Project name: HyalI

Chain sequence(s)	A: RSFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMWT
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.505
• Maximal score value: 2.0148
• Average score: -0.546
• Total score value: -227.6671

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
20	R	A	-1.7047
21	S	A	0.0000
22	F	A	1.0895
23	R	A	-0.1116
24	G	A	-0.2015
25	P	A	-0.5266
26	L	A	0.0000
27	L	A	-0.5690
28	P	A	-0.9219
29	N	A	-1.7201
30	R	A	-1.1709
31	P	A	0.0000
32	F	A	0.0000
33	T	A	0.0000
34	T	A	0.0000
35	V	A	0.0000
36	W	A	0.0000
37	N	A	0.0000
38	A	A	0.0000
39	N	A	-0.2241
40	T	A	0.0000
41	Q	A	-1.2075
42	W	A	-1.5155
43	C	A	0.0000
44	L	A	-1.6311
45	E	A	-2.6989
46	R	A	-3.0299
47	H	A	-2.6695
48	G	A	-1.9140
49	V	A	0.0000
50	D	A	-2.2310
51	V	A	0.0000
52	D	A	-1.4848
53	V	A	0.0130
54	S	A	0.0077
55	V	A	0.2735
56	F	A	0.0000
57	D	A	-0.1945
58	V	A	0.0000
59	V	A	1.1621
60	A	A	0.2645
61	N	A	-0.0867
62	P	A	0.0000
63	G	A	-0.3976
64	Q	A	-0.6901
65	T	A	-0.0695
66	F	A	0.6985
67	R	A	-1.3025
68	G	A	-0.8062
69	P	A	-1.1350
70	D	A	-1.0507
71	M	A	-0.5593
72	T	A	-0.4223
73	I	A	0.0000
74	F	A	0.0000
75	Y	A	-0.2050
76	S	A	-0.5095
77	S	A	-0.4210
78	Q	A	-0.8094
79	L	A	0.0000
80	G	A	-0.6787
81	T	A	0.0313
82	Y	A	0.0000
83	P	A	0.0000
84	Y	A	0.2432
85	Y	A	0.0000
86	T	A	-0.6719
87	P	A	-0.6071
88	T	A	-0.7482
89	G	A	-1.0060
90	E	A	-1.6857
91	P	A	-0.5590
92	V	A	0.7922
93	F	A	1.4671
94	G	A	0.1919
95	G	A	0.0000
96	L	A	0.0000
97	P	A	0.0000
98	Q	A	-1.1623
99	N	A	-1.0939
100	A	A	0.1477
101	S	A	0.6518
102	L	A	0.9676
103	I	A	2.0148
104	A	A	0.7209
105	H	A	0.0000
106	L	A	0.6391
107	A	A	-0.0939
108	R	A	-1.6037
109	T	A	0.0000
110	F	A	0.0356
111	Q	A	-1.0389
112	D	A	-0.7745
113	I	A	0.0000
114	L	A	0.4236
115	A	A	-0.0770
116	A	A	-0.4601
117	I	A	0.0000
118	P	A	-0.6112
119	A	A	-0.7295
120	P	A	-1.3670
121	D	A	-2.5256
122	F	A	0.0000
123	S	A	-1.6169
124	G	A	0.0000
125	L	A	0.0000
126	A	A	0.0000
127	V	A	0.0000
128	I	A	0.0000
129	D	A	-0.6831
130	W	A	0.0000
131	E	A	-1.8904
132	A	A	-0.9570
133	W	A	0.0000
134	R	A	-0.8798
135	P	A	0.0000
136	R	A	-0.8334
137	W	A	-0.5923
138	A	A	-0.1939
139	F	A	0.0000
140	N	A	0.0000
141	W	A	-0.7585
142	D	A	-1.7944
143	T	A	-1.0442
144	K	A	-1.2256
145	D	A	-1.2255
146	I	A	-0.8875
147	Y	A	0.0000
148	R	A	-1.5423
149	Q	A	-1.7958
150	R	A	-1.4464
151	S	A	0.0000
152	R	A	-2.1977
153	A	A	-1.2828
154	L	A	-0.8928
155	V	A	0.0000
156	Q	A	-1.5868
157	A	A	-1.0625
158	Q	A	-1.5682
159	H	A	-1.5291
160	P	A	-1.5782
161	D	A	-2.0882
162	W	A	-1.1724
163	P	A	-1.0196
164	A	A	-1.0879
165	P	A	-1.1634
166	Q	A	-1.3760
167	V	A	0.0000
168	E	A	-2.7007
169	A	A	-1.7232
170	V	A	-1.5405
171	A	A	0.0000
172	Q	A	-2.3339
173	D	A	-2.6428
174	Q	A	-2.3796
175	F	A	0.0000
176	Q	A	-1.7789
177	G	A	-1.8012
178	A	A	-1.4267
179	A	A	0.0000
180	R	A	-1.7966
181	A	A	-0.8065
182	W	A	0.0000
183	M	A	0.0000
184	A	A	-0.7641
185	G	A	-0.5769
186	T	A	0.0000
187	L	A	0.0000
188	Q	A	-1.0700
189	L	A	-0.1208
190	G	A	0.0000
191	R	A	-1.0373
192	A	A	-0.3839
193	L	A	-0.2559
194	R	A	0.0000
195	P	A	-1.7372
196	R	A	-2.6509
197	G	A	0.0000
198	L	A	0.0000
199	W	A	0.0000
200	G	A	0.0000
201	F	A	0.0000
202	Y	A	-0.2894
203	G	A	-0.4001
204	F	A	0.0000
205	P	A	0.0000
206	D	A	-0.3507
207	C	A	0.0000
208	Y	A	0.0000
209	N	A	0.0000
210	Y	A	0.0972
211	D	A	-1.3119
212	F	A	0.0000
213	L	A	1.0481
214	S	A	-0.2376
215	P	A	-0.7326
216	N	A	-1.3749
217	Y	A	-0.8588
218	T	A	-1.0040
219	G	A	0.0000
220	Q	A	-1.5042
221	C	A	0.0000
222	P	A	-0.9013
223	S	A	-0.7285
224	G	A	-0.8485
225	I	A	0.0000
226	R	A	-1.8775
227	A	A	-1.4627
228	Q	A	-1.5577
229	N	A	0.0000
230	D	A	-2.5553
231	Q	A	-2.0884
232	L	A	0.0000
233	G	A	-1.0574
234	W	A	-0.6529
235	L	A	0.0000
236	W	A	0.0000
237	G	A	-0.6606
238	Q	A	-0.5743
239	S	A	0.0000
240	R	A	-0.9222
241	A	A	0.0000
242	L	A	0.0000
243	Y	A	0.0000
244	P	A	0.0000
245	S	A	-0.0207
246	I	A	0.0000
247	Y	A	0.0320
248	M	A	0.0000
249	P	A	0.3218
250	A	A	0.1224
251	V	A	1.5152
252	L	A	0.0000
253	E	A	-0.9982
254	G	A	-0.8803
255	T	A	-0.6387
256	G	A	-0.9448
257	K	A	-0.6261
258	S	A	0.0000
259	Q	A	-0.9312
260	M	A	-0.5549
261	Y	A	0.0000
262	V	A	0.0000
263	Q	A	-0.7373
264	H	A	-0.6608
265	R	A	0.0000
266	V	A	0.0000
267	A	A	-0.3453
268	E	A	0.0000
269	A	A	0.0000
270	F	A	0.2854
271	R	A	-0.2129
272	V	A	0.0000
273	A	A	0.0000
274	V	A	1.3443
275	A	A	0.2941
276	A	A	-0.2333
277	G	A	-0.3784
278	D	A	0.0000
279	P	A	-0.1918
280	N	A	-0.4580
281	L	A	0.0000
282	P	A	0.0000
283	V	A	0.0000
284	L	A	0.0000
285	P	A	0.0000
286	Y	A	0.0000
287	V	A	0.0000
288	Q	A	0.0000
289	I	A	0.0000
290	F	A	0.0000
291	Y	A	0.0000
292	D	A	-0.5472
293	T	A	-0.8369
294	T	A	-1.1487
295	N	A	-1.7101
296	H	A	-1.4782
297	F	A	-0.3034
298	L	A	0.0000
299	P	A	-0.3368
300	L	A	0.4125
301	D	A	-1.3683
302	E	A	0.0000
303	L	A	0.0000
304	E	A	-0.8591
305	H	A	-1.0881
306	S	A	0.0000
307	L	A	0.0000
308	G	A	0.0000
309	E	A	0.0000
310	S	A	0.0000
311	A	A	0.0000
312	A	A	0.0000
313	Q	A	-0.3561
314	G	A	0.0000
315	A	A	0.0000
316	A	A	0.0000
317	G	A	0.0000
318	V	A	0.0000
319	V	A	0.0000
320	L	A	0.0000
321	W	A	0.3042
322	V	A	0.0000
323	S	A	0.0000
324	W	A	-0.6417
325	E	A	-2.1903
326	N	A	0.0000
327	T	A	0.0000
328	R	A	-2.8921
329	T	A	-2.5553
330	K	A	-2.7987
331	E	A	-2.9109
332	S	A	-2.3421
333	C	A	0.0000
334	Q	A	-2.4525
335	A	A	-1.8439
336	I	A	0.0000
337	K	A	-2.6100
338	E	A	-2.6490
339	Y	A	-1.3267
340	M	A	0.0000
341	D	A	-1.8601
342	T	A	-0.8664
343	T	A	-0.2114
344	L	A	0.0000
345	G	A	0.0000
346	P	A	-0.0984
347	F	A	0.0000
348	I	A	0.0000
349	L	A	0.3784
350	N	A	0.0271
351	V	A	0.0000
352	T	A	0.0000
353	S	A	0.0556
354	G	A	0.0000
355	A	A	0.0000
356	L	A	-0.4596
357	L	A	-0.1981
358	C	A	0.0000
359	S	A	0.0000
360	Q	A	-1.3542
361	A	A	-0.3073
362	L	A	-0.5826
363	C	A	0.0000
364	S	A	-1.3187
365	G	A	-1.3338
366	H	A	-1.6001
367	G	A	0.0000
368	R	A	-0.6628
369	C	A	0.0000
370	V	A	-0.4470
371	R	A	0.0000
372	R	A	-1.0454
373	T	A	-0.9515
374	S	A	-0.7506
375	H	A	-1.1480
376	P	A	-1.4858
377	K	A	-2.0570
378	A	A	-0.9960
379	L	A	-0.2984
380	L	A	0.0000
381	L	A	0.1545
382	L	A	0.0000
383	N	A	-0.8748
384	P	A	-0.5386
385	A	A	-0.3520
386	S	A	-0.6897
387	F	A	0.0000
388	S	A	-0.9080
389	I	A	-0.2958
390	Q	A	-0.7681
391	L	A	-0.0545
392	T	A	-0.3037
393	P	A	-0.6499
394	G	A	-0.7936
395	G	A	-0.8284
396	G	A	-0.6518
397	P	A	-0.4245
398	L	A	-0.2533
399	S	A	-0.2302
400	L	A	-0.4591
401	R	A	-1.8881
402	G	A	-1.1420
403	A	A	-0.2247
404	L	A	0.1138
405	S	A	-0.1796
406	L	A	0.3412
407	E	A	-1.6509
408	D	A	-1.1994
409	Q	A	-0.7123
410	A	A	-0.8064
411	Q	A	-1.2615
412	M	A	0.0000
413	A	A	-0.3854
414	V	A	0.2984
415	E	A	-0.6639
416	F	A	0.0000
417	K	A	-0.9841
418	C	A	-0.6735
419	R	A	-0.7970
420	C	A	-0.8836
421	Y	A	0.0000
422	P	A	-0.2385
423	G	A	-0.2926
424	W	A	-1.5189
425	Q	A	-1.7217
426	A	A	-1.1289
427	P	A	-0.7627
428	W	A	-0.7833
429	C	A	0.0000
430	E	A	-3.1002
431	R	A	-3.5050
432	K	A	-2.7243
433	S	A	-0.8819
434	M	A	0.9118
435	W	A	1.4198
436	T	A	0.4357