| Chain sequence(s) |
A: QVQLQESGPGLVKPSFTLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVQTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAFDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6585 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1239 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8505 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.6831 | |
| 8 | G | A | -0.4417 | |
| 9 | P | A | -0.5499 | |
| 10 | G | A | -0.4616 | |
| 11 | L | A | -0.2255 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -1.3119 | |
| 14 | P | A | -0.6255 | |
| 15 | S | A | -0.0571 | |
| 16 | F | A | 0.8509 | |
| 17 | T | A | -0.0330 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.6277 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.7232 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.2209 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3027 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8538 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2877 | |
| 31 | S | A | 0.0164 | |
| 32 | G | A | 0.1264 | |
| 33 | Y | A | 0.1776 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8043 | |
| 40 | P | A | -0.9998 | |
| 41 | P | A | -1.1161 | |
| 42 | G | A | -1.5020 | |
| 43 | K | A | -2.3799 | |
| 44 | G | A | -1.5453 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6463 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0316 | |
| 53 | Y | A | 0.5901 | |
| 54 | S | A | -0.4307 | |
| 55 | G | A | -1.0181 | |
| 56 | D | A | -1.5379 | |
| 57 | T | A | -0.3333 | |
| 58 | Y | A | 0.8002 | |
| 59 | Y | A | 0.5212 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8670 | |
| 62 | S | A | -1.1235 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0151 | |
| 65 | S | A | -1.2746 | |
| 66 | R | A | -1.3675 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.5836 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.8082 | |
| 71 | V | A | -0.7193 | |
| 72 | Q | A | -1.8626 | |
| 73 | T | A | -1.4839 | |
| 74 | S | A | -1.5498 | |
| 75 | K | A | -2.3511 | |
| 76 | N | A | -1.6526 | |
| 77 | Q | A | -1.4942 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.6228 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6237 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -0.4256 | |
| 84 | S | A | -0.1795 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.2144 | |
| 87 | A | A | -0.2085 | |
| 88 | A | A | 0.0271 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0292 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1099 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6635 | |
| 98 | Y | A | -0.0732 | |
| 99 | G | A | -0.1019 | |
| 100 | S | A | -0.1466 | |
| 101 | Y | A | 0.2448 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4461 | |
| 105 | Y | A | -0.7924 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8496 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.4706 | |
| 111 | T | A | -0.1835 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2866 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.5859 | |
| 116 | S | A | -0.8711 | |
| 117 | A | A | -0.5471 | |
| 118 | S | A | -0.6599 | |
| 119 | T | A | -0.7361 | |
| 120 | K | A | -1.1854 | |
| 121 | G | A | -1.3319 | |
| 122 | P | A | -0.6021 | |
| 123 | S | A | -0.4064 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3073 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8976 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4602 | |
| 131 | S | A | -0.5444 | |
| 132 | R | A | -0.9096 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8881 | |
| 135 | S | A | -1.3582 | |
| 136 | E | A | -2.0794 | |
| 137 | S | A | -1.3121 | |
| 138 | T | A | -0.9402 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | 0.0000 | |
| 147 | D | A | -0.3312 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.4920 | |
| 152 | P | A | -0.6781 | |
| 153 | V | A | -0.6871 | |
| 154 | T | A | -0.6492 | |
| 155 | V | A | -0.4310 | |
| 156 | S | A | -0.5382 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0429 | |
| 159 | S | A | -0.7943 | |
| 160 | G | A | -0.6095 | |
| 161 | A | A | -0.2860 | |
| 162 | L | A | -0.1390 | |
| 163 | T | A | -0.2474 | |
| 164 | S | A | -0.2714 | |
| 165 | G | A | -0.3739 | |
| 166 | V | A | 0.0718 | |
| 167 | H | A | -0.2295 | |
| 168 | T | A | -0.0066 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3816 | |
| 171 | A | A | 0.2660 | |
| 172 | V | A | 0.6291 | |
| 173 | L | A | 1.3937 | |
| 174 | Q | A | 0.4194 | |
| 175 | S | A | 0.0111 | |
| 176 | S | A | -0.1607 | |
| 177 | G | A | 0.1234 | |
| 178 | L | A | 0.2535 | |
| 179 | Y | A | 0.5604 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1851 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6405 | |
| 189 | S | A | -0.6894 | |
| 190 | S | A | -0.5495 | |
| 191 | S | A | -0.6616 | |
| 192 | L | A | -0.8220 | |
| 193 | G | A | -1.1720 | |
| 194 | T | A | -0.8970 | |
| 195 | K | A | -1.6263 | |
| 196 | T | A | -1.4955 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.8955 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -2.1417 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7648 | |
| 205 | P | A | -1.6399 | |
| 206 | S | A | -1.8601 | |
| 207 | N | A | -2.5663 | |
| 208 | T | A | -2.1314 | |
| 209 | K | A | -2.7868 | |
| 210 | V | A | -2.0671 | |
| 211 | D | A | -2.9779 | |
| 212 | K | A | -2.6663 | |
| 213 | R | A | -3.1002 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6182 | |
| 216 | S | A | -1.1028 | |
| 217 | D | B | -1.2260 | |
| 218 | I | B | -0.1956 | |
| 219 | V | B | 0.7435 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.5075 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3667 | |
| 224 | P | B | -0.2405 | |
| 225 | L | B | 0.0409 | |
| 226 | S | B | -0.5083 | |
| 227 | L | B | -0.6763 | |
| 228 | S | B | -1.0750 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.7407 | |
| 231 | P | B | -1.7467 | |
| 232 | G | B | -1.7931 | |
| 233 | Q | B | -2.2373 | |
| 234 | P | B | -2.0690 | |
| 235 | A | B | -1.2572 | |
| 236 | S | B | -0.7689 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8862 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1248 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8520 | |
| 243 | Q | B | -1.3778 | |
| 244 | S | B | -0.7204 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5217 | |
| 247 | H | B | -0.6171 | |
| 248 | S | B | -0.9567 | |
| 249 | N | B | -1.6739 | |
| 250 | G | B | -1.1668 | |
| 251 | N | B | -1.0716 | |
| 252 | T | B | 0.0000 | |
| 253 | Y | B | -0.0792 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1219 | |
| 260 | K | B | -1.3997 | |
| 261 | P | B | -1.4163 | |
| 262 | G | B | -1.6380 | |
| 263 | Q | B | -2.0222 | |
| 264 | S | B | -1.3872 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.2659 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.7279 | |
| 271 | K | B | -1.2141 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -1.1666 | |
| 274 | N | B | -1.6399 | |
| 275 | R | B | -1.9764 | |
| 276 | F | B | -0.7483 | |
| 277 | S | B | -0.6227 | |
| 278 | G | B | -0.8129 | |
| 279 | V | B | -0.9519 | |
| 280 | P | B | -1.3111 | |
| 281 | D | B | -2.2977 | |
| 282 | R | B | -2.1333 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.4028 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.8330 | |
| 287 | G | B | -0.9601 | |
| 288 | S | B | -0.6375 | |
| 289 | G | B | -0.5987 | |
| 290 | T | B | -1.3567 | |
| 291 | D | B | -1.9742 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9846 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5856 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2795 | |
| 298 | R | B | -2.9747 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -1.4938 | |
| 301 | A | B | -1.2090 | |
| 302 | F | B | -0.1322 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7514 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0590 | |
| 315 | V | B | 0.8785 | |
| 316 | P | B | 0.0000 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1240 | |
| 319 | F | B | 0.1231 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.3031 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7770 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.7219 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.9002 | |
| 329 | R | B | -1.4163 | |
| 330 | T | B | -0.2873 | |
| 331 | V | B | -0.0019 | |
| 332 | A | B | -0.1980 | |
| 333 | A | B | -0.1897 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1136 | |
| 336 | V | B | -0.1562 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6920 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.4828 | |
| 343 | D | B | -2.9218 | |
| 344 | E | B | -2.7058 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.0732 | |
| 347 | K | B | -2.6600 | |
| 348 | S | B | -1.6932 | |
| 349 | G | B | -1.0428 | |
| 350 | T | B | -1.0482 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0998 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.9082 | |
| 363 | R | B | -3.1905 | |
| 364 | E | B | -3.2790 | |
| 365 | A | B | -2.3797 | |
| 366 | K | B | -2.4162 | |
| 367 | V | B | -1.0475 | |
| 368 | Q | B | -0.5048 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.7427 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1273 | |
| 373 | N | B | -1.6564 | |
| 374 | A | B | -0.3816 | |
| 375 | L | B | 0.7137 | |
| 376 | Q | B | -0.1997 | |
| 377 | S | B | -0.4627 | |
| 378 | G | B | -0.8972 | |
| 379 | N | B | -0.8149 | |
| 380 | S | B | -1.1111 | |
| 381 | Q | B | -1.3714 | |
| 382 | E | B | -1.9558 | |
| 383 | S | B | -0.9059 | |
| 384 | V | B | -0.8868 | |
| 385 | T | B | -1.2803 | |
| 386 | E | B | -2.3492 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.1294 | |
| 389 | S | B | -1.6931 | |
| 390 | K | B | -2.4201 | |
| 391 | D | B | -2.4477 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.6503 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4396 | |
| 402 | L | B | -0.7987 | |
| 403 | S | B | -1.3606 | |
| 404 | K | B | -2.1135 | |
| 405 | A | B | -2.1247 | |
| 406 | D | B | -2.9945 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.7175 | |
| 409 | K | B | -3.8268 | |
| 410 | H | B | -3.3047 | |
| 411 | K | B | -3.3963 | |
| 412 | V | B | -2.1142 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.8366 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.8158 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.2017 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.8249 | |
| 421 | G | B | -0.5654 | |
| 422 | L | B | -0.3254 | |
| 423 | S | B | -0.4507 | |
| 424 | S | B | -0.4466 | |
| 425 | P | B | -0.5646 | |
| 426 | V | B | 0.0594 | |
| 427 | T | B | -0.4224 | |
| 428 | K | B | -0.7951 | |
| 429 | S | B | -1.0051 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.4947 | |
| 432 | R | B | -2.8654 | |
| 433 | G | B | -2.2645 | |
| 434 | E | B | -2.2207 | |
| 435 | C | B | -0.7089 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine