Project name: rqcp

Chain sequence(s)	A: LKFTKIRDDWIPTQRGELSMKLLSSDDLLDWQLWERPLDWKDVIQNDVSQWQKFISFYKFEPLNSDLSKKSMMDFYLSVIVHPDHEALINLISSKFPYHVPGLLQVALIFIRQGDRSNTNGLLQRALFVFDRALKANIIFDSLNCQLPYIYFFNRQFYLAIFRYIQSLAQRGVIGTASEWTKVLWSLSPLEDPLGCRYFLDHYFLLNNDYQYIIELSNSPLMNCYKQWNTLGFSLAVVLSFLRINEMSSARNALLKAFKHHPLQLSELFKEKLLGDHALTKDLSIDGHSAENLELKAYMARFPLLWNRNEEVTFLHDEMSSILQDYHRGNVTIDSNDGQDHNNINNLQSPFFIAGIPINLLRFAILSEESSVMAAIPSFIWSDNEVYEFDVLPPMPTSKESIEVVENIKTFINEKDLAVL
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.3618
• Maximal score value: 2.1276
• Average score: -0.1915
• Total score value: -80.4449

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	L	A	1.2336
2	K	A	-1.0553
3	F	A	1.6137
4	T	A	-0.0259
5	K	A	-1.3413
6	I	A	1.3572
7	R	A	-1.7530
8	D	A	-2.1940
9	D	A	-1.9944
10	W	A	0.2867
11	I	A	1.5667
12	P	A	0.1667
13	T	A	-0.2585
14	Q	A	-1.4869
15	R	A	-1.8582
16	G	A	-1.0763
17	E	A	-1.6347
18	L	A	0.5463
19	S	A	0.1652
20	M	A	0.5370
21	K	A	-0.2863
22	L	A	0.3216
23	L	A	0.0000
24	S	A	-0.2283
25	S	A	-0.4506
26	D	A	-2.1096
27	D	A	-1.9676
28	L	A	0.5122
29	L	A	-0.1284
30	D	A	-1.2692
31	W	A	0.9056
32	Q	A	0.0000
33	L	A	0.7318
34	W	A	1.0773
35	E	A	-1.0119
36	R	A	-0.6449
37	P	A	-0.0533
38	L	A	0.7409
39	D	A	0.0000
40	W	A	-0.0819
41	K	A	-1.6528
42	D	A	0.0000
43	V	A	0.0000
44	I	A	0.3698
45	Q	A	-0.9454
46	N	A	0.0000
47	D	A	0.0000
48	V	A	0.9096
49	S	A	0.1411
50	Q	A	0.0000
51	W	A	0.9696
52	Q	A	-1.2560
53	K	A	-1.3664
54	F	A	1.7513
55	I	A	0.7294
56	S	A	-0.0642
57	F	A	0.4994
58	Y	A	0.8346
59	K	A	0.0000
60	F	A	0.0000
61	E	A	-0.1231
62	P	A	0.0000
63	L	A	0.0000
64	N	A	0.0000
65	S	A	-0.1445
66	D	A	-0.2018
67	L	A	0.1156
68	S	A	-0.2083
69	K	A	-0.3546
70	K	A	-0.8729
71	S	A	-0.3380
72	M	A	0.2298
73	M	A	0.0000
74	D	A	-0.8362
75	F	A	1.1117
76	Y	A	0.0000
77	L	A	0.2626
78	S	A	-0.0284
79	V	A	0.2196
80	I	A	0.0000
81	V	A	1.5917
82	H	A	-0.6972
83	P	A	-0.5471
84	D	A	-1.0985
85	H	A	-0.6419
86	E	A	-1.8375
87	A	A	-0.3277
88	L	A	0.0000
89	I	A	0.4624
90	N	A	-1.1008
91	L	A	0.0207
92	I	A	0.0000
93	S	A	-0.2548
94	S	A	-0.5106
95	K	A	-1.3837
96	F	A	0.1268
97	P	A	0.0398
98	Y	A	0.2514
99	H	A	0.0000
100	V	A	0.0000
101	P	A	0.0000
102	G	A	0.0000
103	L	A	0.0000
104	L	A	0.0000
105	Q	A	0.0000
106	V	A	0.0000
107	A	A	0.0000
108	L	A	0.0000
109	I	A	0.0000
110	F	A	0.3063
111	I	A	0.2181
112	R	A	-1.9465
113	Q	A	-1.6151
114	G	A	-0.6891
115	D	A	-0.8303
116	R	A	-1.9699
117	S	A	-0.6786
118	N	A	-0.7604
119	T	A	0.0000
120	N	A	-0.5408
121	G	A	-0.3496
122	L	A	0.0000
123	L	A	0.1607
124	Q	A	-0.2743
125	R	A	-0.4119
126	A	A	0.0000
127	L	A	0.3203
128	F	A	0.5611
129	V	A	0.0000
130	F	A	0.0000
131	D	A	-0.7319
132	R	A	-1.9163
133	A	A	0.0000
134	L	A	0.0000
135	K	A	-1.5280
136	A	A	-0.4889
137	N	A	-1.2297
138	I	A	0.2061
139	I	A	1.5671
140	F	A	1.5209
141	D	A	-1.5209
142	S	A	-0.2502
143	L	A	1.4544
144	N	A	-0.0006
145	C	A	-0.0018
146	Q	A	-0.1077
147	L	A	0.0000
148	P	A	0.0000
149	Y	A	0.0000
150	I	A	0.3039
151	Y	A	0.3512
152	F	A	0.0000
153	F	A	0.0000
154	N	A	0.0000
155	R	A	0.0000
156	Q	A	0.0000
157	F	A	0.0000
158	Y	A	0.0000
159	L	A	0.0000
160	A	A	0.0000
161	I	A	0.0000
162	F	A	0.0000
163	R	A	-0.2057
164	Y	A	0.0000
165	I	A	0.1734
166	Q	A	-0.1988
167	S	A	-0.1962
168	L	A	0.0000
169	A	A	-0.1682
170	Q	A	-1.2769
171	R	A	-0.7218
172	G	A	-0.3749
173	V	A	1.1887
174	I	A	2.0951
175	G	A	-0.1001
176	T	A	-0.1143
177	A	A	0.0000
178	S	A	-0.4448
179	E	A	-1.8165
180	W	A	-0.1830
181	T	A	-0.2963
182	K	A	-1.6615
183	V	A	-0.0706
184	L	A	0.0000
185	W	A	0.1195
186	S	A	-0.1616
187	L	A	0.0000
188	S	A	0.0000
189	P	A	-0.0436
190	L	A	0.0197
191	E	A	-0.7562
192	D	A	0.0000
193	P	A	0.0000
194	L	A	0.0000
195	G	A	0.0000
196	C	A	0.0000
197	R	A	-0.3186
198	Y	A	0.0000
199	F	A	0.0000
200	L	A	0.0000
201	D	A	0.0000
202	H	A	0.0000
203	Y	A	0.3205
204	F	A	0.0000
205	L	A	0.3555
206	L	A	0.0832
207	N	A	-1.3931
208	N	A	-1.2906
209	D	A	-0.8081
210	Y	A	0.1376
211	Q	A	-0.5627
212	Y	A	0.3712
213	I	A	0.0000
214	I	A	-0.0740
215	E	A	-1.4182
216	L	A	0.0000
217	S	A	-0.2589
218	N	A	-1.2943
219	S	A	-0.3649
220	P	A	-0.2709
221	L	A	0.0000
222	M	A	0.2674
223	N	A	-0.2928
224	C	A	0.1216
225	Y	A	0.2483
226	K	A	-0.4833
227	Q	A	-0.2326
228	W	A	-0.0017
229	N	A	-0.7999
230	T	A	0.0000
231	L	A	0.0000
232	G	A	-0.0554
233	F	A	0.0000
234	S	A	0.0000
235	L	A	0.0000
236	A	A	0.0000
237	V	A	0.0000
238	V	A	0.0000
239	L	A	0.0000
240	S	A	0.0000
241	F	A	0.0000
242	L	A	-0.2712
243	R	A	-1.4264
244	I	A	0.4172
245	N	A	-1.2568
246	E	A	-1.1558
247	M	A	-0.0867
248	S	A	-0.0492
249	S	A	-0.0690
250	A	A	0.0000
251	R	A	0.0000
252	N	A	-0.3302
253	A	A	0.0000
254	L	A	0.0000
255	L	A	0.0039
256	K	A	-1.0818
257	A	A	0.0000
258	F	A	0.0000
259	K	A	-1.7521
260	H	A	-0.7201
261	H	A	-0.7414
262	P	A	0.1066
263	L	A	1.3624
264	Q	A	-0.6674
265	L	A	0.0000
266	S	A	-0.3331
267	E	A	-1.5912
268	L	A	-0.1205
269	F	A	0.0000
270	K	A	-2.0301
271	E	A	-2.2275
272	K	A	-0.6031
273	L	A	1.5059
274	L	A	0.5703
275	G	A	-0.0988
276	D	A	-0.3864
277	H	A	-0.1701
278	A	A	0.0000
279	L	A	0.0000
280	T	A	-0.2746
281	K	A	-1.4392
282	D	A	-1.9440
283	L	A	-0.1448
284	S	A	-0.1287
285	I	A	-0.1344
286	D	A	-1.7660
287	G	A	-0.4410
288	H	A	-0.1281
289	S	A	-0.0621
290	A	A	0.0144
291	E	A	0.0000
292	N	A	0.0000
293	L	A	1.3027
294	E	A	-1.0537
295	L	A	0.0000
296	K	A	-1.0729
297	A	A	-0.2524
298	Y	A	0.3483
299	M	A	0.2325
300	A	A	-0.2055
301	R	A	-1.4952
302	F	A	-0.1297
303	P	A	0.0623
304	L	A	1.7897
305	L	A	1.9432
306	W	A	0.6377
307	N	A	-1.5024
308	R	A	-2.3105
309	N	A	-1.7892
310	E	A	-1.3296
311	E	A	-0.9195
312	V	A	0.0000
313	T	A	0.0146
314	F	A	0.2216
315	L	A	0.1006
316	H	A	-0.1041
317	D	A	0.0000
318	E	A	-0.6537
319	M	A	0.0000
320	S	A	0.0000
321	S	A	0.0000
322	I	A	0.6498
323	L	A	0.0000
324	Q	A	0.0000
325	D	A	-0.1880
326	Y	A	0.1400
327	H	A	0.0000
328	R	A	-1.8602
329	G	A	-0.6608
330	N	A	-1.2318
331	V	A	0.0674
332	T	A	0.0000
333	I	A	1.0570
334	D	A	-1.5438
335	S	A	0.0000
336	N	A	-0.4052
337	D	A	-0.3106
338	G	A	-0.3294
339	Q	A	-1.3607
340	D	A	-1.1135
341	H	A	-0.7058
342	N	A	-1.4448
343	N	A	-0.8179
344	I	A	0.0000
345	N	A	-0.8031
346	N	A	-1.3042
347	L	A	-0.0253
348	Q	A	-0.7011
349	S	A	-0.3778
350	P	A	0.0712
351	F	A	1.9788
352	F	A	1.1889
353	I	A	2.1064
354	A	A	0.4057
355	G	A	-0.0151
356	I	A	0.3847
357	P	A	0.0000
358	I	A	1.9616
359	N	A	0.1720
360	L	A	0.4356
361	L	A	-0.0078
362	R	A	-1.7338
363	F	A	-0.0057
364	A	A	0.0000
365	I	A	0.0000
366	L	A	0.3259
367	S	A	0.0000
368	E	A	-0.3644
369	E	A	-1.0392
370	S	A	-0.2530
371	S	A	-0.2193
372	V	A	0.0000
373	M	A	0.0000
374	A	A	0.0679
375	A	A	0.1054
376	I	A	0.2090
377	P	A	-0.1522
378	S	A	0.2784
379	F	A	2.1276
380	I	A	1.4131
381	W	A	0.0000
382	S	A	-0.1079
383	D	A	-0.3779
384	N	A	-0.7785
385	E	A	-1.0820
386	V	A	0.3424
387	Y	A	1.0350
388	E	A	-1.2251
389	F	A	1.3861
390	D	A	-0.5456
391	V	A	1.7602
392	L	A	1.4570
393	P	A	0.0000
394	P	A	-0.2032
395	M	A	0.2108
396	P	A	-0.0606
397	T	A	-0.1280
398	S	A	-0.5469
399	K	A	-2.0773
400	E	A	-2.1469
401	S	A	-0.0306
402	I	A	1.6637
403	E	A	-1.4475
404	V	A	0.0000
405	V	A	0.0991
406	E	A	-1.8369
407	N	A	-0.9551
408	I	A	0.0000
409	K	A	-0.8419
410	T	A	-0.1404
411	F	A	0.5935
412	I	A	0.3480
413	N	A	-1.5150
414	E	A	-2.3618
415	K	A	-2.3591
416	D	A	-2.0259
417	L	A	0.0791
418	A	A	0.4576
419	V	A	2.0702
420	L	A	1.8761