Project name: a7bb12540568fc5

Chain sequence(s)	A: PLWIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHERQMVFGVVTAIDLLNFVAAQERDQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.8145
• Maximal score value: 1.4773
• Average score: -0.8578
• Total score value: -427.1779

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
41	P	A	0.5607
42	L	A	0.9510
43	W	A	0.4562
44	I	A	0.2402
45	R	A	-1.6339
46	P	A	0.0000
47	D	A	-1.1233
48	A	A	-1.0855
49	P	A	-1.0950
50	S	A	-1.3144
51	R	A	-1.8347
52	C	A	-0.8904
53	T	A	-0.8122
54	W	A	-0.9980
55	Q	A	-1.0518
56	L	A	-0.3381
57	G	A	-1.0045
58	R	A	-1.9806
59	P	A	-1.5649
60	A	A	-1.3380
61	S	A	-1.4195
62	E	A	-2.3417
63	S	A	-1.6574
64	P	A	-1.1923
65	H	A	-1.3694
66	H	A	-1.6184
67	H	A	-1.3091
68	T	A	-0.6154
69	A	A	-0.4748
70	P	A	-0.9567
71	A	A	-1.2495
72	K	A	-2.3547
73	S	A	-1.6922
74	P	A	-0.8601
75	K	A	-0.9090
76	I	A	1.0061
77	L	A	0.1771
78	P	A	-0.4544
79	D	A	-0.8802
80	I	A	-0.0066
81	L	A	0.0000
82	K	A	-1.8036
83	K	A	-1.7444
84	I	A	-0.7370
85	G	A	-1.1516
86	D	A	-2.2990
87	T	A	0.0000
88	P	A	-0.2225
89	M	A	-0.3082
90	V	A	-0.3283
91	R	A	-2.0412
92	I	A	0.0000
93	N	A	-2.7518
94	K	A	-3.0847
95	I	A	0.0000
96	G	A	0.0000
97	K	A	-3.4015
98	K	A	-2.7379
99	F	A	-1.4798
100	G	A	-2.1358
101	L	A	0.0000
102	K	A	-3.8188
103	C	A	-3.1396
104	E	A	-2.3623
105	L	A	0.0000
106	L	A	0.0000
107	A	A	0.0000
108	K	A	0.0000
109	C	A	0.0000
110	E	A	0.0000
111	F	A	1.1753
112	F	A	1.4773
113	N	A	0.0000
114	A	A	0.1902
115	G	A	0.0000
116	G	A	0.0000
117	S	A	0.0000
118	V	A	0.0000
119	K	A	-0.1039
120	D	A	0.0000
121	R	A	0.0000
122	I	A	0.0000
123	S	A	0.0000
124	L	A	-0.0215
125	R	A	0.0000
126	M	A	0.0000
127	I	A	0.0000
128	E	A	-1.5061
129	D	A	-2.0941
130	A	A	0.0000
131	E	A	-2.7147
132	R	A	-3.3743
133	D	A	-3.3855
134	G	A	-2.5964
135	T	A	-1.9072
136	L	A	0.0000
137	K	A	-2.0123
138	P	A	-1.4495
139	G	A	-1.4878
140	D	A	0.0000
141	T	A	0.0000
142	I	A	0.0000
143	I	A	0.0000
144	E	A	0.0000
145	P	A	0.0000
146	T	A	0.0000
147	S	A	0.0000
148	G	A	0.0000
149	N	A	0.0000
150	T	A	0.0000
151	G	A	0.0000
152	I	A	0.0000
153	G	A	0.0000
154	L	A	0.0000
155	A	A	0.0000
156	L	A	0.4520
157	A	A	0.0000
158	A	A	0.0000
159	A	A	-0.1233
160	V	A	0.1579
161	R	A	-0.9462
162	G	A	-0.9680
163	Y	A	-1.0511
164	R	A	-1.4502
165	C	A	0.0000
166	I	A	0.0000
167	I	A	0.0000
168	V	A	0.0000
169	M	A	0.0000
170	P	A	0.0000
171	E	A	-2.3158
172	K	A	-1.5889
173	M	A	0.0000
174	S	A	0.0000
175	S	A	-0.9833
176	E	A	-1.1424
177	K	A	0.0000
178	V	A	0.0000
179	D	A	-2.3405
180	V	A	-1.2280
181	L	A	0.0000
182	R	A	-2.5392
183	A	A	-1.2727
184	L	A	-0.6098
185	G	A	-1.1810
186	A	A	0.0000
187	E	A	-1.2308
188	I	A	-0.3612
189	V	A	0.1019
190	R	A	-1.0325
191	T	A	0.0000
192	P	A	-1.8834
193	T	A	-1.9299
194	N	A	-2.3056
