Project name: Human Dihydropteridine reductase: 1HDR

Chain sequence(s)	A: EARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.2906
• Maximal score value: 2.4336
• Average score: -0.6919
• Total score value: -163.2952

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
8	E	A	-2.3846
9	A	A	0.0000
10	R	A	-2.8609
11	R	A	-1.8078
12	V	A	0.0000
13	L	A	0.0000
14	V	A	0.0000
15	Y	A	0.0000
16	G	A	0.0000
17	G	A	0.0000
18	R	A	-1.7783
19	G	A	-0.8186
20	A	A	-0.4521
21	L	A	-0.5842
22	G	A	0.0000
23	S	A	-1.4497
24	R	A	-1.8000
25	C	A	0.0000
26	V	A	0.0000
27	Q	A	-1.9428
28	A	A	0.0000
29	F	A	0.0000
30	R	A	-2.3676
31	A	A	-1.5269
32	R	A	-2.4700
33	N	A	-2.4867
34	W	A	0.0000
35	W	A	-1.1004
36	V	A	0.0000
37	A	A	0.0000
38	S	A	0.0000
39	V	A	0.0000
40	D	A	0.0755
41	V	A	1.1630
42	V	A	0.4688
43	E	A	-1.4371
44	N	A	0.0000
45	E	A	-3.1235
46	E	A	-3.2906
47	A	A	-2.0634
48	S	A	-0.9129
49	A	A	-0.7189
50	S	A	-0.7439
51	I	A	0.0000
52	I	A	1.0615
53	V	A	0.0000
54	K	A	-0.1922
55	M	A	0.4604
56	T	A	-0.8815
57	D	A	-2.0553
58	S	A	-1.1793
59	F	A	-0.7142
60	T	A	-1.3268
61	E	A	-2.3861
62	Q	A	0.0000
63	A	A	-1.5340
64	D	A	-2.3820
65	Q	A	-1.5741
66	V	A	0.0000
67	T	A	-1.5056
68	A	A	-1.1170
69	E	A	-1.0049
70	V	A	0.0000
71	G	A	-1.6617
72	K	A	-1.9532
73	L	A	-0.7528
74	L	A	0.0000
75	G	A	-2.1854
76	E	A	-3.0438
77	E	A	-2.6301
78	K	A	-2.5153
79	V	A	0.0000
80	D	A	0.0000
81	A	A	0.0000
82	I	A	0.0000
83	L	A	0.0000
84	C	A	0.0000
85	V	A	-0.0483
86	A	A	-0.3985
87	G	A	-0.0752
88	G	A	0.1007
89	W	A	1.0542
90	A	A	0.4629
91	G	A	0.0462
92	G	A	-0.6657
93	N	A	-1.2311
94	A	A	-0.9376
95	K	A	-2.2114
96	S	A	-1.5931
97	K	A	-2.0856
98	S	A	-1.2325
99	L	A	-0.6105
100	F	A	0.5289
101	K	A	-1.3395
102	N	A	-0.4030
103	C	A	0.0000
104	D	A	-1.4366
105	L	A	0.1450
106	M	A	0.0000
107	W	A	0.0850
108	K	A	-0.6350
109	Q	A	-0.3741
110	S	A	0.0000
111	I	A	0.6805
112	W	A	0.2843
113	T	A	0.0533
114	S	A	0.0000
115	T	A	-0.0110
116	I	A	0.0000
117	S	A	0.0000
118	S	A	0.0000
119	H	A	-1.4152
120	L	A	0.0000
121	A	A	0.0000
122	T	A	-1.4741
123	K	A	-2.3266
124	H	A	0.0000
125	L	A	0.0000
126	K	A	-2.2504
127	E	A	-2.5261
128	G	A	-1.7741
129	G	A	0.0000
130	L	A	0.0000
131	L	A	0.0000
132	T	A	0.0000
133	L	A	0.0000
134	A	A	0.0977
135	G	A	0.0000
136	A	A	0.0000
137	K	A	-0.1508
138	A	A	-0.2124
139	A	A	-0.1906
140	L	A	0.0486
141	D	A	-1.8097
142	G	A	-1.1283
143	T	A	-0.5838
144	P	A	-0.7449
145	G	A	-0.8056
146	M	A	0.2015
147	I	A	0.2003
148	G	A	0.0000
149	Y	A	0.6151
150	G	A	0.1194
151	M	A	0.9084
152	A	A	0.0000
153	K	A	0.0000
154	G	A	-0.0226
155	A	A	-0.0510
156	V	A	0.0000
157	H	A	0.0000
158	Q	A	-0.8331
159	L	A	-0.3978
160	C	A	0.0000
161	Q	A	-0.2612
162	S	A	-1.0109
163	L	A	0.0000
164	A	A	-0.9097
165	G	A	-1.5837
166	K	A	-2.5480
167	N	A	-2.3698
168	S	A	-1.5381
169	G	A	-1.5496
170	M	A	-1.4876
171	P	A	-1.5100
172	P	A	-1.4190
173	G	A	-1.3615
174	A	A	-1.0591
175	A	A	0.0000
176	A	A	0.0000
177	I	A	0.0000
178	A	A	0.0000
179	V	A	0.0000
180	L	A	0.0000
181	P	A	0.8528
182	V	A	1.6969
183	T	A	0.8733
184	L	A	0.4668
185	D	A	-0.3122
186	T	A	-0.2745
187	P	A	-0.5931
188	M	A	-0.0575
189	N	A	-0.7128
190	R	A	-1.9153
191	K	A	-2.1780
192	S	A	-1.2655
193	M	A	-1.2504
194	P	A	-1.9442
195	E	A	-2.5359
196	A	A	-1.9302
197	D	A	-2.3652
198	F	A	-1.1830
199	S	A	-1.6523
200	S	A	-1.1097
201	W	A	0.0000
202	T	A	0.0000
203	P	A	-0.6070
204	L	A	-0.8749
205	E	A	-1.8904
206	F	A	-1.1902
207	L	A	0.0000
208	V	A	0.0000
209	E	A	-2.2079
210	T	A	0.0000
211	F	A	0.0000
212	H	A	-1.3508
213	D	A	-2.0360
214	W	A	0.0000
215	I	A	0.0000
216	T	A	-2.0073
217	G	A	-2.2672
218	K	A	-2.8267
219	N	A	-2.5356
220	R	A	-1.8812
221	P	A	-0.9888
222	S	A	-0.5881
223	S	A	-0.4230
224	G	A	-0.0509
225	S	A	0.2689
226	L	A	0.0000
227	I	A	0.0000
228	Q	A	0.0000
229	V	A	0.0000
230	V	A	-0.2905
231	T	A	0.0000
232	T	A	-1.8285
233	E	A	-2.7646
234	G	A	-2.0420
235	R	A	-2.9404
236	T	A	-1.8846
237	E	A	-1.8301
238	L	A	-0.2377
239	T	A	-0.1994
240	P	A	0.2066
241	A	A	1.0637
242	Y	A	2.3148
243	F	A	2.4336