| Chain sequence(s) |
A: SYELTQPPSVSVAPGQTARISCSGDNIGGTFVSWYQQKPGQAPVLVIYDDNDRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCGTWDMVTNNVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPT B: QVQLVESGGGLVQPGGSLRLSCAASGFTFNSYWINWVRQAPGKGLEWVSGIAYDSSNTLYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGLGAFHWDMQPDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
| Distance of aggregation | 5 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.1780 | |
| 2 | Y | A | -0.1841 | |
| 3 | E | A | -1.7851 | |
| 4 | L | A | 0.0000 | |
| 5 | T | A | -0.0803 | |
| 6 | Q | A | -0.1534 | |
| 7 | P | A | -0.1556 | |
| 8 | P | A | -0.2814 | |
| 9 | S | A | -0.1307 | |
| 10 | V | A | 0.2381 | |
| 11 | S | A | -0.1041 | |
| 12 | V | A | 0.0000 | |
| 13 | A | A | 0.0513 | |
| 14 | P | A | -0.2468 | |
| 15 | G | A | -0.7405 | |
| 16 | Q | A | -1.2955 | |
| 17 | T | A | -0.3112 | |
| 18 | A | A | 0.0000 | |
| 19 | R | A | -1.8465 | |
| 20 | I | A | 0.0000 | |
| 21 | S | A | -0.0998 | |
| 22 | C | A | 0.0000 | |
| 23 | S | A | -0.0980 | |
| 24 | G | A | -0.3984 | |
| 25 | D | A | -2.0364 | |
| 26 | N | A | -1.6320 | |
| 27 | I | A | 0.0000 | |
| 28 | G | A | -0.5528 | |
| 29 | G | A | -0.5114 | |
| 30 | T | A | 0.2675 | |
| 31 | F | A | 1.7803 | |
| 32 | V | A | 0.0000 | |
| 33 | S | A | 0.0000 | |
| 34 | W | A | 0.0000 | |
| 35 | Y | A | 0.0000 | |
| 36 | Q | A | -0.1466 | |
| 37 | Q | A | -0.2543 | |
| 38 | K | A | -0.6635 | |
| 39 | P | A | -0.4449 | |
| 40 | G | A | -0.7319 | |
| 41 | Q | A | -1.2814 | |
| 42 | A | A | -0.2068 | |
| 43 | P | A | 0.0000 | |
| 44 | V | A | 0.9687 | |
| 45 | L | A | 0.0000 | |
| 46 | V | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | Y | A | 0.0164 | |
| 49 | D | A | -1.1457 | |
| 50 | D | A | -0.8420 | |
| 51 | N | A | -1.5604 | |
| 52 | D | A | -1.4907 | |
| 53 | R | A | -0.8108 | |
| 54 | P | A | -0.1849 | |
| 55 | S | A | -0.3065 | |
| 56 | G | A | -0.4494 | |
| 57 | I | A | 0.1941 | |
| 58 | P | A | -0.4014 | |
| 59 | E | A | -1.9054 | |
| 60 | R | A | -0.6960 | |
| 61 | F | A | 0.0000 | |
| 62 | S | A | -0.1154 | |
| 63 | G | A | -0.2910 | |
| 64 | S | A | -0.2591 | |
| 65 | N | A | -0.2679 | |
| 66 | S | A | -0.3609 | |
| 67 | G | A | -0.7761 | |
| 68 | N | A | -1.3650 | |
| 69 | T | A | -0.2766 | |
| 70 | A | A | 0.0000 | |
| 71 | T | A | -0.0230 | |
| 72 | L | A | 0.0000 | |
| 73 | T | A | -0.2172 | |
| 74 | I | A | 0.0000 | |
| 75 | S | A | -0.2770 | |
| 76 | G | A | -0.2676 | |
| 77 | T | A | 0.0000 | |
| 78 | Q | A | -0.8000 | |
| 79 | A | A | -0.4283 | |
| 80 | E | A | -1.8090 | |
| 81 | D | A | 0.0000 | |
| 82 | E | A | -0.5322 | |
| 83 | A | A | 0.0000 | |
| 84 | D | A | -0.4783 | |
| 85 | Y | A | 0.0000 | |
| 86 | Y | A | 0.0000 | |
| 87 | C | A | 0.0000 | |
| 88 | G | A | 0.0000 | |
| 89 | T | A | 0.0000 | |
| 90 | W | A | 0.0000 | |
| 91 | D | A | -0.3045 | |
| 92 | M | A | 1.2980 | |
| 93 | V | A | 1.9684 | |
| 94 | T | A | 0.2743 | |
| 95 | N | A | -0.1478 | |
| 96 | N | A | 0.0000 | |
| 97 | V | A | 0.2305 | |
| 98 | F | A | 0.2401 | |
| 99 | G | A | 0.0000 | |
| 100 | G | A | -0.4747 | |
| 101 | G | A | -0.1317 | |
| 102 | T | A | 0.0000 | |
| 103 | K | A | -0.6376 | |
| 104 | L | A | 0.0000 | |
| 105 | T | A | 0.0000 | |
| 106 | V | A | 0.0000 | |
| 107 | L | A | 0.4260 | |
| 108 | G | A | -0.3039 | |
| 109 | Q | A | -1.2753 | |
| 110 | P | A | -0.7853 | |
| 111 | K | A | -1.7455 | |
| 112 | A | A | -0.2892 | |
| 113 | A | A | 0.0600 | |
| 114 | P | A | 0.0000 | |
| 115 | S | A | -0.1494 | |
| 116 | V | A | 0.0000 | |
| 117 | T | A | -0.0178 | |
| 118 | L | A | 0.0000 | |
| 119 | F | A | 0.0000 | |
| 120 | P | A | -0.0537 | |
| 121 | P | A | 0.0000 | |
| 122 | S | A | -0.0710 | |
| 123 | S | A | -0.5247 | |
| 124 | E | A | -1.6963 | |
| 125 | E | A | 0.0000 | |
| 126 | L | A | -0.2193 | |
| 127 | Q | A | -1.1469 | |
| 128 | A | A | -0.4300 | |
| 129 | N | A | -1.4635 | |
| 130 | K | A | -1.4042 | |
| 131 | A | A | 0.0000 | |
| 132 | T | A | 0.0000 | |
| 133 | L | A | 0.0000 | |
| 134 | V | A | 0.0000 | |
| 135 | C | A | 0.0000 | |
| 136 | L | A | 0.0000 | |
| 137 | I | A | 0.0000 | |
| 138 | S | A | -0.1505 | |
| 139 | D | A | -0.5974 | |
| 140 | F | A | 0.0000 | |
| 141 | Y | A | 0.1365 | |
| 142 | P | A | 0.0000 | |
| 143 | G | A | -0.0509 | |
| 144 | A | A | 0.0692 | |
| 145 | V | A | 0.2825 | |
| 146 | T | A | 0.0308 | |
| 147 | V | A | 0.2559 | |
| 148 | A | A | 0.0468 | |
| 149 | W | A | 0.0000 | |
| 150 | K | A | -0.3028 | |
| 151 | A | A | -0.3724 | |
| 152 | D | A | -1.8269 | |
| 153 | S | A | -0.5712 | |
| 154 | S | A | -0.2721 | |
| 155 | P | A | -0.2435 | |
| 156 | V | A | 0.0784 | |
| 157 | K | A | -1.6123 | |
| 158 | A | A | -0.2862 | |
| 159 | G | A | -0.1744 | |
| 160 | V | A | 0.0339 | |
| 161 | E | A | -0.5724 | |
| 162 | T | A | -0.1430 | |
| 163 | T | A | 0.0000 | |
| 164 | T | A | -0.0847 | |
