Project name: 2mz72chain1ihg

Chain sequence(s)	A: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP; C: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY; B: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.2359
• Maximal score value: 2.1313
• Average score: -0.9485
• Total score value: -432.5116

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
267	K	A	-3.2283
268	H	A	-3.2573
269	Q	A	-2.4064
270	P	A	0.0000
271	G	A	-1.9899
272	G	A	0.0000
273	G	A	-2.4200
274	K	A	-2.5091
275	V	A	-1.4616
276	Q	A	-1.3387
277	I	A	0.8363
278	I	A	1.0905
279	N	A	0.0587
280	K	A	-1.0637
281	K	A	-0.9792
282	L	A	0.7263
283	D	A	-0.1797
284	L	A	0.5692
285	S	A	-0.8757
286	N	A	-1.0165
287	V	A	0.9568
288	Q	A	0.0941
289	S	A	-0.1659
290	K	A	-0.5449
291	C	A	0.3186
292	G	A	0.0000
293	S	A	-0.5401
294	K	A	-2.0519
295	D	A	-2.4891
296	N	A	-1.5706
297	I	A	-0.2693
298	K	A	-1.9267
299	H	A	-0.6429
300	V	A	0.0000
301	P	A	-0.0600
302	G	A	0.5226
303	G	A	-0.2330
304	G	A	-0.8586
305	S	A	-0.1008
306	V	A	1.5988
307	Q	A	0.3648
308	I	A	1.1444
309	V	A	1.7539
310	Y	A	1.2804
311	K	A	-0.9964
312	P	A	-0.4735
267	K	B	-2.7535
268	H	B	-2.9544
269	Q	B	-1.6537
270	P	B	-0.8742
271	G	B	-1.2594
272	G	B	-1.3982
273	G	B	-1.9660
274	K	B	-1.9243
275	V	B	0.0622
276	Q	B	0.0716
277	I	B	2.1313
278	I	B	1.7366
279	N	B	0.8469
280	K	B	-0.3973
281	K	B	-0.1530
282	L	B	1.2075
283	D	B	0.2881
284	L	B	0.9503
285	S	B	-0.5551
286	N	B	-1.1289
287	V	B	0.5898
288	Q	B	-0.0110
289	S	B	-0.8240
290	K	B	-1.5772
291	C	B	-0.2411
292	G	B	-0.2058
293	S	B	-0.1255
294	K	B	-1.4371
295	D	B	-1.6870
296	N	B	-1.1645
297	I	B	0.2351
298	K	B	-1.2218
299	H	B	-0.4323
300	V	B	0.0000
301	P	B	-0.1794
302	G	B	0.1226
303	G	B	-0.3609
304	G	B	-0.9604
305	S	B	0.0000
306	V	B	0.4282
307	Q	B	0.1481
308	I	B	1.1194
309	V	B	1.5571
310	Y	B	1.1888
311	K	B	-0.9670
312	P	B	-0.4583
2	S	C	-1.0306
3	H	C	-1.3785
4	P	C	-1.2623
5	S	C	0.0000
6	P	C	-1.3006
7	Q	C	-1.6667
8	A	C	-1.4237
9	K	C	-2.0689
10	P	C	-1.5463
11	S	C	-1.3524
12	N	C	-1.2354
13	P	C	-1.0725
14	S	C	-1.0096
15	N	C	0.0000
16	P	C	-1.2358
17	R	C	-0.8818
18	V	C	0.0000
19	F	C	0.0550
20	F	C	0.0000
21	D	C	0.0000
22	V	C	0.0000
23	D	C	0.0000
24	I	C	-0.7047
25	G	C	-1.2911
26	G	C	-1.7129
27	E	C	-2.2746
28	R	C	-1.6036
29	V	C	-0.4294
30	G	C	-0.2450
31	R	C	-0.1623
32	I	C	0.0000
33	V	C	0.0000
34	L	C	0.0000
35	E	C	0.0000
36	L	C	0.0000
37	F	C	0.0000
38	A	C	-1.1578
39	D	C	-1.5073
40	I	C	-0.4903
41	V	C	0.0000
42	P	C	-1.2637
43	K	C	-1.6623
44	T	C	0.0000
45	A	C	0.0000
46	E	C	-1.4580
47	N	C	0.0000
48	F	C	0.0000
49	R	C	-1.0721
50	A	C	0.0000
51	L	C	0.0000
52	C	C	0.0000
53	T	C	-1.2557
54	G	C	-1.4900
55	E	C	-2.5228
56	K	C	-2.1971
57	G	C	-0.8059
58	I	C	0.8434
59	G	C	0.0000
60	P	C	-0.3478
61	T	C	-0.6496
62	T	C	-0.6457
63	G	C	-0.3491
64	K	C	-0.3982
65	P	C	-0.4175
66	L	C	0.0000
67	H	C	-0.9199
68	F	C	0.0000
69	K	C	-1.4337
70	G	C	-1.2563
71	C	C	0.0000
72	P	C	0.0000
73	F	C	0.0000
74	H	C	-1.4816
75	R	C	-1.9083
76	I	C	0.0000
77	I	C	-1.2571
78	K	C	-2.4954
79	K	C	-2.2473
80	F	C	-0.2051
81	M	C	0.0000
82	I	C	0.0000
83	Q	C	0.0000
84	G	C	0.0000
85	G	C	0.0000
86	D	C	0.0000
87	F	C	0.0000
88	S	C	-1.2209
89	N	C	-1.9050
90	Q	C	-1.6235
91	N	C	-2.2150
92	G	C	-1.3631
93	T	C	-0.9516
94	G	C	-1.1806
95	G	C	-1.3022
96	E	C	0.0000
97	S	C	0.0000
98	I	C	0.0000
99	Y	C	-0.4711
100	G	C	-1.3456
101	E	C	-2.6824
102	K	C	-3.1058
103	F	C	0.0000
104	E	C	-2.8451
105	D	C	-2.2569
106	E	C	-1.4868
107	N	C	-0.9340
108	F	C	-0.6035
109	H	C	-0.7223
110	Y	C	-0.8271
111	K	C	-1.4947
112	H	C	0.0000
113	D	C	-1.5263
114	K	C	-1.4571
115	E	C	-1.2574
116	G	C	0.0000
117	L	C	0.0000
118	L	C	0.0000
119	S	C	0.0000
120	M	C	0.0000
121	A	C	-0.3834
122	N	C	-0.9365
123	A	C	-0.4695
124	G	C	-0.8019
125	S	C	-1.3701
126	N	C	-2.2972
127	T	C	-1.8754
128	N	C	0.0000
129	G	C	-1.5003
130	S	C	0.0000
131	Q	C	-0.2903
132	F	C	0.0000
133	F	C	0.0000
134	I	C	0.0000
135	T	C	0.0000
136	T	C	0.0000
137	V	C	-0.8040
138	P	C	-1.0537
139	T	C	0.0000
140	P	C	-1.4313
141	H	C	-1.6685
142	L	C	0.0000
143	D	C	-1.6732
144	G	C	-1.6288
145	K	C	-2.1286
146	H	C	0.0000
147	V	C	0.0000
148	V	C	0.0000
149	F	C	0.0000
150	G	C	0.0000
151	Q	C	0.0000
152	V	C	0.0000
153	I	C	0.0000
154	K	C	-0.6861
155	G	C	0.0000
156	M	C	-0.4588
157	G	C	-0.4738
158	V	C	0.0000
159	A	C	0.0000
160	K	C	-1.2491
161	I	C	-0.0450
162	L	C	0.0000
163	E	C	0.0000
164	N	C	-1.9792
165	V	C	-1.3876
166	E	C	-2.2096
167	V	C	-2.0208
168	K	C	-2.6921
169	G	C	-2.1469
170	E	C	-2.7508
171	K	C	-2.8951
172	P	C	0.0000
173	A	C	-1.3699
174	K	C	-1.3472
175	L	C	-0.5119
176	C	C	0.0000
177	V	C	0.0000
178	I	C	0.0000
179	A	C	0.0000
180	E	C	-1.1849
181	C	C	-0.4385
182	G	C	-0.7418
183	E	C	-1.1024
184	L	C	-2.0274
185	K	C	-3.4515
186	E	C	-3.6346
187	G	C	-2.8634
188	D	C	-3.5500
189	D	C	-2.8247
190	W	C	-1.0315
191	G	C	-0.3549
192	I	C	0.2101
193	F	C	0.5306
194	P	C	-0.5151
195	K	C	-0.9160
196	D	C	-1.0279
197	G	C	-1.0605
198	S	C	-0.7910
199	G	C	-0.7609
200	D	C	0.0000
201	S	C	-0.4373
202	H	C	-0.5060
203	P	C	-0.4946
204	D	C	-0.9216
205	F	C	-0.8255
206	P	C	0.0000
207	E	C	-2.5487
208	D	C	-1.4755
209	A	C	-1.7498
210	D	C	-2.4431
211	V	C	-2.5331
212	D	C	-3.4010
213	L	C	-3.2564
214	K	C	-4.0287
215	D	C	-3.7987
216	V	C	0.0000
217	D	C	-2.8622
218	K	C	-2.1850
219	I	C	0.0000
220	L	C	-1.0284
221	L	C	-0.0521
222	I	C	0.0000
223	S	C	0.0000
224	E	C	-2.0172
225	D	C	-2.4598
226	L	C	0.0000
227	K	C	-1.7495
228	N	C	-2.3214
229	I	C	-1.3301
230	G	C	0.0000
231	N	C	-1.2112
232	T	C	-0.9812
233	F	C	-1.1201
234	F	C	-1.2556
235	K	C	-1.9062
236	S	C	-1.3574
237	Q	C	-1.4425
238	N	C	-1.4966
239	W	C	0.0000
240	E	C	-2.1749
241	M	C	-1.3673
242	A	C	0.0000
243	I	C	-1.2642
244	K	C	-1.9503
245	K	C	0.0000
246	Y	C	0.0000
247	T	C	-0.7637
248	K	C	0.0000
249	V	C	0.0000
250	L	C	-0.8614
251	R	C	-1.7408
252	Y	C	0.0000
253	V	C	0.0000
254	E	C	-2.6266
255	G	C	-2.3214
256	S	C	0.0000
257	R	C	-4.0824
258	A	C	-2.1112
259	A	C	-2.4631
260	A	C	-3.3825
261	E	C	-3.8559
262	D	C	-3.6511
263	A	C	-2.6470
264	D	C	-4.1680
265	G	C	0.0000
266	A	C	-2.2868
267	K	C	-2.5227
268	L	C	0.0000
269	Q	C	-1.1335
270	P	C	-0.6685
271	V	C	0.0000
272	A	C	0.0000
273	L	C	-0.4421
274	S	C	-0.1535
275	C	C	0.0000
276	V	C	0.0000
277	L	C	-0.3875
278	N	C	-0.2278
279	I	C	0.0000
280	G	C	0.0000
281	A	C	-0.3833
282	C	C	0.0000
283	K	C	-1.1497
284	L	C	-0.6784
285	K	C	-1.1326
286	M	C	-1.1566
287	S	C	-0.9512
288	D	C	-1.0504
289	W	C	-1.1008
290	Q	C	-1.5411
291	G	C	-1.2684
292	A	C	0.0000
293	V	C	0.0000
294	D	C	-2.0159
295	S	C	-1.5292
296	C	C	0.0000
297	L	C	-1.0125
298	E	C	-2.1727
299	A	C	0.0000
300	L	C	-1.2891
301	E	C	-2.0766
302	I	C	-0.9966
303	D	C	-1.1489
304	P	C	-1.0194
305	S	C	-0.8915
306	N	C	-0.7480
307	T	C	-1.1000
308	K	C	-1.4183
309	A	C	0.0000
310	L	C	0.0000
311	Y	C	-0.6494
312	R	C	-0.7044
313	R	C	-0.8300
314	A	C	0.0000
315	Q	C	-0.6149
316	G	C	0.0000
317	W	C	-1.0691
318	Q	C	0.0000
319	G	C	-0.7097
320	L	C	-0.7878
321	K	C	-2.1521
322	E	C	-1.9920
323	Y	C	-1.9441
324	D	C	-2.4689
325	Q	C	-1.9559
326	A	C	0.0000
327	L	C	-1.1217
328	A	C	-1.1123
329	D	C	0.0000
330	L	C	0.0000
331	K	C	-1.8900
332	K	C	-1.7479
333	A	C	0.0000
334	Q	C	-2.3488
335	E	C	-2.3832
336	I	C	-0.6929
337	A	C	-1.5804
338	P	C	-2.3218
339	E	C	-2.9391
340	D	C	-2.6852
341	K	C	-2.8152
342	A	C	-1.4439
343	I	C	0.0000
344	Q	C	-1.8081
345	A	C	-0.7227
346	E	C	-0.8901
347	L	C	0.0000
348	L	C	0.0081
349	K	C	-1.4651
350	V	C	0.0000
351	K	C	-2.0609
352	Q	C	-2.5678
353	K	C	-2.7937
354	I	C	-3.3178
355	K	C	-4.0606
356	A	C	-3.5195
357	Q	C	-4.2042
358	K	C	-5.0307
359	D	C	-5.2359
360	K	C	-4.8972
361	E	C	-4.9515
362	K	C	-4.1711
363	A	C	-2.2947
364	A	C	-0.3831
365	Y	C	1.3565