Project name: 4x7t:H

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNWIRQAPGKGLEWVASITYDGSTNYNPSVKGRITISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFGHWHFAVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.9468
• Maximal score value: 2.4745
• Average score: -0.5522
• Total score value: -122.583

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1542
2	V	H	-1.3429
3	Q	H	-1.3324
4	L	H	0.0000
5	V	H	1.0732
6	E	H	0.0000
7	S	H	-0.3000
8	G	H	-1.0408
9	G	H	-0.6519
10	G	H	-0.2712
11	L	H	0.0006
12	V	H	-0.6000
13	Q	H	-1.5589
14	P	H	-1.4770
15	G	H	-1.4867
16	G	H	-1.3411
17	S	H	-1.7491
18	L	H	0.0000
19	R	H	-2.4710
20	L	H	0.0000
21	S	H	-0.5095
22	C	H	0.0000
23	A	H	-0.0235
24	V	H	0.0000
25	S	H	-0.7888
26	G	H	-1.2081
27	Y	H	-0.5313
28	S	H	-0.6816
29	I	H	0.0000
30	T	H	-0.6109
31	S	H	0.0874
32	G	H	0.0000
33	Y	H	0.2193
34	S	H	0.0000
35	W	H	0.0000
36	N	H	0.0000
37	W	H	0.0000
38	I	H	0.0000
39	R	H	0.0000
40	Q	H	-0.5219
41	A	H	-1.1440
42	P	H	-1.0626
43	G	H	-1.4599
44	K	H	-2.2339
45	G	H	-0.9678
46	L	H	0.5966
47	E	H	0.0917
48	W	H	0.4371
49	V	H	0.0000
50	A	H	0.0000
51	S	H	0.0000
52	I	H	0.0000
53	T	H	-0.2737
54	Y	H	0.3346
55	D	H	-1.3188
56	G	H	-0.9004
57	S	H	-0.8905
58	T	H	-0.8820
59	N	H	-1.5508
60	Y	H	-1.2277
61	N	H	-1.1041
62	P	H	-1.3414
63	S	H	-0.9302
64	V	H	0.0000
65	K	H	-2.3641
66	G	H	-1.6322
67	R	H	-1.5680
68	I	H	0.0000
69	T	H	-1.1878
70	I	H	0.0000
71	S	H	-0.7742
72	R	H	-1.5461
73	D	H	-2.3019
74	D	H	-2.9468
75	S	H	-2.2519
76	K	H	-2.7190
77	N	H	-2.0403
78	T	H	0.0000
79	F	H	0.0000
80	Y	H	0.0000
81	L	H	0.0000
82	Q	H	-1.7484
83	M	H	0.0000
84	N	H	-2.0087
85	S	H	-1.4518
86	L	H	0.0000
87	R	H	-2.4381
88	A	H	-1.6943
89	E	H	-2.4337
90	D	H	0.0000
91	T	H	-0.7523
92	A	H	0.0000
93	V	H	0.3100
94	Y	H	0.0000
95	Y	H	0.4163
96	C	H	0.0000
97	A	H	0.0000
98	R	H	-0.1368
99	G	H	0.0000
100	S	H	0.2337
101	H	H	0.0938
102	Y	H	1.6573
103	F	H	2.0896
104	G	H	0.6340
105	H	H	0.3928
106	W	H	0.4102
107	H	H	-0.2647
108	F	H	0.1261
109	A	H	0.2209
110	V	H	0.0581
111	W	H	0.3470
112	G	H	-0.0710
113	Q	H	-0.7768
114	G	H	-0.1570
115	T	H	0.0330
116	L	H	0.2116
117	V	H	0.0000
118	T	H	-0.3604
119	V	H	0.0000
120	S	H	-0.6723
121	S	H	-0.5794
122	A	H	-0.4629
123	S	H	-0.6252
124	T	H	-0.8896
125	K	H	-1.5587
126	G	H	-1.7408
127	P	H	-0.7780
128	S	H	-0.1453
129	V	H	0.0000
130	F	H	1.3427
131	P	H	0.1288
132	L	H	0.4543
133	A	H	-0.8305
134	P	H	0.0000
135	S	H	-1.3894
136	S	H	-1.5797
137	K	H	-2.2310
138	S	H	-1.3434
139	T	H	-0.8646
140	S	H	-0.7754
141	G	H	-1.0922
142	G	H	-0.8091
143	T	H	-0.4483
144	A	H	0.0000
145	A	H	0.1115
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.7790
150	V	H	0.0000
151	K	H	-0.3573
152	D	H	-0.9583
153	Y	H	0.0000
154	F	H	0.0000
155	P	H	0.0000
156	E	H	-0.3766
157	P	H	-0.6615
158	V	H	-0.7043
159	T	H	-0.6182
160	V	H	-0.2470
161	S	H	-0.5584
162	W	H	0.0000
163	N	H	-0.9048
164	S	H	-0.7572
165	G	H	-0.5920
166	A	H	-0.2766
167	L	H	-0.0723
168	T	H	-0.3225
169	S	H	-0.3685
170	G	H	-0.4659
171	V	H	-0.0090
172	H	H	-0.3817
173	T	H	0.2458
174	F	H	1.0703
175	P	H	0.7471
176	A	H	1.2731
177	V	H	2.4745
178	L	H	2.0311
179	Q	H	0.6085
180	S	H	0.0566
181	S	H	-0.2850
182	G	H	0.1059
183	L	H	0.1202
184	Y	H	0.7151
185	S	H	0.6363
186	L	H	0.0000
187	S	H	0.7123
188	S	H	0.0000
189	V	H	0.4649
190	V	H	0.0000
191	T	H	-0.2026
192	V	H	0.0000
193	P	H	-0.5438
194	S	H	-0.8914
195	S	H	-0.6380
196	S	H	-0.5993
197	L	H	-1.0534
198	G	H	-1.0175
199	T	H	-0.7410
200	Q	H	-1.2584
201	T	H	-1.1540
202	Y	H	0.0000
203	I	H	-1.5085
204	C	H	0.0000
205	N	H	-1.6111
206	V	H	0.0000
207	N	H	-2.0304
208	H	H	0.0000
209	K	H	-2.7837
210	P	H	-1.6251
211	S	H	-1.9232
212	N	H	-2.6504
213	T	H	-2.1356
214	K	H	-2.6976
215	V	H	-1.6515
216	D	H	-2.7100
217	K	H	-2.0365
218	K	H	-2.5435
219	V	H	0.0000
220	E	H	-2.8218
221	P	H	-2.1695
222	K	H	-2.4383