Project name: 2mz72chain1nmv

Chain sequence(s)	A: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP; C: MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE; B: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8659
• Maximal score value: 2.184
• Average score: -1.0595
• Total score value: -270.1784

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
267	K	A	-3.1478
268	H	A	-3.2002
269	Q	A	-2.0977
270	P	A	-1.3234
271	G	A	-1.2853
272	G	A	-1.4378
273	G	A	-2.2259
274	K	A	-2.0429
275	V	A	-0.3152
276	Q	A	-0.8821
277	I	A	1.0411
278	I	A	1.3011
279	N	A	-0.1994
280	K	A	-1.1336
281	K	A	-0.9710
282	L	A	0.7162
283	D	A	-0.0646
284	L	A	0.8110
285	S	A	-0.7679
286	N	A	-0.9309
287	V	A	1.0475
288	Q	A	0.2024
289	S	A	-0.1704
290	K	A	-0.5003
291	C	A	0.2977
292	G	A	0.0000
293	S	A	-0.3780
294	K	A	-1.9856
295	D	A	-2.2916
296	N	A	-1.1076
297	I	A	-0.0892
298	K	A	-1.6444
299	H	A	-0.4066
300	V	A	0.0000
301	P	A	-0.1456
302	G	A	0.2180
303	G	A	-1.1207
304	G	A	-0.5822
305	S	A	0.1529
306	V	A	1.7441
307	Q	A	0.5312
308	I	A	1.3347
309	V	A	1.9133
310	Y	A	1.3430
311	K	A	-0.9319
312	P	A	-0.4248
267	K	B	-1.8706
268	H	B	-2.2593
269	Q	B	-1.1762
270	P	B	-0.6241
271	G	B	-1.0659
272	G	B	-1.1557
273	G	B	-1.3975
274	K	B	-1.8374
275	V	B	0.1548
276	Q	B	0.1115
277	I	B	2.1840
278	I	B	1.7851
279	N	B	0.9442
280	K	B	-0.0462
281	K	B	-0.2320
282	L	B	1.1624
283	D	B	0.5113
284	L	B	1.2233
285	S	B	-0.0747
286	N	B	-0.3009
287	V	B	1.0197
288	Q	B	0.0899
289	S	B	-0.7162
290	K	B	-1.7425
291	C	B	-0.2707
292	G	B	0.0000
293	S	B	-0.9354
294	K	B	-2.5490
295	D	B	-3.1083
296	N	B	-1.9267
297	I	B	-0.6996
298	K	B	-2.2868
299	H	B	-0.7913
300	V	B	0.0000
301	P	B	-0.1055
302	G	B	0.5364
303	G	B	-0.2308
304	G	B	-0.8618
305	S	B	-0.1190
306	V	B	1.6240
307	Q	B	0.3724
308	I	B	1.2038
309	V	B	1.7871
310	Y	B	1.3068
311	K	B	-1.0196
312	P	B	-0.5179
1	M	C	-0.5734
2	A	C	-1.7759
3	D	C	-3.5437
4	E	C	-3.4030
5	E	C	-3.8278
6	K	C	-3.4423
7	L	C	-1.9640
8	P	C	-1.3920
9	P	C	-0.4221
10	G	C	-0.2511
11	W	C	-1.2484
12	E	C	-2.4123
13	K	C	-1.9542
14	R	C	-1.7068
15	M	C	-0.5905
16	S	C	-1.2903
17	R	C	-2.2344
18	S	C	-1.3594
19	S	C	-1.3573
20	G	C	-1.4314
21	R	C	-1.8255
22	V	C	-0.3389
23	Y	C	-0.5729
24	Y	C	-0.7719
25	F	C	-0.9427
26	N	C	0.0000
27	H	C	-0.7800
28	I	C	0.8985
29	T	C	-0.3917
30	N	C	-1.1112
31	A	C	-0.2986
32	S	C	-0.5890
33	Q	C	-0.2072
34	W	C	-0.2569
35	E	C	-1.1817
36	R	C	-2.5403
37	P	C	-1.7574
38	S	C	-2.0750
39	G	C	-3.0259
40	N	C	-2.5278
41	S	C	-1.3295
42	S	C	-0.8371
43	S	C	-1.1185
44	G	C	-1.8531
45	G	C	-1.8549
46	K	C	-2.8961
47	N	C	-3.1706
48	G	C	-2.4449
49	Q	C	-2.6566
50	G	C	-2.3881
51	E	C	-2.7034
52	P	C	-2.1718
53	A	C	-1.6989
54	R	C	-2.8058
55	V	C	0.0000
56	R	C	-1.7817
57	C	C	0.0000
58	S	C	0.0000
59	H	C	0.0000
60	L	C	0.0000
61	L	C	0.0000
62	V	C	0.0000
63	K	C	0.0000
64	H	C	0.0000
65	S	C	-2.0287
66	Q	C	-2.3681
67	S	C	0.0000
68	R	C	-3.6214
69	R	C	-3.7624
70	P	C	-2.9612
71	S	C	-2.5862
72	S	C	-1.3307
73	W	C	-0.0274
74	R	C	-1.5801
75	Q	C	-2.6282
76	E	C	-3.4120
77	K	C	-3.4426
78	I	C	0.0000
79	T	C	-1.6808
80	R	C	-2.0642
81	T	C	-2.3675
82	K	C	-3.3125
83	E	C	-3.6009
84	E	C	-2.9508
85	A	C	0.0000
86	L	C	-2.0273
87	E	C	-2.9386
88	L	C	-1.1454
89	I	C	0.0000
90	N	C	-1.8735
91	G	C	-1.5165
92	Y	C	0.0000
93	I	C	-1.7019
94	Q	C	-2.7411
95	K	C	-3.3563
96	I	C	0.0000
97	K	C	-3.2755
98	S	C	-2.8083
99	G	C	-3.0201
100	E	C	-3.6419
101	E	C	-3.6092
102	D	C	-3.8659
103	F	C	0.0000
104	E	C	-3.2011
105	S	C	-2.2597
106	L	C	0.0000
107	A	C	0.0000
108	S	C	-2.0534
109	Q	C	-1.6065
110	F	C	-0.4431
111	S	C	0.0000
112	D	C	-0.4326
113	C	C	-0.2254
114	S	C	-0.5872
115	S	C	-0.8639
116	A	C	-1.7276
117	K	C	-2.0372
118	A	C	-1.7022
119	R	C	-2.7027
120	G	C	0.0000
121	D	C	-1.1512
122	L	C	-0.0799
123	G	C	-0.5822
124	A	C	-1.1934
125	F	C	0.0000
126	S	C	-2.1233
127	R	C	-3.2433
128	G	C	-2.7710
129	Q	C	-2.3675
130	M	C	-1.5797
131	Q	C	-2.1719
132	K	C	-2.8800
133	P	C	-1.2964
134	F	C	0.0000
135	E	C	0.0000
136	D	C	-2.4249
137	A	C	-1.0924
138	S	C	0.0000
139	F	C	-1.0103
140	A	C	-0.6041
141	L	C	-0.8899
142	R	C	-2.1447
143	T	C	-1.8385
144	G	C	-1.6121
145	E	C	-1.5050
146	M	C	-0.5759
147	S	C	0.0000
148	G	C	-0.0985
149	P	C	0.1135
150	V	C	0.8466
151	F	C	1.4533
152	T	C	0.0000
153	D	C	-2.4050
154	S	C	-1.7984
155	G	C	0.0000
156	I	C	0.0000
157	H	C	0.0000
158	I	C	0.0000
159	I	C	0.0000
160	L	C	-0.8342
161	R	C	-1.4458
162	T	C	-1.7594
163	E	C	-2.7804