Project name: FVIII

Chain sequence(s)	A: ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQFDDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYEDSYED
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9695
• Maximal score value: 2.6892
• Average score: -0.5476
• Total score value: -379.4942

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	A	A	-0.6430
2	T	A	-1.1175
3	R	A	-1.9536
4	R	A	-1.9153
5	Y	A	-0.8063
6	Y	A	-0.2483
7	L	A	0.0000
8	G	A	0.0000
9	A	A	0.0000
10	V	A	0.1323
11	E	A	-0.8731
12	L	A	-0.5083
13	S	A	-0.4371
14	W	A	0.0000
15	D	A	0.0370
16	Y	A	0.0000
17	M	A	-0.5281
18	Q	A	-1.5007
19	S	A	-1.1930
20	D	A	-0.7850
21	L	A	0.6874
22	G	A	-0.0421
23	E	A	-0.1838
24	L	A	0.8210
25	P	A	0.3305
26	V	A	0.6833
27	D	A	-1.1496
28	A	A	-0.6734
29	R	A	-0.8171
30	F	A	0.8684
31	P	A	0.0518
32	P	A	-0.4858
33	R	A	-1.1152
34	V	A	0.4170
35	P	A	-0.2803
36	K	A	-0.9857
37	S	A	0.3984
38	F	A	1.6376
39	P	A	0.8692
40	F	A	1.3411
41	N	A	-0.0366
42	T	A	0.7377
43	S	A	0.8636
44	V	A	2.0999
45	V	A	1.7718
46	Y	A	0.0000
47	K	A	-0.9434
48	K	A	0.0000
49	T	A	0.0000
50	L	A	-0.0558
51	F	A	0.0000
52	V	A	0.0000
53	E	A	-0.9024
54	F	A	-0.3427
55	T	A	-0.7581
56	D	A	-1.7687
57	H	A	-0.8111
58	L	A	1.2188
59	F	A	2.3823
60	N	A	0.8981
61	I	A	1.3826
62	A	A	-0.1449
63	K	A	-1.5385
64	P	A	-1.1881
65	R	A	-1.5917
66	P	A	-0.6567
67	P	A	-0.7915
68	W	A	0.1482
69	M	A	0.0000
70	G	A	-0.9225
71	L	A	0.0000
72	L	A	0.0000
73	G	A	0.0000
74	P	A	-0.2426
75	T	A	-0.1160
76	I	A	0.0000
77	Q	A	-0.3128
78	A	A	-0.7295
79	E	A	-0.9296
80	V	A	0.0000
81	Y	A	-0.0976
82	D	A	-0.7781
83	T	A	-0.5537
84	V	A	0.0000
85	V	A	-0.4570
86	I	A	0.0000
87	T	A	-0.1226
88	L	A	0.0000
89	K	A	-0.2183
90	N	A	0.0000
91	M	A	0.2416
92	A	A	-0.2190
93	S	A	-0.2537
94	H	A	-0.2474
95	P	A	0.4864
96	V	A	0.0000
97	S	A	0.0000
98	L	A	0.0000
99	H	A	-0.1569
100	A	A	0.0000
101	V	A	0.7492
102	G	A	0.5283
103	V	A	0.0033
104	S	A	0.1727
105	Y	A	0.4942
106	W	A	0.4925
107	K	A	-1.6521
108	A	A	-1.0609
109	S	A	0.0000
110	E	A	-1.0327
111	G	A	0.0000
112	A	A	-1.8634
113	E	A	-2.3245
114	Y	A	-0.9253
115	D	A	-2.2265
116	D	A	-2.5142
117	Q	A	-2.2413
118	T	A	-2.3791
119	S	A	-2.4997
120	Q	A	-3.3284
121	R	A	-3.7931
122	E	A	-3.6490
123	K	A	-3.8737
124	E	A	-3.4642
125	D	A	-1.9299
126	D	A	0.0000
127	K	A	-1.2277
128	V	A	0.0000
129	F	A	1.3652
130	P	A	0.3541
131	G	A	-0.2537
132	G	A	-0.0434
133	S	A	-0.3518
134	H	A	-0.7004
135	T	A	-0.2203
136	Y	A	0.0000
137	V	A	0.4338
138	W	A	0.0000
139	Q	A	-0.1341
140	V	A	0.0000
141	L	A	-0.7006
142	K	A	-2.3525
143	E	A	-2.3596
144	N	A	-1.2561
145	G	A	-1.0195
146	P	A	-0.4075
147	M	A	0.4739
148	A	A	0.2496
149	S	A	-0.2983
150	D	A	-0.7444
151	P	A	-0.0193
152	L	A	0.7641
153	C	A	0.4969
154	L	A	0.3942
155	T	A	0.0000
156	Y	A	0.7257
157	S	A	0.0000
158	Y	A	0.0000
159	L	A	0.2584
160	S	A	0.0000
161	H	A	-0.9170
162	V	A	-1.2236
163	D	A	-1.8161
164	L	A	-0.2870
165	V	A	-0.5789
166	K	A	-1.7106
167	D	A	0.0000
168	L	A	0.0000
169	N	A	0.0000
170	S	A	0.0000
171	G	A	0.0000
172	L	A	0.0000
173	I	A	0.0000
174	G	A	0.0000
175	A	A	0.0000
176	L	A	0.0000
177	L	A	0.0000
178	V	A	0.0000
179	C	A	0.0000
180	R	A	-1.2648
181	E	A	-2.3211
182	G	A	-1.5990
183	S	A	-1.5355
184	L	A	-1.2293
185	A	A	-1.7555
186	K	A	-2.8983
187	E	A	-2.6749
188	K	A	-2.6051
189	T	A	-2.0230
190	Q	A	-2.0712
191	T	A	-0.9813
192	L	A	0.5017
193	H	A	-0.0225
194	K	A	-0.7658
195	F	A	0.1737
196	I	A	0.0000
197	L	A	0.0000
198	L	A	0.0000
199	F	A	0.0000
200	A	A	0.0000
201	V	A	0.0000
202	F	A	0.0000
203	D	A	-1.6227
204	E	A	0.0000
205	G	A	-1.3139
206	K	A	-1.8588
207	S	A	-1.2559
208	W	A	-1.0926
209	H	A	-1.6603
210	S	A	-1.7790
211	E	A	-2.7428
212	T	A	-2.1646
213	K	A	-2.7930
214	N	A	-2.3426
222	A	A	0.0359
223	A	A	-0.0666
224	S	A	-0.4852
225	A	A	-0.2207
226	R	A	-0.2023
227	A	A	0.7498
228	W	A	0.4501
229	P	A	-0.8128
230	K	A	-2.0710
231	M	A	-1.1174
232	H	A	0.0000
233	T	A	0.0000
234	V	A	0.0000
235	N	A	0.0000
236	G	A	0.0000
237	Y	A	0.0000
238	V	A	-1.0556
239	N	A	-1.9840
240	R	A	-1.4981
241	S	A	0.0000
242	L	A	0.0000
243	P	A	-0.3010
244	G	A	0.0501
245	L	A	0.0000
246	I	A	0.1786
247	G	A	0.0000
248	C	A	-1.4409
249	H	A	-2.1621
250	R	A	-2.7381
251	K	A	-2.4004
252	S	A	-0.8120
253	V	A	0.2858
254	Y	A	0.6266
255	W	A	0.0000
256	H	A	0.0000
257	V	A	0.0000
258	I	A	0.0000
259	G	A	0.0000
260	M	A	0.0000
261	G	A	0.0000
262	T	A	0.2037
263	T	A	-0.0907
264	P	A	-0.2452
265	E	A	-0.4019
266	V	A	0.4448
267	H	A	0.0000
268	S	A	0.1065
269	I	A	0.0000
270	F	A	-0.2274
271	L	A	0.0000
272	E	A	-1.5943
273	G	A	-1.1899
274	H	A	-0.6314
275	T	A	0.0000
276	F	A	0.0000
277	L	A	-0.5882
278	V	A	0.0000
279	R	A	-2.6714
280	N	A	-2.7113
281	H	A	-1.6489
282	R	A	0.0000
283	Q	A	-0.5967
284	A	A	-0.1487
285	S	A	0.0000
286	L	A	0.0000
287	E	A	-0.3446
288	I	A	0.0000
289	S	A	0.6466
290	P	A	0.8680
291	I	A	2.0857
292	T	A	1.3311
293	F	A	1.1962
294	L	A	0.5269
295	T	A	0.1660
296	A	A	0.0000
297	Q	A	0.2113
298	T	A	0.0000
299	L	A	-0.1477
300	L	A	0.0000
301	M	A	-1.0483
302	D	A	-1.8900
303	L	A	-1.2626
304	G	A	-1.3970
305	Q	A	-1.7887
306	F	A	-0.7961
307	L	A	-0.5140
308	L	A	0.0000
309	F	A	-0.2191
310	C	A	0.0000
311	H	A	-0.3498
312	I	A	0.0061
313	S	A	-0.5442
314	S	A	-0.9295
315	H	A	-0.9973
316	Q	A	-1.7747
317	H	A	-2.2049
318	D	A	-2.3242
319	G	A	0.0000
320	M	A	0.0000
321	E	A	0.0000
322	A	A	0.0000
323	Y	A	-0.4255
324	V	A	0.0000
325	K	A	-1.1467
326	V	A	0.0000
327	D	A	-2.1260
328	S	A	-1.3712
329	C	A	-1.4574
330	P	A	-1.6666
331	E	A	-2.8430
332	E	A	-3.1153
333	P	A	-2.1606
334	Q	A	-1.7204
360	F	A	0.7547
361	D	A	-2.0846
362	D	A	-3.2445
363	D	A	-3.7342
364	N	A	-2.8857
365	S	A	-1.8867
366	P	A	-0.5713
367	S	A	0.5811
368	F	A	2.6892
369	I	A	2.5712
370	Q	A	0.9562
371	I	A	1.6433
372	R	A	-0.7294
373	S	A	-0.0875
374	V	A	0.7079
375	A	A	-0.3331
376	K	A	-2.3773
377	K	A	-3.4003
378	H	A	-2.9057
379	P	A	-2.2673
380	K	A	-2.2191
381	T	A	-0.7512
382	W	A	0.1657
383	V	A	0.7320
384	H	A	0.1924
385	Y	A	-0.3199
386	I	A	0.0000
387	A	A	0.0000
388	A	A	0.0000
389	E	A	-1.0888
390	E	A	-1.8900
391	E	A	-2.4380
392	D	A	-2.7802
393	W	A	-1.6816
394	D	A	-1.4060
395	Y	A	0.0000
396	A	A	0.0000
397	P	A	0.2208
398	L	A	1.2776
399	V	A	2.4444
400	L	A	2.1906
401	A	A	0.0563
402	P	A	-1.7150
403	D	A	-2.9271
404	D	A	-2.9115
405	R	A	-1.6497
406	S	A	-1.2444
407	Y	A	-0.2184
408	K	A	-0.4017
409	S	A	0.0000
410	Q	A	-0.9572
411	Y	A	0.0000
412	L	A	0.0000
413	N	A	-0.8571
414	N	A	-2.1980
415	G	A	-1.6219
416	P	A	-1.3381
417	Q	A	-2.2736
418	R	A	-2.2137
419	I	A	0.0000
420	G	A	0.0000
421	R	A	-1.2802
422	K	A	-1.8341
423	Y	A	0.0000
424	K	A	-2.3166
425	K	A	0.0000
426	V	A	0.0000
427	R	A	0.0000
428	F	A	0.0000
429	M	A	0.2429
430	A	A	0.0000
431	Y	A	-0.8048
432	T	A	-1.6129
433	D	A	-2.2990
434	E	A	-0.9977
435	T	A	-0.2242
436	F	A	0.4220
437	K	A	-1.9034
438	T	A	-1.8253
439	R	A	-2.3022
440	E	A	-1.0296
441	A	A	0.4007
442	I	A	1.0782
443	Q	A	-0.8611
444	H	A	-1.2418
445	E	A	-1.0451
446	S	A	0.0000
447	G	A	0.0000
448	I	A	0.0000
449	L	A	0.0000
450	G	A	0.0000
451	P	A	0.2285
452	L	A	0.1405
453	L	A	0.0000
454	Y	A	0.1110
455	G	A	0.0000
456	E	A	-0.8642
457	V	A	0.0000
458	G	A	-0.4462
459	D	A	0.0000
460	T	A	0.0000
461	L	A	0.0000
462	L	A	0.3544
463	I	A	0.0000
464	I	A	0.0000
465	F	A	0.0000
466	K	A	-0.2520
467	N	A	0.0000
468	Q	A	-1.4497
469	A	A	-1.4703
470	S	A	-1.4396
471	R	A	-2.0478
472	P	A	-1.3594
473	Y	A	0.0000
474	N	A	0.0000
475	I	A	0.0000
476	Y	A	0.0000
477	P	A	0.0000
478	H	A	-0.3449
479	G	A	-0.4030
480	I	A	0.0000
481	T	A	-0.9092
482	D	A	-1.5977
483	V	A	0.0000
484	R	A	-2.3706
485	P	A	0.0000
486	L	A	-0.3925
487	Y	A	0.4832
488	S	A	-1.0359
489	R	A	-2.7539
490	R	A	-3.1734
491	L	A	-2.2194
492	P	A	-1.2060
493	K	A	-2.3294
494	G	A	-1.4602
495	V	A	-1.3549
496	K	A	-2.2276
497	H	A	-1.5797
498	L	A	0.0000
499	K	A	-0.6058
500	D	A	-1.1431
501	F	A	0.8603
502	P	A	0.0000
503	I	A	0.3624
504	L	A	0.0000
505	P	A	-1.4066
506	G	A	-1.7378
507	E	A	-1.5764
508	I	A	0.0844
509	F	A	0.4356
510	K	A	0.0934
511	Y	A	0.0000
512	K	A	-0.7597
513	W	A	0.0000
514	T	A	-0.7445
515	V	A	0.0000
516	T	A	0.3650
517	V	A	1.5625
518	E	A	0.6448
519	D	A	0.0000
520	G	A	0.0000
521	P	A	0.0000
522	T	A	-1.0601
523	K	A	-2.2132
524	S	A	-1.7085
525	D	A	0.0000
526	P	A	-0.7200
527	R	A	-1.2719
528	C	A	0.0000
529	L	A	0.0000
530	T	A	0.0000
531	R	A	0.0000
532	Y	A	0.1175
533	Y	A	0.0000
534	S	A	0.0000
535	S	A	0.0000
536	F	A	-0.2790
537	V	A	-0.0905
538	N	A	-0.7606
539	M	A	-0.8025
540	E	A	-1.9148
541	R	A	-1.7525
542	D	A	0.0000
543	L	A	-0.6710
544	A	A	-0.9498
545	S	A	0.0000
546	G	A	0.0000
547	L	A	0.0000
548	I	A	0.0000
549	G	A	0.0000
550	P	A	0.0000
551	L	A	0.0000
552	L	A	0.0000
553	I	A	0.0000
554	C	A	0.0000
555	Y	A	-0.6717
556	K	A	-2.5030
557	E	A	-2.9856
558	S	A	-1.2743
559	V	A	-0.1918
560	D	A	-2.5814
561	Q	A	-3.1215
562	R	A	-3.9695
563	G	A	-2.5764
564	N	A	-1.7868
565	Q	A	-0.7447
566	I	A	1.6389
567	M	A	0.7258
568	S	A	-1.2137
569	D	A	-2.4683
570	K	A	-1.8878
571	R	A	-1.3815
572	N	A	-0.7132
573	V	A	0.0000
574	I	A	0.0000
575	L	A	0.0000
576	F	A	0.0000
577	S	A	0.0000
578	V	A	-0.0922
579	F	A	0.0000
580	D	A	-1.0520
581	E	A	0.0000
582	N	A	-1.4314
583	R	A	-1.9783
584	S	A	0.0000
585	W	A	-0.5800
586	Y	A	0.0000
587	L	A	-0.6118
588	T	A	-1.0617
589	E	A	-2.0782
590	N	A	0.0000
591	I	A	-1.5065
592	Q	A	-2.4815
593	R	A	-2.6549
594	F	A	-1.7165
595	L	A	0.0000
596	P	A	-1.4178
597	N	A	-1.1781
598	P	A	-1.1298
599	A	A	-0.8421
600	G	A	-0.7719
601	V	A	-0.7755
602	Q	A	-1.2826
603	L	A	-0.0327
604	E	A	-2.1139
605	D	A	-2.1145
606	P	A	-1.9068
607	E	A	-2.8871
608	F	A	-1.9322
609	Q	A	-1.8996
610	A	A	-1.0442
611	S	A	0.0000
612	N	A	0.0000
613	I	A	-0.2286
614	M	A	0.0000
615	H	A	0.0000
616	S	A	0.0000
617	I	A	0.0000
618	N	A	0.0000
619	G	A	0.0000
620	Y	A	0.0000
621	V	A	0.0000
622	F	A	-0.1562
623	D	A	0.0166
624	S	A	-0.3515
625	L	A	-0.6498
626	Q	A	-0.4898
627	L	A	0.0000
628	S	A	-0.1937
629	V	A	0.0000
630	C	A	-0.0438
631	L	A	-0.0566
632	H	A	-0.9258
633	E	A	-0.6281
634	V	A	0.4350
635	A	A	0.0000
636	Y	A	0.3756
637	W	A	0.0000
638	Y	A	0.0000
639	I	A	0.0000
640	L	A	0.0000
641	S	A	0.0000
642	I	A	0.0000
643	G	A	-0.6393
644	A	A	-0.5781
645	Q	A	-0.9124
646	T	A	-0.5230
647	D	A	-0.2325
648	F	A	0.0000
649	L	A	1.3396
650	S	A	0.0000
651	V	A	0.0000
652	F	A	0.0000
653	F	A	2.3389
654	S	A	2.0723
655	G	A	2.0535
656	Y	A	2.0123
657	T	A	1.7293
658	F	A	0.0000
659	K	A	-2.4121
660	H	A	0.0000
661	K	A	-1.8474
662	M	A	-0.2652
663	V	A	0.5723
664	Y	A	0.3178
665	E	A	-2.2960
666	D	A	-1.9860
667	T	A	-1.1707
668	L	A	0.5890
669	T	A	0.0000
670	L	A	0.0000
671	F	A	1.8505
672	P	A	0.0000
673	F	A	0.2138
674	S	A	-0.2596
675	G	A	-0.3811
676	E	A	0.0000
677	T	A	0.0000
678	V	A	0.5461
679	F	A	0.0000
680	M	A	0.0000
681	S	A	-0.5720
682	M	A	0.0000
683	E	A	-1.6907
684	N	A	0.0000
685	P	A	-0.2070
686	G	A	0.6288
687	L	A	2.4491
688	W	A	2.4964
689	I	A	1.8268
690	L	A	0.0000
691	G	A	0.7568
692	C	A	0.0000
693	H	A	0.1958
694	N	A	0.0000
695	S	A	-0.2053
696	D	A	-0.3269
697	F	A	0.2987
698	R	A	-1.7511
699	N	A	-1.4342
700	R	A	-2.1156
701	G	A	-1.4296
702	M	A	0.0000
703	T	A	0.0000
704	A	A	0.0000
705	L	A	0.0250
706	L	A	0.0000
707	K	A	0.1629
708	V	A	0.0000
709	S	A	0.8688
710	S	A	0.6046
711	C	A	-0.7240
712	D	A	-2.7174
713	K	A	-3.0283
714	N	A	-2.5749
715	T	A	-1.8857
716	G	A	-1.5064
717	D	A	-2.0375
718	Y	A	-0.0120
719	Y	A	0.3659
720	E	A	-1.6665
721	D	A	-2.1227
722	S	A	-1.4094
723	Y	A	-1.1242
724	E	A	-2.9695
725	D	A	-3.4890