Project name: sigma1_1

Status: done

submitted: 2019-01-17 17:04:37, status changed: 2019-01-17 17:17:24
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Chain sequence(s) A: RWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLF
C: QWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFG
B: MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLF
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.389
Maximal score value
3.77
Average score
0.0648
Total score value
42.1177

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
8 R A -0.9214
9 W A 0.7863
10 A A 0.9588
11 W A 1.6819
12 A A 1.6647
13 A A 2.0470
14 L A 3.1087
15 L A 3.0323
16 L A 3.4613
17 A A 3.0719
18 V A 3.4418
19 A A 2.9081
20 A A 2.6030
21 V A 3.5509
22 L A 3.7244
23 T A 2.6045
24 Q A 2.3989
25 V A 3.7700
26 V A 3.3894
27 W A 3.3520
28 L A 3.3452
29 W A 2.9098
30 L A 2.1897
31 G A 1.0221
32 T A 0.7051
33 Q A 0.3276
34 S A 0.3006
35 F A 0.7308
36 V A 0.4832
37 F A 0.0000
38 Q A -1.7575
39 R A -1.9387
40 E A -2.4161
41 E A -1.9896
42 I A 0.0000
43 A A 0.0000
44 Q A -2.5261
45 L A 0.0000
46 A A 0.0000
47 R A -2.4515
48 Q A -2.1689
49 Y A 0.0000
50 A A -1.1632
51 G A -1.0023
52 L A -0.8419
53 D A -1.9018
54 H A -1.7888
55 E A -2.1200
56 L A -0.8523
57 A A 0.0000
58 F A 0.0000
59 S A -0.5256
60 R A -1.0917
61 L A 0.0000
62 I A 0.1064
63 V A 0.7284
64 E A -0.2933
65 L A 0.0000
66 R A -0.7059
67 R A -1.4391
68 L A -0.1641
69 H A -0.6849
70 P A -0.8304
71 G A -0.0895
72 H A -0.1520
73 V A 0.0000
74 L A 0.0000
75 P A -1.7969
76 D A -2.8521
77 E A -2.9734
78 E A -2.4790
79 L A -1.6125
80 Q A -1.2640
81 W A -0.4006
82 V A 0.0000
83 F A 0.0000
84 V A 0.2652
85 N A 0.0000
86 A A 0.0000
87 G A 0.0000
88 G A -0.7475
89 W A 0.0000
90 M A 0.0000
91 G A 0.0000
92 A A 0.0000
93 M A 0.0000
94 C A 0.0000
95 L A 0.0000
96 L A 0.0000
97 H A 0.0000
98 A A 0.0000
99 S A 0.6376
100 L A 1.2819
101 S A 0.7428
102 E A 0.0000
103 Y A 0.0000
104 V A 0.0000
105 L A 0.0769
106 L A 0.0000
107 F A 0.0000
108 G A 0.0000
109 T A 0.0000
110 A A 0.0000
111 L A 0.0000
112 G A 0.0000
113 S A 0.0000
114 R A -1.1241
115 G A 0.0000
116 H A 0.0000
117 S A -0.5937
118 G A 0.0000
119 R A -0.3809
120 Y A 0.1769
121 W A 0.8274
122 A A 0.0000
123 E A -0.4218
124 I A 0.0000
125 S A 0.0000
126 D A -0.2564
127 T A 0.0000
128 I A 0.0000
129 I A 0.0000
130 S A -0.6017
131 G A -0.2799
132 T A 0.1785
133 F A 0.0000
134 H A -0.2622
135 Q A 0.0000
136 W A 0.0000
137 R A -2.9195
138 E A -2.4810
139 G A -1.6215
140 T A -1.5636
141 T A -1.8124
142 K A -2.5003
143 S A -1.6975
144 E A -0.7928
145 V A 0.5604
