Project name: 4kaq:H

Chain sequence(s)	H: VQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSAASTTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.9522
• Maximal score value: 2.5042
• Average score: -0.5058
• Total score value: -111.2815

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	V	H	0.9853
3	Q	H	-0.8072
4	L	H	0.0000
5	Q	H	-1.9829
6	Q	H	-1.0662
7	P	H	-0.9392
8	G	H	-0.9675
9	A	H	0.0000
10	E	H	-1.2016
11	L	H	-0.6213
12	V	H	0.0000
13	K	H	-1.9337
14	P	H	-1.2342
15	G	H	-1.1127
16	A	H	-0.9192
17	S	H	-1.1195
18	V	H	0.0000
19	K	H	-1.9547
20	M	H	0.0000
21	S	H	-0.9342
22	C	H	0.0000
23	K	H	-1.8861
24	A	H	0.0000
25	S	H	-0.6379
26	G	H	-0.0123
27	Y	H	0.2937
28	T	H	0.1852
29	F	H	0.0000
30	T	H	-0.6579
31	S	H	0.0248
32	Y	H	0.5633
33	N	H	-0.2886
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	0.0000
39	Q	H	-0.5357
40	T	H	0.0000
41	P	H	-0.9119
42	G	H	-1.4416
43	R	H	-2.1160
44	G	H	-0.9195
45	L	H	0.4682
46	E	H	-0.3963
47	W	H	0.0073
48	I	H	0.0000
49	G	H	0.0000
50	A	H	0.0000
51	I	H	0.0000
52	Y	H	-0.9769
53	P	H	0.0000
54	G	H	-1.3303
55	N	H	-2.2382
56	G	H	-2.2315
57	D	H	-2.3735
58	T	H	-1.1778
59	S	H	-0.8482
60	Y	H	-1.1501
61	N	H	-1.8124
62	Q	H	-2.7193
63	K	H	-2.9522
64	F	H	0.0000
65	K	H	-2.9362
66	G	H	-1.9928
67	K	H	-1.4706
68	A	H	0.0000
69	T	H	-0.8515
70	L	H	0.0000
71	T	H	-0.8016
72	A	H	-1.3253
73	D	H	-1.7823
74	K	H	-2.4403
75	S	H	-1.3804
76	S	H	-1.2417
77	S	H	-1.2549
78	T	H	0.0000
79	A	H	0.0000
80	Y	H	-0.5069
81	M	H	0.0000
82	Q	H	-1.2784
83	L	H	0.0000
84	S	H	-0.9000
85	S	H	-0.8549
86	L	H	0.0000
87	T	H	-1.2502
88	S	H	-1.4073
89	E	H	-1.9612
90	D	H	0.0000
91	S	H	-0.7615
92	A	H	0.0000
93	V	H	0.3199
94	Y	H	0.0000
95	Y	H	0.4132
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	S	H	0.8252
100	T	H	1.1639
101	Y	H	1.7301
102	Y	H	1.4342
103	G	H	-0.1780
104	G	H	-0.5913
105	D	H	-0.6270
106	W	H	1.2778
107	Y	H	1.5953
108	F	H	0.9028
109	N	H	-0.0438
110	V	H	0.3000
111	W	H	0.2998
112	G	H	0.0000
113	A	H	-0.1599
114	G	H	-0.0610
115	T	H	0.0000
116	T	H	-0.1586
117	V	H	0.0000
118	T	H	-0.6024
119	V	H	0.0000
120	S	H	-0.6672
121	A	H	-0.6502
122	A	H	-0.3760
123	S	H	-0.5181
124	T	H	-0.5959
125	K	H	-1.0589
126	G	H	-1.4165
127	P	H	-0.3290
128	S	H	0.0117
129	V	H	0.0000
130	F	H	1.1914
131	P	H	0.1788
132	L	H	0.3756
133	A	H	-0.5212
134	P	H	0.0000
135	S	H	-1.1574
136	S	H	-1.2486
137	K	H	-1.9444
138	S	H	-1.0675
139	T	H	-1.0777
140	S	H	-0.9385
141	G	H	-0.8578
142	G	H	-0.9105
143	T	H	-0.6411
144	A	H	0.0000
145	A	H	-0.2066
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.8145
150	V	H	0.0000
151	K	H	-0.1435
152	D	H	-0.3359
153	Y	H	0.0000
154	F	H	-0.1401
155	P	H	0.0000
156	E	H	-0.4813
157	P	H	-0.7378
158	V	H	0.0000
159	T	H	-0.6080
160	V	H	-0.1744
161	S	H	-0.4023
162	W	H	0.0000
163	N	H	-0.8356
164	S	H	-0.7267
165	G	H	-0.5696
166	A	H	-0.2804
167	L	H	-0.0677
168	T	H	-0.3327
169	S	H	-0.3905
170	G	H	-0.5057
171	V	H	-0.0752
172	H	H	-0.5870
173	T	H	-0.0090
174	F	H	0.7262
175	P	H	0.6047
176	A	H	1.2392
177	V	H	2.5042
178	L	H	2.1669
179	Q	H	0.7069
180	S	H	0.0641
181	S	H	-0.2160
182	G	H	0.2677
183	L	H	0.4110
184	Y	H	0.9041
185	S	H	0.0000
186	L	H	0.0000
187	S	H	0.6438
188	S	H	0.0000
189	V	H	0.3822
190	V	H	0.0000
191	T	H	-0.2531
192	V	H	0.0000
193	P	H	-0.6096
194	S	H	-0.6738
195	S	H	-0.5588
196	S	H	-0.5390
197	L	H	-0.7668
198	G	H	-0.9594
199	T	H	-0.6696
200	Q	H	-1.1452
201	T	H	-1.1007
202	Y	H	0.0000
203	I	H	-1.4678
204	C	H	0.0000
205	N	H	-1.5259
206	V	H	0.0000
207	N	H	-1.8102
208	H	H	0.0000
209	K	H	-2.8041
210	P	H	-1.6123
211	S	H	-1.7910
212	N	H	-2.4996
213	T	H	-2.2373
214	K	H	-2.6248
215	V	H	-1.7359
216	D	H	-2.6493
217	K	H	-2.0109
218	K	H	-2.5360
219	V	H	0.0000
220	E	H	-2.4820
221	P	H	-1.1706