Project name: 1JNY elongation factor alpha 1

Chain sequence(s)	A: KPHLNLIVIGHVDHGKSTLVGRLLMDRGFIDEKTVKEAEEAAKKLGKESEKFAFLLDRLKEEMRFETKKYFFTIIDAPGHRDFVKNMITGASQADAAILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLDQLIVAVNKMDLTEPPYDEKRYKEIVDQVSKFMRSYGFNTNKVRFVPVVAPSGDNITHKSENMKWYNGPTLEEYLDQLELPPKPVDKPLRIPIQDVYSISGVGTVPVGRVESGVLKVGDKIVFMPAGKVGEVRSIETHHTKMDKAEPGDNIGFNVRGVEKKDIKRGDVVGHPNNPPTVADEFTARIIVVWHPTALANGYTPVLHVHTASVACRVSELVSKLDPRTGQEAEKNPQFLKQGDVAIVKFKPIKPLCVEKYNEFPPLGRFAMRDMGKTVGVGIIVDVKP; B: KPHLNLIVIGHVDHGKSTLVGRLLMDRGFIDEKTVKEAEEAAKKLGKESEKFAFLLDRMRFETKKYFFTIIDAPGHRDFVKNMITGASQADAAILVVSAKKGEYEAGMSVEGQTREHIILAKTMGLDQLIVAVNKMDLTEPPYDEKRYKEIVDQVSKFMRSYGFNTNKVRFVPVVAPSGDNITHKSENMKWYNGPTLEEYLDQLELPPKPVDKPLRIPIQDVYSISGVGTVPVGRVESGVLKVGDKIVFMPAGKVGEVRSIETHHTKMDKAEPGDNIGFNVRGVEKKDIKRGDVVGHPNNPPTVADEFTARIIVVWHPTALANGYTPVLHVHTASVACRVSELVSKLDPRTGQEAEKNPQFLKQGDVAIVKFKPIKPLCVEKYNEFPPLGRFAMRDMGKTVGVGIIVDVKPA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.7951
• Maximal score value: 1.8505
• Average score: -1.0419
• Total score value: -861.6503

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
4	K	A	-2.5350
5	P	A	-1.4534
6	H	A	-1.8796
7	L	A	0.0000
8	N	A	-1.4044
9	L	A	0.0000
10	I	A	0.0000
11	V	A	0.0000
12	I	A	0.0000
13	G	A	0.0000
14	H	A	-0.1420
15	V	A	0.6261
16	D	A	-1.1203
17	H	A	0.0000
18	G	A	-0.5951
19	K	A	-0.4872
20	S	A	-0.5150
21	T	A	-0.4352
22	L	A	0.0000
23	V	A	0.1572
24	G	A	0.0000
25	R	A	-0.4003
26	L	A	0.0000
27	L	A	0.0000
28	M	A	0.3678
29	D	A	-0.4807
30	R	A	-0.7618
31	G	A	0.2887
32	F	A	1.2490
33	I	A	-0.1206
34	D	A	-2.6325
35	E	A	-3.7019
36	K	A	-3.9123
37	T	A	0.0000
38	V	A	-2.8446
39	K	A	-4.4816
40	E	A	-4.3738
41	A	A	0.0000
42	E	A	-3.9522
43	E	A	-4.1375
44	A	A	-3.2037
45	A	A	-3.7553
46	K	A	-4.1039
47	K	A	-2.8928
48	L	A	-1.5133
49	G	A	-2.5565
50	K	A	-3.4376
51	E	A	-3.3794
52	S	A	-2.0079
53	E	A	-2.4020
54	K	A	-2.4187
55	F	A	0.0000
56	A	A	-0.8303
57	F	A	-1.2417
58	L	A	0.0000
59	L	A	-1.6722
60	D	A	-3.2080
61	R	A	-2.8805
62	L	A	-2.4211
63	K	A	-3.8878
64	E	A	-4.1596
65	E	A	-3.5055
77	M	A	0.9454
78	R	A	-0.0784
79	F	A	0.0000
80	E	A	-1.4429
81	T	A	0.0000
82	K	A	-2.9310
83	K	A	-2.9596
84	Y	A	0.0000
85	F	A	-1.4131
86	F	A	0.0000
87	T	A	-0.5898
88	I	A	0.0208
89	I	A	-0.7752
90	D	A	-2.4133
91	A	A	-1.4830
92	P	A	0.0000
93	G	A	-2.2964
94	H	A	-3.2163
95	R	A	-3.7434
96	D	A	-3.2653
97	F	A	0.0000
98	V	A	0.0000
99	K	A	-1.3560
100	N	A	-1.4742
101	M	A	-0.6072
102	I	A	0.0000
103	T	A	-0.3602
104	G	A	-0.5081
105	A	A	-0.5215
106	S	A	-1.1199
107	Q	A	-1.3246
108	A	A	-1.3908
109	D	A	-2.0048
110	A	A	0.0000
111	A	A	0.0000
112	I	A	0.0000
113	L	A	0.0000
114	V	A	0.0000
115	V	A	0.0000
116	S	A	0.0000
117	A	A	0.0000
118	K	A	-2.0948
119	K	A	-2.7271
120	G	A	-1.9933
121	E	A	-1.7764
122	Y	A	0.0000
123	E	A	-1.4900
124	A	A	-0.9017
125	G	A	0.0000
126	M	A	-0.7160
127	S	A	-0.2956
128	V	A	0.5352
129	E	A	-1.2307
130	G	A	0.0000
131	Q	A	-0.5949
132	T	A	0.0000
133	R	A	-0.5698
134	E	A	-0.9558
135	H	A	0.0000
136	I	A	0.0000
137	I	A	0.1100
138	L	A	0.0000
139	A	A	0.0000
140	K	A	-0.8359
141	T	A	-0.4202
142	M	A	-0.6867
143	G	A	-1.1037
144	L	A	0.0000
145	D	A	-1.7198
146	Q	A	-2.2571
147	L	A	0.0000
148	I	A	0.0000
149	V	A	0.0000
150	A	A	0.0000
151	V	A	0.0000
152	N	A	0.0000
153	K	A	-0.6671
154	M	A	0.0000
155	D	A	-1.1269
156	L	A	-0.5608
157	T	A	0.0000
158	E	A	-2.5267
159	P	A	-1.5404
160	P	A	-1.3409
161	Y	A	-1.3910
162	D	A	-1.9392
163	E	A	-2.4105
164	K	A	-3.0712
165	R	A	0.0000
166	Y	A	0.0000
167	K	A	-3.0582
168	E	A	-2.9616
169	I	A	0.0000
170	V	A	-1.9592
171	D	A	-2.7888
172	Q	A	-2.7557
173	V	A	0.0000
174	S	A	-2.3860
175	K	A	-2.8379
176	F	A	-1.5617
177	M	A	0.0000
178	R	A	-2.9137
179	S	A	-1.3523
180	Y	A	-0.4344
181	G	A	-1.1285
182	F	A	0.0000
183	N	A	-2.7326
184	T	A	-2.7348
185	N	A	-2.8382
186	K	A	-3.0389
187	V	A	0.0000
188	R	A	-1.5318
189	F	A	-0.3220
190	V	A	0.0000
191	P	A	0.0000
192	V	A	0.0000
193	V	A	0.0000
194	A	A	0.0000
195	P	A	-0.4318
196	S	A	-0.3873
197	G	A	0.0000
198	D	A	0.0000
199	N	A	0.0000
200	I	A	0.0000
201	T	A	-1.0830
202	H	A	-1.8851
203	K	A	-2.9348
204	S	A	-2.5552
205	E	A	-3.1993
206	N	A	-2.6911
207	M	A	0.0000
208	K	A	-2.7979
209	W	A	-1.3707
210	Y	A	-1.5580
211	N	A	-1.7192
212	G	A	-1.0081
213	P	A	-1.1442
214	T	A	0.0000
215	L	A	0.0000
216	E	A	-1.1975
217	E	A	-1.6912
218	Y	A	-1.0113
219	L	A	0.0000
220	D	A	0.0000
221	Q	A	-2.2539
222	L	A	0.0000
223	E	A	-2.0502
224	L	A	-0.9370
225	P	A	-1.1227
226	P	A	-1.8842
227	K	A	-2.2919
228	P	A	-1.9263
229	V	A	-1.3748
230	D	A	-2.3731
231	K	A	-1.8720
232	P	A	-1.1817
233	L	A	0.0000
234	R	A	0.0000
235	I	A	0.0000
236	P	A	0.0000
237	I	A	0.0000
238	Q	A	-2.1424
239	D	A	-1.2897
240	V	A	-0.6240
241	Y	A	0.9015
242	S	A	0.7606
243	I	A	1.4853
244	S	A	0.4604
245	G	A	0.0714
246	V	A	0.4903
247	G	A	-0.0700
248	T	A	-0.5799
249	V	A	0.0000
250	P	A	0.0000
251	V	A	-0.6919
252	G	A	0.0000
253	R	A	-2.2733
254	V	A	0.0000
255	E	A	-1.2964
256	S	A	0.0000
257	G	A	0.0000
258	V	A	-0.9182
259	L	A	0.0000
260	K	A	-2.6890
261	V	A	-2.0754
262	G	A	-2.2691
263	D	A	-2.4297
264	K	A	-3.0047
265	I	A	0.0000
266	V	A	0.0000
267	F	A	0.0000
268	M	A	-0.3323
269	P	A	-0.6430
270	A	A	-0.7639
271	G	A	-0.4792
272	K	A	-0.9464
273	V	A	-0.7138
274	G	A	0.0000
275	E	A	-3.1222
276	V	A	0.0000
277	R	A	-3.0054
278	S	A	-2.2769
279	I	A	0.0000
280	E	A	-2.6121
281	T	A	-2.0717
282	H	A	-2.1065
283	H	A	-2.1226
284	T	A	-1.9284
285	K	A	-2.8908
286	M	A	-2.3429
287	D	A	-3.0328
288	K	A	-2.6952
289	A	A	0.0000
290	E	A	-1.7032
291	P	A	-1.5672
292	G	A	-1.5307
293	D	A	-2.0513
294	N	A	-2.1158
295	I	A	0.0000
296	G	A	-1.0796
297	F	A	0.0000
298	N	A	-0.8826
299	V	A	0.0000
300	R	A	-2.8699
301	G	A	-2.0781
302	V	A	0.0000
303	E	A	-3.2054
304	K	A	-2.8167
305	K	A	-3.1252
306	D	A	-2.6145
307	I	A	0.0000
308	K	A	-3.2175
309	R	A	-3.0686
310	G	A	0.0000
311	D	A	-1.4682
312	V	A	0.0000
313	V	A	0.0000
314	G	A	0.0000
315	H	A	-1.2516
316	P	A	-1.4484
317	N	A	-1.9658
318	N	A	-1.5751
319	P	A	-0.9015
320	P	A	0.0000
321	T	A	-0.4821
322	V	A	-0.5043
323	A	A	0.0000
324	D	A	-2.5639
325	E	A	-2.4262
326	F	A	0.0000
327	T	A	0.0000
328	A	A	0.0000
329	R	A	-0.3742
330	I	A	0.0000
331	I	A	0.0000
332	V	A	0.0000
333	V	A	0.6058
334	W	A	-0.1656
335	H	A	0.0000
336	P	A	-0.7435
337	T	A	-0.6861
338	A	A	-0.5308
339	L	A	0.0000
340	A	A	-0.6589
341	N	A	-1.9428
342	G	A	-1.6329
343	Y	A	-0.9430
344	T	A	-0.8158
345	P	A	0.0000
346	V	A	0.1697
347	L	A	0.0000
348	H	A	-0.6831
349	V	A	0.0000
350	H	A	-0.7185
351	T	A	-1.1287
352	A	A	0.0000
353	S	A	-0.6097
354	V	A	0.0000
355	A	A	-0.0985
356	C	A	0.0000
357	R	A	-2.0441
358	V	A	0.0000
359	S	A	-1.8598
360	E	A	-1.8270
361	L	A	0.0000
362	V	A	-1.3178
363	S	A	0.0000
364	K	A	-2.1590
365	L	A	0.0000
366	D	A	-1.9595
367	P	A	-2.3813
368	R	A	-3.0962
369	T	A	-2.0442
370	G	A	-1.6063
371	Q	A	-2.0494
372	E	A	-3.0717
373	A	A	-2.5592
374	E	A	-3.6553
375	K	A	-3.4758
376	N	A	-2.2470
377	P	A	0.0000
378	Q	A	-1.4153
379	F	A	0.0044
380	L	A	0.0000
381	K	A	-1.6149
382	Q	A	-1.6294
383	G	A	-1.0441
384	D	A	-0.9178
385	V	A	0.0000
386	A	A	0.0000
387	I	A	-0.5575
388	V	A	0.0000
389	K	A	-1.4434
390	F	A	0.0000
391	K	A	-2.1485
392	P	A	0.0000
393	I	A	0.4022
394	K	A	-1.1924
395	P	A	-1.0605
396	L	A	0.0000
397	C	A	0.0000
398	V	A	0.0000
399	E	A	0.0000
400	K	A	-1.9908
401	Y	A	-1.6571
402	N	A	-2.5218
403	E	A	-2.7399
404	F	A	0.0000
405	P	A	-1.2658
406	P	A	-0.8338
407	L	A	0.0000
408	G	A	0.0000
409	R	A	-0.6965
410	F	A	0.0000
411	A	A	-0.3436
412	M	A	0.0000
413	R	A	-1.4189
414	D	A	-1.0998
415	M	A	0.0000
416	G	A	-1.2256
417	K	A	-1.2697
418	T	A	-0.6205
419	V	A	0.0000
420	G	A	0.0000
421	V	A	0.1157
422	G	A	0.0000
423	I	A	-0.3745
424	I	A	0.0000
425	V	A	-0.9702
426	D	A	-1.7606
427	V	A	-1.6714
428	K	A	-2.4016
429	P	A	-1.5748
4	K	B	-2.4529
5	P	B	-1.4050
6	H	B	-1.1153
7	L	B	0.0000
8	N	B	-0.6417
9	L	B	0.0000
10	I	B	0.0000
11	V	B	0.0000
12	I	B	0.0000
13	G	B	0.0000
14	H	B	0.0592
15	V	B	0.6538
16	D	B	-1.0988
17	H	B	0.0000
18	G	B	-0.5230
19	K	B	-0.4159
20	S	B	-0.4586
21	T	B	-0.3279
22	L	B	0.0000
23	V	B	-0.0369
24	G	B	0.0000
25	R	B	-0.4188
26	L	B	0.0000
27	L	B	0.0000
28	M	B	0.1325
29	D	B	-0.6986
30	R	B	-1.1015
31	G	B	-0.1204
32	F	B	0.7244
33	I	B	-0.6213
34	D	B	-2.5650
35	E	B	-3.5084
36	K	B	-4.2737
37	T	B	-3.6342
38	V	B	-3.1355
39	K	B	-4.5502
40	E	B	-4.3406
41	A	B	0.0000
42	E	B	-4.3383
43	E	B	-4.7951
44	A	B	0.0000
45	A	B	0.0000
46	K	B	-4.4350
47	K	B	-3.4495
48	L	B	-2.2472
49	G	B	-2.7902
50	K	B	-3.4352
51	E	B	-3.9689
52	S	B	-2.2125
53	E	B	-2.4644
54	K	B	-2.4945
55	F	B	-0.8699
56	A	B	-0.8375
57	F	B	-1.4083
58	L	B	0.0000
59	L	B	-0.7959
60	D	B	-2.2850
61	R	B	-2.5769
77	M	B	0.6135
78	R	B	-0.9331
79	F	B	0.0000
80	E	B	-1.5063
81	T	B	0.0000
82	K	B	-3.0069
83	K	B	-3.0639
84	Y	B	0.0000
85	F	B	-1.1907
86	F	B	0.0000
87	T	B	0.0000
88	I	B	0.0000
89	I	B	0.2813
90	D	B	0.0000
91	A	B	0.0000
92	P	B	0.0000
93	G	B	-1.8316
94	H	B	-2.7644
95	R	B	-3.2618
96	D	B	-2.2876
97	F	B	0.0000
98	V	B	0.0000
99	K	B	-1.0803
100	N	B	-0.8455
101	M	B	0.0000
102	I	B	0.0000
103	T	B	-0.3307
104	G	B	0.0000
105	A	B	-0.3772
106	S	B	0.0000
107	Q	B	-1.2457
108	A	B	-0.7598
109	D	B	-1.0739
110	A	B	0.0000
111	A	B	0.0000
112	I	B	0.0000
113	L	B	0.0000
114	V	B	0.0000
115	V	B	0.0000
116	S	B	0.0000
117	A	B	0.0000
118	K	B	-1.9960
119	K	B	-2.6124
120	G	B	-1.7355
121	E	B	-1.5824
122	Y	B	0.0000
123	E	B	-1.2955
124	A	B	-0.7118
125	G	B	0.0000
126	M	B	-0.4390
127	S	B	-0.0905
128	V	B	0.6653
129	E	B	-1.4470
130	G	B	0.0000
131	Q	B	0.0000
132	T	B	0.0000
133	R	B	-0.2778
134	E	B	-0.5388
135	H	B	0.0000
136	I	B	0.0000
137	I	B	0.2695
138	L	B	0.0562
139	A	B	0.0000
140	K	B	-0.6484
141	T	B	0.0000
142	M	B	-0.6889
143	G	B	-1.1261
144	L	B	0.0000
145	D	B	-1.8938
146	Q	B	-1.6457
147	L	B	0.0000
148	I	B	0.0000
149	V	B	0.0000
150	A	B	0.0000
151	V	B	0.0000
152	N	B	0.0000
153	K	B	-0.6167
154	M	B	0.0000
155	D	B	-1.0414
156	L	B	-0.3639
157	T	B	0.0000
158	E	B	-2.6352
159	P	B	-1.7244
160	P	B	-1.3149
161	Y	B	-1.6070
162	D	B	0.0000
163	E	B	-3.3168
164	K	B	-3.6817
165	R	B	-3.0844
166	Y	B	0.0000
167	K	B	-3.9039
168	E	B	-3.8282
169	I	B	0.0000
170	V	B	-2.2736
171	D	B	-3.2851
172	Q	B	-2.5285
173	V	B	0.0000
174	S	B	-2.4788
175	K	B	-2.8884
176	F	B	0.0000
177	M	B	0.0000
178	R	B	-2.6349
179	S	B	-1.3021
180	Y	B	-0.2370
181	G	B	-1.2489
182	F	B	0.0000
183	N	B	-2.5857
184	T	B	-2.4407
185	N	B	-2.2633
186	K	B	-2.1566
187	V	B	0.0000
188	R	B	-0.5699
189	F	B	-0.0738
190	V	B	0.0000
191	P	B	0.0000
192	V	B	0.0000
193	V	B	0.0000
194	A	B	0.0000
195	P	B	-0.3885
196	S	B	-0.4705
197	G	B	0.0000
198	D	B	0.0000
199	N	B	0.0000
200	I	B	0.0000
201	T	B	-1.0867
202	H	B	-1.7730
203	K	B	-2.9555
204	S	B	0.0000
205	E	B	-3.2425
206	N	B	-2.5890
207	M	B	0.0000
208	K	B	-2.9095
209	W	B	-1.3135
210	Y	B	-1.6167
211	N	B	-1.7416
212	G	B	-0.9246
213	P	B	-1.0656
214	T	B	0.0000
215	L	B	0.0000
216	E	B	-1.2014
217	E	B	-1.6121
218	Y	B	-0.8017
219	L	B	0.0000
220	D	B	0.0000
221	Q	B	-2.2894
222	L	B	0.0000
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