| Chain sequence(s) |
A: QTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERAAAKVKYLTGEK S: DLEMLAPYIPMDDDFQL |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 184 | Q | A | -1.3439 | |
| 185 | T | A | -1.3544 | |
| 186 | K | A | -1.6874 | |
| 187 | P | A | -0.8346 | |
| 188 | L | A | -0.0246 | |
| 189 | P | A | -0.1902 | |
| 190 | A | A | -0.2451 | |
| 191 | L | A | 0.0409 | |
| 192 | K | A | -0.7653 | |
| 193 | L | A | 0.0000 | |
| 194 | A | A | 0.0000 | |
| 195 | L | A | -0.6970 | |
| 196 | E | A | -1.4323 | |
| 197 | Y | A | -0.3567 | |
| 198 | I | A | 0.0000 | |
| 199 | V | A | 0.0000 | |
| 200 | P | A | -1.4583 | |
| 201 | C | A | -1.1296 | |
| 202 | M | A | 0.0000 | |
| 203 | N | A | -2.5252 | |
| 204 | K | A | -2.7183 | |
| 205 | H | A | -2.3376 | |
| 206 | G | A | 0.0000 | |
| 207 | I | A | -0.5200 | |
| 208 | C | A | 0.0000 | |
| 209 | V | A | -0.0586 | |
| 210 | V | A | 0.0000 | |
| 211 | D | A | -1.9306 | |
| 212 | D | A | -2.5056 | |
| 213 | F | A | 0.0000 | |
| 214 | L | A | 0.0000 | |
| 215 | G | A | -2.5171 | |
| 216 | K | A | -3.5448 | |
| 217 | E | A | -3.2891 | |
| 218 | T | A | -2.3897 | |
| 219 | G | A | 0.0000 | |
| 220 | Q | A | -3.0590 | |
| 221 | Q | A | -2.8983 | |
| 222 | I | A | 0.0000 | |
| 223 | G | A | 0.0000 | |
| 224 | D | A | -2.3523 | |
| 225 | E | A | -2.0375 | |
| 226 | V | A | 0.0000 | |
| 227 | R | A | -1.8938 | |
| 228 | A | A | -1.5211 | |
| 229 | L | A | -1.4937 | |
| 230 | H | A | -2.0669 | |
| 231 | D | A | -2.5350 | |
| 232 | T | A | -1.8484 | |
| 233 | G | A | -2.1554 | |
| 234 | K | A | -2.5488 | |
| 235 | F | A | 0.0000 | |
| 236 | T | A | -1.6548 | |
| 237 | D | A | -2.5845 | |
| 238 | G | A | 0.0000 | |
| 239 | Q | A | -1.5706 | |
| 240 | L | A | 0.0000 | |
| 241 | V | A | -0.2588 | |
| 242 | S | A | -1.2977 | |
| 243 | Q | A | -2.3692 | |
| 244 | K | A | -3.5080 | |
| 245 | S | A | -2.5711 | |
| 246 | D | A | -2.9948 | |
| 247 | S | A | -2.7129 | |
| 248 | S | A | -2.8661 | |
| 249 | K | A | -3.2326 | |
| 250 | D | A | -2.5912 | |
| 251 | I | A | 0.0000 | |
| 252 | R | A | 0.0000 | |
| 253 | G | A | 0.0000 | |
| 254 | D | A | 0.0000 | |
| 255 | K | A | -1.8881 | |
| 256 | I | A | 0.0000 | |
| 257 | T | A | 0.0000 | |
| 258 | W | A | -0.0257 | |
| 259 | I | A | 0.0000 | |
| 260 | E | A | -1.9345 | |
| 261 | G | A | 0.0000 | |
| 262 | K | A | -2.8818 | |
| 263 | E | A | -2.4014 | |
| 264 | P | A | -1.7257 | |
| 265 | G | A | -1.7678 | |
| 266 | C | A | 0.0000 | |
| 267 | E | A | -2.7049 | |
| 268 | T | A | 0.0000 | |
| 269 | I | A | 0.0000 | |
| 270 | G | A | -1.2651 | |
| 271 | L | A | 0.0636 | |
| 272 | L | A | 0.0000 | |
| 273 | M | A | 0.0000 | |
| 274 | S | A | -0.1813 | |
| 275 | S | A | -0.3562 | |
| 276 | M | A | 0.0000 | |
| 277 | D | A | 0.0000 | |
| 278 | D | A | -1.2081 | |
| 279 | L | A | 0.0000 | |
| 280 | I | A | 0.0000 | |
| 281 | R | A | -2.7245 | |
| 282 | H | A | -1.8036 | |
| 283 | C | A | 0.0000 | |
| 284 | N | A | -2.7354 | |
| 285 | G | A | -2.8063 | |
| 286 | K | A | -2.8245 | |
| 287 | L | A | 0.0000 | |
| 288 | G | A | -1.6254 | |
| 289 | S | A | -1.2154 | |
| 290 | Y | A | -1.8904 | |
| 291 | K | A | -3.0878 | |
| 292 | I | A | 0.0000 | |
| 293 | N | A | -1.8164 | |
| 294 | G | A | 0.0000 | |
| 295 | R | A | 0.0000 | |
| 296 | T | A | 0.0000 | |
| 297 | K | A | -0.7452 | |
| 298 | A | A | 0.0000 | |
| 299 | M | A | 0.0000 | |
| 300 | V | A | 0.0000 | |
| 301 | A | A | 0.0000 | |
| 302 | C | A | 0.0000 | |
