Project name: wild

Chain sequence(s)	A: MRSGSHHHHHHRSDITSLYKKAGSAAAPFTMENLYFQSYQGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0142
• Maximal score value: 2.025
• Average score: -0.5925
• Total score value: -231.67

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.0962
2	R	A	-1.5552
3	S	A	-0.6551
4	G	A	-0.5180
5	S	A	-0.3347
6	H	A	0.0000
7	H	A	-0.5658
8	H	A	-0.7219
9	H	A	-1.1742
10	H	A	-1.8493
11	H	A	-1.6186
12	R	A	-1.7769
13	S	A	0.0000
14	D	A	0.0000
15	I	A	0.8003
16	T	A	0.0274
17	S	A	0.0880
18	L	A	0.1944
19	Y	A	0.0000
20	K	A	-1.5175
21	K	A	-2.2408
22	A	A	-1.2019
23	G	A	-1.2877
24	S	A	-0.8704
25	A	A	0.0000
26	A	A	-0.0192
27	A	A	0.3618
28	P	A	-0.0984
29	F	A	0.0000
30	T	A	-0.6906
31	M	A	-0.6549
32	E	A	-2.0561
33	N	A	-1.4113
34	L	A	0.0487
35	Y	A	0.6471
36	F	A	0.0485
37	Q	A	-0.9244
38	S	A	-1.0007
39	Y	A	-0.9850
40	Q	A	0.0000
41	G	A	-0.6474
42	N	A	-0.9077
43	S	A	0.0000
44	D	A	-0.3645
45	C	A	0.3458
46	Y	A	1.0708
47	F	A	0.0000
48	G	A	0.0000
49	N	A	0.0000
50	G	A	0.0000
51	S	A	0.0000
52	A	A	-0.9859
53	Y	A	0.0000
54	R	A	-0.7839
55	G	A	-0.6649
56	T	A	-0.3891
57	H	A	-0.2291
58	S	A	-0.1004
59	L	A	-0.2571
60	T	A	0.0000
61	E	A	-2.1901
62	S	A	-1.3931
63	G	A	-1.1614
64	A	A	-0.8103
65	S	A	-0.2620
66	C	A	0.0000
67	L	A	0.0009
68	P	A	-0.8802
69	W	A	0.0000
70	N	A	-1.2181
71	S	A	0.3734
72	M	A	1.5897
73	I	A	2.0250
74	L	A	0.0000
75	I	A	0.6962
76	G	A	-0.1485
77	K	A	-0.4219
78	V	A	0.6994
79	Y	A	0.9143
80	T	A	0.3792
81	A	A	-0.0084
82	Q	A	-0.3049
83	N	A	-0.4859
84	P	A	-0.5288
85	S	A	-0.9327
86	A	A	0.0000
87	Q	A	0.0000
88	A	A	0.0000
89	L	A	0.0000
90	G	A	0.0000
91	L	A	0.0000
92	G	A	-1.5667
93	K	A	-2.3874
94	H	A	-1.4050
95	N	A	0.0000
96	Y	A	-0.2213
97	C	A	0.0000
98	R	A	0.0000
99	N	A	0.0000
100	P	A	-1.1572
101	D	A	-2.0428
102	G	A	-1.6830
103	D	A	-1.3343
104	A	A	-0.8529
105	K	A	-1.0335
106	P	A	0.0000
107	W	A	-0.1751
108	C	A	0.0000
109	H	A	0.0000
110	V	A	0.0000
111	L	A	-1.1551
112	K	A	-2.7385
113	N	A	-3.1595
114	R	A	-3.5115
115	R	A	-3.0588
116	L	A	-1.1484
117	T	A	-0.6339
118	W	A	0.1533
119	E	A	-0.6129
120	Y	A	-0.3317
121	C	A	0.0000
122	D	A	-1.4621
123	V	A	0.0000
