Project name: b9de6544aed4d67

Chain sequence(s)	A: ELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.2482
• Maximal score value: 2.4028
• Average score: -0.8504
• Total score value: -270.4299

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
39	E	A	-1.9452
40	L	A	-0.7068
41	E	A	-2.3425
42	L	A	-2.8062
43	D	A	-4.1158
44	E	A	-4.7806
45	Q	A	-4.1133
46	Q	A	-4.1503
47	R	A	-5.2482
48	K	A	-4.7747
49	R	A	-3.3951
50	L	A	-2.7698
51	E	A	-3.0432
52	A	A	-1.7963
53	F	A	-1.1909
54	L	A	-1.1810
55	T	A	-1.2893
56	Q	A	-1.4165
57	K	A	-1.7440
58	Q	A	-2.4218
59	K	A	-2.7563
60	V	A	0.0000
61	G	A	-2.4078
62	E	A	-2.7271
63	L	A	-2.0797
64	K	A	-3.0125
65	D	A	-2.9433
66	D	A	-3.3642
67	D	A	-3.4026
68	F	A	-2.4698
69	E	A	-2.3118
70	K	A	-1.7168
71	I	A	0.2379
72	S	A	-0.8071
73	E	A	-1.6035
74	L	A	-0.5954
75	G	A	-0.5333
76	A	A	-0.4137
77	G	A	-0.7055
78	N	A	-1.4665
79	G	A	-1.0853
80	G	A	-0.6013
81	V	A	-0.1868
82	V	A	-0.2116
83	F	A	-0.7229
84	K	A	-0.6775
85	V	A	0.0000
86	S	A	-0.6900
87	H	A	0.0000
88	K	A	-2.4689
89	P	A	-1.3854
90	S	A	-1.1513
91	G	A	-0.8669
92	L	A	0.0703
93	V	A	0.4993
94	M	A	0.0000
95	A	A	0.0000
96	R	A	0.0000
97	K	A	-0.2445
98	L	A	-0.0422
99	I	A	0.0000
100	H	A	-1.7330
101	L	A	-1.5934
102	E	A	-2.7507
103	I	A	0.0000
104	K	A	-2.5411
105	P	A	-1.7296
106	A	A	-0.7329
107	I	A	-1.0081
108	R	A	-2.5421
109	N	A	-2.6829
110	Q	A	-2.7725
111	I	A	0.0000
112	I	A	-1.7023
113	R	A	-2.6813
114	E	A	-1.4338
115	L	A	0.0000
116	Q	A	-0.8433
117	V	A	0.7040
118	L	A	0.2304
119	H	A	0.0000
120	E	A	-0.3036
121	C	A	-0.5780
122	N	A	-1.3666
123	S	A	0.0000
124	P	A	-0.6201
125	Y	A	-0.0177
126	I	A	0.0000
127	V	A	0.0000
128	G	A	-0.2572
129	F	A	0.0000
130	Y	A	-0.5329
131	G	A	-0.6653
132	A	A	-0.6382
133	F	A	-0.8211
134	Y	A	-1.1648
135	S	A	-1.7181
136	D	A	-2.3795
137	G	A	-2.2676
138	E	A	-1.8573
139	I	A	0.0000
140	S	A	0.0000
141	I	A	0.0000
142	C	A	0.0000
143	M	A	0.0000
144	E	A	-0.2391
145	H	A	-0.2355
146	M	A	0.0000
147	D	A	-0.8744
148	G	A	0.0000
149	G	A	-0.4686
150	S	A	-0.6003
151	L	A	0.0000
152	D	A	-1.7574
153	Q	A	-1.8609
154	V	A	0.0000
155	L	A	0.0000
156	K	A	-3.1648
157	K	A	-2.9514
158	A	A	-1.9334
159	G	A	-1.9530
160	R	A	-1.6600
161	I	A	0.0000
162	P	A	-0.7062
163	E	A	-0.7772
164	Q	A	-1.5896
165	I	A	0.0000
166	L	A	0.0000
167	G	A	0.0000
168	K	A	-1.1039
169	V	A	0.0000
170	S	A	0.0000
171	I	A	-0.6442
172	A	A	0.0000
173	V	A	0.0000
174	I	A	0.0000
175	K	A	-0.3122
176	G	A	0.0000
177	L	A	0.0000
178	T	A	-0.9397
179	Y	A	-1.1217
180	L	A	0.0000
181	R	A	-1.6612
182	E	A	-2.8058
183	K	A	-2.8306
184	H	A	-1.2750
185	K	A	-0.8364
186	I	A	0.0260
187	M	A	-0.1452
188	H	A	-1.0847
189	R	A	0.0000
190	D	A	-1.3974
191	V	A	0.0000
192	K	A	-1.4854
193	P	A	0.0000
194	S	A	-0.8905
195	N	A	-0.7893
196	I	A	0.0000
197	L	A	-0.1987
198	V	A	0.0000
199	N	A	0.0000
200	S	A	-1.2993
201	R	A	-2.1415
202	G	A	-1.5099
203	E	A	-0.9995
204	I	A	0.0000
205	K	A	0.0000
206	L	A	0.0000
207	C	A	-0.0237
208	D	A	-0.1777
209	F	A	-0.6004
210	G	A	-1.0577
211	V	A	0.0000
212	S	A	-0.6817
213	G	A	-0.6923
214	Q	A	-0.4494
215	L	A	0.0000
216	I	A	0.4584
217	D	A	-1.2079
218	S	A	0.0000
219	M	A	-0.1739
220	A	A	-0.2661
221	N	A	-0.7448
222	S	A	-0.3733
223	F	A	0.9497
224	V	A	1.6435
225	G	A	0.1317
226	T	A	-0.6566
227	R	A	-1.4108
228	S	A	-0.3260
229	Y	A	0.8243
230	M	A	0.2548
231	S	A	-0.5588
232	P	A	-1.1173
233	E	A	-2.5931
234	R	A	-1.8076
235	L	A	-0.3188
236	Q	A	-1.4533
237	G	A	0.0000
238	T	A	-0.9572
239	H	A	-1.5013
240	Y	A	-0.6474
241	S	A	-0.3703
242	V	A	-0.3660
243	Q	A	-0.8163
244	S	A	-0.6417
245	D	A	0.0000
246	I	A	0.0000
247	W	A	-0.2754
248	S	A	0.0000
249	M	A	0.0000
250	G	A	0.0000
251	L	A	-0.3053
252	S	A	0.0000
253	L	A	0.0000
254	V	A	0.0000
255	E	A	-0.6408
256	M	A	0.0000
257	A	A	0.0000
258	V	A	0.0000
259	G	A	-1.0632
260	R	A	-0.7584
261	Y	A	0.1528
262	P	A	0.0000
263	I	A	0.0000
264	P	A	-0.3503
265	P	A	-0.8971
266	P	A	-1.3865
267	D	A	-2.6116
268	A	A	-1.8517
269	K	A	-2.2731
270	E	A	-1.5774
271	L	A	-1.1087
272	E	A	-1.1275
273	L	A	0.5551
274	M	A	0.1244
275	F	A	0.0975
276	G	A	-0.1681
277	C	A	-0.3559
278	Q	A	-1.0064
305	R	A	-1.9831
306	P	A	-1.1934
307	P	A	-0.5121
308	M	A	0.0905
309	A	A	1.2405
310	I	A	2.4028
311	F	A	2.1787
312	E	A	0.3197
313	L	A	1.0459
314	L	A	1.6273
315	D	A	-0.4874
316	Y	A	-0.0560
317	I	A	0.3924
318	V	A	0.6485
319	N	A	-1.0558
320	E	A	-1.1770
321	P	A	-0.7952
322	P	A	-0.6115
323	P	A	0.0000
324	K	A	-1.5543
325	L	A	0.0000
326	P	A	-0.5584
327	S	A	-0.4287
328	G	A	-0.2453
329	V	A	0.1868
330	F	A	0.0000
331	S	A	0.2640
332	L	A	0.9636
333	E	A	-0.4472
334	F	A	0.0000
335	Q	A	-0.6670
336	D	A	-1.1094
337	F	A	0.0000
338	V	A	0.0000
339	N	A	-1.5425
340	K	A	-1.4312
341	C	A	0.0000
342	L	A	0.0000
343	I	A	-0.9438
344	K	A	-1.2445
345	N	A	-1.6773
346	P	A	-1.3805
347	A	A	-1.3398
348	E	A	-2.3416
349	R	A	-1.7173
350	A	A	0.0000
351	D	A	-1.5434
352	L	A	0.0000
353	K	A	-1.9218
354	Q	A	-1.3976
355	L	A	0.0000
356	M	A	-0.8963
357	V	A	-0.1715
358	H	A	0.0000
359	A	A	-0.6751
360	F	A	0.0000
361	I	A	0.0000
362	K	A	-2.3594
363	R	A	-2.1396
364	S	A	0.0000
365	D	A	-3.2375
366	A	A	-2.2030
367	E	A	-2.7940
368	E	A	-2.8814
369	V	A	-2.1691
370	D	A	-2.3109
371	F	A	0.0000
372	A	A	-1.2990
373	G	A	-1.0789
374	W	A	-0.4527
375	L	A	0.0000
376	C	A	-0.5386
377	S	A	-0.3563
378	T	A	-0.4195
379	I	A	-0.6626
380	G	A	-0.5696
381	L	A	-0.2651
382	N	A	-1.0968