| 303 | Y | A | 0.0000 | |
| 304 | P | A | -0.4261 | |
| 305 | G | A | -0.2293 | |
| 306 | N | A | -0.9839 | |
| 307 | G | A | -0.4482 | |
| 308 | T | A | -0.7720 | |
| 309 | G | A | -0.7204 | |
| 310 | Y | A | 0.0000 | |
| 311 | V | A | -0.6461 | |
| 312 | R | A | -1.5520 | |
| 313 | H | A | 0.0000 | |
| 314 | V | A | 0.0000 | |
| 315 | D | A | 0.0000 | |
| 316 | N | A | 0.0000 | |
| 317 | P | A | 0.0000 | |
| 318 | N | A | -1.0499 | |
| 319 | G | A | -1.0971 | |
| 320 | D | A | 0.0000 | |
| 321 | G | A | 0.0000 | |
| 322 | R | A | 0.0000 | |
| 323 | C | A | 0.0000 | |
| 324 | V | A | 0.0000 | |
| 325 | T | A | 0.0000 | |
| 326 | C | A | 0.0000 | |
| 327 | I | A | 0.0000 | |
| 328 | Y | A | 0.0000 | |
| 329 | Y | A | 0.0000 | |
| 330 | L | A | 0.0000 | |
| 331 | N | A | 0.0000 | |
| 332 | K | A | -3.1262 | |
| 333 | D | A | -2.9595 | |
| 334 | W | A | 0.0000 | |
| 335 | D | A | -1.6423 | |
| 336 | A | A | -0.9644 | |
| 337 | K | A | -1.1397 | |
| 338 | V | A | 0.9272 | |
| 339 | S | A | 0.4698 | |
| 340 | G | A | -0.0480 | |
| 341 | G | A | 0.0000 | |
| 342 | I | A | 0.0000 | |
| 343 | L | A | 0.0000 | |
| 344 | R | A | -0.6682 | |
| 345 | I | A | 0.0000 | |
| 346 | F | A | -0.9978 | |
| 347 | P | A | -1.8583 | |
| 348 | E | A | -3.2791 | |
| 349 | G | A | -2.4134 | |
| 350 | K | A | -2.5717 | |
| 351 | A | A | -1.3185 | |
| 352 | Q | A | -1.2816 | |
| 353 | F | A | 0.2085 | |
| 354 | A | A | -0.0100 | |
| 355 | D | A | -0.9407 | |
| 356 | I | A | 0.0000 | |
| 357 | E | A | -1.4041 | |
| 358 | P | A | 0.0000 | |
| 359 | K | A | -2.2949 | |
| 360 | F | A | -2.1801 | |
| 361 | D | A | 0.0000 | |
| 362 | R | A | -1.3072 | |
| 363 | L | A | 0.0000 | |
| 364 | L | A | 0.0000 | |
| 365 | F | A | 0.0000 | |
| 366 | F | A | 0.0000 | |
| 367 | W | A | 0.0000 | |
| 368 | S | A | 0.0000 | |
| 369 | D | A | -1.7671 | |
| 370 | R | A | -2.7926 | |
| 371 | R | A | -2.8158 | |
| 372 | N | A | 0.0000 | |
| 373 | P | A | -1.3317 | |
| 374 | H | A | 0.0000 | |
| 375 | E | A | -1.1026 | |
| 376 | V | A | 0.0000 | |
| 377 | Q | A | -0.5887 | |
| 378 | P | A | -0.1904 | |
| 379 | A | A | 0.0000 | |
| 380 | Y | A | 1.0175 | |
| 381 | A | A | 0.4104 | |
| 382 | T | A | -0.0970 | |
| 383 | R | A | 0.0000 | |
| 384 | Y | A | 0.0000 | |
| 385 | A | A | 0.0000 | |
| 386 | I | A | 0.0000 | |
| 387 | T | A | 0.0000 | |
| 388 | V | A | 0.0000 | |
| 389 | W | A | 0.0000 | |
| 390 | Y | A | 0.0000 | |
| 391 | F | A | 0.0000 | |
| 392 | D | A | 0.0000 | |
| 393 | A | A | -1.6991 | |
| 394 | D | A | -2.3354 | |
| 395 | E | A | -1.3954 | |
| 396 | R | A | 0.0000 | |
| 397 | A | A | -0.5704 | |
| 398 | A | A | -0.2712 | |
| 399 | A | A | 0.0000 | |
| 400 | K | A | 0.1478 | |
| 401 | V | A | 1.5781 | |
| 402 | K | A | -0.1251 | |
| 403 | Y | A | 1.3509 | |
| 404 | L | A | 1.7640 | |
| 405 | T | A | -0.0027 | |
| 406 | G | A | -1.4545 | |
| 407 | E | A | -2.8213 | |
| 408 | K | A | -2.7067 | |
| 558 | D | S | -2.1908 | |
| 559 | L | S | -1.5537 | |
| 560 | E | S | -1.8417 | |
| 561 | M | S | -1.6553 | |
| 562 | L | S | -1.1562 | |
| 563 | A | S | 0.0000 | |
| 564 | P | S | 0.0000 | |
| 565 | Y | S | 0.2766 | |
| 566 | I | S | 0.0000 | |
| 567 | P | S | -0.9591 | |
| 568 | M | S | -0.6789 | |
| 569 | D | S | -2.6515 | |
| 570 | D | S | -2.7003 | |
| 571 | D | S | -1.8819 | |
| 572 | F | S | -1.1101 | |
| 573 | Q | S | -1.2337 | |
| 574 | L | S | -0.7721 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine