Project name: LAG3

Chain sequence(s)	H: QVQLVESGGGLVKPGGSLRLSCAASGFRFSDYYMFWIRQAPGKGLEWVATINDGGDYTNYPDSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARESGIYYDWASFGYWGQGTLVTVSSDIVMTQSPLSLSVTPGEPASISCRSSKSLKYSNGITYLYWYLQKPGQSPQLLIYQMSNLASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCAQNLELPWTFGGGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.0102
• Maximal score value: 1.7728
• Average score: -0.2642
• Total score value: -61.8324

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2029
2	V	H	-0.1841
3	Q	H	-0.6410
4	L	H	0.0000
5	V	H	0.7832
6	E	H	0.0000
7	S	H	-0.2496
8	G	H	-0.3175
9	G	H	-0.2503
10	G	H	0.0033
11	L	H	1.4986
12	V	H	0.0000
13	K	H	-1.7418
14	P	H	-0.5029
15	G	H	-0.5365
16	G	H	-0.2563
17	S	H	-0.2672
18	L	H	-0.1690
19	R	H	-1.8282
20	L	H	0.0000
21	S	H	-0.0502
22	C	H	0.0000
23	A	H	0.1250
24	A	H	0.0000
25	S	H	-0.2914
26	G	H	-0.3230
27	F	H	0.8757
28	R	H	-1.6065
29	F	H	0.0000
30	S	H	-0.1773
31	D	H	-0.7304
32	Y	H	-0.0023
33	Y	H	0.0000
34	M	H	0.0000
35	F	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.1363
40	A	H	-0.0559
41	P	H	-0.3378
42	G	H	-0.8276
43	K	H	-1.8218
44	G	H	-0.5073
45	L	H	0.0000
46	E	H	-0.7380
47	W	H	0.0946
48	V	H	0.0000
49	A	H	0.0000
50	T	H	0.0000
51	I	H	0.0000
52	N	H	-0.2150
53	D	H	-0.4526
54	G	H	-0.4721
55	G	H	-0.4708
56	D	H	-1.5667
57	Y	H	0.9465
58	T	H	0.1311
59	N	H	-0.3724
60	Y	H	0.1038
61	P	H	-0.3345
62	D	H	-2.0102
63	S	H	-0.5012
64	V	H	0.0000
65	K	H	-1.9773
66	G	H	-0.8367
67	R	H	-0.3931
68	F	H	0.0000
69	T	H	-0.0633
70	I	H	0.0000
71	S	H	-0.2981
72	R	H	-1.1735
73	D	H	-0.7369
74	N	H	-1.3523
75	A	H	-0.4889
76	K	H	-1.7446
77	N	H	-0.7648
78	S	H	-0.0752
79	L	H	0.0000
80	Y	H	0.2648
81	L	H	0.0000
82	Q	H	-0.4169
83	M	H	0.0000
84	N	H	-0.6237
85	S	H	-0.3340
86	L	H	0.0000
87	R	H	-1.3383
88	A	H	-0.5223
89	E	H	-1.8092
90	D	H	0.0000
91	T	H	-0.0266
92	A	H	0.0000
93	V	H	0.6001
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	E	H	0.0000
100	S	H	-0.0239
101	G	H	0.0000
102	I	H	0.9101
103	Y	H	0.7847
104	Y	H	1.1832
105	D	H	-0.6636
106	W	H	0.9843
107	A	H	0.2207
108	S	H	0.0282
109	F	H	0.2456
110	G	H	0.0491
111	Y	H	0.3299
112	W	H	0.1739
113	G	H	0.0000
114	Q	H	-1.2115
115	G	H	-0.2943
116	T	H	0.2644
117	L	H	1.5993
118	V	H	0.0000
119	T	H	0.1403
120	V	H	0.0000
121	S	H	-0.1753
122	S	H	-0.4131
123	D	H	-1.7894
124	I	H	0.0000
125	V	H	1.7728
126	M	H	0.0000
127	T	H	-0.0709
128	Q	H	0.0000
129	S	H	-0.2254
130	P	H	0.0180
131	L	H	0.9291
132	S	H	0.0144
133	L	H	0.1698
134	S	H	-0.5283
135	V	H	0.0000
136	T	H	-0.2834
137	P	H	-0.3462
138	G	H	-0.8504
139	E	H	-1.9508
140	P	H	-0.8705
141	A	H	0.0000
142	S	H	-0.2724
143	I	H	0.0000
144	S	H	-0.1798
145	C	H	0.0000
146	R	H	-1.9901
147	S	H	0.0000
148	S	H	-0.4504
149	K	H	-1.7551
150	S	H	-0.4851
151	L	H	0.0000
152	K	H	-1.2199
153	Y	H	-0.0709
154	S	H	-0.2375
155	N	H	-0.4586
156	G	H	-0.4828
157	I	H	0.1580
158	T	H	0.0000
159	Y	H	0.0000
160	L	H	0.0000
161	Y	H	0.0000
162	W	H	0.0000
163	Y	H	0.0000
164	L	H	0.0000
165	Q	H	0.0000
166	K	H	-0.9188
167	P	H	-0.4986
168	G	H	-0.7359
169	Q	H	-1.2903
170	S	H	-0.2499
171	P	H	0.0000
172	Q	H	-1.1316
173	L	H	0.0000
174	L	H	0.0000
175	I	H	0.0000
176	Y	H	0.3458
177	Q	H	-0.0156
178	M	H	0.1293
179	S	H	-0.2488
180	N	H	-0.6211
181	L	H	0.4253
182	A	H	0.0705
183	S	H	-0.2975
184	G	H	-0.4724
185	V	H	0.0787
186	P	H	-0.3807
187	D	H	-1.8473
188	R	H	-0.5807
189	F	H	0.0000
190	S	H	-0.1510
191	G	H	-0.1364
192	S	H	-0.2516
193	G	H	-0.2384
194	S	H	-0.2615
195	G	H	-0.1645
196	T	H	-0.2840
197	D	H	-1.5247
198	F	H	0.0000
199	T	H	-0.0374
200	L	H	0.0000
201	K	H	-1.3582
202	I	H	0.0000
203	S	H	-0.6054
204	R	H	-1.9190
205	V	H	0.0000
206	E	H	-1.3773
207	A	H	-0.5308
208	E	H	-1.8091
209	D	H	0.0000
210	V	H	0.3364
211	G	H	0.0000
212	V	H	0.0500
213	Y	H	0.0000
214	Y	H	0.0000
215	C	H	0.0000
216	A	H	0.0000
217	Q	H	0.0000
218	N	H	0.0000
219	L	H	-0.0467
220	E	H	-0.9821
221	L	H	0.2066
222	P	H	0.0000
223	W	H	0.0000
224	T	H	0.0000
225	F	H	0.0000
226	G	H	0.0000
227	G	H	-0.4755
228	G	H	-0.1358
229	T	H	0.0000
230	K	H	-0.9181
231	L	H	0.0000
232	E	H	-1.2691
233	I	H	0.7829
234	K	H	-1.4707