Project name: a82ba64ee263abf

Chain sequence(s)	A: LPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3946
• Maximal score value: 4.297
• Average score: -0.3623
• Total score value: -206.8561

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
154	L	A	0.5512
155	P	A	-0.8001
156	E	A	-1.2698
157	A	A	-0.7035
158	R	A	-1.7731
159	K	A	-1.3277
160	L	A	-0.2142
161	L	A	0.5808
162	G	A	0.0493
163	L	A	0.0000
164	A	A	-0.0018
165	Y	A	0.5243
166	P	A	-0.5255
167	E	A	0.0000
168	R	A	-2.2301
169	R	A	-2.6864
170	R	A	-1.6213
171	L	A	0.0000
172	A	A	-1.0338
173	A	A	-0.5666
174	A	A	0.0000
175	V	A	0.2761
176	G	A	0.2051
177	F	A	0.8319
178	L	A	0.0000
179	T	A	0.7025
180	M	A	1.2778
181	S	A	0.8601
182	S	A	0.0000
183	V	A	2.0841
184	I	A	2.0119
185	S	A	0.9718
186	M	A	0.0000
187	S	A	1.3358
188	A	A	1.1848
189	P	A	0.0000
190	F	A	1.4425
191	F	A	1.6663
192	L	A	1.6310
193	G	A	0.0000
194	K	A	0.3096
195	I	A	1.4369
196	I	A	1.4455
197	D	A	0.9153
198	V	A	1.6156
199	I	A	1.9466
200	Y	A	1.8635
201	T	A	1.0423
202	N	A	0.5225
203	P	A	0.4848
204	T	A	0.2416
205	V	A	0.5826
206	D	A	-1.3389
207	Y	A	-1.0088
208	S	A	-1.3368
209	D	A	-2.2903
210	N	A	-1.8826
211	L	A	-0.1768
212	T	A	-0.4679
213	R	A	-1.4038
214	L	A	0.1998
215	C	A	1.1918
216	L	A	1.7784
217	G	A	1.3532
218	L	A	2.3638
219	S	A	2.3146
220	A	A	2.5934
221	V	A	3.5814
222	F	A	3.8479
223	L	A	3.2829
224	C	A	2.5600
225	G	A	2.2204
226	A	A	1.5108
227	A	A	1.2942
228	A	A	0.0000
229	N	A	0.5724
230	A	A	1.0533
231	I	A	1.7159
232	R	A	1.0246
233	V	A	1.3716
234	Y	A	1.4744
235	L	A	0.4223
236	M	A	0.0000
237	Q	A	-1.4266
238	T	A	-1.0621
239	S	A	0.0000
240	G	A	0.0000
241	Q	A	-2.9585
242	R	A	-3.3199
243	I	A	0.0000
244	V	A	-2.2087
245	N	A	-3.0486
246	R	A	-2.4132
247	L	A	0.0000
248	R	A	-1.9623
249	T	A	-0.8243
250	S	A	-0.4211
251	L	A	0.0000
252	F	A	1.5983
253	S	A	0.7079
254	S	A	-0.0587
255	I	A	0.0000
256	L	A	1.6721
257	R	A	-0.4286
258	Q	A	0.0000
259	E	A	0.0000
260	V	A	0.4274
261	A	A	-0.3294
262	F	A	0.0000
263	F	A	-0.2806
264	D	A	-1.7018
265	K	A	-2.3267
266	T	A	-1.8631
267	R	A	-2.4400
268	T	A	-1.3462
269	G	A	-1.2384
270	E	A	-1.5755
271	L	A	0.0000
272	I	A	0.0589
273	N	A	-1.2593
274	R	A	-1.0521
275	L	A	0.0000
276	S	A	-0.6899
277	S	A	-0.5740
278	D	A	0.0000
279	T	A	0.0000
280	A	A	-0.7432
281	L	A	-0.6491
282	L	A	0.0000
283	G	A	0.0000
284	R	A	-1.7412
285	S	A	0.0000
286	V	A	0.0000
287	T	A	0.0000
288	E	A	-1.4330
289	N	A	0.0000
290	L	A	-0.3597
291	S	A	0.0000
292	D	A	-2.0410
293	G	A	0.0000
294	L	A	-0.4391
295	R	A	-1.3958
296	A	A	0.0000
297	G	A	-0.1824
298	A	A	-0.0097
299	Q	A	0.0000
300	A	A	0.7989
301	S	A	0.0773
302	V	A	1.1526
303	G	A	0.0000
304	I	A	1.2991
305	S	A	1.0861
306	M	A	1.4938
307	M	A	0.0000
308	F	A	1.6251
309	F	A	2.3851
310	V	A	1.2286
311	S	A	0.0000
312	P	A	0.1760
313	N	A	-0.6356
314	L	A	0.0000
315	A	A	0.0000
316	T	A	0.2534
317	F	A	0.5267
318	V	A	1.0534
319	L	A	1.2349
320	S	A	0.7851
321	V	A	1.1595
322	V	A	1.6548
323	P	A	1.4435
324	P	A	1.6248
325	V	A	2.3069
326	S	A	2.6708
327	I	A	4.1719
328	I	A	4.2970
329	A	A	3.0159
330	V	A	3.4996
331	I	A	3.4909
332	Y	A	1.9315
333	G	A	0.0000
334	R	A	-1.3050
335	Y	A	-0.4283
336	L	A	0.0000
337	R	A	-3.3783
338	K	A	-3.1953
339	L	A	0.0000
340	T	A	-2.5160
341	K	A	-3.1422
342	V	A	-1.4445
343	T	A	0.0000
344	Q	A	-2.1374
345	D	A	-2.5249
346	S	A	-1.3803
347	L	A	-1.1169
348	A	A	-1.3054
349	Q	A	-2.0954
350	A	A	0.0000
351	T	A	-1.6647
352	Q	A	-2.3390
353	L	A	-1.7295
354	A	A	-1.3098
355	E	A	-2.6121
356	E	A	-2.4399
357	R	A	-1.2990
358	I	A	0.0859
359	G	A	-1.0280
360	N	A	-1.7124
361	V	A	-1.0343
362	R	A	-1.9697
363	T	A	-1.2563
364	V	A	0.0000
365	R	A	-2.3395
366	A	A	-0.7250
367	F	A	0.4827
368	G	A	-1.0108
369	K	A	-1.2541
370	E	A	-1.1070
371	M	A	-0.1383
372	T	A	-0.6844
373	E	A	-0.4548
374	I	A	0.6477
375	E	A	-1.4548
376	K	A	-1.3474
377	Y	A	-0.6750
378	A	A	-1.0173
379	S	A	-1.5481
380	K	A	-1.6641
381	V	A	-1.0951
382	D	A	-2.0870
383	H	A	-1.8555
384	V	A	0.0000
385	M	A	-1.3216
386	Q	A	-2.2812
387	L	A	-1.4021
388	A	A	-1.2665
389	R	A	-2.1733
390	K	A	-1.6080
391	E	A	-1.2976
392	A	A	-0.4476
393	F	A	0.8187
394	A	A	0.4348
395	R	A	-0.0235
396	A	A	0.7141
397	G	A	0.5564
398	F	A	1.1548
399	F	A	1.7345
400	G	A	0.6777
401	A	A	0.8515
402	T	A	0.7543
403	G	A	0.6518
404	L	A	1.4732
405	S	A	1.2354
406	G	A	0.4385
407	N	A	0.3113
408	L	A	1.8770
409	I	A	1.8986
410	V	A	1.9892
411	L	A	2.3829
412	S	A	1.7137
413	V	A	0.0000
414	L	A	2.3078
415	Y	A	2.2512
416	K	A	0.8619
417	G	A	0.0000
418	G	A	1.0144
419	L	A	1.3792
420	L	A	0.4243
421	M	A	0.2759
422	G	A	-0.0577
423	S	A	-0.1937
424	A	A	-0.2845
425	H	A	-0.8440
426	M	A	0.0000
427	T	A	-0.2441
428	V	A	0.2896
429	G	A	0.0000
430	E	A	-0.4329
431	L	A	0.0000
432	S	A	0.2458
433	S	A	0.0000
434	F	A	0.0000
435	L	A	0.9168
436	M	A	1.0808
437	Y	A	0.0000
438	A	A	1.4746
439	F	A	2.5871
440	W	A	2.1364
441	V	A	1.8928
442	G	A	1.8116
443	I	A	2.8086
444	S	A	0.0000
445	I	A	2.4040
446	G	A	1.2814
447	G	A	0.5811
448	L	A	0.7442
449	S	A	0.7952
450	S	A	0.0088
451	F	A	0.3093
452	Y	A	1.1752
453	S	A	0.0577
454	E	A	-0.6711
455	L	A	0.3921
456	M	A	0.5363
457	K	A	-1.0745
458	G	A	0.0000
459	L	A	-0.2299
460	G	A	-0.6362
461	A	A	0.0000
462	G	A	0.0000
463	G	A	-1.3554
464	R	A	-1.4846
465	L	A	0.0000
466	W	A	-1.8127
467	E	A	-2.8530
468	L	A	0.0000
469	L	A	-1.4029
470	E	A	-2.8379
471	R	A	-2.9360
472	E	A	-3.0972
473	P	A	-1.8234
474	K	A	-2.0721
475	L	A	-1.2199
476	P	A	-1.3300
477	F	A	-0.3538
478	N	A	-1.3302
479	E	A	-1.9392
480	G	A	-0.7327
481	V	A	1.0544
482	I	A	2.0502
483	L	A	-0.0023
484	N	A	-2.1172
485	E	A	-3.1560
486	K	A	-3.1652
487	S	A	-2.1092
488	F	A	-1.7644
489	Q	A	-2.0966
490	G	A	0.0000
491	A	A	-1.0304
492	L	A	0.0000
493	E	A	-2.1148
494	F	A	0.0000
495	K	A	-2.6317
496	N	A	-2.6767
497	V	A	0.0000
498	H	A	-1.8088
499	F	A	0.0000
500	A	A	-0.6380
501	Y	A	-0.5564
502	P	A	-1.0141
503	A	A	-1.5562
504	R	A	-2.0123
505	P	A	-1.5646
506	E	A	-2.0074
507	V	A	-0.4978
508	P	A	-0.8206
509	I	A	-0.8399
510	F	A	0.0000
511	Q	A	-2.5616
512	D	A	-2.8591
513	F	A	0.0000
514	S	A	-1.8793
515	L	A	0.0000
516	S	A	-0.8577
517	I	A	0.0000
518	P	A	-0.7838
519	S	A	-0.8067
520	G	A	-1.2323
521	S	A	-0.5717
522	V	A	-0.6932
523	T	A	0.0000
524	A	A	0.0000
525	L	A	0.0000
526	V	A	0.1374
527	G	A	-0.4340
528	P	A	-0.6897
529	S	A	-0.5373
530	G	A	-0.7947
531	S	A	-0.9792
532	G	A	-0.6700
533	K	A	0.0000
534	S	A	-0.3093
535	T	A	0.0000
536	V	A	0.0000
537	L	A	0.1711
538	S	A	0.2529
539	L	A	0.0000
540	L	A	0.0000
541	L	A	0.3071
542	R	A	0.0000
543	L	A	0.6218
544	Y	A	0.1675
545	D	A	-0.8075
546	P	A	-0.4178
547	A	A	-0.2673
548	S	A	-1.1258
549	G	A	-1.5583
550	T	A	-1.5158
551	I	A	0.0000
552	S	A	-1.5943
553	L	A	0.0000
554	D	A	-1.1056
555	G	A	-1.0294
556	H	A	-1.2301
557	D	A	-1.6503
558	I	A	0.0000
559	R	A	-2.5870
560	Q	A	-1.9018
561	L	A	0.0000
562	N	A	0.0000
563	P	A	0.0000
564	V	A	0.9316
565	W	A	0.5486
566	L	A	0.0000
567	R	A	-0.0662
568	S	A	-0.7535
569	K	A	-0.7621
570	I	A	0.0000
571	G	A	0.0000
572	T	A	-0.2160
573	V	A	0.0000
574	S	A	-0.7185
575	Q	A	-1.4686
576	E	A	-1.8552
577	P	A	0.0000
578	I	A	1.6301
579	L	A	0.0000
580	F	A	1.6984
581	S	A	0.2342
582	C	A	-0.1650
583	S	A	-0.3973
584	I	A	0.0000
585	A	A	-0.9286
586	E	A	-1.3621
587	N	A	0.0000
588	I	A	0.0000
589	A	A	0.0000
590	Y	A	-0.3126
591	G	A	-1.0558
592	A	A	-1.6258
593	D	A	-2.5301
594	D	A	-2.3831
595	P	A	-1.5616
596	S	A	-1.1679
597	S	A	-1.0809
598	V	A	-1.0820
599	T	A	-1.0297
600	A	A	-1.5270
601	E	A	-3.0531
602	E	A	-2.7211
603	I	A	-2.1730
604	Q	A	-2.9299
605	R	A	-3.3946
606	V	A	0.0000
607	A	A	0.0000
608	E	A	-1.9766
609	V	A	-1.1692
610	A	A	0.0000
611	N	A	-0.4708
612	A	A	0.0000
613	V	A	-1.2328
614	A	A	-0.8510
615	F	A	-0.6865
616	I	A	0.0000
617	R	A	-2.5552
618	N	A	-2.0885
619	F	A	-1.3415
620	P	A	-1.4812
621	Q	A	-1.9839
622	G	A	-1.7666
623	F	A	-1.3477
624	N	A	-1.7871
625	T	A	0.0000
626	V	A	0.3817
627	V	A	0.0000
628	G	A	0.3287
629	E	A	-1.4706
630	K	A	-1.8139
631	G	A	-0.0673
632	V	A	1.4244
633	L	A	1.4102
634	L	A	0.0000
635	S	A	-0.3165
636	G	A	-1.1538
637	G	A	0.0000
638	Q	A	-0.3974
639	K	A	-0.5248
640	Q	A	-0.7207
641	R	A	0.0000
642	I	A	0.0000
643	A	A	0.0000
644	I	A	0.0000
645	A	A	0.0000
646	R	A	-0.6069
647	A	A	0.0000
648	L	A	0.0000
649	L	A	-1.0947
650	K	A	-1.5495
651	N	A	-1.7082
652	P	A	0.0000
653	K	A	-1.2898
654	I	A	0.0000
655	L	A	0.0000
656	L	A	0.0000
657	L	A	0.0000
658	D	A	0.0000
659	E	A	-0.9521
660	A	A	-0.8779
661	T	A	-0.5628
662	S	A	-0.4250
663	A	A	-0.6179
664	L	A	-0.8571
665	D	A	-2.2099
666	A	A	-1.4803
667	E	A	-2.0381
668	N	A	0.0000
669	E	A	-1.3772
670	Y	A	-0.1898
671	L	A	-0.2842
672	V	A	0.0000
673	Q	A	-1.7630
674	E	A	-1.7158
675	A	A	0.0000
676	L	A	-1.6117
677	D	A	-3.0675
678	R	A	-2.5274
679	L	A	0.0000
680	M	A	-1.7130
681	D	A	-2.6677
682	G	A	-1.5950
683	R	A	0.0000
684	T	A	0.0000
685	V	A	0.0000
686	L	A	0.0000
687	V	A	0.0000
688	I	A	0.0000
689	A	A	0.0000
690	H	A	-0.5724
691	R	A	-0.9696
692	L	A	0.2056
693	S	A	-0.7272
694	T	A	-1.2280
695	I	A	-1.2106
696	K	A	-2.5835
697	N	A	-2.1502
698	A	A	0.0000
699	N	A	-1.8388
700	M	A	-1.1787
701	V	A	0.0000
702	A	A	0.0000
703	V	A	-0.2634
704	L	A	0.0000
705	D	A	-1.9353
706	Q	A	-2.2432
707	G	A	0.0000
708	K	A	-2.2218
709	I	A	-0.9557
710	T	A	-0.9819
711	E	A	-1.0043
712	Y	A	0.0599
713	G	A	-0.7763
714	K	A	-2.0266
715	H	A	0.0000
716	E	A	-2.7941
717	E	A	-2.6492
718	L	A	-1.3280
719	L	A	-0.5315
720	S	A	-1.8263
721	K	A	-2.5838
722	P	A	-1.7987
723	N	A	-2.0148
724	G	A	-1.3042