Project name: b24922701153887
Status: done
submitted: 2018-12-15 23:30:16, status changed: 2018-12-15 23:43:14
Settings
|
Chain sequence(s)
|
B: MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-4.0121
-
Maximal score value
-
1.5029
-
Average score
-
-0.9481
-
Total score value
-
-280.6372
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 1 |
M |
B |
1.3194 |
|
| 2 |
L |
B |
1.0088 |
|
| 3 |
S |
B |
-0.2181 |
|
| 4 |
P |
B |
-1.1764 |
|
| 5 |
K |
B |
-2.3837 |
|
| 6 |
D |
B |
-2.5117 |
|
| 7 |
I |
B |
-1.3272 |
|
| 8 |
L |
B |
-0.2689 |
|
| 9 |
R |
B |
-0.6798 |
|
| 10 |
K |
B |
-1.7760 |
|
| 11 |
D |
B |
-1.8879 |
|
| 12 |
L |
B |
-1.2065 |
|
| 13 |
K |
B |
-0.7539 |
|
| 14 |
L |
B |
0.6025 |
|
| 15 |
V |
B |
0.0000 |
|
| 16 |
H |
B |
-1.0832 |
|
| 17 |
G |
B |
-0.4765 |
|
| 18 |
Y |
B |
-0.1646 |
|
| 19 |
P |
B |
-0.3506 |
|
| 20 |
M |
B |
0.0000 |
|
| 21 |
T |
B |
0.0000 |
|
| 22 |
C |
B |
0.0000 |
|
| 23 |
A |
B |
0.0000 |
|
| 24 |
F |
B |
0.0000 |
|
| 25 |
A |
B |
-0.2390 |
|
| 26 |
S |
B |
-1.1436 |
|
| 27 |
N |
B |
-2.3045 |
|
| 28 |
W |
B |
0.0000 |
|
| 29 |
E |
B |
-3.2866 |
|
| 30 |
K |
B |
-3.0340 |
|
| 31 |
I |
B |
0.0000 |
|
| 32 |
E |
B |
-3.2792 |
|
| 33 |
Q |
B |
-3.0976 |
|
| 34 |
F |
B |
0.0000 |
|
| 35 |
H |
B |
-2.2550 |
|
| 36 |
S |
B |
0.0000 |
|
| 37 |
R |
B |
-2.1303 |
|
| 38 |
P |
B |
-2.4029 |
|
| 39 |
D |
B |
-2.5655 |
|
| 40 |
D |
B |
0.0000 |
|
| 41 |
I |
B |
0.0000 |
|
| 42 |
V |
B |
0.0000 |
|
| 43 |
I |
B |
0.0000 |
|
| 44 |
A |
B |
0.0000 |
|
| 45 |
T |
B |
0.0000 |
|
| 46 |
Y |
B |
0.0000 |
|
| 47 |
P |
B |
0.0000 |
|
| 48 |
K |
B |
-0.1803 |
|
| 49 |
S |
B |
0.0000 |
|
| 50 |
G |
B |
-0.0865 |
|
| 51 |
T |
B |
0.0000 |
|
| 52 |
T |
B |
0.0000 |
|
| 53 |
W |
B |
0.1635 |
|
| 54 |
V |
B |
0.0000 |
|
| 55 |
S |
B |
0.0000 |
|
| 56 |
E |
B |
0.0000 |
|
| 57 |
I |
B |
0.0000 |
|
| 58 |
I |
B |
0.0000 |
|
| 59 |
D |
B |
0.0000 |
|
| 60 |
M |
B |
0.0000 |
|
| 61 |
I |
B |
0.0000 |
|
| 62 |
L |
B |
-0.5423 |
|
| 63 |
N |
B |
-1.3980 |
|
| 64 |
D |
B |
-2.0376 |
|
| 65 |
G |
B |
0.0000 |
|
| 66 |
D |
B |
-2.3021 |
|
| 67 |
I |
B |
-2.0428 |
|
