Project name: a50dae6cbb2e9db

Chain sequence(s)	A: PSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5428
• Maximal score value: 1.6307
• Average score: -0.7773
• Total score value: -319.4823

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
137	P	A	-0.0148
138	S	A	0.2566
139	L	A	0.9503
140	E	A	0.0000
141	D	A	-0.1401
142	L	A	1.1222
143	L	A	0.0000
144	F	A	0.0000
145	Y	A	-0.0649
146	T	A	-0.1626
147	I	A	0.0000
148	A	A	0.0000
149	E	A	-2.4226
150	G	A	-2.1507
151	Q	A	-2.6519
152	E	A	-3.2171
153	K	A	-2.7601
154	I	A	0.0000
155	P	A	-0.5288
156	V	A	0.0000
157	H	A	-1.1037
158	K	A	-1.3680
159	F	A	0.0000
160	I	A	-0.7455
161	T	A	-0.8756
162	A	A	-0.6844
163	L	A	0.0000
164	K	A	-1.4251
165	S	A	-0.7705
166	T	A	0.0000
167	G	A	0.0000
168	L	A	0.0000
169	R	A	-1.4383
170	T	A	-1.1028
171	S	A	-0.9723
172	D	A	0.0000
173	P	A	-1.4081
174	R	A	-1.3323
175	L	A	0.0000
176	K	A	-3.1978
177	E	A	-3.3790
178	C	A	0.0000
179	M	A	0.0000
180	D	A	-2.8770
181	M	A	-1.8789
182	L	A	0.0000
183	R	A	-1.7106
184	L	A	-0.0744
185	T	A	0.0000
186	L	A	-0.3048
187	Q	A	-0.8102
188	T	A	-0.6690
189	T	A	-0.5441
190	S	A	-1.0981
191	D	A	-1.8630
192	G	A	-0.6124
193	V	A	0.3544
194	M	A	-0.7769
195	L	A	0.0000
196	D	A	-3.4204
197	K	A	-3.0481
198	D	A	-3.2739
199	L	A	-2.2438
200	F	A	0.0000
201	K	A	-2.7065
202	K	A	-2.9291
203	C	A	0.0000
204	V	A	0.0000
205	Q	A	-1.8407
206	S	A	-1.5224
207	N	A	-0.7554
208	I	A	0.0000
209	V	A	1.6307
210	L	A	0.4721
211	L	A	0.0000
212	T	A	-0.0296
213	Q	A	-1.2576
214	A	A	0.0000
215	F	A	0.0000
216	R	A	-2.0642
217	R	A	-3.1669
218	K	A	-2.8414
219	F	A	0.0000
220	V	A	-1.1207
221	I	A	0.0000
222	P	A	-2.4133
223	D	A	-2.0716
224	F	A	0.0000
225	M	A	-0.0578
226	S	A	-0.3130
227	F	A	0.0000
228	T	A	0.0000
229	S	A	-0.8624
230	H	A	-1.2942
231	I	A	0.0000
232	D	A	-2.1722
233	E	A	-3.0568
234	L	A	0.0000
235	Y	A	0.0000
236	E	A	-3.5428
237	S	A	-2.6137
238	A	A	0.0000
239	K	A	-3.4586
240	K	A	-3.3115
241	Q	A	-2.2886
242	S	A	-2.0681
243	G	A	-1.5680
244	G	A	-2.0910
245	K	A	-2.5880
246	V	A	-1.4797
247	A	A	-1.2971
248	D	A	-2.0069
249	Y	A	-0.2668
250	I	A	0.0000
251	P	A	-1.1227
252	Q	A	-0.9602
253	L	A	0.0000
254	A	A	-1.8224
255	K	A	-2.0430
256	F	A	-1.1082
257	S	A	-0.9682
258	P	A	-1.6209
259	D	A	-2.2490
260	L	A	-0.9710
261	W	A	0.0000
262	G	A	0.0000
263	V	A	0.0000
264	S	A	0.0000
265	V	A	0.0000
266	C	A	0.0000
267	T	A	0.0000
268	V	A	-0.2324
269	D	A	-0.6973
270	G	A	0.0000
271	Q	A	0.0000
272	R	A	-0.6823
273	H	A	-0.4501
274	S	A	-0.6747
275	T	A	-0.9061
276	G	A	-1.1842
277	D	A	-1.2548
278	T	A	0.0000
279	K	A	-1.6460
280	V	A	-0.5646
281	P	A	-0.2698
282	F	A	0.0000
283	C	A	0.0000
284	L	A	0.0000
285	Q	A	0.0000
286	S	A	0.0000
287	C	A	0.0000
288	V	A	0.0000
289	K	A	0.0000
290	P	A	0.0000
291	L	A	0.0000
292	K	A	0.0000
293	Y	A	0.0000
294	A	A	0.0000
295	I	A	0.0000
296	A	A	0.0000
297	V	A	0.0000
298	N	A	-1.0099
299	D	A	-1.1580
300	L	A	-0.4656
301	G	A	-0.8489
302	T	A	-1.3884
303	E	A	-2.0324
304	Y	A	-1.1102
305	V	A	0.0000
306	H	A	-1.8026
307	R	A	-2.1985
308	Y	A	-1.2758
309	V	A	0.0000
310	G	A	-2.2480
311	K	A	-2.7110
312	E	A	-2.8438
313	P	A	-1.4956
314	S	A	-1.3245
315	G	A	-1.0706
316	L	A	-0.3333
317	R	A	-1.4091
318	F	A	-0.5996
319	N	A	-1.6927
320	K	A	-1.7219
321	L	A	-0.2194
322	F	A	0.1255
323	L	A	0.0000
324	N	A	-2.1204
325	E	A	-3.2917
326	D	A	-3.4499
327	D	A	-3.2240
328	K	A	-2.4720
329	P	A	0.0000
330	H	A	0.0000
331	N	A	0.0000
332	P	A	0.0000
333	M	A	0.0000
334	V	A	0.3195
335	N	A	-0.2671
336	A	A	0.0000
337	G	A	0.0000
338	A	A	0.0000
339	I	A	0.0000
340	V	A	0.0000
341	V	A	0.0000
342	T	A	0.0000
343	S	A	0.0000
344	L	A	0.0000
345	I	A	0.0000
346	K	A	-1.9303
347	Q	A	-1.6515
348	G	A	-1.4128
349	V	A	-1.3304
350	N	A	-2.0426
351	N	A	-1.8902
352	A	A	-1.6106
353	E	A	-2.7340
354	K	A	-2.0943
355	F	A	-1.6795
356	D	A	-2.4118
357	Y	A	-1.5328
358	V	A	0.0000
359	M	A	-1.1043
360	Q	A	-1.6196
361	F	A	0.0000
362	L	A	0.0000
363	N	A	-1.3830
364	K	A	-1.9992
365	M	A	0.0000
366	A	A	0.0000
367	G	A	0.0000
368	N	A	-1.7575
369	E	A	-0.8991
370	Y	A	-0.0563
371	V	A	-0.0250
372	G	A	0.1436
373	F	A	0.0863
374	S	A	-0.5961
375	N	A	-1.3279
376	A	A	-0.8128
377	T	A	0.0000
378	F	A	-1.2839
379	Q	A	-2.0575
380	S	A	-1.5669
381	E	A	0.0000
382	R	A	-2.5367
383	E	A	-2.9216
384	S	A	-2.1806
385	G	A	0.0000
386	D	A	-3.0101
387	R	A	-2.6403
388	N	A	0.0000
389	F	A	-0.3253
390	A	A	-0.4052
391	I	A	0.0000
392	G	A	0.0000
393	Y	A	0.0517
394	Y	A	-0.6190
395	L	A	0.0000
396	K	A	-2.7266
397	E	A	-3.0264
398	K	A	-3.0313
399	K	A	-3.3686
400	C	A	0.0000
401	F	A	-1.6845
402	P	A	-1.6520
403	E	A	-2.4699
404	G	A	-1.9191
405	T	A	-1.8247
406	D	A	-1.9618
407	M	A	0.0000
408	V	A	0.5412
409	G	A	-0.4635
410	I	A	0.0000
411	L	A	0.0000
412	D	A	-0.4479
413	F	A	0.0000
414	Y	A	0.0000
415	F	A	0.0000
416	Q	A	-0.5757
417	L	A	0.0000
418	C	A	0.0000
419	S	A	0.0000
420	I	A	0.0000
421	E	A	0.0435
422	V	A	0.0000
423	T	A	0.0000
424	C	A	0.0000
425	E	A	-0.6822
426	S	A	0.0000
427	A	A	0.0000
428	S	A	0.0000
429	V	A	0.0000
430	M	A	0.0000
431	A	A	0.0000
432	A	A	0.0000
433	T	A	0.0000
434	L	A	0.0000
435	A	A	0.0000
436	N	A	-0.7574
437	G	A	-1.0042
438	G	A	0.0000
439	F	A	-0.7499
440	C	A	0.0000
441	P	A	0.0000
442	I	A	0.0000
443	T	A	-1.3494
444	G	A	-1.6489
445	E	A	-2.7294
446	R	A	-2.5800
447	V	A	0.0000
448	L	A	0.0000
449	S	A	-1.1471
450	P	A	-1.3289
451	E	A	-1.7454
452	A	A	0.0000
453	V	A	0.0000
454	R	A	-2.2982
455	N	A	-1.5961
456	T	A	0.0000
457	L	A	-0.6833
458	S	A	-1.1815
459	L	A	0.0000
460	M	A	0.0000
461	H	A	-0.3060
462	S	A	-0.5978
463	C	A	-0.7552
464	G	A	0.0000
465	M	A	0.0000
466	Y	A	-0.3425
467	D	A	-1.7078
468	F	A	-0.8671
469	S	A	0.0000
470	G	A	-0.5500
471	Q	A	-0.7048
472	F	A	0.0000
473	A	A	0.1374
474	F	A	1.1140
475	H	A	-0.5170
476	V	A	0.0000
477	G	A	0.0000
478	L	A	0.0000
479	P	A	0.0000
480	A	A	0.0000
481	K	A	0.0000
482	S	A	0.0000
483	G	A	0.0000
484	V	A	0.0249
485	A	A	0.0000
486	G	A	0.0000
487	G	A	0.0000
488	I	A	0.0000
489	L	A	0.0000
490	L	A	0.0000
491	V	A	0.0000
492	V	A	0.0000
493	P	A	-1.1236
494	N	A	-1.4017
495	V	A	0.0000
496	M	A	0.0000
497	G	A	0.0000
498	M	A	0.0000
499	M	A	0.0000
500	C	A	0.0000
501	W	A	0.0000
502	S	A	0.0000
503	P	A	0.0000
504	P	A	0.0000
505	L	A	0.0000
506	D	A	-1.8970
507	K	A	-2.3605
508	M	A	-1.0979
509	G	A	-1.0120
510	N	A	0.0000
511	S	A	0.0000
512	V	A	-0.8565
513	K	A	0.0000
514	G	A	0.0000
515	I	A	-0.0024
516	H	A	-0.5532
517	F	A	0.0000
518	C	A	0.0000
519	H	A	-0.7782
520	D	A	-0.8241
521	L	A	0.0000
522	V	A	0.0000
523	S	A	-0.5465
524	L	A	0.0263
525	C	A	0.0000
526	N	A	0.0000
527	F	A	0.0000
528	H	A	-0.5472
529	N	A	-0.6701
530	Y	A	0.5340
531	D	A	-0.9186
532	N	A	-1.5942
533	L	A	-0.7822
534	R	A	-2.1880
535	H	A	-2.0505
536	F	A	-0.8974
537	A	A	-1.0243
538	K	A	-1.4226
539	K	A	-0.3650
540	L	A	0.8155
541	D	A	0.0000
542	P	A	0.0000
543	R	A	-1.6553
544	R	A	-2.3416
545	E	A	-3.1863
546	G	A	-1.7063
600	E	A	-0.6060