Project name: aea6e396c4c25b3

Chain sequence(s)	A: QHGPNVCAVQKVIGTNRKYFTNCKQWYQRKICGKSTVISYECCPGYEKVPGEKGCPAALPLSNLYETLGVVGSTTTQLYTDRTEKLRPEMEGPGSFTIFAPSNEAWASLPAEVLDSLVSNVNIELLNALRYHMVGRRVLTDELKHGMTLTSMYQNSNIQIHHYPNGIVTVNCARLLKADHHATNGVVHLIDKVISTITNNIQQIIEIEDTFETLRAAVAASGLNTMLEGNGQYTLLAPTNEAFEKIPSETLNRILGDPEALRDLLNNHILKSAMCAEAIVAGLSVETLEGTTLEVGCSGDMLTINGKAIISNKDILATNGVIHYIDELLIPDSAKTLFELAAESDVSTAIDLFRQAGLGNHLSGSERLTLLAPLNSVFKDGTPPIDAHTRNLLRNHIIKDQLASKYLYHGQTLETLGGKKLRVFVYRNSLCIENSCIAAHDKRGRYGTLFTMDRVLTPPMGTVMDVLKGDNRFSMLVAAIQSAGLTETLNREGVYTVFAPTNEAFRALPPRERSRLLGDAKELANILKYHIGDEILVSGGIGALVRLKSLQGDKLEVSLKNNVVSVNKEPVAEPDIMATNGVVHVITNVLQPPAN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0103
• Maximal score value: 1.1138
• Average score: -0.896
• Total score value: -533.1406

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
43	Q	A	-1.9316
44	H	A	-1.9628
45	G	A	-2.1586
46	P	A	-1.4452
47	N	A	-1.5575
48	V	A	-1.3493
49	C	A	0.0000
50	A	A	0.0000
51	V	A	0.0000
52	Q	A	0.0000
53	K	A	-0.1526
54	V	A	0.0000
55	I	A	0.4566
56	G	A	-0.3220
57	T	A	-0.9899
58	N	A	-1.8814
59	R	A	-1.3689
60	K	A	-0.8064
61	Y	A	0.0507
62	F	A	0.0607
63	T	A	-0.3161
64	N	A	-1.2417
65	C	A	-0.4365
66	K	A	-0.6524
67	Q	A	-0.7307
68	W	A	0.4906
69	Y	A	0.0033
70	Q	A	-1.2853
71	R	A	-2.3614
72	K	A	-2.2319
73	I	A	0.0000
74	C	A	-1.2473
75	G	A	-1.8114
76	K	A	-2.0175
77	S	A	-1.3012
78	T	A	-0.4218
79	V	A	1.1046
80	I	A	1.1138
81	S	A	0.3882
82	Y	A	0.0150
83	E	A	-1.7194
84	C	A	-1.3824
85	C	A	-0.7871
86	P	A	-0.8920
87	G	A	-0.1798
88	Y	A	-0.9735
89	E	A	-2.4844
90	K	A	-3.2645
91	V	A	-1.8828
92	P	A	-1.4856
93	G	A	-1.9524
94	E	A	-3.1845
95	K	A	-3.4500
96	G	A	-2.7755
97	C	A	0.0000
98	P	A	-1.4817
99	A	A	-1.0142
100	A	A	-0.2872
101	L	A	0.1436
102	P	A	0.6131
103	L	A	0.9888
104	S	A	-0.1216
105	N	A	-1.3761
106	L	A	0.0000
107	Y	A	-1.6773
108	E	A	-1.8223
109	T	A	0.0000
110	L	A	0.0000
111	G	A	0.0454
112	V	A	0.9644
113	V	A	0.0000
114	G	A	0.0059
115	S	A	0.0000
116	T	A	0.0913
117	T	A	-0.0609
118	T	A	0.0000
119	Q	A	-0.4180
120	L	A	0.6548
121	Y	A	-0.2571
122	T	A	0.0000
123	D	A	-2.5275
124	R	A	-2.6166
125	T	A	0.0000
126	E	A	-4.0103
127	K	A	-3.7681
128	L	A	0.0000
129	R	A	-3.5527
130	P	A	-2.8428
131	E	A	-2.7805
132	M	A	0.0000
133	E	A	-3.0543
134	G	A	-1.8495
135	P	A	-1.2273
136	G	A	-1.5575
137	S	A	-1.5775
138	F	A	0.0000
139	T	A	0.0000
140	I	A	0.0000
141	F	A	0.0000
142	A	A	0.0000
143	P	A	0.0000
144	S	A	0.0000
145	N	A	-1.6115
146	E	A	-2.3517
147	A	A	0.0000
148	W	A	0.0000
149	A	A	-0.7819
150	S	A	-0.6974
151	L	A	-0.3577
152	P	A	-0.5324
153	A	A	-1.0196
154	E	A	-1.9209
155	V	A	-0.3502
156	L	A	-0.6651
157	D	A	-2.0224
158	S	A	-1.0505
159	L	A	-0.5685
160	V	A	-0.4274
161	S	A	-0.7774
162	N	A	-0.8157
163	V	A	-0.9413
164	N	A	-1.4673
165	I	A	0.5566
166	E	A	-0.3643
167	L	A	0.0000
168	L	A	-0.9710
169	N	A	-0.6471
170	A	A	-0.2319
171	L	A	0.0000
172	R	A	-0.8365
173	Y	A	0.0000
174	H	A	0.0000
175	M	A	0.0000
176	V	A	0.0000
177	G	A	-1.5087
178	R	A	-2.3351
179	R	A	-2.6768
180	V	A	0.0000
181	L	A	-1.3044
182	T	A	-1.4641
183	D	A	-2.5567
184	E	A	-1.9696
185	L	A	0.0000
186	K	A	-2.6398
187	H	A	-2.1190
188	G	A	-1.2228
189	M	A	-0.2346
190	T	A	-0.3636
191	L	A	0.0000
192	T	A	-1.2527
193	S	A	0.0000
194	M	A	-1.0202
195	Y	A	-1.1971
196	Q	A	-1.9566
197	N	A	-2.0499
198	S	A	-1.5277
199	N	A	-1.7154
200	I	A	0.0000
201	Q	A	-0.3237
202	I	A	0.0000
203	H	A	-0.6485
204	H	A	-1.3412
205	Y	A	-1.0243
206	P	A	-1.1532
207	N	A	-1.5488
208	G	A	-1.3220
209	I	A	-0.6036
210	V	A	0.0000
211	T	A	0.0000
212	V	A	0.0000
213	N	A	0.0000
214	C	A	0.0000
215	A	A	0.0000
216	R	A	0.0000
217	L	A	0.0901
218	L	A	0.0263
219	K	A	-0.3448
220	A	A	-0.2746
221	D	A	-1.0289
222	H	A	-0.3656
223	H	A	-0.8078
224	A	A	0.0000
225	T	A	-0.4469
226	N	A	0.0000
227	G	A	-1.1693
228	V	A	0.0000
229	V	A	0.0000
230	H	A	0.0000
231	L	A	0.0000
232	I	A	0.0000
233	D	A	-1.0049
234	K	A	-0.9060
235	V	A	-0.3353
236	I	A	0.0000
237	S	A	-0.1101
238	T	A	-0.2289
239	I	A	-0.0581
240	T	A	-0.3444
241	N	A	-0.4830
242	N	A	-0.9590
243	I	A	0.0000
244	Q	A	0.0000
245	Q	A	-1.0246
246	I	A	-0.2866
247	I	A	0.0000
248	E	A	-1.6333
249	I	A	0.1411
250	E	A	-1.3574
251	D	A	-2.4977
252	T	A	-1.8987
253	F	A	0.0000
254	E	A	-2.7051
255	T	A	-1.7319
256	L	A	0.0000
257	R	A	-1.5660
258	A	A	-0.7574
259	A	A	0.0000
260	V	A	0.0000
261	A	A	-0.3357
262	A	A	-0.3432
263	S	A	-0.8962
264	G	A	-0.7639
265	L	A	0.0000
266	N	A	-1.1634
267	T	A	-1.0425
268	M	A	-0.7682
269	L	A	0.0000
270	E	A	-2.0226
271	G	A	-1.6994
272	N	A	-1.9483
273	G	A	-1.7285
274	Q	A	-1.8210
275	Y	A	-1.0991
276	T	A	0.0000
277	L	A	0.0000
278	L	A	0.0000
279	A	A	0.0000
280	P	A	0.0000
281	T	A	0.0000
282	N	A	-2.7745
283	E	A	-3.3907
284	A	A	0.0000
285	F	A	0.0000
286	E	A	-3.4966
287	K	A	-3.3157
288	I	A	-1.9774
289	P	A	-1.6653
290	S	A	-2.0244
291	E	A	-2.4094
292	T	A	0.0000
293	L	A	-1.5445
294	N	A	-2.0638
295	R	A	-1.6547
296	I	A	0.0000
297	L	A	-0.7681
298	G	A	-1.1450
299	D	A	-1.4148
300	P	A	-1.5888
301	E	A	-2.2198
302	A	A	0.0000
303	L	A	0.0000
304	R	A	-1.8768
305	D	A	-1.5152
306	L	A	0.0000
307	L	A	0.0000
308	N	A	-0.6310
309	N	A	0.0000
310	H	A	0.0000
311	I	A	0.0000
312	L	A	0.0000
313	K	A	-2.2106
314	S	A	-1.4854
315	A	A	0.0000
316	M	A	-0.3728
317	C	A	0.0000
318	A	A	-0.6584
319	E	A	-0.6829
320	A	A	0.0000
321	I	A	0.0000
322	V	A	-0.3076
323	A	A	-0.5706
324	G	A	-0.7359
325	L	A	-0.2195
326	S	A	-1.1636
327	V	A	0.0000
328	E	A	-2.5896
329	T	A	0.0000
330	L	A	-1.0158
331	E	A	-1.1314
332	G	A	-1.2055
333	T	A	-1.1551
334	T	A	-1.3829
335	L	A	0.0000
336	E	A	-2.5418
337	V	A	0.0000
338	G	A	-0.8656
339	C	A	-0.8231
340	S	A	-1.0817
341	G	A	-1.2879
342	D	A	-1.6320
343	M	A	-0.5933
344	L	A	0.0000
345	T	A	0.0000
346	I	A	0.0000
347	N	A	-2.0684
348	G	A	-1.9762
349	K	A	-2.3709
350	A	A	-0.9455
351	I	A	-0.9619
352	I	A	0.0000
353	S	A	-0.8983
354	N	A	-1.4543
355	K	A	-1.4116
356	D	A	-0.7109
357	I	A	0.0200
358	L	A	0.2344
359	A	A	0.0000
360	T	A	-0.9391
361	N	A	0.0000
362	G	A	0.0000
363	V	A	0.0000
364	I	A	0.0000
365	H	A	0.0000
366	Y	A	-0.7363
367	I	A	0.0000
368	D	A	-2.0218
369	E	A	-2.4546
370	L	A	0.0000
371	L	A	-0.1917
372	I	A	-0.0454
373	P	A	0.0000
374	D	A	-1.3234
375	S	A	-1.3967
376	A	A	0.0000
377	K	A	-0.8541
378	T	A	0.0000
379	L	A	0.0000
380	F	A	-0.7718
381	E	A	-0.7227
382	L	A	0.0000
383	A	A	0.0000
384	A	A	-1.4673
385	E	A	-2.2464
386	S	A	-1.8093
387	D	A	-2.2673
388	V	A	0.0000
389	S	A	-1.6085
390	T	A	-1.3887
391	A	A	0.0000
392	I	A	0.0000
393	D	A	-2.7354
394	L	A	0.0000
395	F	A	0.0000
396	R	A	-3.3736
397	Q	A	-2.7505
398	A	A	0.0000
399	G	A	-1.8718
400	L	A	0.0000
401	G	A	-2.1557
402	N	A	-2.0228
403	H	A	-1.6580
404	L	A	0.0000
405	S	A	-0.9856
406	G	A	-1.3581
407	S	A	-1.5053
408	E	A	-2.9015
409	R	A	-3.4844
410	L	A	0.0000
411	T	A	0.0000
412	L	A	0.0000
413	L	A	0.0000
414	A	A	0.0000
415	P	A	0.0000
416	L	A	-0.5995
417	N	A	-1.1579
418	S	A	-1.2269
419	V	A	-0.4543
420	F	A	-1.2049
421	K	A	-2.5562
422	D	A	-2.7069
423	G	A	-1.8517
424	T	A	-1.0363
425	P	A	-0.6166
426	P	A	-0.7135
427	I	A	-0.8598
428	D	A	-1.3644
429	A	A	-1.3679
430	H	A	-1.8935
431	T	A	0.0000
432	R	A	-2.4380
433	N	A	-2.3013
434	L	A	-1.1903
435	L	A	0.0000
436	R	A	-1.7106
437	N	A	-1.4972
438	H	A	0.0000
439	I	A	0.0000
440	I	A	0.0000
441	K	A	-3.5553
442	D	A	-3.6097
443	Q	A	-2.3829
444	L	A	-1.1063
445	A	A	-0.7688
446	S	A	0.0000
447	K	A	-0.8941
448	Y	A	0.8756
449	L	A	0.0000
450	Y	A	0.9069
451	H	A	-0.4235
452	G	A	-0.6074
453	Q	A	-0.4321
454	T	A	-1.1846
455	L	A	0.0000
456	E	A	-3.2863
457	T	A	0.0000
458	L	A	-1.6589
459	G	A	-1.6371
460	G	A	-2.0322
461	K	A	-2.4795
462	K	A	-2.8994
463	L	A	0.0000
464	R	A	-1.1143
465	V	A	0.0000
466	F	A	0.2841
467	V	A	-0.1515
468	Y	A	-0.9255
469	R	A	-2.2872
470	N	A	-2.0852
471	S	A	-0.8645
472	L	A	-0.1462
473	C	A	0.0000
474	I	A	0.0000
475	E	A	0.0000
476	N	A	0.0000
477	S	A	0.0000
478	C	A	0.0000
479	I	A	-0.1233
480	A	A	-0.1848
481	A	A	-0.5458
482	H	A	-1.6433
483	D	A	-1.8262
484	K	A	-1.9933
485	R	A	-2.5072
486	G	A	0.0000
487	R	A	-1.4844
488	Y	A	-1.5971
489	G	A	0.0000
490	T	A	0.0000
491	L	A	0.0000
492	F	A	0.0000
493	T	A	0.0000
494	M	A	0.0000
495	D	A	-0.4272
496	R	A	-0.1960
497	V	A	0.3664
498	L	A	0.0000
499	T	A	0.2767
500	P	A	0.0000
501	P	A	0.1798
502	M	A	0.7137
503	G	A	-0.3821
504	T	A	-1.4952
505	V	A	0.0000
506	M	A	0.0000
507	D	A	-2.3064
508	V	A	-1.1294
509	L	A	0.0000
510	K	A	-2.8437
511	G	A	-2.3005
512	D	A	-2.2135
513	N	A	-2.2175
514	R	A	-1.8599
515	F	A	0.0000
516	S	A	-1.0932
517	M	A	-0.4741
518	L	A	0.0000
519	V	A	-0.6972
520	A	A	-0.4722
521	A	A	0.0000
522	I	A	0.0000
523	Q	A	-1.6459
524	S	A	-0.8839
525	A	A	-1.3179
526	G	A	-1.3390
527	L	A	0.0000
528	T	A	-1.8304
529	E	A	-3.0261
530	T	A	-2.0297
531	L	A	0.0000
532	N	A	-3.0078
533	R	A	-3.5077
534	E	A	-2.9404
535	G	A	-1.6464
536	V	A	-0.7460
537	Y	A	-0.7776
538	T	A	0.0000
539	V	A	0.0000
540	F	A	0.0000
541	A	A	0.0000
542	P	A	0.0000
543	T	A	-1.4233
544	N	A	-1.9306
545	E	A	-2.7647
546	A	A	0.0000
547	F	A	0.0000
548	R	A	-2.8517
549	A	A	-1.6831
550	L	A	-1.6482
551	P	A	-1.7945
552	P	A	-2.2503
553	R	A	-3.2113
554	E	A	-3.0304
555	R	A	-2.5350
556	S	A	-1.9553
557	R	A	-2.8685
558	L	A	0.0000
559	L	A	0.1112
560	G	A	-1.1373
561	D	A	-1.5262
562	A	A	-1.5004
563	K	A	-2.4927
564	E	A	-2.3961
565	L	A	0.0000
566	A	A	-1.5879
567	N	A	-1.7579
568	I	A	-1.1074
569	L	A	0.0000
570	K	A	-0.7966
571	Y	A	0.0000
572	H	A	0.0000
573	I	A	0.0000
574	G	A	0.0000
575	D	A	-3.0034
576	E	A	-2.5700
577	I	A	0.0000
578	L	A	0.0000
579	V	A	0.0000
580	S	A	0.0000
581	G	A	-0.4704
582	G	A	0.0000
583	I	A	0.0000
584	G	A	-0.9853
585	A	A	-0.0640
586	L	A	0.0611
587	V	A	0.0000
588	R	A	-3.0397
589	L	A	0.0000
590	K	A	-3.9504
591	S	A	0.0000
592	L	A	-1.1189
593	Q	A	-1.4079
594	G	A	-1.5873
595	D	A	-2.3244
596	K	A	-3.7893
597	L	A	0.0000
598	E	A	-2.7058
599	V	A	0.0000
600	S	A	0.0000
601	L	A	-0.7581
602	K	A	-2.1856
603	N	A	-2.3010
604	N	A	-1.9062
605	V	A	-0.6632
606	V	A	0.0000
607	S	A	-1.2179
608	V	A	0.0000
609	N	A	-2.3554
610	K	A	-2.5015
611	E	A	-2.1179
612	P	A	-1.2439
613	V	A	0.0000
614	A	A	-0.4575
615	E	A	-0.8338
616	P	A	-0.3433
617	D	A	0.0000
618	I	A	0.3505
619	M	A	0.0000
620	A	A	0.0000
621	T	A	-0.6770
622	N	A	0.0000
623	G	A	0.0000
624	V	A	0.0000
625	V	A	0.0000
626	H	A	0.0000
627	V	A	0.0000
628	I	A	0.0000
629	T	A	-1.1184
630	N	A	-1.5902
631	V	A	-0.9212
632	L	A	0.0000
633	Q	A	-1.4993
634	P	A	0.0000
635	P	A	-1.1334
636	A	A	-0.9570
637	N	A	-1.7257