| 68 |
E |
B |
-3.4813 |
|
| 69 |
K |
B |
-3.7806 |
|
| 70 |
C |
B |
0.0000 |
|
| 71 |
K |
B |
-3.3668 |
|
| 72 |
R |
B |
-3.2522 |
|
| 73 |
G |
B |
-1.6465 |
|
| 74 |
F |
B |
-0.2578 |
|
| 75 |
I |
B |
0.0000 |
|
| 76 |
T |
B |
-0.3022 |
|
| 77 |
E |
B |
-1.0830 |
|
| 78 |
K |
B |
0.0000 |
|
| 79 |
V |
B |
0.0000 |
|
| 80 |
P |
B |
0.0000 |
|
| 81 |
M |
B |
0.0038 |
|
| 82 |
L |
B |
0.0000 |
|
| 83 |
E |
B |
0.0000 |
|
| 84 |
M |
B |
-0.0825 |
|
| 85 |
T |
B |
-0.2966 |
|
| 86 |
L |
B |
0.0000 |
|
| 87 |
P |
B |
-0.4719 |
|
| 88 |
G |
B |
-0.2389 |
|
| 89 |
L |
B |
-0.1516 |
|
| 90 |
R |
B |
-0.8794 |
|
| 91 |
T |
B |
-0.7094 |
|
| 92 |
S |
B |
-0.6448 |
|
| 93 |
G |
B |
0.0000 |
|
| 94 |
I |
B |
0.0000 |
|
| 95 |
E |
B |
-2.2380 |
|
| 96 |
Q |
B |
-2.1721 |
|
| 97 |
L |
B |
0.0000 |
|
| 98 |
E |
B |
-3.2560 |
|
| 99 |
K |
B |
-3.1108 |
|
| 100 |
N |
B |
-2.0368 |
|
| 101 |
P |
B |
-1.1473 |
|
| 102 |
S |
B |
-1.3806 |
|
| 103 |
P |
B |
-1.0979 |
|
| 104 |
R |
B |
0.0000 |
|
| 105 |
I |
B |
0.0000 |
|
| 106 |
V |
B |
0.0000 |
|
| 107 |
K |
B |
-0.0915 |
|
| 108 |
T |
B |
0.0000 |
|
| 109 |
H |
B |
0.0000 |
|
| 110 |
L |
B |
0.0000 |
|
| 111 |
P |
B |
0.0000 |
|
| 112 |
T |
B |
-1.4574 |
|
| 113 |
D |
B |
-2.2065 |
|
| 114 |
L |
B |
0.0000 |
|
| 115 |
L |
B |
0.0000 |
|
| 116 |
P |
B |
0.0000 |
|
| 117 |
K |
B |
-3.0307 |
|
| 118 |
S |
B |
-2.5951 |
|
| 119 |
F |
B |
0.0000 |
|
| 120 |
W |
B |
-2.1562 |
|
| 121 |
E |
B |
-2.9483 |
|
| 122 |
N |
B |
-2.8787 |
|
| 123 |
N |
B |
-2.5495 |
|
| 124 |
C |
B |
0.0000 |
|
| 125 |
K |
B |
-1.0946 |
|
| 126 |
M |
B |
0.0000 |
|
| 127 |
I |
B |
0.0000 |
|
| 128 |
Y |
B |
0.0000 |
|
| 129 |
L |
B |
0.0000 |
|
| 130 |
A |
B |
0.0000 |
|
| 131 |
R |
B |
0.0000 |
|
| 132 |
N |
B |
0.0000 |
|
| 133 |
A |
B |
0.0000 |
|
| 134 |
K |
B |
0.0000 |
|
| 135 |
D |
B |
0.0000 |
|
| 136 |
V |
B |
0.0000 |
|
| 137 |
S |
B |
0.0000 |
|
| 138 |
V |
B |
0.0000 |
|
| 139 |
S |
B |
-0.2212 |
|
| 140 |
Y |
B |
0.0000 |
|
| 141 |
Y |
B |
0.4399 |
|
| 142 |
H |
B |
-0.1079 |
|
| 143 |
F |
B |
-0.0039 |
|
| 144 |
D |
B |
0.0000 |
|
| 145 |
L |
B |
0.1302 |
|
| 146 |
M |
B |
0.0000 |
|
| 147 |
N |
B |
0.0000 |
|
| 148 |
N |
B |
0.1496 |
|
| 149 |
L |
B |
0.0000 |
|
| 150 |
Q |
B |
0.0000 |
|
| 151 |
P |
B |
0.0375 |
|
| 152 |
F |
B |
1.5029 |
|
| 153 |
P |
B |
0.0000 |
|
| 154 |
G |
B |
-0.2269 |
|
| 155 |
T |
B |
-0.9677 |
|
| 156 |
W |
B |
-1.6014 |
|
| 157 |
E |
B |
-3.1546 |
|
| 158 |
E |
B |
-3.4355 |
|
| 159 |
Y |
B |
0.0000 |
|
| 160 |
L |
B |
0.0000 |
|
| 161 |
E |
B |
-3.5554 |
|
| 162 |
K |
B |
-2.9050 |
|
| 163 |
F |
B |
0.0000 |
|
| 164 |
L |
B |
0.0000 |
|
| 165 |
T |
B |
-1.2540 |
|
| 166 |
G |
B |
0.0000 |
|
| 167 |
K |
B |
-2.2149 |
|
| 168 |
V |
B |
0.0000 |
|
| 169 |
A |
B |
0.0000 |
|
| 170 |
Y |
B |
0.0000 |
|
| 171 |
G |
B |
0.0000 |
|
| 172 |
S |
B |
-0.4794 |
|
| 173 |
W |
B |
0.0000 |
|
| 174 |
F |
B |
0.0000 |
|
| 175 |
T |
B |
-0.3658 |
|
| 176 |
H |
B |
0.0000 |
|
| 177 |
V |
B |
0.0000 |
|
| 178 |
K |
B |
-1.0671 |
|
| 179 |
N |
B |
-1.6012 |
|
| 180 |
W |
B |
0.0000 |
|
| 181 |
W |
B |
-1.6605 |
|
| 182 |
K |
B |
-3.1135 |
|
| 183 |
K |
B |
-3.0209 |
|
| 184 |
K |
B |
-3.0019 |
|
| 185 |
E |
B |
-3.6661 |
|
| 186 |
E |
B |
-3.4178 |
|
| 187 |
H |
B |
0.0000 |
|
| 188 |
P |
B |
-1.3378 |
|
| 189 |
I |
B |
0.0000 |
|
| 190 |
L |
B |
0.0000 |
|
| 191 |
F |
B |
-0.0116 |
|
| 192 |
L |
B |
0.0000 |
|
| 193 |
Y |
B |
-0.2546 |
|
| 194 |
Y |
B |
0.0000 |
|
| 195 |
E |
B |
0.0000 |
|
| 196 |
D |
B |
-1.5895 |
|
| 197 |
M |
B |
0.0000 |
|
| 198 |
K |
B |
-1.4033 |
|
| 199 |
E |
B |
-2.3695 |
|
| 200 |
N |
B |
-2.9513 |
|
| 201 |
P |
B |
-2.8748 |
|
| 202 |
K |
B |
-3.6895 |
|
| 203 |
E |
B |
-3.8039 |
|
| 204 |
E |
B |
-3.1277 |
|
| 205 |
I |
B |
0.0000 |
|
| 206 |
K |
B |
-3.3463 |
|
| 207 |
K |
B |
-3.3147 |
|
| 208 |
I |
B |
0.0000 |
|
| 209 |
I |
B |
0.0000 |
|
| 210 |
R |
B |
-3.4300 |
|
| 211 |
F |
B |
-1.8301 |
|
| 212 |
L |
B |
0.0000 |
|
| 213 |
E |
B |
-2.9793 |
|
| 214 |
K |
B |
-2.4870 |
|
| 215 |
N |
B |
-2.8576 |
|
| 216 |
L |
B |
-2.3484 |
|
| 217 |
N |
B |
-3.1854 |
|
| 218 |
D |
B |
-4.0121 |
|
| 219 |
E |
B |
-3.7225 |
|
| 220 |
I |
B |
-2.8048 |
|
| 221 |
L |
B |
0.0000 |
|
| 222 |
D |
B |
-3.7254 |
|
| 223 |
R |
B |
-2.5678 |
|
| 224 |
I |
B |
0.0000 |
|
| 225 |
I |
B |
-1.5142 |
|
| 226 |
H |
B |
-1.5976 |
|
| 227 |
H |
B |
0.0000 |
|
| 228 |
T |
B |
0.0000 |
|
| 229 |
S |
B |
-0.6918 |
|
| 230 |
F |
B |
-1.3648 |
|
| 231 |
E |
B |
-2.3664 |
|
| 232 |
V |
B |
-1.3402 |
|
| 233 |
M |
B |
0.0000 |
|
| 234 |
K |
B |
-2.3289 |
|
| 235 |
D |
B |
-2.5233 |
|
| 236 |
N |
B |
-1.5220 |
|
| 237 |
P |
B |
-0.9854 |
|
| 238 |
L |
B |
-0.7204 |
|
| 239 |
V |
B |
0.0000 |
|
| 240 |
N |
B |
-0.6512 |
|
| 241 |
Y |
B |
0.0000 |
|
| 242 |
T |
B |
-0.3676 |
|
| 243 |
H |
B |
-0.0449 |
|
| 244 |
L |
B |
-0.0472 |
|
| 245 |
P |
B |
-0.1479 |
|
| 246 |
T |
B |
-0.3103 |
|
| 247 |
T |
B |
-0.0241 |
|
| 248 |
V |
B |
0.0000 |
|
| 249 |
M |
B |
0.0000 |
|
| 250 |
D |
B |
-0.9958 |
|
| 251 |
H |
B |
-1.0282 |
|
| 252 |
S |
B |
-1.2507 |
|
| 253 |
K |
B |
-1.9008 |
|
| 254 |
S |
B |
-1.0112 |
|
| 255 |
P |
B |
-0.9701 |
|
| 256 |
F |
B |
-0.5150 |
|
| 257 |
M |
B |
-1.0397 |
|
| 258 |
R |
B |
-1.0382 |
|
| 259 |
K |
B |
-1.9185 |
|
| 260 |
G |
B |
-1.2155 |
|
| 261 |
T |
B |
-0.6725 |
|
| 262 |
A |
B |
-0.9975 |
|
| 263 |
G |
B |
-1.1633 |
|
| 264 |
D |
B |
0.0000 |
|
| 265 |
W |
B |
0.0000 |
|
| 266 |
K |
B |
-2.2280 |
|
| 267 |
N |
B |
-1.9073 |
|
| 268 |
Y |
B |
-0.7957 |
|
| 269 |
F |
B |
0.0000 |
|
| 270 |
T |
B |
-0.2984 |
|
| 271 |
V |
B |
0.7746 |
|
| 272 |
A |
B |
-0.2143 |
|
| 273 |
Q |
B |
-1.3236 |
|
| 274 |
N |
B |
-1.4758 |
|
| 275 |
E |
B |
-2.4112 |
|
| 276 |
K |
B |
-2.3941 |
|
| 277 |
F |
B |
0.0000 |
|
| 278 |
D |
B |
-2.5293 |
|
| 279 |
A |
B |
-1.8011 |
|
| 280 |
I |
B |
-1.0526 |
|
| 281 |
Y |
B |
-1.5008 |
|
| 282 |
E |
B |
-2.4179 |
|
| 283 |
T |
B |
-1.5084 |
|
| 284 |
E |
B |
-1.6926 |
|
| 285 |
M |
B |
0.0000 |
|
| 286 |
S |
B |
-1.8422 |
|
| 287 |
K |
B |
-2.1808 |
|
| 288 |
T |
B |
-1.4063 |
|
| 289 |
A |
B |
-0.8379 |
|
| 290 |
L |
B |
0.0000 |
|
| 291 |
Q |
B |
-1.1840 |
|
| 292 |
F |
B |
-0.8961 |
|
| 293 |
R |
B |
-1.0047 |
|
| 294 |
T |
B |
-0.9624 |
|
| 295 |
E |
B |
-1.3884 |
|
| 296 |
I |
B |
0.5030 |
|
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine