| Chain sequence(s) |
A: MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA B: MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | 0.2750 | |
| 2 | Q | A | -1.3641 | |
| 3 | L | A | 0.0000 | |
| 4 | K | A | -2.1995 | |
| 5 | P | A | -1.7145 | |
| 6 | M | A | -1.2726 | |
| 7 | E | A | -1.2406 | |
| 8 | I | A | -0.4420 | |
| 9 | N | A | -1.1180 | |
| 10 | P | A | -1.6015 | |
| 11 | E | A | -2.3997 | |
| 12 | M | A | 0.0000 | |
| 13 | L | A | 0.0000 | |
| 14 | N | A | -1.6617 | |
| 15 | K | A | -2.1317 | |
| 16 | V | A | 0.0000 | |
| 17 | L | A | 0.0000 | |
| 18 | S | A | -1.7290 | |
| 19 | R | A | -2.1225 | |
| 20 | L | A | 0.0000 | |
| 21 | G | A | -1.7123 | |
| 22 | V | A | 0.0000 | |
| 23 | A | A | -1.1301 | |
| 24 | G | A | -1.4903 | |
| 25 | Q | A | -1.9036 | |
| 26 | W | A | 0.0000 | |
| 27 | R | A | -1.2349 | |
| 28 | F | A | 0.0000 | |
| 29 | V | A | -0.9121 | |
| 30 | D | A | -1.5137 | |
| 31 | V | A | 0.0000 | |
| 32 | L | A | 0.8410 | |
| 33 | G | A | -0.5917 | |
| 34 | L | A | 0.0000 | |
| 35 | E | A | -3.1046 | |
| 36 | E | A | -3.8713 | |
| 37 | E | A | -3.4757 | |
| 38 | S | A | -1.7494 | |
| 39 | L | A | 0.0000 | |
| 40 | G | A | -1.4940 | |
| 41 | S | A | -0.7903 | |
| 42 | V | A | 0.0000 | |
| 43 | P | A | -0.6050 | |
| 44 | A | A | -0.4567 | |
| 45 | P | A | -0.9813 | |
| 46 | A | A | -0.8227 | |
| 47 | C | A | 0.0000 | |
| 48 | A | A | 0.0000 | |
| 49 | L | A | 0.0000 | |
| 50 | L | A | 0.0000 | |
| 51 | L | A | 0.0000 | |
| 52 | L | A | 0.6258 | |
| 53 | F | A | 0.0000 | |
| 54 | P | A | 0.0000 | |
| 55 | L | A | 0.0000 | |
| 56 | T | A | -0.7561 | |
| 57 | A | A | -0.8370 | |
| 58 | Q | A | -1.3382 | |
| 59 | H | A | -0.7640 | |
| 60 | E | A | -1.3642 | |
| 61 | N | A | -1.6893 | |
| 62 | F | A | -0.3395 | |
| 63 | R | A | -1.4353 | |
| 64 | K | A | -2.5376 | |
| 65 | K | A | -3.3301 | |
| 66 | Q | A | -2.5943 | |
| 67 | I | A | 0.0000 | |
| 68 | E | A | -3.8378 | |
| 69 | E | A | -3.8143 | |
| 70 | L | A | -2.5806 | |
| 71 | K | A | -3.4329 | |
| 72 | G | A | -2.2646 | |
| 73 | Q | A | -2.7801 | |
| 74 | E | A | -2.4875 | |
| 75 | V | A | -1.5202 | |
| 76 | S | A | -1.5557 | |
| 77 | P | A | -1.7690 | |
| 78 | K | A | -2.2983 | |
| 79 | V | A | 0.0000 | |
| 80 | Y | A | 0.0000 | |
| 81 | F | A | 0.0000 | |
| 82 | M | A | 0.0000 | |
| 83 | K | A | -1.7290 | |
| 84 | Q | A | -1.2669 | |
| 85 | T | A | -1.1507 | |
| 86 | I | A | 0.0000 | |
| 87 | G | A | -0.9913 | |
| 88 | N | A | -1.2706 | |
| 89 | S | A | 0.0000 | |
| 90 | C | A | -0.1403 | |
| 91 | G | A | 0.0000 | |
| 92 | T | A | 0.0000 | |
| 93 | I | A | 0.0000 | |
| 94 | G | A | 0.0000 | |
| 95 | L | A | 0.0000 | |
| 96 | I | A | 0.0000 | |
| 97 | H | A | 0.0000 | |
| 98 | A | A | 0.0000 | |
| 99 | V | A | 0.0000 | |
| 100 | A | A | 0.0000 | |
| 101 | N | A | -1.0265 | |
| 102 | N | A | 0.0000 | |
| 103 | Q | A | -2.0807 | |
| 104 | D | A | -2.6641 | |
| 105 | K | A | -2.2860 | |
| 106 | L | A | 0.0000 | |
| 107 | G | A | -1.3553 | |
| 108 | F | A | -1.2818 | |
| 109 | E | A | -2.7190 | |
| 110 | D | A | -2.8830 | |
| 111 | G | A | -1.7764 | |
| 112 | S | A | 0.0000 | |
| 113 | V | A | -0.7089 | |
| 114 | L | A | 0.0000 | |
| 115 | K | A | -1.0367 | |
| 116 | Q | A | -1.3010 | |
| 117 | F | A | 0.0000 | |
| 118 | L | A | 0.0000 | |
| 119 | S | A | -1.3612 | |
| 120 | E | A | -1.7812 | |
| 121 | T | A | 0.0000 | |
| 122 | E | A | -1.5754 | |
| 123 | K | A | 0.0000 | |
| 124 | M | A | 0.0000 | |
| 125 | S | A | -1.9879 | |
| 126 | P | A | -1.8123 | |
| 127 | E | A | -3.2173 | |
| 128 | D | A | -3.2394 | |
| 129 | R | A | 0.0000 | |
| 130 | A | A | 0.0000 | |
| 131 | K | A | -3.4623 | |
| 132 | C | A | 0.0000 | |
| 133 | F | A | 0.0000 | |
| 134 | E | A | -2.6872 | |
| 135 | K | A | -3.0688 | |
| 136 | N | A | -2.4095 | |
| 137 | E | A | -2.5856 | |
| 138 | A | A | -1.3636 | |
| 139 | I | A | 0.0000 | |
| 140 | Q | A | -1.5884 | |
| 141 | A | A | -1.0450 | |
| 142 | A | A | 0.0000 | |
| 143 | H | A | 0.0000 | |
| 144 | D | A | -1.2427 | |
| 145 | A | A | -1.3190 | |
| 146 | V | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | Q | A | -2.7942 | |
| 149 | E | A | -2.8507 | |
| 150 | G | A | -2.3602 | |
| 151 | Q | A | -2.0712 | |
| 152 | C | A | -0.8776 | |
| 153 | R | A | -1.2761 | |
| 154 | V | A | -0.3313 | |
| 155 | D | A | -2.6073 | |
| 156 | D | A | -3.1048 | |
| 157 | K | A | -2.7897 | |
| 158 | V | A | -1.3941 | |
| 159 | N | A | -0.6542 | |
| 160 | F | A | 0.3206 | |
| 161 | H | A | 0.0000 | |
| 162 | F | A | 0.0000 | |
| 163 | I | A | 0.0000 | |
| 164 | L | A | 0.0000 | |
| 165 | F | A | 0.0000 | |
| 166 | N | A | 0.0000 | |
| 167 | N | A | -1.3738 | |
| 168 | V | A | -1.4401 | |
| 169 | D | A | -2.1246 | |
| 170 | G | A | -1.6180 | |
| 171 | H | A | -1.4150 | |
| 172 | L | A | 0.0000 | |
| 173 | Y | A | 0.0000 | |
| 174 | E | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | D | A | 0.0000 | |
| 177 | G | A | 0.0000 | |
| 178 | R | A | -0.7864 | |
| 179 | M | A | 0.0000 | |
| 180 | P | A | -1.6073 | |
| 181 | F | A | -0.8284 | |
| 182 | P | A | 0.0000 | |
| 183 | V | A | -0.2352 | |
| 184 | N | A | -0.9494 | |
| 185 | H | A | -0.8402 | |
| 186 | G | A | -0.8204 | |
| 187 | A | A | -0.6716 | |
| 188 | S | A | -1.4672 | |
| 189 | S | A | -2.1264 | |
| 190 | E | A | -3.0712 | |
| 191 | D | A | -2.9275 | |
| 192 | T | A | -1.9102 | |
| 193 | L | A | 0.0000 | |
| 194 | L | A | -1.4951 | |
| 195 | K | A | -2.4449 | |
| 196 | D | A | -1.8315 | |
| 197 | A | A | 0.0000 | |
| 198 | A | A | 0.0000 | |
| 199 | K | A | -2.4258 | |
| 200 | V | A | -1.4757 | |
| 201 | C | A | 0.0000 | |
| 202 | R | A | -2.5972 | |
| 203 | E | A | -3.3685 | |
| 204 | F | A | 0.0000 | |
| 205 | T | A | -2.2357 | |
| 206 | E | A | -4.0512 | |
| 207 | R | A | -4.0329 | |
| 208 | E | A | -2.9103 | |
| 209 | Q | A | -2.6243 | |
| 210 | G | A | -1.5985 | |
| 211 | E | A | -0.8109 | |
| 212 | V | A | 1.0866 | |
| 213 | R | A | 0.4706 | |
| 214 | F | A | 1.4453 | |
| 215 | S | A | 0.6381 | |
| 216 | A | A | 0.0000 | |
| 217 | V | A | 0.0000 | |
| 218 | A | A | 0.0000 | |
| 219 | L | A | 0.0000 | |
| 220 | C | A | 0.0000 | |
| 221 | K | A | -1.5993 | |
| 222 | A | A | -0.8522 | |
| 223 | A | A | -0.3450 | |
| 1 | M | B | 0.2301 | |
| 2 | Q | B | -1.3376 | |
| 3 | L | B | 0.0000 | |
| 4 | K | B | -2.0692 | |
| 5 | P | B | -1.6931 | |
| 6 | M | B | 0.0000 | |
| 7 | E | B | 0.0000 | |
| 8 | I | B | 0.0260 | |
| 9 | N | B | -1.0146 | |
| 10 | P | B | -1.6489 | |
| 11 | E | B | -2.3903 | |
| 12 | M | B | 0.0000 | |
| 13 | L | B | 0.0000 | |
| 14 | N | B | -1.6165 | |
| 15 | K | B | -2.1351 | |
| 16 | V | B | 0.0000 | |
| 17 | L | B | 0.0000 | |
| 18 | S | B | -1.6566 | |
| 19 | R | B | -2.0633 | |
| 20 | L | B | 0.0000 | |
| 21 | G | B | -1.9570 | |
| 22 | V | B | 0.0000 | |
| 23 | A | B | -1.7466 | |
| 24 | G | B | -1.6034 | |
| 25 | Q | B | -2.0464 | |
| 26 | W | B | 0.0000 | |
| 27 | R | B | -1.3730 | |
| 28 | F | B | 0.0000 | |
| 29 | V | B | -1.0867 | |
| 30 | D | B | -1.6303 | |
| 31 | V | B | 0.0000 | |
| 32 | L | B | 0.6058 | |
| 33 | G | B | 0.0000 | |
| 34 | L | B | 0.0000 | |
| 35 | E | B | -3.4288 | |
| 36 | E | B | -3.8171 | |
| 37 | E | B | -3.1632 | |
| 38 | S | B | -1.7031 | |
| 39 | L | B | 0.0000 | |
| 40 | G | B | -1.5451 | |
| 41 | S | B | -0.9199 | |
| 42 | V | B | 0.0000 | |
| 43 | P | B | -0.3583 | |
| 44 | A | B | -0.5027 | |
| 45 | P | B | -0.8572 | |
| 46 | A | B | -0.8223 | |
| 47 | C | B | 0.0000 | |
| 48 | A | B | 0.0000 | |
| 49 | L | B | 0.0000 | |
| 50 | L | B | 0.0000 | |
| 51 | L | B | 0.0000 | |
| 52 | L | B | 0.4189 | |
| 53 | F | B | 0.0000 | |
| 54 | P | B | 0.0000 | |
| 55 | L | B | 0.0000 | |
| 56 | T | B | -0.8688 | |
| 57 | A | B | -0.6943 | |
| 58 | Q | B | -1.2015 | |
| 59 | H | B | -1.2492 | |
| 60 | E | B | -1.0800 | |
| 61 | N | B | -1.1380 | |
| 62 | F | B | -0.3183 | |
| 63 | R | B | -1.4732 | |
| 64 | K | B | -2.2373 | |
| 65 | K | B | -2.8796 | |
| 66 | Q | B | -2.6220 | |
| 67 | I | B | 0.0000 | |
| 68 | E | B | -3.6319 | |
| 69 | E | B | -3.5209 | |
| 70 | L | B | -2.3651 | |
| 71 | K | B | -2.7955 | |
| 72 | G | B | -2.3375 | |
| 73 | Q | B | -1.8037 | |
| 74 | E | B | -2.2756 | |
| 75 | V | B | -1.6952 | |
| 76 | S | B | -1.8292 | |
| 77 | P | B | -1.9363 | |
| 78 | K | B | -2.4237 | |
| 79 | V | B | 0.0000 | |
| 80 | Y | B | 0.0000 | |
| 81 | F | B | 0.0000 | |
| 82 | M | B | 0.0000 | |
| 83 | K | B | -1.2703 | |
| 84 | Q | B | -1.0991 | |
| 85 | T | B | -0.9990 | |
| 86 | I | B | 0.0000 | |
| 87 | G | B | -0.9927 | |
| 88 | N | B | -1.2554 | |
| 89 | S | B | 0.0000 | |
| 90 | C | B | -0.1964 | |
| 91 | G | B | 0.0000 | |
| 92 | T | B | 0.0000 | |
| 93 | I | B | 0.0000 | |
| 94 | G | B | 0.0000 | |
| 95 | L | B | 0.0000 | |
| 96 | I | B | 0.0000 | |
| 97 | H | B | 0.0000 | |
| 98 | A | B | 0.0000 | |
| 99 | V | B | 0.0000 | |
| 100 | A | B | 0.0000 | |
| 101 | N | B | -1.1017 | |
| 102 | N | B | -1.5084 | |
| 103 | Q | B | -2.1010 | |
| 104 | D | B | -2.7510 | |
| 105 | K | B | -2.5478 | |
| 106 | L | B | 0.0000 | |
| 107 | G | B | -2.0868 | |
| 108 | F | B | -1.9783 | |
| 109 | E | B | -3.0052 | |
| 110 | D | B | -3.1240 | |
| 111 | G | B | -2.0806 | |
| 112 | S | B | 0.0000 | |
| 113 | V | B | -1.1927 | |
| 114 | L | B | 0.0000 | |
| 115 | K | B | -2.3475 | |
| 116 | Q | B | -2.4471 | |
| 117 | F | B | 0.0000 | |
| 118 | L | B | 0.0000 | |
| 119 | S | B | -2.4475 | |
| 120 | E | B | -2.9925 | |
| 121 | T | B | 0.0000 | |
| 122 | E | B | -2.8764 | |
| 123 | K | B | -3.0184 | |
| 124 | M | B | -2.0011 | |
| 125 | S | B | 0.0000 | |
| 126 | P | B | -1.6006 | |
| 127 | E | B | -2.4258 | |
| 128 | D | B | -2.1711 | |
| 129 | R | B | 0.0000 | |
| 130 | A | B | 0.0000 | |
| 131 | K | B | -2.8151 | |
| 132 | C | B | -2.2411 | |
| 133 | F | B | 0.0000 | |
| 134 | E | B | -2.5149 | |
| 135 | K | B | -3.0565 | |
| 136 | N | B | -2.3530 | |