146 F A 0.6473
147 Y A 0.9553
148 P A -0.2504
149 G A -1.2768
150 E A -1.1327
151 T A -0.6856
152 V A 0.0000
153 V A 0.6050
154 H A 0.0000
155 G A -0.4584
156 P A -0.4815
157 G A -0.7739
158 E A -1.8193
159 A A 0.0000
160 T A 0.0000
161 A A 0.0000
162 V A 0.0000
163 E A -0.6118
164 W A 0.0000
165 G A -0.6765
166 P A -0.8357
167 N A -1.5076
168 T A 0.0000
169 W A 0.0000
170 M A 0.0000
171 V A 0.0000
172 E A -0.2018
173 Y A 0.0000
174 G A 0.0000
175 R A -0.3657
176 G A 0.2660
177 V A 0.9762
178 I A 0.0000
179 P A 0.4764
180 S A 0.5061
181 T A 0.4025
182 L A 0.3754
183 A A 0.0005
184 F A 0.0000
185 A A 0.2454
186 L A 0.9941
187 A A 0.0000
188 D A 0.0000
189 T A 0.0000
190 V A 1.5817
191 F A 1.2148
192 S A 0.0000
193 T A 0.0000
194 Q A 0.0096
195 D A 0.0000
196 F A 2.4820
197 L A 1.7906
198 T A 0.0000
199 L A 1.7845
200 F A 1.7305
201 Y A 0.8603
202 T A 0.5471
203 L A 0.2813
204 R A -1.3904
205 S A -1.1300
206 Y A -0.5755
207 A A -1.3231
208 R A -2.0643
209 G A 0.0000
210 L A -0.4682
211 R A -1.3598
212 L A -0.1132
213 E A 0.0000
214 L A 1.7378
215 T A 1.8157
216 T A 1.9565
217 Y A 3.0079
218 L A 3.4318
219 F A 3.2094
1 M B 1.1398
2 Q B 0.1752
3 W B 1.3786
4 A B 1.1768
5 V B 1.3326
6 G B -0.5500
7 R B -1.9123
8 R B -1.7706
9 W B 0.4611
10 A B 0.7067
11 W B 0.9054
12 A B 1.2689
13 A B 1.8323
14 L B 3.1392
15 L B 3.1490
16 L B 3.2938
17 A B 2.9249
18 V B 3.1252
19 A B 2.4473
20 A B 2.2222
21 V B 3.0418
22 L B 3.0780
23 T B 1.7682
24 Q B 1.7374
25 V B 2.7627
26 V B 2.9452
27 W B 3.0640
28 L B 3.2036
29 W B 2.8959
30 L B 2.5875
31 G B 1.3532
32 T B 0.8169
33 Q B 0.1959
34 S B -0.0463
35 F B -0.0414
36 V B -0.0350
37 F B 0.0000
38 Q B -2.4511
39 R B -3.1823
40 E B -2.6805
41 E B -2.4639
42 I B 0.0000
43 A B 0.0000
44 Q B -2.6936
45 L B 0.0000
46 A B 0.0000
47 R B -3.0702
48 Q B -2.2170
49 Y B -1.4675
50 A B -1.2264
51 G B -1.0570
52 L B -0.8801
53 D B -2.0005
54 H B -1.8288
55 E B -2.2471
56 L B -1.0740
57 A B 0.0000
58 F B 0.0000
59 S B -0.5078
60 R B -0.8668
61 L B 0.0000
62 I B 0.0497
63 V B 0.6845
64 E B -0.4762
65 L B 0.0000
66 R B -0.6981
67 R B -1.3470
68 L B 0.1259
69 H B -0.5135
70 P B -0.9435
71 G B -0.1133
72 H B -0.0945
73 V B 0.0000
74 L B 0.0000
75 P B -1.8265
76 D B -2.9061
77 E B -3.0542
78 E B -2.5319
79 L B -1.5853
80 Q B -1.2236
81 W B -0.3116
82 V B 0.0000
83 F B 0.0000
84 V B 0.2580
85 N B 0.0000
86 A B 0.0000
87 G B 0.0000
88 G B -0.6433
89 W B 0.0000
90 M B 0.0000
91 G B 0.0000
92 A B 0.0000
93 M B 0.0000
94 C B 0.0000
95 L B 0.0000
96 L B 0.0000
97 H B 0.0000
98 A B 0.0000
99 S B 0.8157
100 L B 1.6375
101 S B 0.7299
102 E B 0.0000
103 Y B 0.0000
104 V B 0.0000
105 L B 0.0000
106 L B 0.0000
107 F B 0.0000
108 G B 0.0000
109 T B 0.0000
110 A B 0.0000
111 L B 0.0000
112 G B -0.6310
113 S B 0.0000
114 R B -0.8980
115 G B 0.0000
116 H B 0.0000
117 S B -0.3571
118 G B 0.0000
119 R B -0.3470
120 Y B 0.1289
121 W B 0.7760
122 A B 0.0000
123 E B -1.2390
124 I B 0.0000
125 S B -0.2556
126 D B 0.0000
127 T B 0.0000
128 I B 0.0000
129 I B 0.0000
130 S B -0.4511
131 G B -0.2019
132 T B 0.2189
133 F B 0.0000
134 H B -0.5786
135 Q B 0.0000
136 W B 0.0000
137 R B -1.9102
138 E B -1.6667
139 G B -1.3451
140 T B -1.2055
141 T B 0.0000
142 K B -2.5897
143 S B -2.1715
144 E B -2.0698
145 V B -0.1787
146 F B 0.3331
147 Y B 1.0707
148 P B -0.2380
149 G B -1.3897
150 E B -0.9768
151 T B -0.5022
152 V B 0.0000
153 V B 1.0124
154 H B 0.0000
155 G B -0.4538
156 P B -0.6181
157 G B -0.6380
158 E B -1.2434
159 A B 0.0000
160 T B 0.0000
161 A B 0.0000
162 V B 0.0000
163 E B -0.5160
164 W B 0.0000
165 G B -0.6220
166 P B -0.7818
167 N B -1.3613
168 T B 0.0000
169 W B 0.0000
170 M B 0.0000
171 V B 0.0000
172 E B -0.1096
173 Y B 0.0000
174 G B 0.0000
175 R B -0.5598
176 G B 0.2325
177 V B 1.0679
178 I B 0.0000
179 P B 0.5939
180 S B 0.5627
181 T B 0.0000
182 L B 0.4631
183 A B 0.0352
184 F B 0.0000
185 A B 0.3133
186 L B 0.7366
187 A B 0.0000
188 D B 0.0000
189 T B 0.0000
190 V B 0.9905
191 F B 1.0350
192 S B 0.0000
193 T B 0.0000
194 Q B 0.2680
195 D B 0.0000
196 F B 2.1959
197 L B 1.9154
198 T B 0.0000
199 L B 1.9803
200 F B 2.4886
201 Y B 1.2355
202 T B 0.0000
203 L B 0.4567
204 R B -1.0316
205 S B -0.8550
206 Y B -0.2101
207 A B -1.0907
208 R B -1.6594
209 G B 0.0000
210 L B -0.1020
211 R B -1.1085
212 L B 0.0740
213 E B 0.0000
214 L B 2.2780
215 T B 1.8261
216 T B 2.0461
217 Y B 3.0145
218 L B 3.5568
219 F B 3.2734
2 Q C -0.4978
3 W C 0.8771
4 A C 0.7963
5 V C 0.9078
6 G C -0.5315
7 R C -1.9793
8 R C -1.5843
9 W C 0.5466
10 A C 0.9919
11 W C 1.1173
12 A C 1.3786
13 A C 2.1804
14 L C 3.0132
15 L C 3.0612
16 L C 3.3484
17 A C 2.8879
18 V C 3.0231
19 A C 2.3992
20 A C 2.0313
21 V C 2.8600
22 L C 2.7722
23 T C 1.6163
24 Q C 1.3865
25 V C 2.4442
26 V C 2.8026
27 W C 2.9258
28 L C 2.9430
29 W C 2.6591
30 L C 2.4005
31 G C 1.1869
32 T C 0.5100
33 Q C -0.1352
34 S C -0.1625
35 F C 0.1527
36 V C 0.2383
37 F C 0.0000
38 Q C -2.4869
39 R C -3.3655
40 E C -3.3890
41 E C -2.4773
42 I C 0.0000
43 A C 0.0000
44 Q C -2.6500
45 L C 0.0000
46 A C 0.0000
47 R C -2.3638
48 Q C -2.1312
49 Y C -1.4088
50 A C -1.0148
51 G C -0.8286
52 L C -0.7670
53 D C -1.9772
54 H C 0.0000
55 E C -2.2765
56 L C -1.2239
57 A C 0.0000
58 F C 0.0000
59 S C -0.7815
60 R C -1.4141
61 L C 0.0000
62 I C -0.2545
63 V C 0.3623
64 E C -0.8870
65 L C 0.0000
66 R C -1.0772
67 R C -1.7209
68 L C -0.5184
69 H C -0.6572
70 P C -1.1636
71 G C -0.2268
72 H C -0.2039
73 V C 0.0000
74 L C 0.0000
75 P C -1.6966
76 D C -2.8112
77 E C -2.9312
78 E C -2.2067
79 L C -1.3364
80 Q C -0.9312
81 W C -0.2731
82 V C 0.0000
83 F C 0.0000
84 V C 0.0000
85 N C 0.0000
86 A C 0.0000
87 G C 0.0000
88 G C -0.6528
89 W C 0.0000
90 M C 0.0000
91 G C 0.0000
92 A C 0.0000
93 M C 0.0000
94 C C 0.0000
95 L C 0.0000
96 L C 0.0000
97 H C 0.0000
98 A C 0.0000
99 S C 0.7458
100 L C 1.6071
101 S C 0.7379
102 E C 0.0000
103 Y C 0.0000
104 V C 0.0000
105 L C 0.0903
106 L C 0.0000
107 F C 0.0000
108 G C 0.0000
109 T C 0.0000
110 A C 0.0000
111 L C 0.0000
112 G C 0.0000
113 S C -0.5479
114 R C -0.7434
115 G C 0.0000
116 H C 0.0000
117 S C -0.4907
118 G C 0.0000
119 R C -0.4280
120 Y C 0.0963
121 W C 0.8489
122 A C 0.0000
123 E C -0.3099
124 I C 0.0000
125 S C 0.0858
126 D C 0.0000
127 T C 0.0000
128 I C 0.0000
129 I C 0.0000
130 S C -0.5265
131 G C -0.2504
132 T C 0.2571
133 F C 0.0000
134 H C 0.0876
135 Q C 0.0000
136 W C 0.0000
137 R C -1.9265
138 E C -1.6717
139 G C -1.2676
140 T C -1.1896
141 T C -1.6332
142 K C -2.2486
143 S C -1.2158
144 E C -0.3581
145 V C 1.1476
146 F C 1.0491
147 Y C 1.2789
148 P C -0.0244
149 G C -1.0788
150 E C -0.5518
151 T C -0.3388
152 V C 0.0000
153 V C 1.5504
154 H C 0.0000
155 G C -0.2735
156 P C -0.5009
157 G C -0.8976
158 E C -1.9621
159 A C 0.0000
160 T C 0.0000
161 A C 0.0000
162 V C 0.0000
163 E C -0.5225
164 W C 0.0000
165 G C -0.6294
166 P C -1.0033
167 N C -1.4341
168 T C 0.0000
169 W C 0.0000
170 M C 0.0000
171 V C 0.0000
172 E C 0.0086
173 Y C 0.0000
174 G C 0.0000
175 R C -0.3405
176 G C 0.4505
177 V C 1.1536
178 I C 0.0000
179 P C 0.5902
180 S C 0.5511
181 T C 0.0000
182 L C 0.4684
183 A C 0.1718
184 F C 0.0000
185 A C 0.2237
186 L C 0.5101
187 A C 0.0000
188 D C 0.0000
189 T C 0.0000
190 V C 1.0340
191 F C 1.0258
192 S C 0.0000
193 T C 0.0000
194 Q C -0.1325
195 D C 0.0000
196 F C 2.3153
197 L C 1.6816
198 T C 0.0000
199 L C 1.5851
200 F C 1.5740
201 Y C 0.7912
202 T C 0.0000
203 L C 0.3607
204 R C -1.1407
205 S C 0.0000
206 Y C -0.2169
207 A C -0.8844
208 R C -1.0675
209 G C 0.0000
210 L C -0.1201
211 R C -1.0463
212 L C -0.0045
213 E C 0.6973
214 L C 1.8611
215 T C 1.6190
216 T C 1.6123
217 Y C 2.6483
218 L C 3.2491
219 F C 2.9678
220 G C 1.3401

 

Laboratory of Theory of Biopolymers 2015