Project name: a2c0a5a4ff70397

Chain sequence(s)	A: KYCPKTYTFDDGKVIIKAGARVEEEKVKRLYWASKEVNSQFFRVYGIDKPLEEGNPDDILTMVIYNSPEEYKLNSVLYGYDTNNGGMYIEPEGTFFTYEREAQESTYTLEELFRHEYTHYLQGRYAVPGQWGRTKLYDNDRLTWYEEGGAELFAGSTRTSGILPRKSIVSNIHNTTRNNRYKLSDTVHSKYGASFEFYNYACMFMDYMYNKDMGILNKLNDLAKNNDVDGYDNYIRDLSSNHALNDKYQDHMQERIDNYENLTVPFVADDYLVRHAYKNPNEIYSEISEVAKLKDAKSEVKKSQYFSTFTLRGSYTGGVSKGKLEDQKAMNKFIDDSLKKLDTYSWSGYKTLTAYFTNYKVDSSNKVTYDVVFHGYLPNEG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8087
• Maximal score value: 2.4874
• Average score: -0.917
• Total score value: -349.3818

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
341	K	A	-1.6795
342	Y	A	-0.6729
343	C	A	-1.1094
344	P	A	-1.2806
345	K	A	-1.7940
346	T	A	-0.7387
347	Y	A	0.0000
348	T	A	-0.9876
349	F	A	0.0000
350	D	A	-1.7124
351	D	A	-2.5571
352	G	A	-1.7786
353	K	A	-1.8248
354	V	A	-0.7559
355	I	A	-0.1671
356	I	A	0.0000
357	K	A	-0.7324
358	A	A	0.0000
359	G	A	0.0000
360	A	A	-1.8343
361	R	A	-2.7010
362	V	A	0.0000
363	E	A	-3.8087
364	E	A	-3.6196
365	E	A	-3.3075
366	K	A	-2.6011
367	V	A	0.0000
368	K	A	-1.7523
369	R	A	-1.4109
370	L	A	0.0000
371	Y	A	0.0000
372	W	A	0.0000
373	A	A	0.0000
374	S	A	0.0000
375	K	A	-0.2732
376	E	A	0.0000
377	V	A	0.0000
378	N	A	-0.2686
379	S	A	0.0000
380	Q	A	0.0000
381	F	A	0.0000
382	F	A	0.0000
383	R	A	0.0000
384	V	A	0.0000
385	Y	A	0.0000
386	G	A	-0.3673
387	I	A	-0.4336
388	D	A	-0.9396
389	K	A	-1.9012
390	P	A	-1.6882
391	L	A	-1.0033
392	E	A	-1.9922
393	E	A	-2.9181
394	G	A	-2.0061
395	N	A	-2.0240
396	P	A	-1.5853
397	D	A	0.0000
398	D	A	-2.4511
399	I	A	-0.8302
400	L	A	0.0000
401	T	A	-0.3643
402	M	A	0.0000
403	V	A	0.0728
404	I	A	0.0000
405	Y	A	0.0000
406	N	A	-1.2909
407	S	A	-1.8445
408	P	A	0.0000
409	E	A	-2.3129
410	E	A	-1.4326
411	Y	A	0.0000
412	K	A	-1.4464
413	L	A	0.4375
414	N	A	0.0111
415	S	A	0.4267
416	V	A	2.2547
417	L	A	2.4874
418	Y	A	1.4723
419	G	A	0.8250
420	Y	A	0.5447
421	D	A	0.0247
422	T	A	0.0000
423	N	A	-1.1665
424	N	A	-0.6099
425	G	A	0.0000
426	G	A	0.0000
427	M	A	0.0000
428	Y	A	0.0590
429	I	A	-0.3397
430	E	A	0.0000
431	P	A	-1.1732
432	E	A	-1.9383
433	G	A	0.0000
434	T	A	0.0000
435	F	A	0.0000
436	F	A	0.2633
437	T	A	0.0000
438	Y	A	-0.5932
439	E	A	-1.5913
440	R	A	0.0000
441	E	A	-2.7413
442	A	A	-1.9017
443	Q	A	-2.4213
444	E	A	-2.6230
445	S	A	-1.4474
446	T	A	-0.7985
447	Y	A	-0.4039
448	T	A	-0.4015
449	L	A	0.0000
450	E	A	0.0000
451	E	A	0.0000
452	L	A	0.0000
453	F	A	0.0000
454	R	A	0.0000
455	H	A	0.0000
456	E	A	0.0000
457	Y	A	0.0000
458	T	A	0.0000
459	H	A	0.0000
460	Y	A	0.0000
461	L	A	0.0000
462	Q	A	0.0000
463	G	A	-0.2627
464	R	A	-1.1837
465	Y	A	0.0000
466	A	A	0.0000
467	V	A	0.0000
468	P	A	-0.8224
469	G	A	-1.3612
470	Q	A	-1.4849
471	W	A	-0.8571
472	G	A	-2.1610
473	R	A	-2.8391
474	T	A	-2.4242
475	K	A	-3.2716
476	L	A	0.0000
477	Y	A	-2.4094
478	D	A	-3.3640
479	N	A	-2.9550
480	D	A	-2.3613
481	R	A	-1.9923
482	L	A	0.0000
483	T	A	0.0000
484	W	A	0.0000
485	Y	A	0.0000
486	E	A	0.0000
487	E	A	0.0000
488	G	A	0.0000
489	G	A	0.0000
490	A	A	0.0000
491	E	A	0.0000
492	L	A	0.0000
493	F	A	0.0000
494	A	A	0.0000
495	G	A	0.0000
496	S	A	0.0000
497	T	A	0.2568
498	R	A	-0.3988
499	T	A	-1.3334
500	S	A	-0.8769
501	G	A	0.0000
502	I	A	0.0000
503	L	A	0.3300
504	P	A	0.1190
505	R	A	0.0000
506	K	A	-1.1133
507	S	A	0.0000
508	I	A	0.0000
509	V	A	0.0000
510	S	A	-1.0891
511	N	A	-1.4428
512	I	A	0.0000
513	H	A	-1.8980
514	N	A	-1.8822
515	T	A	-1.7601
516	T	A	-1.9627
517	R	A	-2.9142
518	N	A	-2.6713
519	N	A	-2.5555
520	R	A	0.0000
521	Y	A	-1.5659
522	K	A	-2.3354
523	L	A	0.0000
524	S	A	-2.0237
525	D	A	-2.2229
526	T	A	0.0000
527	V	A	0.0000
528	H	A	-2.0507
529	S	A	0.0000
530	K	A	-2.2886
531	Y	A	-0.7890
532	G	A	-0.7485
533	A	A	-0.5662
534	S	A	-0.8357
535	F	A	-0.8217
536	E	A	-1.5175
537	F	A	0.0000
538	Y	A	0.0000
539	N	A	0.0000
540	Y	A	0.0000
541	A	A	0.0000
542	C	A	0.0000
543	M	A	0.0000
544	F	A	0.0000
545	M	A	0.0000
546	D	A	0.0000
547	Y	A	0.0000
548	M	A	0.0000
549	Y	A	-0.6927
550	N	A	-1.4178
551	K	A	-2.3004
552	D	A	-1.4770
553	M	A	0.0000
554	G	A	-0.8709
555	I	A	-0.7773
556	L	A	0.0000
557	N	A	-1.1340
558	K	A	-1.7216
559	L	A	0.0000
560	N	A	0.0000
561	D	A	-2.5180
562	L	A	0.0000
563	A	A	0.0000
564	K	A	-1.8726
565	N	A	-2.3822
566	N	A	-2.5138
567	D	A	-2.6995
568	V	A	0.0000
569	D	A	-2.7270
570	G	A	-2.3787
571	Y	A	0.0000
572	D	A	-2.3907
573	N	A	-2.9969
574	Y	A	-2.1832
575	I	A	0.0000
576	R	A	-3.4270
577	D	A	-3.3817
578	L	A	0.0000
579	S	A	-2.4026
580	S	A	-1.9413
581	N	A	-2.3581
582	H	A	-2.3981
583	A	A	-1.7300
584	L	A	0.0000
585	N	A	0.0000
586	D	A	-3.5133
587	K	A	-3.4806
588	Y	A	0.0000
589	Q	A	0.0000
590	D	A	-3.6324
591	H	A	0.0000
592	M	A	0.0000
593	Q	A	-3.0385
594	E	A	-3.3732
595	R	A	-2.7311
596	I	A	0.0000
597	D	A	-3.4036
598	N	A	-3.1317
599	Y	A	-2.6105
600	E	A	-3.0091
601	N	A	-2.6020
602	L	A	-1.4495
603	T	A	-0.1855
604	V	A	0.8359
605	P	A	0.0000
606	F	A	1.7799
607	V	A	0.0000
608	A	A	-0.5342
609	D	A	-1.6528
610	D	A	-1.4909
611	Y	A	0.0000
612	L	A	-1.0134
613	V	A	-0.4321
614	R	A	-1.1789
615	H	A	0.0000
616	A	A	0.1941
617	Y	A	0.3859
618	K	A	-0.5190
619	N	A	-1.7097
620	P	A	-1.5231
621	N	A	-2.2771
622	E	A	-2.4206
623	I	A	0.0000
624	Y	A	-1.6024
625	S	A	-1.6544
626	E	A	-1.7957
627	I	A	0.0000
628	S	A	-2.5739
629	E	A	-2.8222
630	V	A	0.0000
631	A	A	0.0000
632	K	A	-2.7852
633	L	A	0.0000
634	K	A	-3.5692
635	D	A	-3.1382
636	A	A	-2.5819
637	K	A	-2.7927
638	S	A	-1.4797
639	E	A	-0.8351
640	V	A	0.4394
641	K	A	-1.1082
642	K	A	-2.2969
643	S	A	0.0000
644	Q	A	-1.2355
645	Y	A	-0.2216
646	F	A	-0.7685
647	S	A	-1.0694
648	T	A	0.0000
649	F	A	0.0000
650	T	A	0.0000
651	L	A	0.0000
652	R	A	-1.8151
653	G	A	0.0000
654	S	A	-1.9187
655	Y	A	-1.2329
656	T	A	-0.9344
657	G	A	-0.3946
658	G	A	-0.2522
659	V	A	0.4525
660	S	A	-1.3848
661	K	A	-2.4320
662	G	A	-1.9005
663	K	A	-2.3638
664	L	A	-1.7762
665	E	A	-3.0287
666	D	A	0.0000
667	Q	A	-1.9507
668	K	A	-2.4999
669	A	A	-1.9851
670	M	A	0.0000
671	N	A	-1.7184
672	K	A	-2.5097
673	F	A	-1.4953
674	I	A	0.0000
675	D	A	-2.3159
676	D	A	-3.2581
677	S	A	0.0000
678	L	A	0.0000
679	K	A	-3.1213
680	K	A	-2.5764
681	L	A	0.0000
682	D	A	-1.5511
683	T	A	-0.9186
684	Y	A	-0.4419
685	S	A	-0.1323
686	W	A	0.0000
687	S	A	-0.3110
688	G	A	0.0000
689	Y	A	0.0000
690	K	A	-0.9948
691	T	A	0.0000
692	L	A	0.0000
693	T	A	0.0000
694	A	A	0.0000
695	Y	A	0.0000
696	F	A	0.0000
697	T	A	0.0000
698	N	A	-0.7356
699	Y	A	-0.9526
700	K	A	-1.9686
701	V	A	-1.0475
702	D	A	-1.5551
703	S	A	-1.2614
704	S	A	-0.9701
705	N	A	-1.7000
706	K	A	-1.2694
707	V	A	0.0000
708	T	A	-0.8804
709	Y	A	0.0000
710	D	A	-1.1767
711	V	A	0.0000
712	V	A	0.0000
713	F	A	0.0000
714	H	A	0.0000
715	G	A	0.0000
716	Y	A	-0.0640
717	L	A	0.0000
718	P	A	0.0000
719	N	A	-2.2799
720	E	A	-2.5893
721	G	A	-1.6882