Project name: baad87023bd4388

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSKELEFKNGKCIFNGMNMAKTTVQYTDPTRCTAYFCEPGKHEMIIKGCPPPDDYDYEAYYDPTRWPDCCEAYKGGGGSTVQYHQLIKCSQNYSAEVMGVVTRDAIIGSQMTAKIKLRVYDTILKELKLRVTLFTPEGTVVPCIEHFGSCVYDVCEDVPDDKKTMWTTKCPVKPGTYWRNLIFRVSPKLLKHIGSGHLIAALMLESKGKKLSCQALHLRVYKTRPTTDIWDGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7921
• Maximal score value: 1.5777
• Average score: -0.8538
• Total score value: -449.9477

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-3.5206
2	H	A	-3.2763
3	H	A	-3.2740
4	E	A	-3.2780
5	G	A	-2.4612
6	Q	A	-3.0111
7	P	A	-1.7542
8	R	A	-2.1096
9	S	A	0.0000
10	V	A	0.7691
11	C	A	0.0000
12	A	A	-0.2791
13	L	A	-0.7764
14	E	A	0.0000
15	E	A	-1.0594
16	N	A	-1.9284
17	A	A	0.0000
18	K	A	0.0000
19	R	A	-2.2746
20	A	A	-1.2974
21	L	A	0.0000
22	I	A	-0.7235
23	S	A	-0.8657
24	C	A	-0.4964
25	V	A	0.0000
26	Q	A	-1.2959
27	T	A	-0.8612
28	H	A	-1.1945
29	L	A	-1.0563
30	T	A	-1.1931
31	A	A	-1.4203
32	D	A	-2.4600
33	T	A	-1.9366
34	T	A	-1.8670
35	Q	A	-2.4348
36	K	A	-2.2389
37	L	A	0.0000
38	S	A	-1.5232
39	A	A	-1.1702
40	V	A	-1.3125
41	K	A	-1.2275
42	D	A	-1.3977
43	Q	A	-1.8449
44	L	A	0.0000
45	H	A	-2.2153
46	C	A	-2.4867
47	D	A	-3.0806
48	D	A	-1.8953
49	V	A	0.0000
50	Y	A	0.0000
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	0.0000
56	I	A	0.0000
57	C	A	0.0000
58	D	A	0.0000
59	R	A	-3.7921
60	N	A	-3.1868
61	N	A	-2.5969
62	G	A	-2.5315
63	T	A	-1.6565
64	L	A	-1.1514
65	E	A	-1.0596
66	H	A	-1.0068
67	P	A	0.0000
68	S	A	-0.8528
69	N	A	-1.0609
70	E	A	-1.7137
71	F	A	-1.3556
72	F	A	-1.1472
73	S	A	-1.7799
74	N	A	-2.0237
75	A	A	-1.6520
76	E	A	-2.2522
77	K	A	-2.0527
78	T	A	-1.8898
79	D	A	-2.1862
80	I	A	-0.7624
81	R	A	-1.2743
82	S	A	-0.7757
83	A	A	-0.5305
84	V	A	0.6035
85	V	A	0.5199
86	T	A	-0.4968
87	C	A	-0.9276
88	R	A	-2.2123
89	E	A	-2.6591
90	N	A	0.0000
91	L	A	0.0000
92	Q	A	-3.3116
93	R	A	-3.0049
94	Q	A	0.0000
95	A	A	0.0000
96	E	A	-2.3302
97	A	A	-1.5701
98	A	A	0.0000
99	K	A	-1.9136
100	T	A	-1.2446
101	S	A	0.0000
102	G	A	0.0000
103	G	A	0.0000
104	G	A	0.0000
105	G	A	0.0000
106	S	A	0.0000
107	K	A	0.0000
108	E	A	0.0000
109	L	A	-0.4378
110	E	A	-1.5635
111	F	A	-0.9798
112	K	A	-2.5507
113	N	A	-2.3413
114	G	A	-1.5685
115	K	A	-1.7273
116	C	A	0.0000
117	I	A	-0.9725
118	F	A	0.0000
119	N	A	0.0000
120	G	A	0.0000
121	M	A	0.0000
122	N	A	0.0000
123	M	A	-0.4915
124	A	A	0.0000
125	K	A	-1.8192
126	T	A	-1.1648
127	T	A	-1.1180
128	V	A	0.0000
129	Q	A	-1.5733
130	Y	A	0.0000
131	T	A	-1.1750
132	D	A	-1.0652
133	P	A	-0.7076
134	T	A	-0.5937
135	R	A	-0.7562
136	C	A	0.0000
137	T	A	0.0000
138	A	A	0.0000
139	Y	A	0.0000
140	F	A	0.0832
141	C	A	0.0000
142	E	A	-0.8527
143	P	A	-1.4461
144	G	A	-2.0208
145	K	A	-2.6867
146	H	A	-2.4124
147	E	A	-2.1569
148	M	A	0.0000
149	I	A	0.0000
150	I	A	0.0000
151	K	A	-0.1144
152	G	A	0.0000
153	C	A	0.0000
154	P	A	-0.8169
155	P	A	-1.5555
156	P	A	0.0000
157	D	A	-2.7076
158	D	A	-2.4580
159	Y	A	-1.1335
160	D	A	-2.2050
161	Y	A	-1.3603
162	E	A	-1.6946
163	A	A	-0.9894
164	Y	A	-0.8248
165	Y	A	0.0000
166	D	A	-1.6900
167	P	A	-1.4934
168	T	A	-1.4590
169	R	A	-2.1883
170	W	A	-1.2981
171	P	A	-1.0705
172	D	A	-1.4547
173	C	A	-1.0074
174	C	A	0.0000
175	E	A	-2.3648
176	A	A	0.0000
177	Y	A	-1.8281
178	K	A	-2.4076
179	G	A	-1.9938
180	G	A	-2.1017
181	G	A	-1.6064
182	G	A	-1.1326
183	S	A	0.0000
184	T	A	-1.1704
185	V	A	-0.8178
186	Q	A	-1.0813
187	Y	A	-0.6364
188	H	A	-1.0013
189	Q	A	-0.9408
190	L	A	0.0225
191	I	A	0.5874
192	K	A	-0.9001
193	C	A	-0.7207
194	S	A	-1.2345
195	Q	A	-2.0162
196	N	A	-1.8527
197	Y	A	-1.4162
198	S	A	0.0000
199	A	A	0.0000
200	E	A	-0.3265
201	V	A	0.0945
202	M	A	0.2382
203	G	A	0.1657
204	V	A	0.0000
205	V	A	0.3226
206	T	A	-0.7079
207	R	A	-1.7964
208	D	A	-1.6330
209	A	A	0.0000
210	I	A	-0.1453
211	I	A	0.2843
212	G	A	-0.6326
213	S	A	-0.7705
214	Q	A	-1.2382
215	M	A	0.0000
216	T	A	0.0000
217	A	A	0.0000
218	K	A	-0.7464
219	I	A	0.0000
220	K	A	-0.0058
221	L	A	0.0000
222	R	A	-0.7979
223	V	A	0.0000
224	Y	A	-0.1856
225	D	A	-1.5582
226	T	A	-1.1387
227	I	A	0.0000
228	L	A	-0.2057
229	K	A	-1.7343
230	E	A	-2.3007
231	L	A	0.0000
232	K	A	-1.7690
233	L	A	0.0000
234	R	A	-0.4149
235	V	A	0.0000
236	T	A	0.0000
237	L	A	0.0000
238	F	A	0.5179
239	T	A	0.0000
240	P	A	-1.1216
241	E	A	-1.9686
242	G	A	-0.7930
243	T	A	-0.0277
244	V	A	1.5777
245	V	A	0.0000
246	P	A	0.8383
247	C	A	1.1843
248	I	A	1.2181
249	E	A	-1.1768
250	H	A	-1.5674
251	F	A	-0.2163
252	G	A	0.0000
253	S	A	0.7050
254	C	A	0.7365
255	V	A	1.0987
256	Y	A	-0.2466
257	D	A	-1.6102
258	V	A	0.0000
259	C	A	0.0000
260	E	A	-3.7444
261	D	A	-3.2557
262	V	A	-2.6444
263	P	A	-2.7700
264	D	A	-3.7107
265	D	A	-3.0905
266	K	A	-2.6649
267	K	A	-3.0478
268	T	A	-1.0495
269	M	A	0.2323
270	W	A	0.7816
271	T	A	-0.2942
272	T	A	-1.8396
273	K	A	-2.1334
274	C	A	-1.5209
275	P	A	-0.7722
276	V	A	0.0000
277	K	A	-1.9100
278	P	A	-1.4337
279	G	A	-0.9200
280	T	A	-0.1505
281	Y	A	0.4730
282	W	A	0.6407
283	R	A	-0.4883
284	N	A	-0.9223
285	L	A	0.0000
286	I	A	0.5713
287	F	A	0.0000
288	R	A	-2.1055
289	V	A	0.0000
290	S	A	0.0000
291	P	A	-1.9344
292	K	A	-2.6655
293	L	A	0.0000
294	L	A	0.0000
295	K	A	-2.8401
296	H	A	-2.5643
297	I	A	0.0000
298	G	A	-1.3984
299	S	A	-0.8071
300	G	A	-0.8147
301	H	A	-1.0178
302	L	A	0.0000
303	I	A	-0.1654
304	A	A	0.0000
305	A	A	0.0357
306	L	A	0.0000
307	M	A	-0.2558
308	L	A	0.0000
309	E	A	-2.3236
310	S	A	0.0000
311	K	A	-2.9746
312	G	A	-2.4841
313	K	A	-2.9353
314	K	A	-2.4158
315	L	A	0.0000
316	S	A	0.0000
317	C	A	-0.4334
318	Q	A	0.0000
319	A	A	0.1254
320	L	A	0.0000
321	H	A	-0.6839
322	L	A	0.0000
323	R	A	-1.2240
324	V	A	0.0000
325	Y	A	-0.3508
326	K	A	0.0000
327	T	A	0.0000
328	R	A	-1.6264
329	P	A	-1.2945
330	T	A	0.0000
331	T	A	0.0000
332	D	A	0.0002
333	I	A	0.9962
334	W	A	0.7300
335	D	A	0.0000
336	G	A	-1.5052
337	G	A	-0.7880
338	G	A	-0.8399
339	G	A	-0.3131
340	S	A	-0.6719
341	S	A	-1.0452
342	E	A	-1.6009
343	I	A	-0.1308
344	K	A	-0.6366
345	Y	A	0.1214
346	H	A	0.0000
347	N	A	0.0000
348	Y	A	0.0000
349	N	A	0.0000
350	S	A	-1.1825
351	N	A	-1.6254
352	G	A	-1.2753
353	F	A	-1.1363
354	N	A	-2.0856
355	P	A	0.0000
356	K	A	-2.3202
357	G	A	-1.5289
358	P	A	-1.2702
359	G	A	-0.8821
360	P	A	-0.6231
361	G	A	0.0000
362	I	A	0.0000
363	L	A	0.0000
364	F	A	0.0000
365	G	A	0.0000
366	D	A	0.0000
367	A	A	0.0000
368	F	A	0.0000
369	I	A	0.0000
370	P	A	-1.1122
371	A	A	0.0000
372	I	A	0.0000
373	V	A	-0.6444
374	Q	A	-0.9007
375	P	A	-0.9167
376	V	A	0.0000
377	S	A	-0.8167
378	Q	A	-1.2410
379	I	A	-0.5010
380	F	A	-0.3216
381	P	A	-0.7049
382	G	A	-0.8318
383	P	A	-0.7650
384	G	A	-0.8199
385	P	A	-0.9617
386	G	A	0.0000
387	I	A	0.0000
388	L	A	0.0000
389	F	A	0.0000
390	N	A	0.0000
391	S	A	0.0000
392	L	A	0.0000
393	Q	A	-0.1406
394	Y	A	-0.0296
395	T	A	-0.3161
396	N	A	-0.7615
397	V	A	0.1479
398	V	A	0.3732
399	K	A	-0.6739
400	D	A	-1.8617
401	Y	A	-0.7842
402	W	A	-0.3306
403	G	A	-0.8072
404	N	A	-1.2400
405	D	A	-1.3753
406	L	A	0.3996
407	G	A	-0.4787
408	P	A	-1.4046
409	G	A	-1.4437
410	P	A	-1.2775
411	G	A	-1.5713
412	K	A	-2.7714
413	E	A	-2.5001
414	T	A	-1.0343
415	V	A	-0.2454
416	L	A	0.7673
417	R	A	-0.0356
418	V	A	0.4822
419	A	A	0.4290
420	V	A	1.2740
421	T	A	-0.1089
422	A	A	-0.7004
423	Q	A	-1.3651
424	H	A	-0.9097
425	P	A	-0.7964
426	K	A	-1.6739
427	P	A	-0.7893
428	A	A	-0.2481
429	S	A	0.0000
430	L	A	0.0000
431	M	A	0.0000
432	G	A	0.0000
433	P	A	-1.0987
434	G	A	-0.7609
435	P	A	-0.9204
436	G	A	-0.9229
437	Y	A	-1.4203
438	D	A	-2.3810
439	A	A	-1.6795
440	G	A	-1.1544
441	I	A	-0.9397
442	E	A	-1.6522
443	L	A	0.0000
444	A	A	0.0000
445	H	A	-1.1067
446	L	A	0.0000
447	L	A	0.0000
448	A	A	0.0000
449	F	A	0.0000
450	N	A	0.0000
451	K	A	0.0000
452	Y	A	0.0000
453	G	A	0.0000
454	P	A	-1.3481
455	G	A	-1.0928
456	P	A	-0.7553
457	G	A	-0.9213
458	H	A	-1.3208
459	D	A	-1.8670
460	K	A	-2.3577
461	K	A	-2.6369
462	Q	A	-1.7931
463	F	A	-1.2004
464	A	A	0.0000
465	A	A	0.0000
466	L	A	0.0000
467	M	A	0.0000
468	L	A	0.1616
469	Y	A	0.0000
470	E	A	0.0000
471	E	A	-0.9211
472	D	A	-2.1132
473	G	A	-1.6571
474	T	A	-1.2341
475	L	A	0.0000
476	R	A	-1.3597
477	V	A	0.0000
478	E	A	0.0000
479	G	A	0.0000
480	V	A	0.0000
481	G	A	0.0000
482	P	A	-1.2082
483	G	A	0.0000
484	P	A	0.0000
485	G	A	-1.3027
486	K	A	0.0000
487	R	A	-2.4665
488	H	A	-2.1823
489	G	A	-2.3510
490	K	A	-2.6084
491	R	A	-3.1812
492	L	A	0.0000
493	R	A	-1.8593
494	V	A	0.0289
495	T	A	-0.6339
496	K	A	-1.2005
497	V	A	0.2072
498	I	A	1.2611
499	P	A	-0.3763
500	H	A	-0.9610
501	A	A	-0.8923
502	K	A	-1.8219
503	Y	A	-1.3286
504	N	A	-2.4785
505	E	A	-2.7448
506	K	A	-3.1714
507	S	A	-2.4390
508	E	A	-2.5328
509	A	A	-1.2333
510	A	A	0.0000
511	A	A	-1.5904
512	K	A	-1.4112
513	F	A	0.9572
514	Y	A	0.1925
515	P	A	-0.0011
516	S	A	-0.2524
517	Y	A	-0.6431
518	H	A	-1.4248
519	S	A	-0.9832
520	T	A	-1.0971
521	P	A	-1.5192
522	Q	A	-2.4516
523	R	A	-2.8007
524	P	A	-1.7353
525	G	A	-1.3472
526	T	A	-1.4332
527	P	A	-1.0501