| Chain sequence(s) |
A: DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIETDRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK B: YNPYPEDGDIEIG |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 987 | D | A | -2.7524 | |
| 988 | E | A | -2.8047 | |
| 989 | W | A | -1.5751 | |
| 990 | E | A | -1.7776 | |
| 991 | V | A | -1.6352 | |
| 992 | S | A | -1.7492 | |
| 993 | R | A | -2.3678 | |
| 994 | E | A | -2.6390 | |
| 995 | K | A | -2.9227 | |
| 996 | I | A | 0.0000 | |
| 997 | T | A | -0.6556 | |
| 998 | L | A | 0.3670 | |
| 999 | L | A | 0.0940 | |
| 1000 | R | A | -1.8971 | |
| 1001 | E | A | -2.3403 | |
| 1002 | L | A | -1.3685 | |
| 1003 | G | A | -1.6187 | |
| 1004 | Q | A | -1.8084 | |
| 1005 | G | A | -1.0664 | |
| 1006 | S | A | -0.9476 | |
| 1007 | F | A | 0.0000 | |
| 1008 | G | A | -1.3632 | |
| 1009 | M | A | -0.9160 | |
| 1010 | V | A | 0.0000 | |
| 1011 | Y | A | -0.8803 | |
| 1012 | E | A | -1.1480 | |
| 1013 | G | A | 0.0000 | |
| 1014 | N | A | -1.7029 | |
| 1015 | A | A | 0.0000 | |
| 1016 | R | A | -4.1476 | |
| 1017 | D | A | -3.6499 | |
| 1018 | I | A | -1.8950 | |
| 1019 | I | A | -1.5830 | |
| 1020 | K | A | -2.4884 | |
| 1021 | G | A | -2.1293 | |
| 1022 | E | A | -2.9075 | |
| 1023 | A | A | -2.7236 | |
| 1024 | E | A | -4.0459 | |
| 1025 | T | A | -2.9238 | |
| 1026 | R | A | -2.4420 | |
| 1027 | V | A | 0.0000 | |
| 1028 | A | A | 0.0000 | |
| 1029 | V | A | 0.0000 | |
| 1030 | K | A | -0.3265 | |
| 1031 | T | A | -0.6004 | |
| 1032 | V | A | -1.2889 | |
| 1033 | N | A | -2.5457 | |
| 1034 | E | A | -2.6378 | |
| 1035 | S | A | -1.5530 | |
| 1036 | A | A | 0.0000 | |
| 1037 | S | A | -1.0034 | |
| 1038 | L | A | -0.0267 | |
| 1039 | R | A | -1.9107 | |
| 1040 | E | A | -2.1614 | |
| 1041 | R | A | -1.9351 | |
| 1042 | I | A | -0.8034 | |
| 1043 | E | A | -1.9329 | |
| 1044 | F | A | 0.0000 | |
| 1045 | L | A | -0.1997 | |
| 1046 | N | A | -1.4836 | |
| 1047 | E | A | 0.0000 | |
| 1048 | A | A | 0.0000 | |
| 1049 | S | A | -0.7647 | |
| 1050 | V | A | -0.9275 | |
| 1051 | M | A | 0.0000 | |
| 1052 | K | A | -1.4955 | |
| 1053 | G | A | -1.0738 | |
| 1054 | F | A | 0.0000 | |
| 1055 | T | A | -0.6728 | |
| 1056 | C | A | -0.4254 | |
| 1057 | H | A | -0.8240 | |
| 1058 | H | A | 0.0000 | |
| 1059 | V | A | 0.0000 | |
| 1060 | V | A | 0.0000 | |
| 1061 | R | A | -1.5845 | |
| 1062 | L | A | 0.0000 | |
| 1063 | L | A | -0.1054 | |
| 1064 | G | A | 0.0000 | |
| 1065 | V | A | -0.7711 | |
| 1066 | V | A | 0.0000 | |
| 1067 | S | A | -1.5369 | |
| 1068 | K | A | -2.4270 | |
| 1069 | G | A | -2.0218 | |
| 1070 | Q | A | -2.0008 | |
| 1071 | P | A | -1.6557 | |
| 1072 | T | A | -0.7658 | |
| 1073 | L | A | 0.0000 | |
| 1074 | V | A | 0.0000 | |
| 1075 | V | A | 0.0000 | |
| 1076 | M | A | 0.0000 | |
| 1077 | E | A | -0.8475 | |
| 1078 | L | A | -0.7250 | |
| 1079 | M | A | 0.0000 | |
| 1080 | A | A | -0.7501 | |
| 1081 | H | A | -0.5329 | |
| 1082 | G | A | -0.4379 | |
| 1083 | D | A | 0.0000 | |
| 1084 | L | A | 0.0000 | |
| 1085 | K | A | 0.0000 | |
| 1086 | S | A | -0.5280 | |
| 1087 | Y | A | -0.1768 | |
| 1088 | L | A | 0.0000 | |
| 1089 | R | A | -1.2207 | |
| 1090 | S | A | -1.7907 | |
| 1091 | L | A | 0.0000 | |
| 1092 | R | A | -1.9019 | |
| 1093 | P | A | -2.1766 | |
| 1094 | E | A | -2.8157 | |
| 1095 | A | A | -2.6471 | |
| 1096 | E | A | -3.1856 | |
| 1097 | N | A | -2.8685 | |
| 1098 | N | A | -2.8117 | |
| 1099 | P | A | -1.8971 | |
| 1100 | G | A | -1.8987 | |
| 1101 | R | A | -2.4562 | |
| 1102 | P | A | -1.5049 | |
| 1103 | P | A | -0.9638 | |
| 1104 | P | A | 0.0000 | |
| 1105 | T | A | -0.5820 | |
| 1106 | L | A | -0.2999 | |
| 1107 | Q | A | -1.6742 | |
| 1108 | E | A | -1.6529 | |
| 1109 | M | A | -0.7567 | |
| 1110 | I | A | 0.0000 | |
| 1111 | Q | A | -1.0863 | |
| 1112 | M | A | 0.0000 | |
| 1113 | A | A | 0.0000 | |
| 1114 | A | A | 0.0000 | |
| 1115 | E | A | 0.0000 | |
| 1116 | I | A | 0.0000 | |
| 1117 | A | A | 0.0000 | |
| 1118 | D | A | 0.0000 | |
| 1119 | G | A | 0.0000 | |
| 1120 | M | A | 0.0000 | |
| 1121 | A | A | 0.0000 | |
| 1122 | Y | A | 0.0000 | |
| 1123 | L | A | 0.0000 | |
| 1124 | N | A | -1.1963 | |
| 1125 | A | A | -1.2087 | |
| 1126 | K | A | -1.5030 | |
| 1127 | K | A | -2.7926 | |
| 1128 | F | A | -2.1915 | |
| 1129 | V | A | 0.0000 | |
| 1130 | H | A | 0.0000 | |
| 1131 | R | A | -0.6040 | |
| 1132 | D | A | -0.3923 | |
| 1133 | L | A | 0.0000 | |
| 1134 | A | A | 0.0000 | |
| 1135 | A | A | 0.0000 | |
| 1136 | R | A | -0.4169 | |
| 1137 | N | A | 0.0000 | |
| 1138 | C | A | 0.0000 | |
| 1139 | M | A | 0.0000 | |
| 1140 | V | A | 0.0000 | |
| 1141 | A | A | -0.5669 | |
| 1142 | H | A | -1.4116 | |
| 1143 | D | A | -1.5339 | |
| 1144 | F | A | 0.1833 | |
| 1145 | T | A | -0.2537 | |
| 1146 | V | A | 0.0000 | |
| 1147 | K | A | 0.0000 | |
| 1148 | I | A | 0.0000 | |
| 1149 | G | A | 0.0000 | |
| 1150 | D | A | -0.3933 | |
| 1151 | F | A | 0.0000 | |
| 1152 | G | A | -0.9698 | |
| 1153 | M | A | -0.7073 | |
| 1154 | T | A | -1.5528 | |
| 1155 | R | A | -3.1122 | |
| 1156 | D | A | -3.5372 | |
| 1157 | I | A | 0.0000 | |
| 1159 | E | A | -2.7525 | |
| 1160 | T | A | -2.1649 | |
| 1161 | D | A | -2.7796 | |
| 1164 | R | A | -3.0207 | |
| 1165 | K | A | -3.1501 | |
| 1166 | G | A | -2.9182 | |
| 1167 | G | A | -2.4415 | |
| 1168 | K | A | -3.0480 | |
| 1169 | G | A | -1.4462 | |
| 1170 | L | A | 0.1816 | |
| 1171 | L | A | -0.2019 | |
| 1172 | P | A | 0.0000 | |
| 1173 | V | A | 0.0000 | |
| 1174 | R | A | -0.3583 | |
| 1175 | W | A | 0.0000 | |
| 1176 | M | A | 0.0000 | |
| 1177 | A | A | 0.0000 | |
| 1178 | P | A | 0.0000 | |
| 1179 | E | A | -0.9039 | |
| 1180 | S | A | 0.0000 | |
| 1181 | L | A | 0.0000 | |
| 1182 | K | A | -2.5945 | |
| 1183 | D | A | -2.6172 | |
| 1184 | G | A | 0.0000 | |
| 1185 | V | A | -1.5203 | |
| 1186 | F | A | 0.0000 | |
| 1187 | T | A | -0.8719 | |
| 1188 | T | A | -0.5466 | |
| 1189 | S | A | -0.3753 | |
| 1190 | S | A | 0.0000 | |
| 1191 | D | A | 0.0000 | |
| 1192 | M | A | 0.0000 | |
| 1193 | W | A | 0.0000 | |
| 1194 | S | A | 0.0000 | |
| 1195 | F | A | 0.0000 | |
| 1196 | G | A | 0.0000 | |
| 1197 | V | A | 0.0000 | |
| 1198 | V | A | 0.0000 | |
| 1199 | L | A | 0.0000 | |
| 1200 | W | A | 0.0000 | |
| 1201 | E | A | 0.0000 | |
| 1202 | I | A | 0.0000 | |
| 1203 | T | A | -0.5045 | |
| 1204 | S | A | -0.8309 | |
| 1205 | L | A | -0.2858 | |
| 1206 | A | A | 0.0000 | |
| 1207 | E | A | -1.0380 | |
| 1208 | Q | A | -1.1122 | |
| 1209 | P | A | 0.0000 | |
| 1210 | Y | A | 0.0000 | |
| 1211 | Q | A | -1.5096 | |
| 1212 | G | A | -1.0244 | |
| 1213 | L | A | -0.8345 | |
| 1214 | S | A | -1.3784 | |
| 1215 | N | A | -2.4522 | |
| 1216 | E | A | -3.2995 | |
| 1217 | Q | A | -2.3887 | |
| 1218 | V | A | 0.0000 | |
| 1219 | L | A | 0.0000 | |
| 1220 | K | A | -2.7692 | |
| 1221 | F | A | -0.9643 | |
| 1222 | V | A | 0.0000 | |
| 1223 | M | A | -1.2566 | |
| 1224 | D | A | -1.8661 | |
| 1225 | G | A | -0.6639 | |
| 1226 | G | A | -0.1859 | |
| 1227 | Y | A | 0.2798 | |
| 1228 | L | A | 0.0000 | |
| 1229 | D | A | -2.1161 | |
| 1230 | Q | A | -2.3022 | |
| 1231 | P | A | -1.9007 | |
| 1232 | D | A | -2.7101 | |
| 1233 | N | A | -2.4255 | |
| 1234 | C | A | -1.6821 | |
| 1235 | P | A | -1.7309 | |
| 1236 | E | A | -2.7959 | |
| 1237 | R | A | -1.9342 | |
| 1238 | V | A | 0.0000 | |
| 1239 | T | A | -2.1801 | |
| 1240 | D | A | -2.6833 | |
| 1241 | L | A | 0.0000 | |
| 1242 | M | A | 0.0000 | |
| 1243 | R | A | -1.4013 | |
| 1244 | M | A | -0.1671 | |
| 1245 | C | A | 0.0000 | |
| 1246 | W | A | 0.0000 | |
| 1247 | Q | A | 0.1707 | |
| 1248 | F | A | 0.7288 | |
| 1249 | N | A | -0.4113 | |
| 1250 | P | A | -0.5363 | |
| 1251 | N | A | -1.0350 | |
| 1252 | M | A | 0.1291 | |
| 1253 | R | A | 0.0000 | |
| 1254 | P | A | -0.4555 | |
| 1255 | T | A | -0.7921 | |
| 1256 | F | A | 0.0000 | |
| 1257 | L | A | -0.7207 | |
| 1258 | E | A | -1.8296 | |
| 1259 | I | A | 0.0000 | |
| 1260 | V | A | 0.0000 | |
| 1261 | N | A | -1.6811 | |
| 1262 | L | A | -0.5299 | |
| 1263 | L | A | 0.0000 | |
| 1264 | K | A | -2.4651 | |
| 1265 | D | A | -2.7868 | |
| 1266 | D | A | -2.3439 | |
| 1267 | L | A | -2.0602 | |
| 1268 | H | A | -1.9497 | |
| 1269 | P | A | -1.3535 | |
| 1270 | S | A | -1.0556 | |
| 1271 | F | A | 0.0000 | |
| 1272 | P | A | -1.3148 | |
| 1273 | E | A | -1.8511 | |
| 1274 | V | A | -0.6502 | |
| 1275 | S | A | 0.0000 | |
| 1276 | F | A | 0.0000 | |
| 1277 | F | A | -1.3471 | |
| 1278 | H | A | -1.7805 | |
| 1279 | S | A | -2.2819 | |
| 1280 | E | A | -3.2921 | |
| 1281 | E | A | -3.4558 | |
| 1282 | N | A | -2.6767 | |
| 1283 | K | A | -2.8774 | |
| 621 | Y | B | -0.8646 | |
| 622 | N | B | -1.3080 | |
| 623 | P | B | -1.2127 | |
| 624 | Y | B | -1.0170 | |
| 625 | P | B | -1.0427 | |
| 626 | E | B | -1.9831 | |
| 627 | D | B | 0.0000 | |
| 629 | G | B | -1.4252 | |
| 630 | D | B | -2.2458 | |
| 631 | I | B | 0.0000 | |
| 632 | E | B | -3.3651 | |
| 633 | I | B | 0.0000 | |
| 634 | G | B | -2.8699 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine