Project name: a3894c3a6143598

Chain sequence(s)	I: MMSGAPSATQPATAETQHIADQVRSQLEEKYNKKFPVFKAVSFKSQVVAGTNYFIKVHVGDEDFVHLRVFQSLPHENKPLTLSNYQTNKAKHDELTYF; E: IPEYVDWRQKGAVTPVKNQGSCGSWAFSAVVTIEGIIKIRTGNLNQYSEQELLDCDRRSYGCNGGYPWSALQLVAQYGIHYRNTYPYEGVQRYCRSREKGPYAAKTDGVRQVQPYNQGALLYSIANQPVSVVLQAAGKDFQLYRGGIFVGPCGNKVDHAVAAVGYGPNYILIKNSWGTGWGENGYIRIKRGTGNSYGVCGLYTSSFYPVKN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1598
• Maximal score value: 1.8346
• Average score: -0.6841
• Total score value: -211.3954

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	I	E	1.8346
2	P	E	0.4455
3	E	E	-0.9787
4	Y	E	0.4573
5	V	E	0.0000
6	D	E	-0.9241
7	W	E	0.0000
8	R	E	-2.0800
9	Q	E	-2.5461
10	K	E	-2.6691
11	G	E	-1.7803
12	A	E	0.0000
13	V	E	-0.6451
14	T	E	0.0000
15	P	E	-0.4354
16	V	E	-0.5445
17	K	E	-0.8265
18	N	E	-1.4042
19	Q	E	0.0000
20	G	E	-0.5899
21	S	E	-0.1682
22	C	E	0.0000
23	G	E	0.0000
24	S	E	0.0000
26	W	E	0.0000
27	A	E	0.0000
28	F	E	0.0000
29	S	E	0.0000
30	A	E	0.0000
31	V	E	0.0000
32	V	E	0.1716
33	T	E	0.0000
34	I	E	0.0000
35	E	E	0.0000
36	G	E	0.0000
37	I	E	0.0000
38	I	E	0.0000
39	K	E	-1.1952
40	I	E	-0.9585
41	R	E	-1.5652
42	T	E	-1.1288
43	G	E	-1.3190
44	N	E	-1.5886
45	L	E	-0.4946
46	N	E	-0.6313
47	Q	E	-0.6896
48	Y	E	0.0000
49	S	E	0.0000
50	E	E	0.0000
51	Q	E	0.0000
52	E	E	0.0000
53	L	E	0.0000
54	L	E	0.0000
55	D	E	0.0000
56	C	E	0.0000
57	D	E	0.0000
58	R	E	-2.5182
59	R	E	-2.4810
60	S	E	0.0000
61	Y	E	-0.1641
62	G	E	0.0000
63	C	E	0.0000
64	N	E	-0.0220
65	G	E	0.0000
66	G	E	0.0000
67	Y	E	0.2444
68	P	E	0.0000
69	W	E	-0.1380
70	S	E	0.0000
71	A	E	0.0000
72	L	E	0.0000
73	Q	E	-0.8858
74	L	E	-0.7111
75	V	E	0.0000
76	A	E	-1.3118
77	Q	E	-1.3524
78	Y	E	-0.1551
79	G	E	0.0000
80	I	E	0.0000
81	H	E	0.0000
82	Y	E	-0.1205
83	R	E	-0.8535
84	N	E	-1.3812
85	T	E	-0.7629
86	Y	E	0.0000
87	P	E	-0.7528
88	Y	E	-0.6518
89	E	E	-0.8666
90	G	E	-0.4951
91	V	E	0.0969
92	Q	E	-0.7188
93	R	E	-1.1889
94	Y	E	0.4199
95	C	E	-0.4245
96	R	E	-1.2706
97	S	E	0.0000
98	R	E	-3.0707
99	E	E	-3.1972
100	K	E	-2.2130
101	G	E	-1.8138
102	P	E	-0.9211
103	Y	E	-0.1153
104	A	E	-0.0436
105	A	E	-0.1539
106	K	E	-1.3017
107	T	E	0.0000
108	D	E	-2.4248
109	G	E	-1.6626
110	V	E	-1.1276
111	R	E	-2.2294
112	Q	E	-2.1590
113	V	E	0.0000
114	Q	E	-1.7583
115	P	E	-0.5670
116	Y	E	0.2095
117	N	E	-0.6662
118	Q	E	-0.6216
119	G	E	-0.2581
120	A	E	-0.1504
121	L	E	0.0000
122	L	E	0.0000
123	Y	E	1.3594
124	S	E	0.1611
125	I	E	0.0000
126	A	E	0.2705
127	N	E	-0.6524
128	Q	E	0.0000
129	P	E	0.0000
130	V	E	0.0000
131	S	E	0.0000
132	V	E	0.0000
133	V	E	0.0000
134	L	E	0.0000
135	Q	E	0.0000
136	A	E	0.0000
137	A	E	-0.7995
138	G	E	-1.2026
139	K	E	-2.1000
140	D	E	-1.9469
141	F	E	0.0000
142	Q	E	0.0000
143	L	E	-0.8909
144	Y	E	0.0000
145	R	E	-2.3342
146	G	E	-1.4746
147	G	E	-0.3118
148	I	E	0.3866
149	F	E	0.0000
150	V	E	1.6255
151	G	E	0.4726
152	P	E	-0.2886
153	C	E	-0.5620
154	G	E	-0.8198
155	N	E	-1.2798
156	K	E	-2.0021
157	V	E	-0.7735
158	D	E	-0.4975
159	H	E	0.0000
160	A	E	0.0000
161	V	E	0.0000
162	A	E	0.0000
163	A	E	0.0000
164	V	E	0.0000
165	G	E	0.0000
166	Y	E	0.0000
167	G	E	0.0000
168	P	E	-1.0660
169	N	E	-1.5984
170	Y	E	-0.5059
171	I	E	0.0000
172	L	E	0.0000
173	I	E	0.0000
174	K	E	0.0000
175	N	E	0.0000
176	S	E	0.0000
177	W	E	0.0000
178	G	E	-1.0446
179	T	E	-1.2079
180	G	E	-1.4838
181	W	E	0.0000
182	G	E	-1.7833
183	E	E	-1.8529
184	N	E	-1.9554
185	G	E	0.0000
186	Y	E	0.0000
187	I	E	0.0000
188	R	E	-0.3815
189	I	E	0.0000
190	K	E	-0.4292
191	R	E	-1.1212
192	G	E	-1.4601
193	T	E	-1.0287
194	G	E	-1.1321
195	N	E	-1.1817
196	S	E	-0.3419
197	Y	E	0.5387
198	G	E	0.0000
199	V	E	0.0554
200	C	E	0.0000
201	G	E	0.0000
202	L	E	0.0000
203	Y	E	0.0000
204	T	E	0.0678
205	S	E	0.0946
206	S	E	0.0000
207	F	E	-0.7790
208	Y	E	-0.5644
209	P	E	0.0000
210	V	E	-1.0079
211	K	E	-1.6501
212	N	E	-1.9173
6	M	I	0.8177
7	M	I	0.8302
8	S	I	0.0000
9	G	I	0.0731
10	A	I	0.0181
11	P	I	-0.1357
12	S	I	-0.2928
13	A	I	-0.3007
14	T	I	-0.7922
15	Q	I	-0.9869
16	P	I	-0.5839
17	A	I	-0.9160
18	T	I	-0.9394
19	A	I	-1.1886
20	E	I	-2.3487
21	T	I	0.0000
22	Q	I	-2.1965
23	H	I	-2.7445
24	I	I	-1.7489
25	A	I	0.0000
26	D	I	-3.1639
27	Q	I	-2.4029
28	V	I	0.0000
29	R	I	-2.1589
30	S	I	-2.2063
31	Q	I	-2.0226
32	L	I	0.0000
33	E	I	0.0000
34	E	I	-3.7056
35	K	I	-2.9299
36	Y	I	-2.1669
37	N	I	-3.2578
38	K	I	-3.5941
39	K	I	-2.9651
40	F	I	-1.3200
43	P	I	-0.5699
44	V	I	-0.1451
45	F	I	0.0000
46	K	I	-1.8504
47	A	I	0.0000
48	V	I	-0.5528
49	S	I	-0.7378
50	F	I	-0.1569
51	K	I	-0.3157
52	S	I	-0.1456
53	Q	I	0.0000
54	V	I	0.0000
55	V	I	0.0000
56	A	I	0.0000
57	G	I	0.0000
58	T	I	0.0000
59	N	I	0.0000
60	Y	I	0.1484
61	F	I	0.0000
62	I	I	0.0000
63	K	I	0.0000
64	V	I	0.0000
65	H	I	-1.9728
66	V	I	0.0000
67	G	I	-2.4637
68	D	I	-3.3432
92	E	I	-4.1598
93	D	I	-4.1309
94	F	I	0.0000
95	V	I	0.0000
96	H	I	0.0000
97	L	I	0.0000
98	R	I	-0.2778
99	V	I	0.0000
100	F	I	-0.1395
101	Q	I	-0.8127
102	S	I	-1.3424
102A	L	I	0.0000
103	P	I	-1.4796
104	H	I	-1.8910
105	E	I	-2.9603
105A	N	I	-3.0335
106	K	I	-2.9486
107	P	I	-1.6908
108	L	I	-0.7416
109	T	I	-0.5820
110	L	I	0.0000
111	S	I	-0.5150
112	N	I	-0.7187
113	Y	I	-0.4233
114	Q	I	-0.7578
115	T	I	-1.0891
115A	N	I	-2.2426
116	K	I	-2.7329
117	A	I	-2.9244
118	K	I	-3.1641
119	H	I	-2.5697
120	D	I	-2.6527
121	E	I	-2.6984
122	L	I	0.0000
123	T	I	-0.4754
124	Y	I	0.2070
125	F	I	0.3499