| Chain sequence(s) |
A: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP B: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 267 | K | A | -3.0335 | |
| 268 | H | A | -3.0243 | |
| 269 | Q | A | -2.0165 | |
| 270 | P | A | -1.2241 | |
| 271 | G | A | -1.3934 | |
| 272 | G | A | -1.5611 | |
| 273 | G | A | -2.1419 | |
| 274 | K | A | -2.0471 | |
| 275 | V | A | -0.2057 | |
| 276 | Q | A | -0.5731 | |
| 277 | I | A | 1.6682 | |
| 278 | I | A | 1.6122 | |
| 279 | N | A | 0.2971 | |
| 280 | K | A | -0.9839 | |
| 281 | K | A | -0.9717 | |
| 282 | L | A | 0.6411 | |
| 283 | D | A | -0.7027 | |
| 284 | L | A | -0.6499 | |
| 285 | S | A | -1.4186 | |
| 286 | N | A | -2.1206 | |
| 287 | V | A | -1.0806 | |
| 288 | Q | A | -1.0248 | |
| 289 | S | A | -1.7195 | |
| 290 | K | A | -1.8532 | |
| 291 | C | A | -0.1653 | |
| 292 | G | A | 0.0000 | |
| 293 | S | A | 0.0000 | |
| 294 | K | A | -1.6232 | |
| 295 | D | A | -2.4204 | |
| 296 | N | A | -1.5674 | |
| 297 | I | A | -0.6809 | |
| 298 | K | A | -1.5916 | |
| 299 | H | A | -0.7327 | |
| 300 | V | A | 0.0000 | |
| 301 | P | A | 0.0081 | |
| 302 | G | A | 0.5166 | |
| 303 | G | A | -0.2103 | |
| 304 | G | A | -0.7078 | |
| 305 | S | A | -0.0605 | |
| 306 | V | A | 1.5646 | |
| 307 | Q | A | 0.3969 | |
| 308 | I | A | 1.3001 | |
| 309 | V | A | 1.7110 | |
| 310 | Y | A | 1.2487 | |
| 311 | K | A | -0.9354 | |
| 312 | P | A | -0.5334 | |
| 2 | S | B | -1.0976 | |
| 3 | H | B | -1.4662 | |
| 4 | P | B | -1.3937 | |
| 5 | S | B | 0.0000 | |
| 6 | P | B | -1.3207 | |
| 7 | Q | B | -1.6725 | |
| 8 | A | B | -1.4072 | |
| 9 | K | B | -2.0346 | |
| 10 | P | B | -1.5202 | |
| 11 | S | B | -1.3208 | |
| 12 | N | B | -1.1764 | |
| 13 | P | B | -1.0430 | |
| 14 | S | B | -0.9944 | |
| 15 | N | B | 0.0000 | |
| 16 | P | B | -1.2474 | |
| 17 | R | B | -0.9376 | |
| 18 | V | B | 0.0000 | |
| 19 | F | B | 0.0000 | |
| 20 | F | B | 0.0000 | |
| 21 | D | B | 0.0000 | |
| 22 | V | B | 0.0000 | |
| 23 | D | B | 0.0000 | |
| 24 | I | B | -0.7252 | |
| 25 | G | B | -1.1277 | |
| 26 | G | B | -1.6798 | |
| 27 | E | B | -2.7567 | |
| 28 | R | B | -2.9920 | |
| 29 | V | B | -1.2352 | |
| 30 | G | B | -0.7209 | |
| 31 | R | B | -0.5784 | |
| 32 | I | B | 0.0000 | |
| 33 | V | B | 0.0000 | |
| 34 | L | B | 0.0000 | |
| 35 | E | B | 0.0000 | |
| 36 | L | B | 0.0000 | |
| 37 | F | B | 0.0000 | |
| 38 | A | B | -1.1855 | |
| 39 | D | B | -1.5214 | |
| 40 | I | B | -0.5334 | |
| 41 | V | B | 0.0000 | |
| 42 | P | B | -1.3051 | |
| 43 | K | B | -1.6965 | |
| 44 | T | B | 0.0000 | |
| 45 | A | B | 0.0000 | |
| 46 | E | B | -1.5182 | |
| 47 | N | B | 0.0000 | |
| 48 | F | B | 0.0000 | |
| 49 | R | B | -1.1537 | |
| 50 | A | B | 0.0000 | |
| 51 | L | B | 0.0000 | |
| 52 | C | B | 0.0000 | |
| 53 | T | B | -1.5198 | |
| 54 | G | B | -1.6504 | |
| 55 | E | B | -2.5592 | |
| 56 | K | B | -2.2337 | |
| 57 | G | B | -0.9946 | |
| 58 | I | B | 0.5809 | |
| 59 | G | B | 0.0000 | |
| 60 | P | B | -0.4547 | |
| 61 | T | B | -0.7580 | |
| 62 | T | B | -0.8864 | |
| 63 | G | B | -0.6189 | |
| 64 | K | B | -1.1593 | |
| 65 | P | B | -0.8935 | |
| 66 | L | B | 0.0000 | |
| 67 | H | B | -1.3424 | |
| 68 | F | B | 0.0000 | |
| 69 | K | B | -2.3498 | |
| 70 | G | B | -1.4933 | |
| 71 | C | B | 0.0000 | |
| 72 | P | B | 0.0000 | |
| 73 | F | B | 0.0000 | |
| 74 | H | B | 0.0000 | |
| 75 | R | B | -2.2048 | |
| 76 | I | B | 0.0000 | |
| 77 | I | B | -1.3522 | |
| 78 | K | B | -2.5969 | |
| 79 | K | B | -2.1739 | |
| 80 | F | B | -0.0231 | |
| 81 | M | B | 0.0000 | |
| 82 | I | B | 0.0000 | |
| 83 | Q | B | 0.0000 | |
| 84 | G | B | 0.0000 | |
| 85 | G | B | 0.0000 | |
| 86 | D | B | 0.0000 | |
| 87 | F | B | -1.3378 | |
| 88 | S | B | -1.5471 | |
| 89 | N | B | -2.3118 | |
| 90 | Q | B | -2.3014 | |
| 91 | N | B | -2.5359 | |
| 92 | G | B | -1.5609 | |
| 93 | T | B | -1.0849 | |
| 94 | G | B | -1.3082 | |
| 95 | G | B | -1.4990 | |
| 96 | E | B | 0.0000 | |
| 97 | S | B | 0.0000 | |
| 98 | I | B | -0.6283 | |
| 99 | Y | B | -0.2755 | |
| 100 | G | B | -1.2277 | |
| 101 | E | B | -2.6229 | |
| 102 | K | B | -3.0535 | |
| 103 | F | B | 0.0000 | |
| 104 | E | B | -2.8421 | |
| 105 | D | B | -2.2524 | |
| 106 | E | B | -1.4930 | |
| 107 | N | B | -0.9520 | |
| 108 | F | B | -0.6367 | |
| 109 | H | B | -0.8019 | |
| 110 | Y | B | -0.9306 | |
| 111 | K | B | -1.6247 | |
| 112 | H | B | 0.0000 | |
| 113 | D | B | -1.5082 | |
| 114 | K | B | -1.3276 | |
| 115 | E | B | -0.9855 | |
| 116 | G | B | 0.0000 | |
| 117 | L | B | 0.0000 | |
| 118 | L | B | 0.0000 | |
| 119 | S | B | 0.0000 | |
| 120 | M | B | 0.0000 | |
| 121 | A | B | -0.3719 | |
| 122 | N | B | -0.9127 | |
| 123 | A | B | -0.4439 | |
| 124 | G | B | -0.7592 | |
| 125 | S | B | -1.3467 | |
| 126 | N | B | -2.2831 | |
| 127 | T | B | -1.8637 | |
| 128 | N | B | 0.0000 | |
| 129 | G | B | -1.4467 | |
| 130 | S | B | 0.0000 | |
| 131 | Q | B | -0.3316 | |
| 132 | F | B | 0.0000 | |
| 133 | F | B | 0.0000 | |
| 134 | I | B | 0.0000 | |
| 135 | T | B | 0.0000 | |
| 136 | T | B | 0.0000 | |
| 137 | V | B | -0.5628 | |
| 138 | P | B | -0.9037 | |
| 139 | T | B | 0.0000 | |
| 140 | P | B | -1.3750 | |
| 141 | H | B | -1.6444 | |
| 142 | L | B | 0.0000 | |
| 143 | D | B | -1.6774 | |
| 144 | G | B | -1.6286 | |
| 145 | K | B | -2.0847 | |
| 146 | H | B | 0.0000 | |
| 147 | V | B | 0.0000 | |
| 148 | V | B | 0.0000 | |
| 149 | F | B | 0.0000 | |
| 150 | G | B | 0.0000 | |
| 151 | Q | B | 0.0000 | |
| 152 | V | B | 0.0000 | |
| 153 | I | B | 0.0000 | |
| 154 | K | B | -0.7057 | |
| 155 | G | B | 0.0000 | |
| 156 | M | B | -0.5181 | |
| 157 | G | B | -0.5482 | |
| 158 | V | B | 0.0000 | |
| 159 | A | B | 0.0000 | |
| 160 | K | B | -1.5595 | |
| 161 | I | B | -0.1845 | |
| 162 | L | B | 0.0000 | |
| 163 | E | B | 0.0000 | |
| 164 | N | B | -2.1620 | |
| 165 | V | B | -1.5100 | |
| 166 | E | B | -2.7141 | |
| 167 | V | B | -2.3393 | |
| 168 | K | B | -2.9056 | |
| 169 | G | B | -2.4309 | |
| 170 | E | B | -3.2976 | |
| 171 | K | B | -2.9574 | |
| 172 | P | B | 0.0000 | |
| 173 | A | B | -1.2248 | |
| 174 | K | B | -0.7619 | |
| 175 | L | B | 0.6595 | |
| 176 | C | B | 0.0000 | |
| 177 | V | B | -0.5538 | |
| 178 | I | B | 0.0000 | |
| 179 | A | B | -1.7829 | |
| 180 | E | B | -2.0205 | |
| 181 | C | B | -1.2847 | |
| 182 | G | B | -1.1498 | |
| 183 | E | B | -1.1816 | |
| 184 | L | B | -2.0705 | |
| 185 | K | B | -3.4495 | |
| 186 | E | B | -3.6315 | |
| 187 | G | B | -2.8566 | |
| 188 | D | B | -3.5390 | |
| 189 | D | B | -2.8151 | |
| 190 | W | B | -1.0608 | |
| 191 | G | B | -0.4248 | |
| 192 | I | B | 0.1551 | |
| 193 | F | B | 0.4557 | |
| 194 | P | B | -0.7989 | |
| 195 | K | B | -1.6189 | |
| 196 | D | B | -1.6089 | |
| 197 | G | B | -1.2475 | |
| 198 | S | B | -0.8212 | |
| 199 | G | B | -0.7937 | |
| 200 | D | B | 0.0000 | |
| 201 | S | B | -0.4549 | |
| 202 | H | B | -0.4691 | |
| 203 | P | B | -0.4134 | |
| 204 | D | B | -0.7097 | |
| 205 | F | B | -0.6754 | |
| 206 | P | B | 0.0000 | |
| 207 | E | B | -2.5071 | |
| 208 | D | B | -1.4463 | |
| 209 | A | B | -1.7212 | |
| 210 | D | B | -2.4439 | |
| 211 | V | B | -2.5218 | |
| 212 | D | B | -3.3866 | |
| 213 | L | B | -3.0388 | |
| 214 | K | B | -3.7361 | |
| 215 | D | B | -3.5668 | |
| 216 | V | B | 0.0000 | |
| 217 | D | B | -2.7896 | |
| 218 | K | B | -2.1530 | |
| 219 | I | B | 0.0000 | |
| 220 | L | B | -1.0118 | |
| 221 | L | B | -0.0295 | |
| 222 | I | B | 0.0000 | |
| 223 | S | B | 0.0000 | |
| 224 | E | B | -1.9473 | |
| 225 | D | B | -2.4255 | |
| 226 | L | B | 0.0000 | |
| 227 | K | B | -1.7147 | |
| 228 | N | B | -2.2811 | |
| 229 | I | B | -1.3031 | |
| 230 | G | B | 0.0000 | |
| 231 | N | B | -1.2157 | |
| 232 | T | B | -1.0770 | |
| 233 | F | B | -1.1544 | |
| 234 | F | B | -1.3344 | |
| 235 | K | B | -2.1003 | |
| 236 | S | B | -1.5798 | |
| 237 | Q | B | -2.1792 | |
| 238 | N | B | -1.5499 | |
| 239 | W | B | -1.3305 | |
| 240 | E | B | -1.6135 | |
| 241 | M | B | -1.0965 | |
| 242 | A | B | 0.0000 | |
| 243 | I | B | -0.9776 | |
| 244 | K | B | -1.7364 | |
| 245 | K | B | 0.0000 | |
| 246 | Y | B | 0.0000 | |
| 247 | T | B | -0.7414 | |
| 248 | K | B | 0.0000 | |
| 249 | V | B | 0.0000 | |
| 250 | L | B | -0.7656 | |
| 251 | R | B | -1.4397 | |
| 252 | Y | B | 0.0000 | |
| 253 | V | B | 0.0000 | |
| 254 | E | B | -1.8872 | |
| 255 | G | B | -1.8353 | |
| 256 | S | B | 0.0000 | |
| 257 | R | B | -2.7431 | |
| 258 | A | B | -1.5025 | |
| 259 | A | B | -1.9125 | |
| 260 | A | B | -2.7119 | |
| 261 | E | B | -3.0529 | |
| 262 | D | B | -2.7599 | |
| 263 | A | B | -2.1909 | |
| 264 | D | B | -3.0291 | |
| 265 | G | B | -2.8911 | |
| 266 | A | B | -2.0584 | |
| 267 | K | B | -2.2346 | |
| 268 | L | B | 0.0000 | |
| 269 | Q | B | -0.6610 | |
| 270 | P | B | -0.4948 | |
| 271 | V | B | 0.0000 | |
| 272 | A | B | 0.0000 | |
| 273 | L | B | -0.3751 | |
| 274 | S | B | -0.1007 | |
| 275 | C | B | 0.0000 | |
| 276 | V | B | 0.0000 | |
| 277 | L | B | -0.4641 | |
| 278 | N | B | -0.1836 | |
| 279 | I | B | 0.0000 | |
| 280 | G | B | 0.0000 | |
| 281 | A | B | -0.5989 | |
| 282 | C | B | 0.0000 | |
| 283 | K | B | -1.1250 | |
| 284 | L | B | -0.9744 | |
| 285 | K | B | -1.8017 | |
| 286 | M | B | -0.6848 | |
| 287 | S | B | -0.7490 | |
| 288 | D | B | -0.8303 | |
| 289 | W | B | -0.9312 | |
| 290 | Q | B | -1.2409 | |
| 291 | G | B | -0.9612 | |
| 292 | A | B | 0.0000 | |
| 293 | V | B | 0.0000 | |
| 294 | D | B | -1.6136 | |
| 295 | S | B | 0.0000 | |
| 296 | C | B | 0.0000 | |
| 297 | L | B | -0.9103 | |
| 298 | E | B | -2.2055 | |
| 299 | A | B | 0.0000 | |
| 300 | L | B | -1.2168 | |
| 301 | E | B | -2.0459 | |
| 302 | I | B | -0.9161 | |
| 303 | D | B | -1.0705 | |
| 304 | P | B | -0.6838 | |
| 305 | S | B | -0.6329 | |
| 306 | N | B | 0.0000 | |
| 307 | T | B | -1.1070 | |
| 308 | K | B | -1.6531 | |
| 309 | A | B | 0.0000 | |
| 310 | L | B | 0.0000 | |
| 311 | Y | B | -0.8915 | |
| 312 | R | B | -0.9315 | |
| 313 | R | B | -0.8744 | |
| 314 | A | B | 0.0000 | |
| 315 | Q | B | -0.7087 | |
| 316 | G | B | 0.0000 | |
| 317 | W | B | -1.0872 | |
| 318 | Q | B | 0.0000 | |
| 319 | G | B | -0.6569 | |
| 320 | L | B | -0.7368 | |
| 321 | K | B | -2.1509 | |
| 322 | E | B | -1.9880 | |
| 323 | Y | B | -1.9861 | |
| 324 | D | B | -2.4877 | |
| 325 | Q | B | -1.9757 | |
| 326 | A | B | 0.0000 | |
| 327 | L | B | -1.2244 | |
| 328 | A | B | -1.2235 | |
| 329 | D | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | K | B | -2.2281 | |
| 332 | K | B | -2.0055 | |
| 333 | A | B | 0.0000 | |
| 334 | Q | B | -2.4372 | |
| 335 | E | B | -2.5077 | |
| 336 | I | B | -0.6582 | |
| 337 | A | B | -1.5999 | |
| 338 | P | B | -2.3387 | |
| 339 | E | B | -2.8961 | |
| 340 | D | B | -2.5984 | |
| 341 | K | B | -2.6934 | |
| 342 | A | B | -1.3331 | |
| 343 | I | B | 0.0000 | |
| 344 | Q | B | -1.6002 | |
| 345 | A | B | -0.5170 | |
| 346 | E | B | 0.0000 | |
| 347 | L | B | -0.5958 | |
| 348 | L | B | 0.0711 | |
| 349 | K | B | -1.4446 | |
| 350 | V | B | 0.0000 | |
| 351 | K | B | -2.2676 | |
| 352 | Q | B | -2.6626 | |
| 353 | K | B | -2.8534 | |
| 354 | I | B | -3.3773 | |
| 355 | K | B | -4.0971 | |
| 356 | A | B | -3.5308 | |
| 357 | Q | B | -4.1544 | |
| 358 | K | B | -4.9581 | |
| 359 | D | B | -5.2004 | |
| 360 | K | B | -4.8719 | |
| 361 | E | B | -4.9265 | |
| 362 | K | B | -4.1532 | |
| 363 | A | B | -2.2860 | |
| 364 | A | B | -0.3825 | |
| 365 | Y | B | 1.3566 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine