Project name: 9fda774566ef3fe

Chain sequence(s)	A: SIGPVADLTISNGAVSPDGFSRQAILVNDVFPSPLITGNKGDRFQLNVIDNMTNHTMLKSTSIHWHGFFQHGTNWADGPAFVNQCPISTGHAFLYDFQVPDQAGTFWYHSHLSTQYCDGLRGPIVVYDPQDPHKSLYDVDDDSTVITLADWYHLAAKVGPAAPTADATLINGLGRSIDTLNADLAVITVTKGKRYRFRLVSLSCDPNYTFSIDGHSLTVIEADGVNLKPQTVDSIQIFPAQRYSFVLNADQDVDNYWIRALPNSGTRNFDGGVNSAILRYEGAAPVEPTTTQTPSTQPLVESALTTLEGTAAPGNPTPGGVDLALNMAFGFAGGRFTINGASFTPPTVPVLLQILSGAQSAQDLLPSGSVYSLPANADIEISLPATSAAPGFPHPFHLHGHTFAVVRSAGSSTYNYANPVYRDVVNTGSPGDNVTIRFRTDNPGPWFLHCHIDFHLEAGFTVVMAEDIPEVAATNPVPQAWSDLCPTYDALSPDDQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3492
• Maximal score value: 1.441
• Average score: -0.4885
• Total score value: -242.2945

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	S	A	-0.4313
2	I	A	0.4045
3	G	A	0.0569
4	P	A	-0.2581
5	V	A	0.8458
6	A	A	-0.0161
7	D	A	-1.4135
8	L	A	0.0000
9	T	A	-0.9677
10	I	A	0.0000
11	S	A	-0.9518
12	N	A	-1.0204
13	G	A	-0.6927
14	A	A	-0.2982
15	V	A	0.0438
16	S	A	-0.0211
17	P	A	0.0000
18	D	A	0.0000
19	G	A	-0.7366
20	F	A	0.2892
21	S	A	-0.1076
22	R	A	0.0000
23	Q	A	-1.1780
24	A	A	0.0000
25	I	A	0.0000
26	L	A	-0.4272
27	V	A	0.0000
28	N	A	-1.0898
29	D	A	-1.3591
30	V	A	0.3915
31	F	A	0.4539
32	P	A	0.2333
33	S	A	0.0000
34	P	A	0.1012
35	L	A	-0.1572
36	I	A	0.0000
37	T	A	-0.3894
38	G	A	0.0000
39	N	A	-1.9348
40	K	A	-2.6987
41	G	A	-2.4099
42	D	A	-2.5171
43	R	A	-2.7870
44	F	A	0.0000
45	Q	A	-0.6680
46	L	A	0.0000
47	N	A	-0.4255
48	V	A	0.0000
49	I	A	-0.4943
50	D	A	0.0000
51	N	A	-1.5717
52	M	A	0.0000
53	T	A	-1.2692
54	N	A	-1.4074
55	H	A	-1.4649
56	T	A	-0.6241
57	M	A	0.0000
58	L	A	-0.8980
59	K	A	-1.4073
60	S	A	0.0000
61	T	A	0.0000
62	S	A	0.0000
63	I	A	0.0000
64	H	A	0.0000
65	W	A	0.0000
66	H	A	0.0000
67	G	A	0.0663
68	F	A	0.0000
69	F	A	-0.3475
70	Q	A	0.0000
71	H	A	-1.3163
72	G	A	-0.6019
73	T	A	-0.4647
74	N	A	0.0000
75	W	A	0.0000
76	A	A	0.0000
77	D	A	0.0000
78	G	A	0.0000
79	P	A	0.0000
80	A	A	0.0000
81	F	A	0.3299
82	V	A	0.0000
83	N	A	0.0000
84	Q	A	0.0000
85	C	A	0.0000
86	P	A	0.0000
87	I	A	0.0000
88	S	A	0.0000
89	T	A	-1.0843
90	G	A	-1.1602
91	H	A	-1.0320
92	A	A	-0.4837
93	F	A	0.0000
94	L	A	0.1496
95	Y	A	0.0000
96	D	A	-0.7566
97	F	A	0.0000
98	Q	A	-2.8449
99	V	A	0.0000
100	P	A	-2.3800
101	D	A	-2.3434
102	Q	A	-1.5574
103	A	A	-1.0291
104	G	A	0.0000
105	T	A	0.0000
106	F	A	0.0000
107	W	A	0.0000
108	Y	A	0.0000
109	H	A	0.0000
110	S	A	0.0000
111	H	A	0.0000
112	L	A	0.0000
113	S	A	-0.6304
114	T	A	0.0000
115	Q	A	0.0000
116	Y	A	0.0000
117	C	A	0.0000
118	D	A	0.0000
119	G	A	0.0000
120	L	A	0.0000
121	R	A	0.0000
122	G	A	0.0000
123	P	A	0.0000
124	I	A	0.0000
125	V	A	0.0000
126	V	A	0.0000
127	Y	A	-0.9158
128	D	A	-1.5329
129	P	A	-1.5388
130	Q	A	-1.9273
131	D	A	-1.6178
132	P	A	-1.1504
133	H	A	0.0000
134	K	A	-2.1047
135	S	A	-1.0401
136	L	A	-0.4994
137	Y	A	-1.1437
138	D	A	-1.7766
139	V	A	-1.3810
140	D	A	-1.6758
141	D	A	-2.2056
142	D	A	-2.5129
143	S	A	-1.4483
144	T	A	0.0000
145	V	A	0.0000
146	I	A	0.0000
147	T	A	0.0000
148	L	A	0.0000
149	A	A	0.0000
150	D	A	0.0000
151	W	A	0.0000
152	Y	A	0.0000
153	H	A	0.6165
154	L	A	1.4410
155	A	A	0.0000
156	A	A	0.0935
157	K	A	-0.4420
158	V	A	1.3503
159	G	A	0.7297
160	P	A	0.0561
161	A	A	-0.3692
162	A	A	-0.4496
163	P	A	-0.0508
164	T	A	-0.2843
165	A	A	-0.3568
166	D	A	-0.3621
167	A	A	0.0000
168	T	A	0.0000
169	L	A	0.0000
170	I	A	0.0000
171	N	A	-0.1718
172	G	A	0.0000
173	L	A	-0.1153
174	G	A	0.0000
175	R	A	0.0000
176	S	A	0.0000
177	I	A	0.7098
178	D	A	-0.8816
179	T	A	-0.6109
180	L	A	-0.6506
181	N	A	-1.6054
182	A	A	-1.5355
183	D	A	-1.8844
184	L	A	0.0000
185	A	A	0.0000
186	V	A	0.6414
187	I	A	0.0000
188	T	A	-0.5820
189	V	A	0.0000
190	T	A	-1.9948
191	K	A	-3.2302
192	G	A	-2.6561
193	K	A	-2.5035
194	R	A	-2.0857
195	Y	A	0.0000
196	R	A	0.0000
197	F	A	0.0000
198	R	A	0.0000
199	L	A	0.0000
200	V	A	0.0000
201	S	A	0.0000
202	L	A	0.0000
203	S	A	0.0000
204	C	A	0.0000
205	D	A	-0.3824
206	P	A	0.0000
207	N	A	-0.5007
208	Y	A	0.0000
209	T	A	-0.4595
210	F	A	0.0000
211	S	A	-0.4653
212	I	A	0.0000
213	D	A	0.0000
214	G	A	-1.2254
215	H	A	0.0000
216	S	A	-0.7849
217	L	A	0.0000
218	T	A	-0.5576
219	V	A	0.0000
220	I	A	0.0000
221	E	A	0.0000
222	A	A	0.0000
223	D	A	0.0000
224	G	A	-0.0818
225	V	A	-0.0521
226	N	A	-0.7687
227	L	A	0.0000
228	K	A	-1.9821
229	P	A	-1.0264
230	Q	A	-0.8990
231	T	A	-0.8300
232	V	A	0.0000
233	D	A	-1.0423
234	S	A	0.0000
235	I	A	0.0000
236	Q	A	-0.7645
237	I	A	0.0000
238	F	A	-0.2312
239	P	A	0.0000
240	A	A	0.0000
241	Q	A	0.0000
242	R	A	0.0000
243	Y	A	0.0000
244	S	A	0.0000
245	F	A	0.0000
246	V	A	0.0000
247	L	A	0.0000
248	N	A	-2.3156
249	A	A	0.0000
250	D	A	-3.3492
251	Q	A	-2.6483
252	D	A	-2.5082
253	V	A	-1.5566
254	D	A	-1.4755
255	N	A	0.0000
256	Y	A	0.0000
257	W	A	-0.2434
258	I	A	0.0000
259	R	A	0.0000
260	A	A	0.0000
261	L	A	-0.6796
262	P	A	0.0000
263	N	A	-1.4224
264	S	A	-1.1305
265	G	A	-1.3407
266	T	A	-1.4175
267	R	A	-2.6676
268	N	A	-2.2591
269	F	A	-1.3851
270	D	A	-1.8276
271	G	A	-0.9506
272	G	A	0.0000
273	V	A	0.0000
274	N	A	0.0000
275	S	A	0.0000
276	A	A	0.0000
277	I	A	0.0000
278	L	A	0.0000
279	R	A	-0.7155
280	Y	A	0.0000
281	E	A	-2.3209
282	G	A	-1.5093
283	A	A	-0.8321
284	A	A	-0.1447
285	P	A	0.2901
286	V	A	0.9169
287	E	A	-0.4501
288	P	A	0.0000
289	T	A	-0.3924
290	T	A	-0.6870
291	T	A	-0.7444
292	Q	A	-1.3654
293	T	A	-0.9484
294	P	A	-0.8431
295	S	A	-0.9871
296	T	A	-0.9013
297	Q	A	-1.3431
298	P	A	-0.6626
299	L	A	0.0000
300	V	A	1.0592
301	E	A	0.3361
302	S	A	0.1498
303	A	A	0.2555
304	L	A	0.0000
305	T	A	-1.0074
306	T	A	0.0000
307	L	A	-1.2232
308	E	A	-2.0655
309	G	A	-1.4547
310	T	A	-0.8177
311	A	A	-0.7120
312	A	A	-0.7025
313	P	A	-0.8965
314	G	A	-1.5241
315	N	A	-1.7740
316	P	A	-0.9522
317	T	A	-0.7577
318	P	A	-0.6957
319	G	A	-1.0525
320	G	A	-1.2622
321	V	A	-1.4085
322	D	A	-2.1303
323	L	A	-0.4764
324	A	A	-0.4993
325	L	A	-0.3624
326	N	A	-1.3147
327	M	A	0.0000
328	A	A	-0.6811
329	F	A	0.0000
330	G	A	-0.2352
331	F	A	-0.1308
332	A	A	-0.5980
333	G	A	-1.1357
334	G	A	-1.3912
335	R	A	-2.2038
336	F	A	0.0000
337	T	A	-0.7350
338	I	A	0.0000
339	N	A	-1.3328
340	G	A	-0.8623
341	A	A	-0.8411
342	S	A	-0.7440
343	F	A	0.0000
344	T	A	-0.4830
345	P	A	-0.1722
346	P	A	0.0000
347	T	A	0.1406
348	V	A	0.8005
349	P	A	0.0000
350	V	A	0.0000
351	L	A	0.0000
352	L	A	0.6147
353	Q	A	0.0000
354	I	A	0.0000
355	L	A	0.2482
356	S	A	-0.1809
357	G	A	-0.6479
358	A	A	-1.0196
359	Q	A	-1.7666
360	S	A	-1.4590
361	A	A	-1.0422
362	Q	A	-1.7432
363	D	A	-1.6237
364	L	A	0.0000
365	L	A	0.7606
366	P	A	0.2973
367	S	A	-0.3700
368	G	A	-0.7354
369	S	A	0.0000
370	V	A	0.0000
371	Y	A	-0.0743
372	S	A	-0.4057
373	L	A	0.0000
374	P	A	-1.1365
375	A	A	-1.6348
376	N	A	-2.5351
377	A	A	0.0000
378	D	A	-2.0722
379	I	A	0.0000
380	E	A	0.0000
381	I	A	0.0000
382	S	A	-0.5743
383	L	A	0.0000
384	P	A	-0.6519
385	A	A	-0.3905
386	T	A	-0.3515
387	S	A	-0.2273
388	A	A	0.1060
389	A	A	0.0000
390	P	A	-0.0714
391	G	A	-0.2535
392	F	A	0.2684
393	P	A	0.0614
394	H	A	0.0000
395	P	A	0.0000
396	F	A	0.0000
397	H	A	0.0000
398	L	A	0.0000
399	H	A	0.0000
400	G	A	0.0000
401	H	A	0.0000
402	T	A	-0.0892
403	F	A	0.0000
404	A	A	0.0000
405	V	A	0.0000
406	V	A	0.0000
407	R	A	-0.4019
408	S	A	0.0000
409	A	A	-0.5109
410	G	A	-0.6438
411	S	A	-0.3906
412	S	A	-0.4960
413	T	A	-0.1129
414	Y	A	0.1781
415	N	A	-0.3141
416	Y	A	-0.4574
417	A	A	-0.4928
418	N	A	-1.0259
419	P	A	0.0000
420	V	A	0.0000
421	Y	A	0.1017
422	R	A	0.0000
423	D	A	0.0000
424	V	A	0.0000
425	V	A	0.0000
426	N	A	-0.1555
427	T	A	0.0000
428	G	A	0.0000
429	S	A	-0.4792
430	P	A	-0.6073
431	G	A	-0.9310
432	D	A	-0.9811
433	N	A	-0.8306
434	V	A	0.0000
435	T	A	0.0000
436	I	A	0.0000
437	R	A	0.0000
438	F	A	0.0000
439	R	A	-2.9194
440	T	A	0.0000
441	D	A	-2.7865
442	N	A	0.0000
443	P	A	-1.3003
444	G	A	0.0000
445	P	A	0.0000
446	W	A	0.0000
447	F	A	0.0000
448	L	A	0.0000
449	H	A	0.0000
450	C	A	0.0000
451	H	A	0.0000
452	I	A	0.0000
453	D	A	0.0000
454	F	A	0.0000
455	H	A	0.0000
456	L	A	-0.8359
457	E	A	-1.7873
458	A	A	-1.4529
459	G	A	0.0000
460	F	A	0.0000
461	T	A	0.0000
462	V	A	0.0000
463	V	A	0.0000
464	M	A	0.0000
465	A	A	0.0000
466	E	A	0.0000
467	D	A	-1.2264
468	I	A	0.0000
469	P	A	-1.2634
470	E	A	-1.6261
471	V	A	0.0000
472	A	A	-0.3330
473	A	A	-0.5046
474	T	A	-0.5533
475	N	A	0.0000
476	P	A	-0.0298
477	V	A	0.2711
478	P	A	-0.4944
479	Q	A	-1.3438
480	A	A	-0.6865
481	W	A	0.0000
482	S	A	-0.7730
483	D	A	-1.2241
484	L	A	0.0000
485	C	A	-0.6279
486	P	A	-1.0059
487	T	A	-0.8587
488	Y	A	-0.9682
489	D	A	-1.7216
490	A	A	-0.8390
491	L	A	-1.0587
492	S	A	-1.3705
493	P	A	-1.6191
494	D	A	-2.7560
495	D	A	-2.3459
496	Q	A	-1.8207