1049	M	A	0.0000
1050	H	A	-1.4252
1051	I	A	0.0000
1052	D	A	-2.6441
1053	D	A	-2.7169
1054	S	A	-1.3100
1055	Y	A	-0.3997
1056	Q	A	-1.1084
1057	A	A	0.0000
1058	S	A	0.7409
1059	V	A	0.4501
1060	C	A	0.0000
1061	H	A	-0.3634
1062	K	A	-1.0691
1063	A	A	0.0000
1064	Y	A	-1.0541
1065	S	A	-0.8619
1066	E	A	-1.1975
1067	M	A	0.6261
1068	G	A	0.5943
1069	L	A	0.5298
1070	L	A	0.0000
1071	F	A	0.2648
1072	I	A	0.0000
1073	V	A	0.0000
1074	L	A	0.0000
1075	S	A	-0.1923
1076	H	A	-0.6944
1088	P	A	-0.2683
1089	V	A	0.0000
1090	F	A	0.0000
1091	Q	A	0.5992
1092	L	A	0.0000
1093	I	A	0.0000
1094	V	A	1.4774
1095	I	A	0.0000
1096	N	A	0.0000
1097	P	A	0.0000
1098	K	A	-0.7311
1099	T	A	0.1116
1100	T	A	0.1028
1101	L	A	1.3254
1102	S	A	1.2795
1103	V	A	2.1282
1104	G	A	1.6940
1105	V	A	2.4013
1106	M	A	1.6301
1107	L	A	1.2762
1108	Y	A	0.0000
1109	C	A	0.0846
1110	L	A	-0.2369
1111	P	A	-0.4178
1112	P	A	-0.5649
1113	G	A	-0.8332
1114	Q	A	-0.9471
1115	A	A	-0.8096
1116	G	A	-0.9402
1117	R	A	-1.6970
1118	F	A	-0.4412
1119	L	A	0.5306
1120	E	A	-0.4806
1121	G	A	-0.4398
1122	D	A	-0.8864
1123	V	A	0.0000
1124	K	A	-2.0480
1125	D	A	-2.7582
1126	H	A	-1.5033
1128	A	A	0.0000
1129	A	A	0.0000
1130	A	A	0.0000
1131	I	A	0.0000
1132	L	A	0.0000
1133	T	A	-0.5079
1134	S	A	-0.6024
1135	G	A	0.0000
1136	T	A	0.0000
1137	I	A	0.0000
1138	A	A	0.0000
1139	I	A	0.0000
1140	W	A	0.0000
1141	D	A	-0.2038
1142	L	A	0.0000
1143	L	A	1.7989
1144	L	A	1.7201
1145	G	A	0.7174
1146	Q	A	-0.4153
1147	C	A	-0.1783
1148	T	A	-0.4037
1149	A	A	-0.1584
1150	L	A	0.3215
1151	L	A	0.2979
1152	P	A	-0.3260
1153	P	A	-0.6407
1154	V	A	0.0407
1155	S	A	-0.9882
1156	D	A	-2.1945
1157	Q	A	-2.2817
1158	H	A	-1.9051
1159	W	A	0.0000
1160	S	A	-1.0080
1161	F	A	0.0000
1162	V	A	0.0000
1163	K	A	-0.6304
1164	W	A	-0.7989
1165	S	A	0.0000
1166	G	A	-0.8294
1167	T	A	-0.8516
1168	D	A	-1.0113
1169	S	A	-0.8268
1170	H	A	-0.5718
1171	L	A	0.0000
1172	L	A	0.0000
1173	A	A	0.0000
1174	G	A	0.0000
1175	Q	A	0.0000
1176	K	A	-2.7162
1177	D	A	-3.0739
1178	G	A	0.0000
1179	N	A	-2.0148
1180	I	A	0.0000
1181	F	A	0.0389
1182	V	A	0.0000
1183	Y	A	0.0000
1184	H	A	-0.6784
1185	Y	A	-0.5768
1186	S	A	-0.7144
24	L	X	1.4107
25	G	X	0.7375
26	P	X	0.4040
27	I	X	1.1316
28	S	X	0.5799
29	L	X	0.8664
30	N	X	-0.8440
31	W	X	0.0000
32	F	X	-1.2811
33	E	X	-2.1518
34	E	X	-1.7035
35	L	X	-0.8149
36	S	X	-1.2015
37	S	X	-0.7878