| 165 | P | A | -0.1005 | |
| 166 | S | A | -0.3900 | |
| 167 | K | A | -1.6909 | |
| 168 | Q | A | 0.0000 | |
| 169 | S | A | -0.4412 | |
| 170 | N | A | -1.5398 | |
| 171 | N | A | -1.5747 | |
| 172 | K | A | -0.5983 | |
| 173 | Y | A | -0.1174 | |
| 174 | A | A | 0.0000 | |
| 175 | A | A | 0.0000 | |
| 176 | S | A | 0.0000 | |
| 177 | S | A | 0.0000 | |
| 178 | Y | A | 0.0000 | |
| 179 | L | A | 0.0000 | |
| 180 | S | A | -0.0645 | |
| 181 | L | A | 0.1795 | |
| 182 | T | A | 0.0040 | |
| 183 | P | A | -0.3754 | |
| 184 | E | A | -1.9599 | |
| 185 | Q | A | -1.0645 | |
| 186 | W | A | 0.0000 | |
| 187 | K | A | -1.2758 | |
| 188 | S | A | -0.5366 | |
| 189 | H | A | -0.9261 | |
| 190 | R | A | -1.9572 | |
| 191 | S | A | -0.3973 | |
| 192 | Y | A | 0.0000 | |
| 193 | S | A | -0.0376 | |
| 194 | C | A | 0.0000 | |
| 195 | Q | A | -0.4396 | |
| 196 | V | A | 0.0000 | |
| 197 | T | A | -0.0314 | |
| 198 | H | A | 0.0000 | |
| 199 | E | A | -1.9058 | |
| 200 | G | A | -0.8407 | |
| 201 | S | A | -0.3030 | |
| 202 | T | A | 0.0477 | |
| 203 | V | A | 0.2933 | |
| 204 | E | A | -1.8789 | |
| 205 | K | A | -1.1430 | |
| 206 | T | A | -0.1839 | |
| 207 | V | A | 0.1843 | |
| 208 | A | A | 0.0660 | |
| 209 | P | A | -0.0398 | |
| 210 | T | A | -0.0772 | |
| 1 | Q | B | -1.1704 | |
| 2 | V | B | -0.0716 | |
| 3 | Q | B | -1.1384 | |
| 4 | L | B | 0.0000 | |
| 5 | V | B | 0.7427 | |
| 6 | E | B | 0.0000 | |
| 7 | S | B | -0.2761 | |
| 8 | G | B | -0.4189 | |
| 9 | G | B | -0.1434 | |
| 10 | G | B | 0.0188 | |
| 11 | L | B | 1.2377 | |
| 12 | V | B | 0.2495 | |
| 13 | Q | B | -0.9020 | |
| 14 | P | B | -0.4810 | |
| 15 | G | B | -0.5146 | |
| 16 | G | B | -0.2080 | |
| 17 | S | B | -0.2530 | |
| 18 | L | B | -0.1090 | |
| 19 | R | B | -1.6599 | |
| 20 | L | B | 0.0000 | |
| 21 | S | B | -0.0397 | |
| 22 | C | B | 0.0000 | |
| 23 | A | B | 0.0485 | |
| 24 | A | B | 0.0000 | |
| 25 | S | B | -0.3725 | |
| 26 | G | B | -0.5114 | |
| 27 | F | B | 0.1978 | |
| 28 | T | B | -0.0145 | |
| 29 | F | B | 0.0000 | |
| 30 | N | B | -1.2886 | |
| 31 | S | B | -0.2787 | |
| 32 | Y | B | 0.2630 | |
| 33 | W | B | 0.0000 | |
| 34 | I | B | 0.0000 | |
| 35 | N | B | 0.0000 | |
| 36 | W | B | 0.0000 | |
| 37 | V | B | 0.0000 | |
| 38 | R | B | 0.0000 | |
| 39 | Q | B | -0.1333 | |
| 40 | A | B | -0.0577 | |
| 41 | P | B | -0.3373 | |
| 42 | G | B | -0.6935 | |
| 43 | K | B | -1.0703 | |
| 44 | G | B | -0.2328 | |
| 45 | L | B | 0.0000 | |
| 46 | E | B | -0.4672 | |
| 47 | W | B | 0.0000 | |
| 48 | V | B | 0.0000 | |
| 49 | S | B | 0.0000 | |
| 50 | G | B | 0.0000 | |
| 51 | I | B | 0.0000 | |
| 52 | A | B | 0.0000 | |
| 53 | Y | B | 0.1920 | |
| 54 | D | B | -1.2417 | |
| 55 | S | B | -0.4779 | |
| 56 | S | B | -0.4052 | |
| 57 | N | B | -0.8751 | |
| 58 | T | B | -0.1182 | |
| 59 | L | B | 0.3539 | |
| 60 | Y | B | 0.2531 | |
| 61 | A | B | -0.2841 | |
| 62 | D | B | -1.8173 | |
| 63 | S | B | -0.4844 | |
| 64 | V | B | 0.0000 | |
| 65 | K | B | -1.7854 | |
| 66 | G | B | -0.8272 | |
| 67 | R | B | -0.4248 | |
| 68 | F | B | 0.0000 | |
| 69 | T | B | -0.0613 | |
| 70 | I | B | 0.0000 | |
| 71 | S | B | -0.1454 | |
| 72 | R | B | -0.3375 | |
| 73 | D | B | -0.8143 | |
| 74 | N | B | -0.8465 | |
| 75 | S | B | -0.6349 | |
| 76 | K | B | -1.8541 | |
| 77 | N | B | -1.0117 | |
| 78 | T | B | 0.0000 | |
| 79 | L | B | 0.0000 | |
| 80 | Y | B | 0.1509 | |
| 81 | L | B | 0.0000 | |
| 82 | Q | B | -0.4863 | |
| 83 | M | B | 0.0000 | |
| 84 | N | B | -0.6967 | |
| 85 | S | B | -0.2680 | |
| 86 | L | B | 0.0000 | |
| 87 | R | B | -1.1308 | |
| 88 | A | B | -0.4841 | |
| 89 | E | B | -1.8093 | |
| 90 | D | B | 0.0000 | |
| 91 | T | B | -0.0115 | |
| 92 | A | B | 0.0000 | |
| 93 | V | B | 0.4786 | |
| 94 | Y | B | 0.0000 | |
| 95 | Y | B | 0.0000 | |
| 96 | C | B | 0.0000 | |
| 97 | A | B | 0.0000 | |
| 98 | R | B | 0.0000 | |
| 99 | G | B | 0.0000 | |
| 100 | L | B | 0.3432 | |
| 101 | G | B | -0.0592 | |
| 102 | A | B | 0.2222 | |
| 103 | F | B | 0.7993 | |
| 104 | H | B | 0.1459 | |
| 105 | W | B | 0.7881 | |
| 106 | D | B | -0.4409 | |
| 107 | M | B | 0.0000 | |
| 108 | Q | B | 0.0000 | |
| 109 | P | B | 0.0000 | |
| 110 | D | B | -0.0281 | |
| 111 | Y | B | 0.9322 | |
| 112 | W | B | 0.2904 | |
| 113 | G | B | 0.0000 | |
| 114 | Q | B | -1.2136 | |
| 115 | G | B | -0.3034 | |
| 116 | T | B | 0.1950 | |
| 117 | L | B | 1.2195 | |
| 118 | V | B | 0.0000 | |
| 119 | T | B | 0.1326 | |
| 120 | V | B | 0.0000 | |
| 121 | S | B | 0.0000 | |
| 122 | S | B | -0.3012 | |
| 123 | A | B | -0.0726 | |
| 124 | S | B | -0.2225 | |
| 125 | T | B | -0.2416 | |
| 126 | K | B | -0.7975 | |
| 127 | G | B | -0.2302 | |
| 128 | P | B | 0.0000 | |
| 129 | S | B | -0.0716 | |
| 130 | V | B | 0.0000 | |
| 131 | F | B | 0.0000 | |
| 132 | P | B | -0.0445 | |
| 133 | L | B | 0.0000 | |
| 134 | A | B | 0.0302 | |
| 135 | P | B | 0.0000 | |
| 136 | S | B | -0.1642 | |
| 137 | S | B | -0.5456 | |
| 138 | K | B | -1.7462 | |
| 139 | S | B | -0.3520 | |
| 140 | T | B | -0.0699 | |
| 141 | S | B | -0.3052 | |
| 142 | G | B | -0.5200 | |
| 143 | G | B | -0.2195 | |
| 144 | T | B | -0.1108 | |
| 145 | A | B | 0.0000 | |
| 146 | A | B | 0.0014 | |
| 147 | L | B | 0.0000 | |
| 148 | G | B | 0.0000 | |
| 149 | C | B | 0.0000 | |
| 150 | L | B | 0.0000 | |
| 151 | V | B | 0.0000 | |
| 152 | K | B | 0.0000 | |
| 153 | D | B | -0.2320 | |
| 154 | Y | B | 0.0000 | |
| 155 | F | B | 0.0000 | |
| 156 | P | B | -0.1889 | |
| 157 | E | B | -0.9195 | |
| 158 | P | B | -0.4666 | |
| 159 | V | B | 0.1385 | |
| 160 | T | B | 0.0142 | |
| 161 | V | B | 0.2466 | |
| 162 | S | B | -0.0087 | |
| 163 | W | B | 0.0000 | |
| 164 | N | B | -0.3551 | |
| 165 | S | B | -0.3444 | |
| 166 | G | B | -0.4137 | |
| 167 | A | B | 0.0278 | |
| 168 | L | B | 0.2173 | |
| 169 | T | B | -0.0708 | |
| 170 | S | B | -0.3050 | |
| 171 | G | B | -0.3703 | |
| 172 | V | B | 0.3893 | |
| 173 | H | B | -0.1971 | |
| 174 | T | B | -0.0932 | |
| 175 | F | B | 0.0000 | |
| 176 | P | B | -0.1042 | |
| 177 | A | B | -0.0052 | |
| 178 | V | B | 0.0000 | |
| 179 | L | B | 0.5406 | |
| 180 | Q | B | -0.0757 | |
| 181 | S | B | -0.2773 | |
| 182 | S | B | -0.2629 | |
| 183 | G | B | -0.0586 | |
| 184 | L | B | 0.1727 | |
| 185 | Y | B | 0.0000 | |
| 186 | S | B | 0.0000 | |
| 187 | L | B | 0.0000 | |
| 188 | S | B | 0.0000 | |
| 189 | S | B | 0.0000 | |
| 190 | V | B | 0.0000 | |
| 191 | V | B | 0.0000 | |
| 192 | T | B | -0.0404 | |
| 193 | V | B | 0.0000 | |
| 194 | P | B | -0.2833 | |
| 195 | S | B | -0.1665 | |
| 196 | S | B | -0.2319 | |
| 197 | S | B | -0.0224 | |
| 198 | L | B | 0.1768 | |
| 199 | G | B | -0.4291 | |
| 200 | T | B | -0.3220 | |
| 201 | Q | B | -0.9040 | |
| 202 | T | B | -0.1913 | |
| 203 | Y | B | 0.0000 | |
| 204 | I | B | 0.3406 | |
| 205 | C | B | 0.0000 | |
| 206 | N | B | -0.3421 | |
| 207 | V | B | 0.0000 | |
| 208 | N | B | -0.4855 | |
| 209 | H | B | 0.0000 | |
| 210 | K | B | -1.8849 | |
| 211 | P | B | -0.4558 | |
| 212 | S | B | -0.3257 | |
| 213 | N | B | -1.5015 | |
| 214 | T | B | -0.5666 | |
| 215 | K | B | -1.6685 | |
| 216 | V | B | -0.1900 | |
| 217 | D | B | -1.4258 | |
| 218 | K | B | -0.7674 | |
| 219 | K | B | -1.2254 | |
| 220 | V | B | 0.0000 | |
| 221 | E | B | -1.8666 | |
| 222 | P | B | -0.5885 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine