Project name: be2b9fa0a4c8786

Chain sequence(s)	A: FYPSYHSTPQRPGTPEAAAKKELEFKNGKCIFNGMNMAKTTVQYTDPTRCTAYFCEPGKHEMIIKGCPPPDDYDYEAYYDPTRWPDCCEAYKGGGGSNRKGQSFQCGGTILTQRHILTAAHCIYPNGLVAVGAEAYYGNIHKRHGKRLRVTKVIPHAKYNEKSFSHDIAVFVVEKPFQFGTNARPICIPTALVNIAGTDNIVAGWGFIREGGPDTNYLKYTTVTAQPNHICSANYLAFDSRVMYCAYLTATDSCQGDSGGPAMYRVSGGRRYVQVGIVSFGRGCARENVGGGGSVQSHPRCRVPPQIEHCNNLVLQWSFIRRDGRCEQSLVCHQSPNSFQTRAECEALCPPVPKRGPPARTVKCSYWLLHMDRCSANWEASRRDIFGRNHDYMVFTGCGYQKRVVYIYSLRTKSCRVKPWWWKLPRPKKILFGDAFIPAIVQPVSQIFPAFPVVNAPLQIPHGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5606
• Maximal score value: 1.9069
• Average score: -0.7947
• Total score value: -503.8251

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	F	A	1.5779
2	Y	A	1.0169
3	P	A	0.3860
4	S	A	0.0844
5	Y	A	-0.2508
6	H	A	-0.7584
7	S	A	-0.7675
8	T	A	-1.1414
9	P	A	-1.3448
10	Q	A	-2.1431
11	R	A	-2.6810
12	P	A	-1.7013
13	G	A	-1.4986
14	T	A	-1.6630
15	P	A	-1.9455
16	E	A	-2.1065
17	A	A	0.0000
18	A	A	0.0000
19	A	A	0.0000
20	K	A	-1.2367
21	K	A	-1.2238
22	E	A	0.0000
23	L	A	0.0000
24	E	A	-0.5895
25	F	A	0.6192
26	K	A	-0.9695
27	N	A	-1.4800
28	G	A	-1.3648
29	K	A	-1.3964
30	C	A	0.0000
31	I	A	0.0000
32	F	A	0.0000
33	N	A	-1.3528
34	G	A	-1.0927
35	M	A	-1.4835
36	N	A	-2.2076
37	M	A	0.0000
38	A	A	-1.6233
39	K	A	-2.1538
40	T	A	-0.5156
41	T	A	-0.4049
42	V	A	0.0000
43	Q	A	-0.7585
44	Y	A	0.0000
45	T	A	-1.3819
46	D	A	-2.1081
47	P	A	-1.7348
48	T	A	-1.4864
49	R	A	-2.0428
50	C	A	0.0000
51	T	A	0.0000
52	A	A	0.0000
53	Y	A	0.0000
54	F	A	-0.5615
55	C	A	-0.5751
56	E	A	-1.0108
57	P	A	-1.3542
58	G	A	-1.4149
59	K	A	-1.8184
60	H	A	-2.2414
61	E	A	0.0000
62	M	A	0.0000
63	I	A	0.0000
64	I	A	0.0000
65	K	A	-1.8901
66	G	A	-1.5640
67	C	A	-1.1961
68	P	A	-1.1173
69	P	A	-1.2351
70	P	A	-1.9685
71	D	A	-2.9115
72	D	A	-2.9256
73	Y	A	-2.0295
74	D	A	-2.3174
75	Y	A	-1.3802
76	E	A	-0.8495
77	A	A	0.0000
78	Y	A	0.0000
79	Y	A	0.0000
80	D	A	-0.7024
81	P	A	-0.7663
82	T	A	-0.9068
83	R	A	-0.9255
84	W	A	0.0000
85	P	A	-1.0730
86	D	A	0.0000
87	C	A	0.0000
88	C	A	0.0000
89	E	A	0.0000
90	A	A	0.0000
91	Y	A	0.0000
92	K	A	-1.0049
93	G	A	-1.4181
94	G	A	0.0000
95	G	A	-1.4796
96	G	A	-2.0459
97	S	A	-1.8014
98	N	A	-2.8002
99	R	A	-3.4575
100	K	A	-3.1774
101	G	A	-2.2607
102	Q	A	-2.1510
103	S	A	-1.3060
104	F	A	-0.6269
105	Q	A	-0.4660
106	C	A	0.0000
107	G	A	0.0000
108	G	A	0.0000
109	T	A	0.0000
110	I	A	0.0000
111	L	A	0.0000
112	T	A	-0.9305
113	Q	A	-1.7991
114	R	A	-1.8835
115	H	A	-0.7621
116	I	A	0.0000
117	L	A	0.0000
118	T	A	0.0000
119	A	A	0.0000
120	A	A	0.0000
121	H	A	-0.1429
122	C	A	0.0000
123	I	A	0.5823
124	Y	A	0.7339
125	P	A	-0.1889
126	N	A	-0.6155
127	G	A	0.1266
128	L	A	1.0675
129	V	A	0.0000
130	A	A	0.0000
131	V	A	0.0000
132	G	A	0.0000
133	A	A	-0.9950
134	E	A	-1.9067
135	A	A	0.0000
136	Y	A	-0.8016
137	Y	A	0.0000
138	G	A	-1.0307
139	N	A	-1.1088
140	I	A	-1.2021
141	H	A	-1.8142
142	K	A	-2.2870
143	R	A	-2.7545
144	H	A	-2.2819
145	G	A	-1.8713
146	K	A	-2.0191
147	R	A	-1.8501
148	L	A	0.0000
149	R	A	-2.7292
150	V	A	-1.2720
151	T	A	-1.2193
152	K	A	-1.4532
153	V	A	-0.2667
154	I	A	0.0000
155	P	A	-0.3107
156	H	A	0.0000
157	A	A	-0.9358
158	K	A	-2.1368
159	Y	A	-1.7632
160	N	A	-2.7307
161	E	A	-3.2076
162	K	A	-2.8241
163	S	A	-1.6596
164	F	A	-1.1560
165	S	A	-1.2629
166	H	A	-0.9644
167	D	A	0.0000
168	I	A	0.0000
169	A	A	0.0000
170	V	A	0.0000
171	F	A	0.0000
172	V	A	-1.1296
173	V	A	0.0000
174	E	A	-2.4874
175	K	A	-2.4580
176	P	A	-1.7647
177	F	A	0.0000
178	Q	A	-1.8840
179	F	A	-1.0763
180	G	A	-1.1322
181	T	A	-1.0266
182	N	A	-1.4211
183	A	A	0.0000
184	R	A	-2.1629
185	P	A	-1.0724
186	I	A	0.0000
187	C	A	-0.3072
188	I	A	0.0000
189	P	A	0.0000
190	T	A	-0.0743
191	A	A	0.2936
192	L	A	1.3519
193	V	A	0.7280
194	N	A	-0.5662
195	I	A	-0.3330
196	A	A	-0.8097
197	G	A	-0.9230
198	T	A	-1.0644
199	D	A	-1.5866
200	N	A	0.0000
201	I	A	0.0000
202	V	A	0.0000
203	A	A	0.0000
204	G	A	0.0000
205	W	A	0.0000
206	G	A	0.0000
207	F	A	-0.8756
208	I	A	-1.0642
209	R	A	-3.1114
210	E	A	-3.1080
211	G	A	-2.1949
212	G	A	-2.0045
213	P	A	-1.9336
214	D	A	-2.5206
215	T	A	0.0000
216	N	A	-1.5641
217	Y	A	-0.7657
218	L	A	0.0000
219	K	A	0.0000
220	Y	A	0.0000
221	T	A	0.0000
222	T	A	-0.3895
223	V	A	0.0000
224	T	A	-0.4484
225	A	A	0.0000
226	Q	A	0.0000
227	P	A	-0.9104
228	N	A	-1.6216
229	H	A	-0.9455
230	I	A	0.0372
231	C	A	0.0000
232	S	A	-0.0021
233	A	A	0.3538
234	N	A	-0.1041
235	Y	A	0.3822
236	L	A	1.5261
237	A	A	0.7128
238	F	A	0.0760
239	D	A	-1.0033
240	S	A	-1.3476
241	R	A	-2.1739
242	V	A	-1.0144
243	M	A	0.0000
244	Y	A	0.0000
245	C	A	0.0000
246	A	A	0.0000
247	Y	A	-0.1133
248	L	A	0.0000
249	T	A	-1.0287
250	A	A	-1.0635
251	T	A	-0.4736
252	D	A	0.0000
253	S	A	0.0000
254	C	A	-0.4976
255	Q	A	-0.2622
256	G	A	0.0000
257	D	A	0.0000
258	S	A	0.2291
259	G	A	0.0000
260	G	A	0.0000
261	P	A	0.0000
262	A	A	0.0000
263	M	A	0.0000
264	Y	A	-0.6465
265	R	A	-1.6627
266	V	A	-1.1147
267	S	A	-1.0782
268	G	A	-1.5859
269	G	A	-1.9718
270	R	A	-3.0401
271	R	A	-2.8098
272	Y	A	-1.2077
273	V	A	0.0000
274	Q	A	0.0000
275	V	A	0.0000
276	G	A	0.0000
277	I	A	0.0000
278	V	A	0.0000
279	S	A	0.0000
280	F	A	0.5178
281	G	A	-1.0616
282	R	A	-2.4272
283	G	A	0.0000
284	C	A	0.0000
285	A	A	-1.7860
286	R	A	-3.2448
287	E	A	-3.1659
288	N	A	-2.4917
289	V	A	-1.8943
290	G	A	0.0000
291	G	A	0.0000
292	G	A	-0.0127
293	G	A	0.0000
294	S	A	0.0000
295	V	A	0.0764
296	Q	A	0.0000
297	S	A	0.0000
298	H	A	-0.2551
299	P	A	-0.4144
300	R	A	-0.7743
301	C	A	0.0000
302	R	A	-1.0929
303	V	A	0.8657
304	P	A	0.0000
305	P	A	0.0000
306	Q	A	0.0000
307	I	A	0.4183
308	E	A	-0.1052
309	H	A	0.0000
310	C	A	0.0000
311	N	A	-0.9045
312	N	A	-0.9400
313	L	A	0.0000
314	V	A	0.1045
315	L	A	0.2861
316	Q	A	-0.2787
317	W	A	-0.0140
318	S	A	-0.2291
319	F	A	0.0000
320	I	A	-0.8923
321	R	A	-1.8711
322	R	A	-2.6482
323	D	A	-2.6321
324	G	A	-1.9775
325	R	A	-2.4469
326	C	A	-1.3031
327	E	A	-1.3892
328	Q	A	0.0000
329	S	A	0.0000
330	L	A	0.0000
331	V	A	0.0000
332	C	A	0.0000
333	H	A	0.0000
334	Q	A	-0.7943
335	S	A	0.0000
336	P	A	-1.2574
337	N	A	-1.4600
338	S	A	-0.8244
339	F	A	-0.5060
340	Q	A	-0.9369
341	T	A	0.0000
342	R	A	-1.5884
343	A	A	0.0000
344	E	A	0.0000
345	C	A	-0.4076
346	E	A	0.0000
347	A	A	-0.2371
348	L	A	0.2116
349	C	A	0.4534
350	P	A	-0.1189
351	P	A	0.0000
352	V	A	0.7593
353	P	A	-1.3007
354	K	A	-2.3521
355	R	A	-2.7541
356	G	A	-2.1968
357	P	A	-1.6687
358	P	A	-1.3240
359	A	A	-1.6932
360	R	A	-2.2119
361	T	A	-1.3371
362	V	A	0.0000
363	K	A	-1.3158
364	C	A	0.0000
365	S	A	0.0000
366	Y	A	0.0000
367	W	A	0.3744
368	L	A	0.0000
369	L	A	0.0000
370	H	A	0.0000
371	M	A	-1.7361
372	D	A	-3.0250
373	R	A	-2.6563
374	C	A	-1.5278
375	S	A	-1.1988
376	A	A	-0.8842
377	N	A	-1.3073
378	W	A	-0.8916
379	E	A	-1.2373
380	A	A	-1.3518
381	S	A	-1.3825
382	R	A	0.0000
383	R	A	-3.0768
384	D	A	-3.0141
385	I	A	-1.4378
386	F	A	0.0000
387	G	A	-2.4788
388	R	A	-3.5606
389	N	A	-3.5009
390	H	A	0.0000
391	D	A	-2.4389
392	Y	A	-1.3423
393	M	A	0.0000
394	V	A	0.0000
395	F	A	0.0000
396	T	A	0.0000
397	G	A	0.0000
398	C	A	-0.6947
399	G	A	-0.8782
400	Y	A	-1.4297
401	Q	A	-2.3139
402	K	A	-2.4839
403	R	A	-2.6056
404	V	A	0.0000
405	V	A	0.0000
406	Y	A	0.0000
407	I	A	0.0000
408	Y	A	0.0000
409	S	A	-0.6053
410	L	A	-0.9662
411	R	A	-2.8041
412	T	A	-2.2427
413	K	A	-2.3442
414	S	A	-1.8745
415	C	A	-1.9222
416	R	A	-1.8901
417	V	A	0.0000
418	K	A	-0.3784
419	P	A	0.0000
420	W	A	0.0000
421	W	A	0.9621
422	W	A	-0.2744
423	K	A	-1.6848
424	L	A	0.0000
425	P	A	-2.0667
426	R	A	-2.6875
427	P	A	-2.6686
428	K	A	-3.0307
429	K	A	-2.4303
430	I	A	0.0000
431	L	A	-0.1846
432	F	A	0.0000
433	G	A	0.0000
434	D	A	-1.7450
435	A	A	-0.9243
436	F	A	-0.5358
437	I	A	0.0000
438	P	A	0.2842
439	A	A	0.7348
440	I	A	1.7125
441	V	A	1.9069
442	Q	A	0.0000
443	P	A	-0.1036
444	V	A	0.0000
445	S	A	-0.4605
446	Q	A	-1.1239
447	I	A	0.0000
448	F	A	0.0000
449	P	A	-1.1461
450	A	A	0.0000
451	F	A	0.0000
452	P	A	0.0000
453	V	A	0.0000
454	V	A	-0.6061
455	N	A	-1.5133
456	A	A	-0.3871
457	P	A	-0.4428
458	L	A	0.0000
459	Q	A	-0.5611
460	I	A	0.0000
461	P	A	-0.6114
462	H	A	-0.7062
463	G	A	-0.9900
464	G	A	-1.1933
465	G	A	-1.2642
466	G	A	-1.0900
467	S	A	-1.1782
468	S	A	-1.1111
469	E	A	-1.8555
470	I	A	-1.3622
471	K	A	-2.1078
472	Y	A	0.0000
473	H	A	-1.4833
474	N	A	-1.4188
475	Y	A	-1.0126
476	N	A	-1.5269
477	S	A	-1.1296
478	N	A	-1.6336
479	G	A	0.0000
480	F	A	-0.9083
481	N	A	-1.5953
482	P	A	-1.7098
483	K	A	-2.2076
484	G	A	-1.3914
485	P	A	-0.9520
486	G	A	-1.1634
487	P	A	-0.9299
488	G	A	-0.9479
489	I	A	0.0000
490	L	A	0.0000
491	F	A	0.0000
492	G	A	0.0000
493	D	A	0.0000
494	A	A	-0.9022
495	F	A	0.0000
496	I	A	-0.4516
497	P	A	0.0000
498	A	A	-0.8935
499	I	A	0.0000
500	V	A	0.0000
501	Q	A	0.0000
502	P	A	0.0000
503	V	A	0.0000
504	S	A	-0.4099
505	Q	A	-0.7946
506	I	A	0.0000
507	F	A	0.0217
508	P	A	-0.3752
509	G	A	-0.5216
510	P	A	-0.8021
511	G	A	-0.8589
512	P	A	-0.6566
513	G	A	0.0000
514	I	A	0.0000
515	L	A	-0.0926
516	F	A	0.0000
517	N	A	-1.0334
518	S	A	-0.6607
519	L	A	0.0000
520	Q	A	0.0000
521	Y	A	0.0000
522	T	A	-0.2828
523	N	A	0.0000
524	V	A	0.0000
525	V	A	0.0000
526	K	A	-2.1085
527	D	A	-2.0456
528	Y	A	-0.8605
529	W	A	-0.3209
530	G	A	-1.3303
531	N	A	-2.5271
532	D	A	-3.0788
533	L	A	0.0000
534	G	A	-2.0406
535	P	A	-1.7935
536	G	A	-1.7801
537	P	A	-1.7953
538	G	A	-1.9512
539	K	A	-3.0537
540	E	A	-3.1378
541	T	A	0.0000
542	V	A	0.0000
543	L	A	0.0000
544	R	A	0.0000
545	V	A	0.0000
546	A	A	0.0000
547	V	A	0.0000
548	T	A	0.0000
549	A	A	-1.4085
550	Q	A	-2.1732
551	H	A	-2.2190
552	P	A	-1.8505
553	K	A	-2.1972
554	P	A	0.0000
555	A	A	-0.6221
556	S	A	0.0000
557	L	A	0.0000
558	M	A	-0.5004
559	G	A	-0.5411
560	P	A	-0.5452
561	G	A	-0.4881
562	P	A	-0.5613
563	G	A	-0.6439
564	Y	A	-0.4195
565	D	A	-1.3431
566	A	A	-0.7512
567	G	A	-0.8230
568	I	A	-0.9002
569	E	A	-1.7089
570	L	A	0.0000
571	A	A	0.0000
572	H	A	-0.1303
573	L	A	0.3885
574	L	A	0.0000
575	A	A	0.4136
576	F	A	1.4060
577	N	A	-0.3539
578	K	A	-1.0578
579	Y	A	0.2397
580	G	A	0.0120
581	P	A	-0.5165
582	G	A	-0.9263
583	P	A	-1.3158
584	G	A	-1.4285
585	H	A	-1.5639
586	D	A	-2.3845
587	K	A	-3.0982
588	K	A	-2.8037
589	Q	A	-1.8446
590	F	A	-1.6431
591	A	A	0.0000
592	A	A	0.0000
593	L	A	0.0000
594	M	A	0.0000
595	L	A	0.0000
596	Y	A	0.0000
597	E	A	-1.6624
598	E	A	-2.0040
599	D	A	-2.4547
600	G	A	-1.4298
601	T	A	-1.3066
602	L	A	0.0000
603	R	A	-0.6852
604	V	A	0.0000
605	E	A	0.0000
606	G	A	0.0000
607	V	A	0.0000
608	G	A	0.0000
609	P	A	-1.2128
610	G	A	0.0000
611	P	A	-1.1075
612	G	A	-1.0084
613	K	A	-1.2564
614	R	A	-1.6529
615	H	A	-2.2839
616	G	A	-1.7304
617	K	A	0.0000
618	R	A	-1.3379
619	L	A	0.0000
620	R	A	-1.3419
621	V	A	0.0000
622	T	A	-1.3359
623	K	A	-1.5694
624	V	A	0.0000
625	I	A	1.3615
626	P	A	-0.1081
627	H	A	-0.3326
628	A	A	-0.6260
629	K	A	-1.7667
630	Y	A	-0.9249
631	N	A	-2.5548
632	E	A	-3.1777
633	K	A	-2.9120
634	S	A	-1.6202