Project name: b07e5f8b6968267

Chain sequence(s)	A: MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGK; B: MNGTEGPNFYVPFSNKTGVVRSPFEAPQYYLAEPWQFSMLAAYMFLLIMLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTPHEETNNESFVIYMFVVHFIIPLIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWLPYAGVAFYIFTHQGSDFGPIFMTIPAFFAKTSAVYNPVIYIMMNKQFRNCMVTTLCCGK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.615
• Maximal score value: 4.0133
• Average score: 0.2434
• Total score value: 158.1958

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.1326
2	N	A	-0.8920
3	G	A	0.0000
4	T	A	0.0000
5	E	A	-1.7567
6	G	A	-1.1589
7	P	A	-0.8163
8	N	A	-0.7103
9	F	A	-0.5202
10	Y	A	0.0000
11	V	A	0.0000
12	P	A	-0.0551
13	F	A	0.4290
14	S	A	0.0000
15	N	A	-1.3715
16	K	A	-1.7093
17	T	A	-0.9503
18	G	A	-1.1751
19	V	A	-0.3944
20	V	A	-0.7713
21	R	A	-1.9618
22	S	A	-1.3673
23	P	A	0.0000
24	F	A	-0.3581
25	E	A	-1.4295
26	A	A	-0.9083
27	P	A	-0.3247
28	Q	A	0.0000
29	Y	A	0.7130
30	Y	A	0.7024
31	L	A	0.7081
32	A	A	-0.2138
33	E	A	-1.1856
34	P	A	-0.2187
35	W	A	0.3748
36	Q	A	-0.0313
37	F	A	0.2712
38	S	A	0.2815
39	M	A	0.7128
40	L	A	0.0000
41	A	A	0.6371
42	A	A	0.7497
43	Y	A	0.6876
44	M	A	0.0000
45	F	A	0.9466
46	L	A	0.9498
47	L	A	0.0000
48	I	A	1.3923
49	M	A	1.3936
50	L	A	1.5469
51	G	A	0.0000
52	F	A	2.2910
53	P	A	1.2674
54	I	A	1.6792
55	N	A	0.0000
56	F	A	1.8007
57	L	A	1.9994
58	T	A	0.0000
59	L	A	1.7773
60	Y	A	2.2567
61	V	A	0.0000
62	T	A	0.4652
63	V	A	1.6291
64	Q	A	-0.3220
65	H	A	-1.4087
66	K	A	-2.8012
67	K	A	-3.0123
68	L	A	-2.0218
69	R	A	-2.7362
70	T	A	-1.4527
71	P	A	0.0000
72	L	A	0.0135
73	N	A	-0.2849
74	Y	A	0.0710
75	I	A	0.0000
76	L	A	0.3402
77	L	A	0.7907
78	N	A	0.1024
79	L	A	0.0000
80	A	A	0.0000
81	V	A	0.7299
82	A	A	0.0000
83	D	A	0.9817
84	L	A	0.0000
85	F	A	2.0974
86	M	A	1.7021
87	V	A	1.9481
88	F	A	2.6963
89	G	A	1.7200
90	G	A	0.0000
91	F	A	0.0000
92	T	A	0.7251
93	T	A	0.0000
94	T	A	0.0000
95	L	A	0.6796
96	Y	A	0.9971
97	T	A	0.0000
98	S	A	0.3774
99	L	A	0.5676
100	H	A	0.1804
101	G	A	0.2113
102	Y	A	0.4888
103	F	A	0.0000
104	V	A	2.1117
105	F	A	2.4495
106	G	A	0.9572
107	P	A	0.4485
108	T	A	0.6766
109	G	A	0.0000
110	C	A	0.0000
111	N	A	0.3295
112	L	A	1.1643
113	E	A	0.0000
114	G	A	0.0000
115	F	A	1.4034
116	F	A	1.4675
117	A	A	0.4993
118	T	A	0.3082
119	L	A	0.0000
120	G	A	0.3899
121	G	A	0.1089
122	E	A	0.0000
123	I	A	0.0000
124	A	A	0.0000
125	L	A	0.8313
126	W	A	0.9335
127	S	A	0.0000
128	L	A	0.0000
129	V	A	1.0040
130	V	A	1.0988
131	L	A	0.0000
132	A	A	0.0000
133	I	A	1.6500
134	E	A	0.0000
135	R	A	0.0000
136	Y	A	0.7715
137	V	A	0.6015
138	V	A	0.5697
139	V	A	0.0000
140	C	A	-0.0202
141	K	A	-1.1653
142	P	A	-0.5722
143	M	A	-0.3791
144	S	A	-0.9345
145	N	A	-1.4776
146	F	A	-0.7796
147	R	A	-1.7146
148	F	A	-1.4795
149	G	A	-2.0389
150	E	A	-2.5579
151	N	A	-2.2656
152	H	A	-1.5211
153	A	A	0.0000
154	I	A	0.6582
155	M	A	1.0661
156	G	A	0.0000
157	V	A	0.0000
158	A	A	1.9987
159	F	A	2.7856
160	T	A	0.0000
161	W	A	2.2093
162	V	A	3.0714
163	M	A	2.1041
164	A	A	0.0000
165	L	A	2.2999
166	A	A	1.3753
167	C	A	0.0000
168	A	A	0.0000
169	A	A	1.2468
170	P	A	0.9397
171	P	A	0.7156
172	L	A	1.3872
173	V	A	1.9736
174	G	A	0.5251
175	W	A	0.0669
176	S	A	0.0000
177	R	A	-0.1187
178	Y	A	0.0000
179	I	A	0.0000
180	P	A	0.0000
181	E	A	-0.1575
182	G	A	0.0000
183	M	A	0.4734
184	Q	A	0.0000
185	C	A	0.1422
186	S	A	0.0000
187	C	A	0.0000
188	G	A	-0.0009
189	I	A	0.2135
190	D	A	0.0000
191	Y	A	0.0000
192	Y	A	0.0000
193	T	A	-1.0031
194	P	A	-1.6981
195	H	A	-2.4500
196	E	A	-3.6150
197	E	A	-3.2749
198	T	A	-2.0326
199	N	A	-2.8540
200	N	A	0.0000
201	E	A	-1.7912
202	S	A	-0.6692
203	F	A	0.0000
204	V	A	0.0000
205	I	A	1.8882
206	Y	A	1.7617
207	M	A	1.6143
208	F	A	2.7773
209	V	A	3.6682
210	V	A	3.0497
211	H	A	2.4631
212	F	A	3.0582
213	I	A	3.9692
214	I	A	3.9414
215	P	A	0.0000
216	L	A	2.9749
217	I	A	3.2410
218	V	A	3.2900
219	I	A	0.0000
220	F	A	2.3384
221	F	A	2.4781
222	C	A	0.0000
223	Y	A	1.6539
224	G	A	1.2804
225	Q	A	0.4376
226	L	A	0.0000
227	V	A	1.5555
228	F	A	1.9399
229	T	A	0.5920
230	V	A	0.0000
231	K	A	-2.0456
232	E	A	-2.1715
233	A	A	-1.4712
234	A	A	-1.7138
235	A	A	-1.4795
236	Q	A	-2.3734
237	Q	A	-3.0850
238	Q	A	-3.2085
239	E	A	-3.4197
240	S	A	-1.8393
241	A	A	-1.4361
242	T	A	-1.2605
243	T	A	-0.5797
244	Q	A	-1.1420
245	K	A	-1.9542
246	A	A	-0.7761
247	E	A	0.0000
248	K	A	-1.7302
249	E	A	-0.9434
250	V	A	-0.0394
251	T	A	0.0000
252	R	A	-0.8600
253	M	A	0.0000
254	V	A	0.0000
255	I	A	1.1831
256	I	A	2.0120
257	M	A	1.5143
258	V	A	0.0000
259	I	A	2.4887
260	A	A	2.1484
261	F	A	2.1632
262	L	A	2.4810
263	I	A	3.2874
264	C	A	2.4406
265	W	A	2.2219
266	L	A	2.4081
267	P	A	1.7982
268	Y	A	1.6923
269	A	A	0.0000
270	G	A	1.2137
271	V	A	1.4860
272	A	A	0.0000
273	F	A	2.2760
274	Y	A	1.4383
275	I	A	0.0000
276	F	A	0.4647
277	T	A	0.0386
278	H	A	-1.2393
279	Q	A	-2.1179
280	G	A	-1.7239
281	S	A	-1.6427
282	D	A	-2.1347
283	F	A	-0.4992
284	G	A	0.5916
285	P	A	1.2736
286	I	A	2.4516
287	F	A	1.9781
288	M	A	0.0000
289	T	A	0.0000
290	I	A	1.7690
291	P	A	1.6698
292	A	A	0.0000
293	F	A	0.0000
294	F	A	2.3002
295	A	A	0.0000
296	K	A	0.3523
297	T	A	0.7251
298	S	A	0.6650
299	A	A	0.6227
300	V	A	1.3681
301	Y	A	2.0312
302	N	A	0.0000
303	P	A	1.6714
304	V	A	2.6996
305	I	A	2.1298
306	Y	A	0.0000
307	I	A	1.3661
308	M	A	1.6291
309	M	A	0.3572
310	N	A	-0.8134
311	K	A	-2.1952
312	Q	A	-1.9915
313	F	A	0.0000
314	R	A	-1.0598
315	N	A	-1.8257
316	C	A	0.0000
317	M	A	0.0000
318	V	A	0.0574
319	T	A	-0.3564
320	T	A	0.3719
321	L	A	0.9839
322	C	A	1.1543
323	C	A	0.7279
324	G	A	-0.2781
325	K	A	-1.4573
1	M	B	0.0960
2	N	B	-0.8421
3	G	B	0.0000
4	T	B	0.0000
5	E	B	-1.8330
6	G	B	-1.2912
7	P	B	-0.8652
8	N	B	-0.8162
9	F	B	-0.4975
10	Y	B	0.0000
11	V	B	0.0000
12	P	B	-0.0700
13	F	B	0.4653
14	S	B	0.0000
15	N	B	-1.2953
16	K	B	-1.6714
17	T	B	-0.8765
18	G	B	-1.0538
19	V	B	-0.1707
20	V	B	-0.6270
21	R	B	-1.7985
22	S	B	-1.3050
23	P	B	0.0000
24	F	B	-0.3282
25	E	B	-1.4152
26	A	B	-0.8836
27	P	B	-0.3205
28	Q	B	0.0000
29	Y	B	0.5857
30	Y	B	0.6061
31	L	B	0.6545
32	A	B	-0.3608
33	E	B	-1.3477
34	P	B	-0.4172
35	W	B	0.1045
36	Q	B	-0.2350
37	F	B	0.0000
38	S	B	0.1655
39	M	B	0.7563
40	L	B	0.0000
41	A	B	0.5835
42	A	B	0.7577
43	Y	B	0.7207
44	M	B	0.0000
45	F	B	1.0448
46	L	B	1.1297
47	L	B	0.0000
48	I	B	1.6370
49	M	B	1.7003
50	L	B	1.9973
51	G	B	0.0000
52	F	B	2.5220
53	P	B	1.4225
54	I	B	1.7985
55	N	B	0.0000
56	F	B	1.7567
57	L	B	1.9468
58	T	B	0.0000
59	L	B	1.7711
60	Y	B	2.2285
61	V	B	0.0000
62	T	B	0.5218
63	V	B	1.6380
64	Q	B	-0.2832
65	H	B	-1.3632
66	K	B	-2.7815
67	K	B	-2.9831
68	L	B	-1.9665
69	R	B	-2.6647
70	T	B	-1.3892
71	P	B	-0.6930
72	L	B	0.1285
73	N	B	-0.1190
74	Y	B	0.3180
75	I	B	0.0000
76	L	B	0.4792
77	L	B	0.9785
78	N	B	0.3399
79	L	B	0.0000
80	A	B	0.0000
81	V	B	0.9883
82	A	B	0.0000
83	D	B	1.2874
84	L	B	0.0000
85	F	B	2.8318
86	M	B	2.0434
87	V	B	2.1726
88	F	B	2.9454
89	G	B	1.8468
90	G	B	0.0000
91	F	B	0.0000
92	T	B	0.6952
93	T	B	0.9755
94	T	B	0.0000
95	L	B	0.5916
96	Y	B	0.9611
97	T	B	0.0000
98	S	B	0.2923
99	L	B	0.5522
100	H	B	0.2139
101	G	B	0.1519
102	Y	B	0.4665
103	F	B	0.0000
104	V	B	2.0676
105	F	B	2.4272
106	G	B	0.9841
107	P	B	0.5315
108	T	B	0.6849
109	G	B	0.0000
110	C	B	0.0000
111	N	B	0.1758
112	L	B	0.9537
113	E	B	0.0000
114	G	B	0.0000
115	F	B	1.2013
116	F	B	1.5296
117	A	B	0.4545
118	T	B	0.3312
119	L	B	0.8450
120	G	B	0.5434
121	G	B	0.1553
122	E	B	0.0000
123	I	B	0.0000
124	A	B	0.0000
125	L	B	0.7836
126	W	B	0.7730
127	S	B	0.0000
128	L	B	0.0000
129	V	B	0.0000
130	V	B	0.8192
131	L	B	0.0000
132	A	B	0.0000
133	I	B	1.4007
134	E	B	0.0000
135	R	B	0.6065
136	Y	B	0.7188
137	V	B	0.5753
138	V	B	0.6231
139	V	B	0.0000
140	C	B	0.0244
141	K	B	-1.1275
142	P	B	-0.5329
143	M	B	-0.3160
144	S	B	-0.8719
145	N	B	-1.3989
146	F	B	-0.5789
147	R	B	-1.5765
148	F	B	-1.3889
149	G	B	-1.9651
150	E	B	-2.5509
151	N	B	-2.2206
152	H	B	-1.3841
153	A	B	0.0000
154	I	B	0.4419
155	M	B	0.9865
156	G	B	1.1920
157	V	B	0.0000
158	A	B	1.7704
159	F	B	2.3484
160	T	B	0.0000
161	W	B	2.1496
162	V	B	2.9271
163	M	B	1.9748
164	A	B	0.0000
165	L	B	2.3258
166	A	B	1.3813
167	C	B	0.0000
168	A	B	0.0000
169	A	B	1.2296
170	P	B	0.7801
171	P	B	0.3129
172	L	B	1.0644
173	V	B	1.7976
174	G	B	0.3411
175	W	B	0.0223
176	S	B	0.0000
177	R	B	-1.2248
178	Y	B	0.0000
179	I	B	-0.3462
180	P	B	0.0000
181	E	B	-0.2278
182	G	B	0.0000
183	M	B	0.0000
184	Q	B	0.0000
185	C	B	0.0000
186	S	B	0.0000
187	C	B	0.0000
188	G	B	-0.2204
189	I	B	-0.1485
190	D	B	-0.3849
191	Y	B	0.2957
192	Y	B	0.0000
193	T	B	-0.8867
194	P	B	-1.6149
195	H	B	-2.4309
196	E	B	-3.4429
197	E	B	-3.1311
198	T	B	0.0000
199	N	B	-2.4836
200	N	B	0.0000
201	E	B	-1.5360
202	S	B	-0.4971
203	F	B	0.0000
204	V	B	0.0000
205	I	B	1.8510
206	Y	B	1.7038
207	M	B	0.0000
208	F	B	2.6851
209	V	B	3.6266
210	V	B	3.0492
211	H	B	2.4164
212	F	B	2.9475
213	I	B	3.8824
214	I	B	4.0133
215	P	B	0.0000
216	L	B	3.0192
217	I	B	3.3041
218	V	B	3.3225
219	I	B	0.0000
220	F	B	2.5085
221	F	B	2.6344
222	C	B	0.0000
223	Y	B	1.7575
224	G	B	1.4837
225	Q	B	0.7428
226	L	B	0.0000
227	V	B	1.6398
228	F	B	2.0045
229	T	B	0.6282
230	V	B	0.0000
231	K	B	-2.1095
232	E	B	-2.2971
233	A	B	-1.4679
234	A	B	-1.7722
235	A	B	-1.4760
236	Q	B	-2.3510
237	Q	B	-3.0493
238	Q	B	-3.1731
239	E	B	-3.3921
240	S	B	-1.8127
241	A	B	-1.3937
242	T	B	-1.2007
243	T	B	-0.5294
244	Q	B	-1.0523
245	K	B	-1.8139
246	A	B	-0.7158
247	E	B	0.0000
248	K	B	-1.8982
249	E	B	-1.0731
250	V	B	-0.2616
251	T	B	0.0000
252	R	B	-1.4882
253	M	B	0.0000
254	V	B	0.0000
255	I	B	0.6759
256	I	B	1.4625
257	M	B	1.0479
258	V	B	0.0000
259	I	B	2.2411
260	A	B	1.7909
261	F	B	0.0000
262	L	B	2.3289
263	I	B	3.1907
264	C	B	2.3095
265	W	B	2.1510
266	L	B	2.3749
267	P	B	1.8106
268	Y	B	1.7301
269	A	B	0.0000
270	G	B	1.2286
271	V	B	1.5220
272	A	B	0.0000
273	F	B	2.2917
274	Y	B	1.5987
275	I	B	0.0000
276	F	B	0.7293
277	T	B	0.2698
278	H	B	-0.8386
279	Q	B	-1.3128
280	G	B	-1.4049
281	S	B	-1.4820
282	D	B	-2.0214
283	F	B	-0.4432
284	G	B	0.5909
285	P	B	1.2785
286	I	B	2.4664
287	F	B	2.0211
288	M	B	0.0000
289	T	B	0.0000
290	I	B	1.7860
291	P	B	1.6866
292	A	B	0.0000
293	F	B	0.0000
294	F	B	2.2909
295	A	B	0.0000
296	K	B	0.3458
297	T	B	0.5783
298	S	B	0.0000
299	A	B	0.3518
300	V	B	1.1371
301	Y	B	1.1463
302	N	B	0.0000
303	P	B	1.3806
304	V	B	2.4502
305	I	B	1.8117
306	Y	B	0.0000
307	I	B	0.9667
308	M	B	1.4473
309	M	B	0.2010
310	N	B	-1.0479
311	K	B	-2.4536
312	Q	B	-2.3219
313	F	B	0.0000
314	R	B	-1.5509
315	N	B	-2.2580
316	C	B	-1.4573
317	M	B	0.0000
318	V	B	-0.0384
319	T	B	-0.3699
320	T	B	0.4420
321	L	B	1.2073
322	C	B	1.3407
323	C	B	0.8025
324	G	B	-0.2571
325	K	B	-1.4554