124	P	A	-0.2657
125	S	A	-0.1094
126	C	A	0.0589
127	S	A	0.0000
128	T	A	0.0000
129	C	A	0.0000
130	G	A	-0.0145
131	L	A	0.4246
132	R	A	0.0000
133	Q	A	-0.5895
134	Y	A	0.4572
135	S	A	-0.2234
136	Q	A	-0.8994
137	P	A	-1.5070
138	Q	A	-2.0205
139	F	A	-0.9323
140	R	A	-1.0930
141	I	A	1.0748
142	K	A	0.0000
143	G	A	-0.0166
144	G	A	0.2886
145	L	A	1.7255
146	F	A	0.9669
147	A	A	-0.1298
148	D	A	-1.0789
149	I	A	0.0000
150	A	A	0.0000
151	S	A	0.0000
152	H	A	0.0000
153	P	A	0.0000
154	W	A	0.0000
155	Q	A	0.0000
156	A	A	0.0000
157	A	A	0.0000
158	I	A	0.0000
159	F	A	0.0000
160	A	A	0.0000
161	K	A	-2.9992
162	H	A	-3.0835
163	R	A	-3.8766
164	R	A	-4.0142
165	S	A	-2.1985
166	P	A	-1.7189
167	G	A	-2.4542
168	E	A	-3.2079
169	R	A	-2.6184
170	F	A	-0.9628
171	L	A	-0.1665
172	C	A	0.0000
173	G	A	0.0000
174	G	A	0.0000
175	I	A	0.0000
176	L	A	0.0000
177	I	A	0.0000
178	S	A	-0.7667
179	S	A	-1.2541
180	C	A	0.0000
181	W	A	0.0000
182	I	A	0.0000
183	L	A	0.0000
184	S	A	0.0000
185	A	A	0.0000
186	A	A	0.0000
187	H	A	-1.4057
188	C	A	-0.5002
189	F	A	0.0000
190	Q	A	0.0000
191	E	A	-2.6286
192	R	A	-2.6094
193	F	A	-1.6810
194	P	A	-1.4313
195	P	A	-1.7985
196	H	A	-1.9127
197	H	A	-2.1163
198	L	A	0.0000
199	T	A	-1.5024
200	V	A	0.0000
201	I	A	0.0000
202	L	A	-0.3132
203	G	A	0.0000
204	R	A	-0.0449
205	T	A	0.2870
206	Y	A	1.2528
207	R	A	0.8570
208	V	A	2.0101
209	V	A	1.5337
210	P	A	0.5017
211	G	A	-1.0481
212	E	A	-2.1298
213	E	A	-1.8968
214	E	A	-2.6875
215	Q	A	-2.4714
216	K	A	-2.3551
217	F	A	0.0000
218	E	A	-3.2548
219	V	A	0.0000
220	E	A	-2.5669
221	K	A	-1.9627
222	Y	A	-0.5593
223	I	A	-0.4140
224	V	A	-0.6361
225	H	A	-1.3958
226	K	A	-2.5925
227	E	A	-2.7084
228	F	A	-2.1302
229	D	A	-2.5432
230	D	A	-3.1189
231	D	A	-2.9989
232	T	A	-1.4477
233	Y	A	0.0000
234	D	A	-1.8958
235	N	A	-1.7515
236	D	A	0.0000
237	I	A	0.0000
238	A	A	0.0000
239	L	A	0.0000
240	L	A	0.0000
241	Q	A	-1.9486
242	L	A	0.0000
243	K	A	-2.8356
244	S	A	-2.4069
245	D	A	-3.3769
246	S	A	0.0000
247	S	A	0.0000
248	R	A	-2.4031
249	C	A	-1.7302
250	A	A	-1.3159
251	Q	A	-2.2647
252	E	A	-2.1118
253	S	A	-1.5495
254	S	A	0.0000
255	V	A	0.4702
256	V	A	0.0000
257	R	A	-0.9682
258	T	A	0.0000
259	V	A	0.0000
260	C	A	0.3968
261	L	A	0.2119
262	P	A	0.0000
263	P	A	-0.6671
264	A	A	-1.2066
265	D	A	-2.1518
266	L	A	-1.0589
267	Q	A	-1.5142
268	L	A	0.0000
269	P	A	-1.7104
270	D	A	-2.2215
271	W	A	-1.0157
272	T	A	-0.8260
273	E	A	-1.1712
274	C	A	0.0000
275	E	A	0.0000
276	L	A	0.0000
277	S	A	0.0000
278	G	A	0.0000
279	Y	A	0.0000
280	G	A	0.0000
281	K	A	-0.4782
282	H	A	-0.4680
283	E	A	-1.5981
284	A	A	-0.0787
285	L	A	1.1209
286	S	A	0.4899
287	P	A	0.9047
288	F	A	1.7065
289	Y	A	0.6554
290	S	A	0.5051
291	E	A	0.0000
292	R	A	-0.1022
293	L	A	0.0000
294	K	A	0.1328
295	E	A	0.0000
296	A	A	0.0000
297	H	A	0.0000
298	V	A	0.0000
299	R	A	-0.8131
300	L	A	0.0000
301	Y	A	0.0000
302	P	A	-1.0371
303	S	A	-1.2149
304	S	A	-1.2784
305	R	A	-2.4180
306	C	A	0.0000
307	T	A	-0.4359
308	S	A	-0.3362
309	Q	A	0.0000
310	H	A	0.0000
311	L	A	0.6244
312	L	A	1.5206
313	N	A	-0.0395
314	R	A	-0.4375
315	T	A	0.3892
316	V	A	1.5764
317	T	A	0.0893
318	D	A	-1.4663
319	N	A	0.0000
320	M	A	0.0000
321	L	A	-0.1371
322	C	A	0.0000
323	A	A	0.0000
324	G	A	0.0000
325	D	A	-2.0243
326	T	A	-1.2318
327	R	A	0.0000
328	S	A	-1.2881
329	G	A	-1.9209
330	G	A	-1.7975
331	P	A	-1.4965
332	Q	A	-1.8786
333	A	A	-0.9824
334	N	A	-0.5570
335	L	A	0.6930
336	H	A	-0.0519
337	D	A	-0.2039
338	A	A	-0.0778
339	C	A	-0.5807
340	Q	A	0.0000
341	G	A	0.0000
342	D	A	0.0000
343	S	A	-0.0884
344	G	A	0.0000
345	G	A	0.0000
346	P	A	0.0000
347	L	A	0.0000
348	V	A	0.0000
349	C	A	0.0000
350	L	A	-1.2807
351	N	A	0.0000
352	D	A	-2.5450
353	G	A	-1.8047
354	R	A	-1.4201
355	M	A	0.0000
356	T	A	0.0000
357	L	A	0.0000
358	V	A	-0.0118
359	G	A	0.0000
360	I	A	0.0000
361	I	A	0.0000
362	S	A	-0.3166
363	W	A	-0.1625
364	G	A	-0.2932
365	L	A	0.4202
366	G	A	-0.3285
367	C	A	0.0000
368	G	A	-1.2188
369	Q	A	-1.7626
370	K	A	-1.2521
371	D	A	-1.8222
372	V	A	0.0000
373	P	A	0.0000
374	G	A	0.0000
375	V	A	0.0000
376	Y	A	0.0000
377	T	A	0.0000
378	K	A	-0.3982
379	V	A	0.0000
380	T	A	0.0000
381	N	A	0.0000
382	Y	A	0.0000
383	L	A	0.0000
384	D	A	-1.4559
385	W	A	-1.2356
386	I	A	0.0000
387	R	A	-2.8661
388	D	A	-3.0980
389	N	A	-2.0850
390	M	A	0.0000
391	R	A	-2.8651