195	A	A	-2.4149
196	R	A	-3.2965
197	F	A	-2.5164
198	D	A	-3.0822
199	S	A	-2.1698
200	P	A	-1.8924
201	E	A	-2.7883
202	S	A	0.0000
203	H	A	-1.0318
204	V	A	0.0000
205	G	A	0.0000
206	V	A	-0.7657
207	A	A	0.0000
208	W	A	0.0000
209	R	A	-1.7079
210	L	A	-1.2616
211	K	A	-1.7069
212	N	A	-2.3859
213	E	A	-2.7308
214	I	A	-1.5832
215	P	A	-1.4063
216	N	A	-1.9771
217	S	A	0.0000
218	H	A	-0.7944
219	I	A	0.0000
220	L	A	0.0000
221	D	A	0.0000
222	Q	A	0.0000
223	Y	A	0.0000
224	R	A	-1.4341
225	N	A	-0.7826
226	A	A	-0.4613
227	S	A	0.0000
228	N	A	0.0000
229	P	A	-0.0810
230	L	A	-0.1649
231	A	A	0.0000
232	H	A	0.0000
233	Y	A	-0.1531
234	D	A	0.0000
235	T	A	-0.6321
236	T	A	0.0000
237	A	A	0.0000
238	D	A	-1.5370
239	E	A	0.0000
240	I	A	0.0000
241	L	A	0.0000
242	Q	A	-2.5305
243	Q	A	-2.1846
244	C	A	0.0000
245	D	A	-2.9724
246	G	A	-2.6390
247	K	A	-2.6631
248	L	A	0.0000
249	D	A	-1.4475
250	M	A	0.0000
251	L	A	0.0000
252	V	A	0.0000
253	A	A	0.0000
254	S	A	-0.0256
255	V	A	0.0000
256	G	A	0.0007
257	T	A	0.0000
258	G	A	0.0000
259	G	A	0.0000
260	T	A	-0.0101
261	I	A	0.0000
262	T	A	0.0000
263	G	A	0.0000
264	I	A	0.0000
265	A	A	0.0000
266	R	A	-0.7184
267	K	A	-0.9783
268	L	A	0.0000
269	K	A	-1.3065
270	E	A	-1.8515
271	K	A	-2.3155
272	C	A	-1.8185
273	P	A	-1.3079
274	G	A	-1.4391
275	C	A	0.0000
276	R	A	-1.7369
277	I	A	0.0000
278	I	A	0.0000
279	G	A	0.0000
280	V	A	0.0000
281	D	A	0.0000
282	P	A	0.0000
283	E	A	-1.3634
284	G	A	-1.3984
285	S	A	0.0000
286	I	A	-0.4926
287	L	A	0.0000
288	A	A	0.0000
289	E	A	-2.6773
290	P	A	-2.4771
291	E	A	-3.2133
292	E	A	-3.0578
293	L	A	-1.7059
294	N	A	0.0000
295	Q	A	-2.4621
296	T	A	-2.0927
297	E	A	-2.8004
298	Q	A	-2.4025
299	T	A	-1.6198
300	T	A	-1.1410
301	Y	A	-0.7366
302	E	A	-0.8990
303	V	A	0.0000
304	E	A	0.0000
305	G	A	-0.1406
306	I	A	0.0000
307	G	A	0.0000
308	Y	A	-0.3799
309	D	A	-1.5197
310	F	A	0.0000
311	I	A	0.1810
312	P	A	0.0000
313	T	A	-0.9883
314	V	A	-0.5387
315	L	A	0.0000
316	D	A	-0.3820
317	R	A	-0.9412
318	T	A	-0.8605
319	V	A	0.0000
320	V	A	0.0000
321	D	A	-1.6234
322	K	A	-1.9098
323	W	A	0.0000
324	F	A	-0.3096
325	K	A	-0.4272
326	S	A	0.0000
327	N	A	-1.1984
328	D	A	0.0000
329	E	A	-1.5590
330	E	A	-1.0622
331	A	A	0.0000
332	F	A	0.0000
333	T	A	-0.5441
334	F	A	0.0000
335	A	A	0.0000
336	R	A	-0.0868
337	M	A	-0.3831
338	L	A	0.0000
339	I	A	0.3552
340	A	A	-0.1452
341	Q	A	-1.1807
342	E	A	-1.1473
343	G	A	-0.2571
344	L	A	0.0000
345	L	A	1.4526
346	C	A	0.0000
347	G	A	0.0000
348	G	A	0.0000
349	S	A	0.0000
350	A	A	0.0000
351	G	A	0.0000
352	S	A	0.0000
353	T	A	0.0000
354	V	A	0.0000
355	A	A	0.0000
356	V	A	0.0000
357	A	A	0.0000
358	V	A	0.0000
359	K	A	-1.4483
360	A	A	0.0000
361	A	A	0.0000
362	Q	A	-2.6193
363	E	A	-2.9170
364	L	A	0.0000
365	Q	A	-3.6023
366	E	A	-3.4386
367	G	A	-2.2638
368	Q	A	-2.2684
369	R	A	-1.8108
370	C	A	0.0000
371	V	A	0.0000
372	V	A	0.0000
373	I	A	0.0000
374	L	A	0.0000
375	P	A	0.1480
376	D	A	0.0000
377	S	A	0.6249
378	V	A	0.0000
379	R	A	-0.1033
380	N	A	0.0000
381	Y	A	0.0000
382	M	A	0.3193
383	T	A	-0.3033
384	K	A	-0.5685
385	F	A	0.0000
386	L	A	0.0036
387	S	A	-0.7818
388	D	A	-1.9335
389	R	A	-2.6945
390	W	A	-1.7780
391	M	A	0.0000
392	L	A	-2.3551
393	Q	A	-2.5056
394	K	A	-2.3667
395	G	A	-2.1117
396	F	A	-1.6172
397	L	A	-2.5683
398	K	A	-3.8541
399	E	A	-4.1946
400	E	A	-4.8145
401	D	A	-4.5953
402	L	A	-3.4732
403	T	A	-3.3780
404	E	A	-3.9125
405	K	A	-3.2407
406	K	A	-2.0829
407	P	A	-0.5756
408	W	A	0.4739
409	W	A	0.1756
410	W	A	-0.7858
411	H	A	-1.0735
412	L	A	-1.2305
413	R	A	-2.4368
414	V	A	0.0000
415	Q	A	-2.1286
416	E	A	-2.4864
417	L	A	-1.5292
418	G	A	-1.1309
419	L	A	-0.4815
420	S	A	-0.0974
421	A	A	0.2179
422	P	A	0.0293
423	L	A	-0.1926
424	T	A	-0.0362
425	V	A	0.0000
426	L	A	0.1401
427	P	A	-0.4410
428	T	A	-0.4365
429	I	A	-0.1726
430	T	A	-1.0792
431	C	A	0.0000
432	G	A	-1.1802
433	H	A	-1.5760
434	T	A	0.0000
435	I	A	-1.9127
436	E	A	-3.2036
437	I	A	-2.2333
438	L	A	0.0000
439	R	A	-4.0502
440	E	A	-3.8545
441	K	A	-3.3547
442	G	A	-2.7128
443	F	A	-1.6568
444	D	A	-2.2795
445	Q	A	-1.2830
446	A	A	0.0000
447	P	A	0.0000
448	V	A	0.0000
449	V	A	0.0000
450	D	A	-0.7341
451	E	A	-1.7454
452	A	A	-0.8829
453	G	A	-0.8476
454	V	A	0.3383
455	I	A	0.0000
456	L	A	0.2968
457	G	A	0.0000
458	M	A	0.0000
459	V	A	0.0000
460	T	A	-0.5281
461	L	A	-1.1382
462	G	A	-0.8802
463	N	A	-0.2558
464	M	A	0.0000
465	L	A	0.6130
466	S	A	0.1035
467	S	A	-0.5311
468	L	A	0.0882
469	L	A	1.1246
470	A	A	-0.0134
471	G	A	-0.9640
472	K	A	-2.0351
473	V	A	0.0000
474	Q	A	-2.0706
475	P	A	-1.2857
476	S	A	-1.2626
477	D	A	-1.8948
478	Q	A	-2.1441
479	V	A	0.0000
480	G	A	-1.3981
481	K	A	-2.3346
482	V	A	-1.1839
483	I	A	-0.7335
484	Y	A	-0.7064
485	K	A	-1.7497
486	Q	A	-1.7808
487	F	A	-1.0267
488	K	A	-1.2025
489	Q	A	-1.4862
490	I	A	0.0000
491	R	A	-1.9412
492	L	A	-1.4058
493	T	A	-1.1416
494	D	A	0.0000
495	T	A	-1.4216
496	L	A	0.0000
497	G	A	0.0000
498	R	A	-1.9492
499	L	A	0.0000
500	S	A	-1.0951
501	H	A	-1.5459
502	I	A	0.0000
503	L	A	-1.1293
504	E	A	-1.6144
505	M	A	-0.2895
506	D	A	0.0000
507	H	A	-0.9716
508	F	A	0.0000
509	A	A	0.0000
510	L	A	0.0000
511	V	A	0.0000
512	V	A	0.0000
513	H	A	-2.6311
514	E	A	-3.0117
527	R	A	-2.7659
528	Q	A	-2.0990
529	M	A	-1.0299
530	V	A	0.0000
531	F	A	0.0219
532	G	A	0.0000
533	V	A	-0.1178
534	V	A	0.0000
535	T	A	0.2029
536	A	A	0.3485
537	I	A	1.3804
538	D	A	-0.0224
539	L	A	0.0000
540	L	A	1.2606
541	N	A	-0.4797
542	F	A	-0.4565
543	V	A	-0.2669
544	A	A	-1.3041
545	A	A	-1.6575
546	Q	A	-2.6145
547	E	A	-3.4025
548	R	A	-3.8872
549	D	A	-3.8547
550	Q	A	-2.9484