| 137 | E | B | -2.5759 | |
| 138 | A | B | -1.3762 | |
| 139 | I | B | 0.0000 | |
| 140 | Q | B | -1.6370 | |
| 141 | A | B | -1.0477 | |
| 142 | A | B | 0.0000 | |
| 143 | H | B | 0.0000 | |
| 144 | D | B | -1.2519 | |
| 145 | A | B | -1.3521 | |
| 146 | V | B | 0.0000 | |
| 147 | A | B | 0.0000 | |
| 148 | Q | B | -2.7737 | |
| 149 | E | B | -2.7482 | |
| 150 | G | B | -2.2145 | |
| 151 | Q | B | -1.9424 | |
| 152 | C | B | -1.2514 | |
| 153 | R | B | -2.2659 | |
| 154 | V | B | -1.6127 | |
| 155 | D | B | -2.8361 | |
| 156 | D | B | -3.3589 | |
| 157 | K | B | -2.8226 | |
| 158 | V | B | -1.7339 | |
| 159 | N | B | -0.9969 | |
| 160 | F | B | -0.2046 | |
| 161 | H | B | 0.0000 | |
| 162 | F | B | 0.0000 | |
| 163 | I | B | 0.0000 | |
| 164 | L | B | 0.0000 | |
| 165 | F | B | 0.0000 | |
| 166 | N | B | 0.0000 | |
| 167 | N | B | -1.6348 | |
| 168 | V | B | 0.0000 | |
| 169 | D | B | -2.6108 | |
| 170 | G | B | -1.8289 | |
| 171 | H | B | -1.5494 | |
| 172 | L | B | 0.0000 | |
| 173 | Y | B | 0.0000 | |
| 174 | E | B | 0.0000 | |
| 175 | L | B | 0.0000 | |
| 176 | D | B | 0.0000 | |
| 177 | G | B | 0.0000 | |
| 178 | R | B | -0.7038 | |
| 179 | M | B | 0.0000 | |
| 180 | P | B | -1.1733 | |
| 181 | F | B | -0.3628 | |
| 182 | P | B | 0.0000 | |
| 183 | V | B | 0.0000 | |
| 184 | N | B | -0.8038 | |
| 185 | H | B | -0.6339 | |
| 186 | G | B | -0.8293 | |
| 187 | A | B | -0.9691 | |
| 188 | S | B | -1.5403 | |
| 189 | S | B | -2.1351 | |
| 190 | E | B | -3.1645 | |
| 191 | D | B | -2.9472 | |
| 192 | T | B | -1.9092 | |
| 193 | L | B | 0.0000 | |
| 194 | L | B | 0.0000 | |
| 195 | K | B | -2.3551 | |
| 196 | D | B | -1.7792 | |
| 197 | A | B | 0.0000 | |
| 198 | A | B | 0.0000 | |
| 199 | K | B | -2.8555 | |
| 200 | V | B | -1.8847 | |
| 201 | C | B | 0.0000 | |
| 202 | R | B | -3.0813 | |
| 203 | E | B | -3.6515 | |
| 204 | F | B | 0.0000 | |
| 205 | T | B | -2.8333 | |
| 206 | E | B | -3.9529 | |
| 207 | R | B | -3.6960 | |
| 208 | E | B | -2.8305 | |
| 209 | Q | B | -2.1762 | |
| 210 | G | B | -1.5519 | |
| 211 | E | B | -0.4961 | |
| 212 | V | B | 1.0460 | |
| 213 | R | B | -0.0107 | |
| 214 | F | B | 0.9757 | |
| 215 | S | B | 0.4923 | |
| 216 | A | B | 0.0000 | |
| 217 | V | B | 0.0000 | |
| 218 | A | B | 0.0000 | |
| 219 | L | B | 0.0000 | |
| 220 | C | B | 0.0000 | |
| 221 | K | B | -1.6664 | |
| 222 | A | B | -0.7822 | |
| 223 | A | B | -0.4677 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine