Project name: b6073a2f84eb60c

Chain sequence(s)	C: NELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVAQNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSGNELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPIAFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSIPFIPPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFVVDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNASSEEIQRAFA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7844
• Maximal score value: 2.062
• Average score: -0.9929
• Total score value: -343.5606

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
202	N	C	-2.6434
203	E	C	-3.1144
204	L	C	-2.2616
205	K	C	-2.9920
206	P	C	-2.4008
207	E	C	-2.9248
208	Q	C	-2.5280
209	V	C	-1.7307
210	E	C	-2.6392
211	Q	C	-1.6170
212	L	C	0.0000
213	K	C	-1.4430
214	L	C	-0.4523
215	I	C	0.0000
216	M	C	0.0000
217	S	C	-1.2820
218	K	C	-2.0028
219	R	C	-1.7438
220	Y	C	-1.4772
221	D	C	-2.1669
222	G	C	-1.5374
223	S	C	-1.3808
224	Q	C	-1.7971
225	Q	C	-1.6790
226	A	C	-1.0880
227	L	C	0.0000
228	D	C	-1.6776
229	L	C	0.0000
230	K	C	-1.9946
231	G	C	-1.8311
232	L	C	0.0000
233	R	C	-2.2550
234	S	C	-1.2597
235	D	C	0.0000
236	P	C	-0.5900
237	D	C	-0.8034
238	L	C	0.0000
239	V	C	-0.1197
240	A	C	-0.4065
241	Q	C	-1.2565
242	N	C	-1.4878
243	I	C	0.0000
244	D	C	-2.0278
245	V	C	0.0000
246	V	C	-1.6887
247	L	C	0.0000
248	N	C	-2.0714
249	R	C	-3.2443
250	R	C	-3.2941
251	S	C	-2.1424
252	C	C	0.0000
253	M	C	0.0000
254	A	C	-1.4387
255	A	C	0.0000
256	T	C	0.0000
257	L	C	0.0000
258	R	C	-2.7995
259	I	C	0.0000
260	I	C	0.0000
261	E	C	-3.1843
262	E	C	-3.1104
263	N	C	-2.3915
264	I	C	-1.7356
265	P	C	-2.2563
266	E	C	-2.3839
267	L	C	0.0000
268	L	C	-0.9793
269	S	C	-0.8861
270	L	C	0.0000
271	N	C	-0.8968
272	L	C	0.0000
273	S	C	0.0000
274	N	C	-2.3073
275	N	C	0.0000
276	R	C	-2.6160
277	L	C	0.0000
278	Y	C	-1.2929
279	R	C	-2.7889
280	L	C	0.0000
281	D	C	-2.7781
282	D	C	-2.6514
283	M	C	0.0000
284	S	C	-1.6368
285	S	C	-1.1193
286	I	C	0.0000
287	V	C	-0.9924
288	Q	C	-1.5409
289	K	C	-1.9792
290	A	C	0.0000
291	P	C	-1.8758
292	N	C	-2.1924
293	L	C	0.0000
294	K	C	-1.6802
295	I	C	-0.6644
296	L	C	0.0000
297	N	C	-0.6551
298	L	C	0.0000
299	S	C	-1.5842
300	G	C	-1.8170
301	N	C	0.0000
302	E	C	-2.9353
303	L	C	0.0000
304	K	C	-2.7569
305	S	C	-2.0750
306	E	C	-1.9132
307	R	C	-3.1961
308	E	C	0.0000
309	L	C	0.0000
310	D	C	-3.7844
311	K	C	-3.1839
312	I	C	0.0000
313	K	C	-2.5642
314	G	C	-1.8264
315	L	C	0.0000
316	K	C	-2.8268
317	L	C	0.0000
318	E	C	-1.9496
319	E	C	-1.7167
320	L	C	0.0000
321	W	C	-0.7347
322	L	C	0.0000
323	D	C	-2.0564
324	G	C	-1.8295
325	N	C	0.0000
326	S	C	-2.0426
327	L	C	0.0000
328	C	C	-2.0026
329	D	C	-2.6525
330	T	C	-1.6572
331	F	C	-1.9097
332	R	C	-3.1905
333	D	C	-3.4084
334	Q	C	-2.4667
335	S	C	-1.5860
336	T	C	-1.3396
337	Y	C	0.0000
338	I	C	-0.7134
339	S	C	-0.8296
340	A	C	-1.0068
341	I	C	0.0000
342	R	C	0.0000
343	E	C	-2.3654
344	R	C	0.0000
345	F	C	0.0000
346	P	C	-1.4263
347	K	C	-2.2314
348	L	C	0.0000
349	L	C	-1.4298
350	R	C	-2.2785
351	L	C	0.0000
352	D	C	-1.6965
353	G	C	-1.7846
354	H	C	-2.3435
355	E	C	-2.7094
356	L	C	-1.3502
357	P	C	-0.5154
358	P	C	-0.1918
359	P	C	0.6175
360	I	C	2.0620
361	A	C	1.4841
362	F	C	1.7217
363	D	C	-0.5793
364	V	C	0.5036
365	E	C	-1.3568
366	A	C	-0.7211
367	P	C	-0.2978
368	T	C	-0.0857
369	T	C	0.4910
370	L	C	1.3817
371	P	C	0.3356
372	P	C	-0.0679
373	C	C	-0.1745
374	K	C	-1.5510
375	G	C	-0.9580
376	S	C	-0.5226
377	Y	C	-0.2033
378	F	C	-0.7171
379	G	C	-1.1857
380	T	C	-1.6431
381	E	C	-2.8070
382	N	C	-2.3688
383	L	C	-1.5517
384	K	C	-2.0664
385	S	C	-1.4333
386	L	C	-0.8336
387	V	C	0.0000
388	L	C	-0.6397
389	H	C	-1.3903
390	F	C	-0.9158
391	L	C	0.0000
392	Q	C	-1.8068
393	Q	C	-1.7909
394	Y	C	0.0000
395	Y	C	0.0000
396	A	C	-0.7942
397	I	C	-0.9350
398	Y	C	0.0000
399	D	C	-1.0435
400	S	C	-1.3026
401	G	C	-1.8849
402	D	C	-2.7111
403	R	C	0.0000
404	Q	C	-2.0007
405	G	C	-1.6276
406	L	C	0.0000
407	L	C	-1.0381
408	D	C	-2.1784
409	A	C	-1.3359
410	Y	C	0.0000
411	H	C	-1.6768
412	D	C	-2.3937
413	G	C	-1.7475
414	A	C	0.0000
415	C	C	-1.1874
416	C	C	0.0000
417	S	C	0.0000
418	L	C	0.0000
419	S	C	0.1272
420	I	C	0.5566
421	P	C	0.8215
422	F	C	1.8769
423	I	C	1.3126
424	P	C	0.4172
427	P	C	-0.6846
428	A	C	-0.9700
429	R	C	-2.1357
430	S	C	-1.3222
431	S	C	-1.6093
432	L	C	0.0000
433	A	C	-1.6210
434	E	C	-2.3663
435	Y	C	0.0000
436	F	C	-0.8830
437	K	C	-2.0543
438	D	C	-1.6107
439	S	C	-0.6046
440	R	C	-1.0601
441	N	C	-1.0917
442	V	C	-1.1488
443	K	C	-2.4191
444	K	C	-2.5187
445	L	C	-1.9915
446	K	C	-2.7049
447	D	C	-1.7368
448	P	C	-0.7454
449	T	C	-0.2883
450	L	C	-0.2013
451	R	C	-0.2990
452	F	C	0.7215
453	R	C	-1.0167
454	L	C	-0.7001
455	L	C	-0.4660
456	K	C	-1.0374
457	H	C	-1.6004
458	T	C	-1.3884
459	R	C	-1.2146
460	L	C	0.0788
461	N	C	-0.9915
462	V	C	0.0000
463	V	C	0.0000
464	A	C	-0.9552
465	F	C	0.0000
466	L	C	0.0000
467	N	C	-2.6864
468	E	C	-2.3534
469	L	C	0.0000
470	P	C	-1.8414
471	K	C	-2.0219
472	T	C	0.0000
473	Q	C	-1.0132
474	H	C	-0.5841
475	D	C	-0.2584
476	V	C	-0.4470
477	N	C	-0.8746
478	S	C	-0.4810
479	F	C	0.0000
480	V	C	-0.0809
481	V	C	0.0000
482	D	C	-0.9322
483	I	C	0.0000
484	S	C	-0.4627
485	A	C	-0.5017
486	Q	C	-0.8551
487	T	C	-0.3596
488	S	C	-0.2748
489	T	C	0.0240
490	L	C	0.5284
491	L	C	0.0000
492	C	C	-0.0155
493	F	C	0.0000
494	S	C	-0.3499
495	V	C	0.0000
496	N	C	-0.3654
497	G	C	-0.3463
498	V	C	0.0000
499	F	C	0.0000
500	K	C	-1.5780
501	E	C	0.0000
502	V	C	-1.6145
503	D	C	-2.8868
504	G	C	-2.7348
505	K	C	-3.1150
506	S	C	-2.8632
507	R	C	-3.4971
508	D	C	-3.1281
509	S	C	-1.7003
510	L	C	-1.0486
511	R	C	0.0000
512	A	C	0.0000
513	F	C	0.0000
514	T	C	-0.1062
515	R	C	0.0000
516	T	C	-0.4067
517	F	C	0.0000
518	I	C	0.2877
519	A	C	0.0000
520	V	C	0.5515
521	P	C	-0.1817
522	A	C	-0.5426
523	S	C	-0.9830
524	N	C	-1.5681
525	S	C	-0.9371
526	G	C	-0.9417
527	L	C	0.0000
528	C	C	-0.3856
529	I	C	0.0000
530	V	C	-0.2929
531	N	C	-0.7530
532	D	C	0.0000
533	E	C	-0.6706
534	L	C	0.0000
535	F	C	0.3629
536	V	C	0.0000
537	R	C	-0.8258
538	N	C	-1.4940
539	A	C	0.0000
540	S	C	-1.0618
541	S	C	-1.4742
542	E	C	-2.5655
543	E	C	-1.6260
544	I	C	-0.4999
545	Q	C	-1.9114
546	R	C	-2.0383
547	A	C	0.0000
548	F	C	1.1446
549	A	C	0.2970