Project name: aac8ed69e38ca25

Chain sequence(s)	A: VKPNYALKFTLAGHTKAVSSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISSGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSSGKKCLKTLKGHSNYVFCCNFNPQQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSSLIVSSSYDGLCCRIWDTASGQCLKTLIDDDNPPVSFVVKFSPNGKYIILAATLDNTLKLWDYSKGKCLKTTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKKSDC; B: GAARAEVVYLR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4435
• Maximal score value: 0.8162
• Average score: -0.5771
• Total score value: -181.2249

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
31	V	A	0.8162
32	K	A	-1.3768
33	P	A	0.0000
34	N	A	-1.9901
35	Y	A	0.0000
36	A	A	-0.5849
37	L	A	-0.0556
38	K	A	-0.7662
39	F	A	-0.2229
40	T	A	-0.2723
41	L	A	0.0000
42	A	A	0.0052
43	G	A	-0.2540
44	H	A	0.0000
45	T	A	-0.8946
46	K	A	-1.6457
47	A	A	0.0000
48	V	A	0.0000
49	S	A	0.0000
50	S	A	0.0000
51	V	A	0.0000
52	K	A	-0.2260
53	F	A	0.0000
54	S	A	0.0000
55	P	A	-1.6068
56	N	A	-2.2763
57	G	A	0.0000
58	E	A	-1.7248
59	W	A	-0.8730
60	L	A	0.0000
61	A	A	0.0000
62	S	A	0.0000
63	S	A	0.0000
64	S	A	0.0000
65	A	A	0.0000
66	D	A	-1.0148
67	K	A	-1.3839
68	L	A	-0.5230
69	I	A	0.0000
70	K	A	0.0000
71	I	A	0.0000
72	W	A	0.0000
73	G	A	0.0000
74	A	A	0.0000
75	Y	A	-0.1989
76	D	A	-0.9323
77	G	A	-0.7501
78	K	A	-1.2438
79	F	A	0.1233
80	E	A	-1.1683
81	K	A	-0.9118
82	T	A	-0.3228
83	I	A	0.0000
84	S	A	-0.8945
85	G	A	-0.9130
86	H	A	0.0000
87	K	A	-1.8604
88	L	A	-0.7034
89	G	A	0.0000
90	I	A	0.0000
91	S	A	0.0000
92	D	A	0.0000
93	V	A	0.0000
94	A	A	0.0000
95	W	A	0.0000
96	S	A	0.0000
97	S	A	-1.7293
98	D	A	-2.5313
99	S	A	-1.8167
100	N	A	-1.5197
101	L	A	-0.7156
102	L	A	0.0000
103	V	A	0.0000
104	S	A	0.0000
105	A	A	0.0000
106	S	A	0.0000
107	D	A	0.0000
108	D	A	-1.2437
109	K	A	-1.4568
110	T	A	0.0000
111	L	A	0.0000
112	K	A	-0.6606
113	I	A	0.0000
114	W	A	0.0000
115	D	A	-0.9520
116	V	A	0.0000
117	S	A	-0.8248
118	S	A	-1.0493
119	G	A	-1.1377
120	K	A	-1.7757
121	C	A	-0.6851
122	L	A	-0.3679
123	K	A	-1.2654
124	T	A	-0.9543
125	L	A	0.0000
126	K	A	-2.3843
127	G	A	-1.5543
128	H	A	0.0000
129	S	A	-1.0356
130	N	A	-0.8347
131	Y	A	-0.1792
132	V	A	0.0000
133	F	A	0.0000
134	C	A	0.0000
135	C	A	0.0000
136	N	A	-0.2845
137	F	A	0.0000
138	N	A	0.0000
139	P	A	-1.9297
140	Q	A	-2.1964
141	S	A	-1.3984
142	N	A	-1.3154
143	L	A	-0.6232
144	I	A	0.0000
145	V	A	0.0000
146	S	A	0.0000
147	G	A	0.0000
148	S	A	0.0000
149	F	A	-0.4033
150	D	A	-0.9453
151	E	A	-1.2333
152	S	A	0.0000
153	V	A	0.0000
154	R	A	-0.3500
155	I	A	0.0000
156	W	A	0.0000
157	D	A	0.0000
158	V	A	-1.1094
159	K	A	-2.0408
160	T	A	-1.4440
161	G	A	-1.4513
162	K	A	-1.8875
163	C	A	-0.5493
164	L	A	0.3653
165	K	A	-0.3927
166	T	A	-0.2898
167	L	A	0.0000
168	P	A	-0.5931
169	A	A	0.0000
170	H	A	0.0000
171	S	A	-0.6755
172	D	A	-0.8375
173	P	A	0.0000
174	V	A	0.0000
175	S	A	0.0000
176	A	A	0.0000
177	V	A	0.0000
178	H	A	-0.5132
179	F	A	0.0000
180	N	A	0.0000
181	R	A	-3.3298
182	D	A	-2.9312
183	G	A	-1.7348
184	S	A	-1.0068
185	L	A	-0.4333
186	I	A	0.0000
187	V	A	0.0000
188	S	A	0.0000
189	S	A	0.0000
190	S	A	0.0000
191	Y	A	0.0000
192	D	A	-0.8470
193	G	A	0.0000
194	L	A	-0.0350
195	C	A	0.0000
196	R	A	-0.0508
197	I	A	0.0000
198	W	A	0.0000
199	D	A	-0.4689
200	T	A	-0.4017
201	A	A	-0.3978
202	S	A	-0.6705
203	G	A	-0.7407
204	Q	A	-0.9367
205	C	A	0.0078
206	L	A	0.5349
207	K	A	-0.0639
208	T	A	0.1895
209	L	A	0.0000
210	I	A	-0.8740
211	D	A	-2.9394
212	D	A	-3.3944
213	D	A	-3.4435
214	N	A	-2.2376
215	P	A	-1.5954
216	P	A	-0.9537
217	V	A	0.0000
218	S	A	0.0000
219	F	A	0.0000
220	V	A	0.0000
221	K	A	-0.3211
222	F	A	0.0000
223	S	A	0.0000
224	P	A	-1.1375
225	N	A	-1.9956
226	G	A	-1.9092
227	K	A	-1.3945
228	Y	A	-0.6281
229	I	A	0.0000
230	L	A	0.0000
231	A	A	0.0000
232	A	A	0.0000
233	T	A	0.0000
234	L	A	-1.5518
235	D	A	-2.0344
236	N	A	-1.6569
237	T	A	-0.8454
238	L	A	0.0000
239	K	A	0.0000
240	L	A	0.0000
241	W	A	0.0000
242	D	A	0.0000
243	Y	A	-1.0391
244	S	A	-1.4280
245	K	A	-2.3002
246	G	A	-1.7160
247	K	A	-2.1016
248	C	A	-0.6725
249	L	A	0.1307
250	K	A	-0.5837
251	T	A	-0.4378
252	Y	A	0.0000
253	T	A	-0.8760
254	G	A	-0.8206
255	H	A	0.0000
256	K	A	-1.9576
257	N	A	0.0000
258	E	A	-2.6091
259	K	A	-1.6673
260	Y	A	-0.9356
261	C	A	0.0000
262	I	A	0.0000
263	F	A	0.0000
264	A	A	0.0000
265	N	A	-0.0178
266	F	A	0.0000
267	S	A	0.0000
268	V	A	0.6858
269	T	A	-0.0789
270	G	A	-0.6745
271	G	A	-0.4895
272	K	A	-0.8759
273	W	A	0.0000
274	I	A	0.0000
275	V	A	0.0000
276	S	A	0.0000
277	G	A	0.0000
278	S	A	0.0000
279	E	A	0.0000
280	D	A	-1.4046
281	N	A	-1.3439
282	L	A	-1.1736
283	V	A	0.0000
284	Y	A	0.0000
285	I	A	0.0000
286	W	A	0.0000
287	N	A	-1.5173
288	L	A	0.0000
289	Q	A	-1.8784
290	T	A	-1.6095
291	K	A	-2.0969
292	E	A	-2.2213
293	I	A	-0.9351
294	V	A	0.0000
295	Q	A	-1.5582
296	K	A	-1.4030
297	L	A	0.0000
298	Q	A	-1.6644
299	G	A	-0.9689
300	H	A	0.0000
301	T	A	-1.1618
302	D	A	-1.2694
303	V	A	0.0000
304	V	A	0.0000
305	I	A	0.0000
306	S	A	0.0000
307	T	A	0.0000
308	A	A	0.0000
309	C	A	0.0127
310	H	A	0.0000
311	P	A	-0.6790
312	T	A	-0.7339
313	E	A	-1.2308
314	N	A	-1.1864
315	I	A	0.0000
316	I	A	0.0000
317	A	A	0.0000
318	S	A	0.0000
319	A	A	0.0000
320	A	A	0.0000
321	L	A	0.0000
322	E	A	-1.8841
323	N	A	-2.0733
324	D	A	-1.6205
325	K	A	-1.5516
326	T	A	-0.8299
327	I	A	0.0000
328	K	A	-0.1333
329	L	A	0.0000
330	W	A	0.0000
331	K	A	-1.1115
332	S	A	0.0000
333	D	A	-2.4853
334	C	A	-1.3158
2508	G	B	-1.0791
2509	A	B	0.0000
2510	A	B	0.0000
2511	R	B	0.0000
2512	A	B	-1.0834
2513	E	B	-1.4903
2514	V	B	-0.2560
2515	Y	B	0.3040
2516	L	B	0.6193
2517	R	B	-1.0974