| Chain sequence(s) |
A: QVQLQESGPGLVKPSETLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTIEVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHDPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6580 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1233 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8529 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.7720 | |
| 8 | G | A | -0.6215 | |
| 9 | P | A | -0.6449 | |
| 10 | G | A | -0.5256 | |
| 11 | L | A | -0.4992 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.1529 | |
| 14 | P | A | -1.4421 | |
| 15 | S | A | -1.2422 | |
| 16 | E | A | -1.5804 | |
| 17 | T | A | -1.1508 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.7648 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.8270 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1376 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3047 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8558 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2007 | |
| 31 | S | A | 0.0131 | |
| 32 | G | A | 0.1227 | |
| 33 | Y | A | 0.1678 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8023 | |
| 40 | P | A | -0.9913 | |
| 41 | P | A | -1.1111 | |
| 42 | G | A | -1.5000 | |
| 43 | K | A | -2.3696 | |
| 44 | G | A | -1.5302 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6544 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | -0.1521 | |
| 53 | Y | A | 0.5837 | |
| 54 | S | A | -0.4388 | |
| 55 | G | A | -1.2607 | |
| 56 | D | A | -1.7981 | |
| 57 | T | A | -0.6696 | |
| 58 | Y | A | 0.2641 | |
| 59 | Y | A | 0.1088 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -1.1641 | |
| 62 | S | A | -1.1268 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0232 | |
| 65 | S | A | -1.2869 | |
| 66 | R | A | -1.3409 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.8422 | |
| 69 | I | A | 0.0000 | |
| 70 | E | A | -2.1663 | |
| 71 | V | A | -1.0648 | |
| 72 | D | A | -1.4621 | |
| 73 | T | A | -1.2928 | |
| 74 | S | A | -1.3202 | |
| 75 | K | A | -2.1216 | |
| 76 | N | A | -1.4410 | |
| 77 | Q | A | -1.4617 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.9505 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.4714 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -0.9289 | |
| 84 | S | A | -0.9400 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.5546 | |
| 87 | A | A | -0.2041 | |
| 88 | A | A | 0.0287 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0314 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1143 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6567 | |
| 98 | Y | A | -0.0491 | |
| 99 | G | A | -0.0546 | |
| 100 | S | A | -0.0066 | |
| 101 | Y | A | 0.3147 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4122 | |
| 105 | Y | A | -0.7859 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8501 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.5060 | |
| 111 | T | A | -0.2153 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2928 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.8292 | |
| 116 | S | A | -0.9372 | |
| 117 | A | A | -0.5577 | |
| 118 | S | A | -0.6634 | |
| 119 | T | A | -0.7544 | |
| 120 | K | A | -1.1973 | |
| 121 | G | A | -1.3226 | |
| 122 | P | A | -0.6135 | |
| 123 | S | A | -0.5037 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3991 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8950 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4433 | |
| 131 | S | A | -0.5230 | |
| 132 | R | A | -0.8408 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8776 | |
| 135 | S | A | -1.3492 | |
| 136 | E | A | -2.0839 | |
| 137 | S | A | -1.3290 | |
| 138 | T | A | -0.9476 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2824 | |
| 147 | D | A | -0.3910 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.5488 | |
| 152 | P | A | -0.6717 | |
| 153 | V | A | -0.6125 | |
| 154 | T | A | -0.5226 | |
| 155 | V | A | -0.3147 | |
| 156 | S | A | -0.4494 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0235 | |
| 159 | S | A | -0.7661 | |
| 160 | G | A | -0.5940 | |
| 161 | A | A | -0.2855 | |
| 162 | L | A | -0.1378 | |
| 163 | T | A | -0.2471 | |
| 164 | S | A | -0.2729 | |
| 165 | G | A | -0.3904 | |
| 166 | V | A | 0.0724 | |
| 167 | H | A | -0.2450 | |
| 168 | T | A | -0.0007 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3746 | |
| 171 | A | A | 0.2261 | |
| 172 | V | A | 0.5568 | |
| 173 | L | A | 1.3014 | |
| 174 | Q | A | 0.3144 | |
| 175 | S | A | -0.0375 | |
| 176 | S | A | -0.2032 | |
| 177 | G | A | 0.0467 | |
| 178 | L | A | 0.1728 | |
| 179 | Y | A | 0.4669 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1878 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6422 | |
| 189 | S | A | -0.6882 | |
| 190 | S | A | -0.5541 | |
| 191 | S | A | -0.6696 | |
| 192 | L | A | -0.8205 | |
| 193 | G | A | -1.1781 | |
| 194 | T | A | -0.9134 | |
| 195 | K | A | -1.6647 | |
| 196 | T | A | -1.5067 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7170 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.7900 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.6923 | |
| 205 | P | A | -1.6503 | |
| 206 | S | A | -1.8325 | |
| 207 | N | A | -2.5146 | |
| 208 | T | A | -2.0427 | |
| 209 | K | A | -2.6346 | |
| 210 | V | A | -1.9800 | |
| 211 | D | A | -2.9235 | |
| 212 | K | A | -2.7080 | |
| 213 | R | A | -3.1170 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6277 | |
| 216 | S | A | -1.1012 | |
| 217 | D | B | -1.7075 | |
| 218 | I | B | -0.5643 | |
| 219 | V | B | 0.7719 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4404 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3579 | |
| 224 | P | B | -0.2701 | |
| 225 | L | B | 0.0088 | |
| 226 | S | B | -0.5873 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -1.0231 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6618 | |
| 231 | P | B | -2.0224 | |
| 232 | G | B | -1.9004 | |
| 233 | Q | B | -2.3079 | |
| 234 | P | B | -2.1025 | |
| 235 | A | B | -1.2811 | |
| 236 | S | B | -0.7920 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8519 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -1.9729 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8288 | |
| 243 | Q | B | -1.4554 | |
| 244 | S | B | -0.9319 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | -0.1580 | |
| 247 | H | B | -0.9592 | |
| 248 | S | B | -1.1081 | |
| 249 | N | B | -1.7852 | |
| 250 | G | B | -1.3707 | |
| 251 | N | B | -1.2451 | |
| 252 | T | B | -0.5520 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1556 | |
| 260 | K | B | -1.7930 | |
| 261 | P | B | -1.4370 | |
| 262 | G | B | -1.6478 | |
| 263 | Q | B | -2.0434 | |
| 264 | S | B | -1.4097 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.3240 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4294 | |
| 271 | K | B | -0.7952 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9539 | |
| 274 | N | B | -1.3194 | |
| 275 | R | B | -1.7777 | |
| 276 | F | B | -0.6860 | |
| 277 | S | B | -0.5958 | |
| 278 | G | B | -0.8122 | |
| 279 | V | B | -0.9096 | |
| 280 | P | B | -1.2753 | |
| 281 | D | B | -2.2293 | |
| 282 | R | B | -2.0452 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3345 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7772 | |
| 287 | G | B | -0.9597 | |
| 288 | S | B | -0.7515 | |
| 289 | G | B | -0.8026 | |
| 290 | T | B | -1.4247 | |
| 291 | D | B | -1.9431 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9683 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5641 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2775 | |
| 298 | R | B | -3.0397 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6184 | |
| 301 | A | B | -2.3035 | |
| 302 | E | B | -2.4736 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7815 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -1.3518 | |
| 315 | D | B | -1.6036 | |
| 316 | P | B | 0.0000 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | -0.2972 | |
| 319 | F | B | 0.1338 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2505 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.8283 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.7107 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5014 | |
| 329 | R | B | -0.9946 | |
| 330 | T | B | -0.0400 | |
| 331 | V | B | 0.3353 | |
| 332 | A | B | -0.0763 | |
| 333 | A | B | -0.1508 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1349 | |
| 336 | V | B | -0.1358 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.7081 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.6591 | |
| 343 | D | B | -3.1569 | |
| 344 | E | B | -3.1689 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.2583 | |
| 347 | K | B | -2.8169 | |
| 348 | S | B | -1.7966 | |
| 349 | G | B | -1.0557 | |
| 350 | T | B | -1.1113 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0826 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.7802 | |
| 363 | R | B | -3.1715 | |
| 364 | E | B | -3.2849 | |
| 365 | A | B | -2.3932 | |
| 366 | K | B | -2.4483 | |
| 367 | V | B | -1.0628 | |
| 368 | Q | B | -0.5338 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.7770 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1132 | |
| 373 | N | B | -1.6576 | |
| 374 | A | B | -0.3824 | |
| 375 | L | B | 0.7089 | |
| 376 | Q | B | -0.1886 | |
| 377 | S | B | -0.4600 | |
| 378 | G | B | -0.8901 | |
| 379 | N | B | -0.7903 | |
| 380 | S | B | -1.1426 | |
| 381 | Q | B | -1.4792 | |
| 382 | E | B | -1.9995 | |
| 383 | S | B | -0.9151 | |
| 384 | V | B | -0.8529 | |
| 385 | T | B | -1.2787 | |
| 386 | E | B | -2.3560 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2473 | |
| 389 | S | B | -2.4094 | |
| 390 | K | B | -2.7099 | |
| 391 | D | B | -1.9361 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.6745 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4447 | |
| 402 | L | B | -0.8020 | |
| 403 | S | B | -1.3866 | |
| 404 | K | B | -2.1635 | |
| 405 | A | B | -2.1659 | |
| 406 | D | B | -3.0289 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.8244 | |
| 409 | K | B | -3.8748 | |
| 410 | H | B | -3.3294 | |
| 411 | K | B | -3.4586 | |
| 412 | V | B | -2.1847 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.8120 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.7915 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.1969 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.7778 | |
| 421 | G | B | -0.4894 | |
| 422 | L | B | -0.2787 | |
| 423 | S | B | -0.4370 | |
| 424 | S | B | -0.4212 | |
| 425 | P | B | -0.5259 | |
| 426 | V | B | 0.1703 | |
| 427 | T | B | -0.3246 | |
| 428 | K | B | -0.6272 | |
| 429 | S | B | -0.9524 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5723 | |
| 432 | R | B | -3.0208 | |
| 433 | G | B | -2.3460 | |
| 434 | E | B | -2.2501 | |
| 435 | C | B | -0.7282 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine