Project name: FABRY

Chain sequence(s)	A: LDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9143
• Maximal score value: 1.584
• Average score: -0.6593
• Total score value: -257.119

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
32	L	A	-1.5164
33	D	A	-2.4890
34	N	A	-1.8613
35	G	A	-1.4988
36	L	A	-1.0660
37	A	A	-1.1807
38	R	A	-2.1654
39	T	A	-0.9256
40	P	A	0.0000
41	T	A	0.0000
42	M	A	0.0000
43	G	A	0.0000
44	W	A	0.0000
45	L	A	0.0000
46	H	A	0.0000
47	W	A	-0.0808
48	E	A	-1.0240
49	R	A	-1.0224
50	F	A	0.0000
51	M	A	0.4930
52	C	A	0.2687
53	N	A	-0.6978
54	L	A	-0.7577
55	D	A	-3.0175
56	C	A	-2.7656
57	Q	A	-3.1766
58	E	A	-3.8115
59	E	A	-3.9143
60	P	A	-3.1136
61	D	A	-3.2114
62	S	A	-1.8914
63	C	A	0.0000
64	I	A	0.0000
65	S	A	0.0000
66	E	A	0.0000
67	K	A	-2.1535
68	L	A	0.0000
69	F	A	0.0000
70	M	A	-1.1991
71	E	A	-1.8322
72	M	A	0.0000
73	A	A	0.0000
74	E	A	-2.0326
75	L	A	-1.0709
76	M	A	0.0000
77	V	A	-1.1598
78	S	A	-0.9863
79	E	A	-1.2352
80	G	A	-1.1667
81	W	A	0.0000
82	K	A	-1.9030
83	D	A	-2.5028
84	A	A	0.0000
85	G	A	-1.5011
86	Y	A	0.0000
87	E	A	-1.7542
88	Y	A	0.0000
89	L	A	0.0000
90	C	A	0.0000
91	I	A	0.0000
92	D	A	0.0000
93	D	A	0.0000
94	C	A	0.0000
95	W	A	0.0000
96	M	A	0.0000
97	A	A	0.0000
98	P	A	-1.3684
99	Q	A	-2.6287
100	R	A	-3.7201
101	D	A	-3.5612
102	S	A	-2.4573
103	E	A	-2.8685
104	G	A	-2.4943
105	R	A	-2.5071
106	L	A	0.0000
107	Q	A	-1.6720
108	A	A	-1.0563
109	D	A	-1.1355
110	P	A	-1.2780
111	Q	A	-1.5444
112	R	A	0.0000
113	F	A	0.0000
114	P	A	-1.5341
115	H	A	-1.9109
116	G	A	-1.5922
117	I	A	0.0000
118	R	A	-3.0436
119	Q	A	-2.5303
120	L	A	0.0000
121	A	A	0.0000
122	N	A	-2.3455
123	Y	A	-1.4395
124	V	A	0.0000
125	H	A	-1.4477
126	S	A	-1.1513
127	K	A	-1.6071
128	G	A	-1.3023
129	L	A	0.0000
130	K	A	-1.3199
131	L	A	0.0000
132	G	A	0.0000
133	I	A	0.0000
134	Y	A	0.0000
135	A	A	0.0000
136	D	A	0.0000
137	V	A	0.0000
138	G	A	0.0000
139	N	A	-1.0997
140	K	A	-0.7855
141	T	A	0.0000
142	C	A	0.5432
143	A	A	0.2974
144	G	A	-0.1699
145	F	A	-0.4661
146	P	A	-1.1315
147	G	A	-0.7296
148	S	A	0.0000
149	F	A	0.4409
150	G	A	0.0100
151	Y	A	0.1974
152	Y	A	0.0000
153	D	A	-0.6354
154	I	A	-0.1968
155	D	A	0.0000
156	A	A	0.0000
157	Q	A	-1.7197
158	T	A	0.0000
159	F	A	0.0000
160	A	A	0.0000
161	D	A	-2.4401
162	W	A	-1.9571
163	G	A	-1.7879
164	V	A	0.0000
165	D	A	0.0000
166	L	A	0.0000
167	L	A	0.0000
168	K	A	0.0000
169	F	A	0.0000
170	D	A	0.0666
171	G	A	0.0000
172	C	A	0.4071
173	Y	A	0.6001
174	C	A	-0.5642
175	D	A	-1.9164
176	S	A	-1.5103
177	L	A	-1.1482
178	E	A	-2.6255
179	N	A	-1.8298
180	L	A	0.0000
181	A	A	-1.5616
182	D	A	-2.6543
183	G	A	0.0000
184	Y	A	0.0000
185	K	A	-1.2702
186	H	A	-0.7947
187	M	A	0.0000
188	S	A	0.0000
189	L	A	0.2802
190	A	A	0.0000
191	L	A	0.0000
192	N	A	-2.0750
193	R	A	-2.5919
194	T	A	-2.1317
195	G	A	-2.2086
196	R	A	-2.0688
197	S	A	-1.2469
198	I	A	0.0000
199	V	A	0.0000
200	Y	A	0.0000
201	S	A	0.0000
202	C	A	0.0000
203	E	A	0.0000
204	W	A	0.0000
205	P	A	0.0000
206	L	A	0.1859
207	Y	A	0.5717
208	M	A	0.0000
209	W	A	0.2393
210	P	A	0.2654
211	F	A	1.0288
212	Q	A	-1.1762
213	K	A	-2.1947
214	P	A	0.0000
215	N	A	-2.4863
216	Y	A	0.0000
217	T	A	-1.8881
218	E	A	-2.4609
219	I	A	0.0000
220	R	A	-1.8551
221	Q	A	-2.2341
222	Y	A	-1.0065
223	C	A	0.0000
224	N	A	0.0000
225	H	A	0.0000
226	W	A	0.0000
227	R	A	0.0000
228	N	A	0.0000
229	F	A	0.2185
230	A	A	-0.7228
231	D	A	-2.0423
232	I	A	0.0000
233	D	A	-2.8001
234	D	A	-1.3203
235	S	A	-1.2625
236	W	A	0.0000
237	K	A	-2.2010
238	S	A	-1.9240
239	I	A	0.0000
240	K	A	-1.0751
241	S	A	-0.7045
242	I	A	0.0000
243	L	A	0.0000
244	D	A	0.1194
245	W	A	0.6729
246	T	A	0.0000
247	S	A	0.0000
248	F	A	1.3928
249	N	A	-0.1175
250	Q	A	-1.1399
251	E	A	-2.3611
252	R	A	-2.3949
253	I	A	0.0000
254	V	A	-1.5331
255	D	A	-2.4966
256	V	A	0.0000
257	A	A	-1.0095
258	G	A	0.0000
259	P	A	-1.2947
260	G	A	0.0000
261	G	A	0.0000
262	W	A	0.0000
263	N	A	0.0000
264	D	A	0.0000
265	P	A	0.0000
266	D	A	0.0000
267	M	A	0.0000
268	L	A	0.0000
269	V	A	0.0000
270	I	A	0.0000
271	G	A	-0.3042
272	N	A	0.2412
273	F	A	1.5840
274	G	A	-0.0686
275	L	A	0.0000
276	S	A	0.2048
277	W	A	0.0532
278	N	A	-0.2534
279	Q	A	-0.3348
280	Q	A	-0.0135
281	V	A	0.0000
282	T	A	0.0000
283	Q	A	0.0000
284	M	A	0.0000
285	A	A	0.0000
286	L	A	0.0000
287	W	A	0.0000
288	A	A	0.0000
289	I	A	0.0000
290	M	A	0.0000
291	A	A	0.0000
292	A	A	0.0000
293	P	A	0.0000
294	L	A	0.0000
295	F	A	0.0000
296	M	A	0.0000
297	S	A	0.0000
298	N	A	0.0000
299	D	A	-0.7634
300	L	A	0.0000
301	R	A	-0.9851
302	H	A	-1.1859
303	I	A	-0.8126
304	S	A	-0.9058
305	P	A	-1.0606
306	Q	A	-1.3345
307	A	A	0.0000
308	K	A	-0.9057
309	A	A	-0.8997
310	L	A	0.0000
311	L	A	0.0000
312	Q	A	-1.4190
313	D	A	-1.4940
314	K	A	-2.5601
315	D	A	-2.1420
316	V	A	0.0000
317	I	A	0.0000
318	A	A	-0.9684
319	I	A	0.0000
320	N	A	0.0000
321	Q	A	-0.5467
322	D	A	0.0000
323	P	A	-0.6033
324	L	A	-0.2940
325	G	A	0.0000
326	K	A	-1.6294
327	Q	A	0.0000
328	G	A	0.0000
329	Y	A	-0.3150
330	Q	A	0.0000
331	L	A	-0.8908
332	R	A	-2.3368
333	Q	A	-2.7956
334	G	A	-2.6940
335	D	A	-3.1179
336	N	A	-2.9266
337	F	A	0.0000
338	E	A	0.0000
339	V	A	0.0000
340	W	A	0.0000
341	E	A	0.0000
342	R	A	0.0000
343	P	A	-0.4722
344	L	A	0.0000
345	S	A	-0.2271
346	G	A	-0.0273
347	L	A	0.7171
348	A	A	0.0000
349	W	A	0.0000
350	A	A	0.0000
351	V	A	0.0000
352	A	A	0.0000
353	M	A	0.0000
354	I	A	0.0000
355	N	A	0.0000
356	R	A	-1.4067
357	Q	A	-1.4398
358	E	A	-1.1795
359	I	A	0.7206
360	G	A	-0.2094
361	G	A	-0.8192
362	P	A	-0.9495
363	R	A	-1.2362
364	S	A	-1.2251
365	Y	A	-0.9534
366	T	A	-1.2398
367	I	A	-0.6941
368	A	A	-0.6621
369	V	A	0.0000
370	A	A	0.0000
371	S	A	-0.7195
372	L	A	0.0000
373	G	A	0.0000
374	K	A	-1.6557
375	G	A	-0.7988
376	V	A	0.0327
377	A	A	0.0000
378	C	A	0.0000
379	N	A	-1.2470
380	P	A	-0.9436
381	A	A	-0.2225
382	C	A	0.0000
383	F	A	0.3304
384	I	A	0.0000
385	T	A	-1.1750
386	Q	A	-1.2486
387	L	A	0.0000
388	L	A	0.0000
389	P	A	0.2505
390	V	A	0.4537
391	K	A	-1.6641
392	R	A	-2.6867
393	K	A	-2.3521
394	L	A	-0.8464
395	G	A	-0.0230
396	F	A	1.2937
397	Y	A	-0.1219
398	E	A	-1.4121
399	W	A	-0.4999
400	T	A	-0.7684
401	S	A	-1.1428
402	R	A	-2.3213
403	L	A	0.0000
404	R	A	-2.4082
405	S	A	0.0000
406	H	A	-1.7077
407	I	A	0.0000
408	N	A	-1.0530
409	P	A	-0.9910
410	T	A	0.0000
411	G	A	0.0000
412	T	A	0.0000
413	V	A	0.0000
414	L	A	0.0000
415	L	A	0.0000
416	Q	A	-0.6035
417	L	A	0.0000
418	E	A	-0.1764
419	N	A	0.0075
420	T	A	0.2576
421	M	A	0.7473