Project name: 4dec18

Chain sequence(s)	A: QDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAVTGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVVGAWDPTVSVEEVRPQITTALVR
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4269
• Maximal score value: 1.3678
• Average score: -0.9683
• Total score value: -150.0895

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
23	Q	A	-1.6130
24	D	A	-1.9102
25	F	A	0.0000
26	Y	A	0.0000
27	D	A	-2.2138
28	F	A	-1.5678
29	K	A	-1.7840
30	A	A	0.0000
31	V	A	-0.0469
32	N	A	-1.0855
33	I	A	0.0000
34	R	A	-2.8260
35	G	A	-1.9538
36	K	A	-1.5013
37	L	A	0.3849
38	V	A	-0.3710
39	S	A	-1.4981
40	L	A	0.0000
41	E	A	-3.2528
42	K	A	-2.9810
43	Y	A	0.0000
44	R	A	-2.5084
45	G	A	-1.5777
46	S	A	0.0000
47	V	A	0.0000
48	S	A	0.0000
49	L	A	0.0000
50	V	A	0.0000
51	V	A	0.0000
52	N	A	0.0000
53	V	A	0.0000
54	A	A	0.0000
55	S	A	-1.5974
56	E	A	-2.5011
57	C	A	0.0000
58	G	A	-0.9879
59	F	A	-0.5075
60	T	A	0.0000
61	D	A	-2.2740
62	Q	A	-2.2052
63	H	A	0.0000
64	Y	A	0.0000
65	R	A	-2.8209
66	A	A	-2.3089
67	L	A	0.0000
68	Q	A	0.0000
69	Q	A	-2.6770
70	L	A	0.0000
71	Q	A	-2.0988
72	R	A	-3.0527
73	D	A	-2.5811
74	L	A	0.0000
75	G	A	-1.8388
76	P	A	-1.6903
77	H	A	-2.0281
78	H	A	-1.8275
79	F	A	0.0000
80	N	A	-0.8702
81	V	A	0.0000
82	L	A	0.0000
83	A	A	0.0000
84	F	A	0.0000
85	P	A	0.0000
86	C	A	0.0000
87	N	A	-1.6493
88	Q	A	-1.2481
89	F	A	-0.7758
90	G	A	-1.4294
91	Q	A	-2.2700
92	Q	A	-2.1061
93	E	A	0.0000
94	P	A	-2.0844
95	D	A	-2.9109
96	S	A	-2.3953
97	N	A	-2.9408
98	K	A	-3.4269
99	E	A	-2.9728
100	I	A	0.0000
101	E	A	0.0000
102	S	A	-1.6294
103	F	A	-1.0527
104	A	A	0.0000
105	R	A	-1.5498
106	R	A	-2.0157
107	T	A	-1.3398
108	Y	A	-1.4097
109	S	A	-1.1853
110	V	A	0.0000
111	S	A	-0.8407
112	F	A	0.0000
113	P	A	-0.1971
114	M	A	0.0000
115	F	A	0.0000
116	S	A	-1.0496
117	K	A	-0.8342
118	I	A	-0.1381
119	A	A	-0.5396
120	V	A	0.0000
121	T	A	-0.9871
122	G	A	-1.0820
123	T	A	-0.7166
124	G	A	-0.7964
125	A	A	0.0000
126	H	A	-0.8188
127	P	A	-0.9254
128	A	A	0.0000
129	F	A	0.0000
130	K	A	-1.8858
131	Y	A	-1.4149
132	L	A	0.0000
133	A	A	-2.1672
134	Q	A	-2.1676
135	T	A	-1.2402
136	S	A	-1.2043
137	G	A	-1.8532
138	K	A	-2.6028
139	E	A	-2.7505
140	P	A	0.0000
141	T	A	-0.5660
142	W	A	-0.0451
143	N	A	0.0000
144	F	A	0.0000
145	W	A	-0.3029
146	K	A	0.0000
147	Y	A	0.0000
148	L	A	0.0000
149	V	A	0.0000
150	A	A	-0.5424
151	P	A	-1.4080
152	D	A	-2.4088
153	G	A	0.0000
154	K	A	-1.4714
155	V	A	0.1347
156	V	A	1.3678
157	G	A	0.4326
158	A	A	-0.1782
159	W	A	-0.5494
160	D	A	-0.6261
161	P	A	0.0000
162	T	A	0.0694
163	V	A	-0.5695
164	S	A	-1.4420
165	V	A	-2.0941
166	E	A	-2.9898
167	E	A	-3.0140
168	V	A	0.0000
169	R	A	-2.3723
170	P	A	-1.6313
171	Q	A	-1.1884
172	I	A	0.0000
173	T	A	-0.7707
174	A	A	-0.3450
175	L	A	0.1309
176	V	A	-0.9529
177	R	A	-1.9785