| Chain sequence(s) |
A: EFTQSVSRLQSIVAGLKNAPSDQLINIFESCVRNPVENIMKILKGIGETFCQHYTQSTDEQPGSHIDFAVNRLKLAEILYYKILETVMVQETRRLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFPNRPKRTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEERTFQEIMKSYRNQPQANSHVYRSVLLKERGDLIKFYNTIYVGRVKSFALKYPLSPFP B: DLYCYEQLN |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 389 | E | A | -1.0569 | |
| 390 | F | A | 0.5354 | |
| 391 | T | A | -0.2751 | |
| 392 | Q | A | -1.4766 | |
| 393 | S | A | -1.0912 | |
| 394 | V | A | 0.0000 | |
| 395 | S | A | -0.9235 | |
| 396 | R | A | -1.4023 | |
| 397 | L | A | 0.0000 | |
| 398 | Q | A | -0.8855 | |
| 399 | S | A | -0.8794 | |
| 400 | I | A | 0.0000 | |
| 401 | V | A | -0.4917 | |
| 402 | A | A | -0.3768 | |
| 403 | G | A | -0.4363 | |
| 404 | L | A | -0.4122 | |
| 405 | K | A | -1.9757 | |
| 406 | N | A | -1.8171 | |
| 407 | A | A | -1.1205 | |
| 408 | P | A | 0.0000 | |
| 409 | S | A | -1.6337 | |
| 410 | D | A | -2.3240 | |
| 411 | Q | A | -1.9082 | |
| 412 | L | A | 0.0000 | |
| 413 | I | A | -1.3607 | |
| 414 | N | A | -2.3934 | |
| 415 | I | A | 0.0000 | |
| 416 | F | A | 0.0000 | |
| 417 | E | A | -2.2440 | |
| 418 | S | A | -1.4526 | |
| 419 | C | A | 0.0000 | |
| 420 | V | A | 0.4355 | |
| 421 | R | A | -1.4413 | |
| 422 | N | A | -1.8730 | |
| 423 | P | A | 0.0000 | |
| 424 | V | A | -1.4550 | |
| 425 | E | A | -2.2617 | |
| 426 | N | A | -2.2520 | |
| 427 | I | A | 0.0000 | |
| 428 | M | A | -1.6138 | |
| 429 | K | A | -2.7252 | |
| 430 | I | A | -1.9803 | |
| 431 | L | A | 0.0000 | |
| 432 | K | A | -2.8331 | |
| 433 | G | A | -2.1138 | |
| 434 | I | A | 0.0000 | |
| 435 | G | A | 0.0000 | |
| 436 | E | A | -2.5610 | |
| 437 | T | A | -1.8369 | |
| 438 | F | A | 0.0000 | |
| 439 | C | A | -1.0558 | |
| 440 | Q | A | -2.0841 | |
| 441 | H | A | -1.7866 | |
| 442 | Y | A | 0.0000 | |
| 443 | T | A | -1.2523 | |
| 444 | Q | A | -2.1537 | |
| 445 | S | A | -2.1239 | |
| 446 | T | A | -2.0887 | |
| 447 | D | A | -2.9954 | |
| 448 | E | A | -2.8365 | |
| 449 | Q | A | 0.0000 | |
| 450 | P | A | -1.6036 | |
| 451 | G | A | -1.6910 | |
| 452 | S | A | -0.6543 | |
| 453 | H | A | -0.5012 | |
| 454 | I | A | 0.2395 | |
| 455 | D | A | -0.4677 | |
| 456 | F | A | 1.0462 | |
| 457 | A | A | 0.0000 | |
| 458 | V | A | 0.5009 | |
| 459 | N | A | -0.3316 | |
| 460 | R | A | -0.0622 | |
| 461 | L | A | -0.4442 | |
| 462 | K | A | -1.1021 | |
| 463 | L | A | -0.7560 | |
| 464 | A | A | 0.0000 | |
| 465 | E | A | -1.1241 | |
| 466 | I | A | -0.9496 | |
| 467 | L | A | 0.0000 | |
| 468 | Y | A | 0.0000 | |
| 469 | Y | A | 0.0000 | |
| 470 | K | A | -0.7544 | |
| 471 | I | A | 0.0000 | |
| 472 | L | A | 0.0000 | |
| 473 | E | A | -0.8618 | |
| 474 | T | A | -0.6625 | |
| 475 | V | A | -0.5379 | |
| 476 | M | A | 0.0000 | |
| 477 | V | A | -0.4557 | |
| 478 | Q | A | -1.1615 | |
| 479 | E | A | -1.1095 | |
| 480 | T | A | -0.8425 | |
| 481 | R | A | -1.3457 | |
| 482 | R | A | -1.1754 | |
| 483 | L | A | 0.0921 | |
| 484 | H | A | -0.9837 | |
| 485 | G | A | -0.9188 | |
| 486 | M | A | -0.6417 | |
| 487 | D | A | -0.5307 | |
| 488 | M | A | 0.0000 | |
| 489 | S | A | 0.0000 | |
| 490 | V | A | 1.0005 | |
| 491 | L | A | 0.2670 | |
| 492 | L | A | 0.0000 | |
| 493 | E | A | -1.2046 | |
| 494 | Q | A | -1.1825 | |
| 495 | D | A | -1.6706 | |
| 496 | I | A | -0.3271 | |
| 497 | F | A | -0.2990 | |
| 498 | H | A | 0.0000 | |
| 499 | R | A | -0.6691 | |
| 500 | S | A | 0.0000 | |
| 501 | L | A | 0.0000 | |
| 502 | M | A | 0.0000 | |
| 503 | A | A | 0.0000 | |
| 504 | C | A | 0.0000 | |
| 505 | C | A | 0.0000 | |
| 506 | L | A | 0.0000 | |
| 507 | E | A | 0.0000 | |
| 508 | I | A | 0.0000 | |
| 509 | V | A | 0.0000 | |
| 510 | L | A | 0.0000 | |
| 511 | F | A | 0.3470 | |
| 512 | A | A | 0.0000 | |
| 513 | Y | A | 0.4694 | |
| 514 | S | A | 0.0806 | |
| 515 | S | A | 0.0127 | |
| 516 | P | A | -0.2332 | |
| 517 | R | A | 0.0000 | |
| 518 | T | A | -0.0651 | |
| 519 | F | A | 0.0000 | |
| 520 | P | A | -0.5129 | |
| 521 | W | A | -0.6643 | |
| 522 | I | A | 0.0000 | |
| 523 | I | A | 0.0000 | |
| 524 | E | A | -2.2448 | |
| 525 | V | A | -1.3188 | |
| 526 | L | A | 0.0000 | |
| 527 | N | A | -2.0383 | |
| 528 | L | A | 0.0000 | |
| 529 | Q | A | -1.1668 | |
| 530 | P | A | -0.7515 | |
| 531 | F | A | 0.0000 | |
| 532 | Y | A | 0.0233 | |
| 533 | F | A | 0.0000 | |
| 534 | Y | A | 0.0000 | |
| 535 | K | A | -0.8970 | |
| 536 | V | A | 0.0000 | |
| 537 | I | A | 0.0000 | |
| 538 | E | A | -1.8223 | |
| 539 | V | A | -0.8890 | |
| 540 | V | A | 0.0000 | |
| 541 | I | A | -1.3609 | |
| 542 | R | A | -2.1931 | |
| 543 | S | A | -1.5547 | |
| 544 | E | A | 0.0000 | |
| 545 | E | A | -2.3650 | |
| 546 | G | A | -1.3794 | |
| 547 | L | A | 0.0000 | |
| 548 | S | A | -2.2479 | |
| 549 | R | A | -3.1701 | |
| 550 | D | A | -3.0867 | |
| 551 | M | A | 0.0000 | |
| 552 | V | A | -2.3224 | |
| 553 | K | A | -2.9032 | |
| 554 | H | A | -1.7788 | |
| 555 | L | A | 0.0000 | |
| 556 | N | A | -1.8841 | |
| 557 | S | A | -1.3427 | |
| 558 | I | A | 0.0000 | |
| 559 | E | A | -1.4479 | |
| 560 | E | A | -1.1667 | |
| 561 | Q | A | -1.1209 | |
| 562 | I | A | 0.0000 | |
| 563 | L | A | 0.0000 | |
| 564 | E | A | 0.0000 | |
| 565 | S | A | -0.5255 | |
| 566 | L | A | -0.6471 | |
| 567 | A | A | 0.0000 | |
| 568 | W | A | 0.0000 | |
| 569 | S | A | -1.6209 | |
| 570 | H | A | -2.4371 | |
| 571 | D | A | -2.7226 | |
| 572 | S | A | 0.0000 | |
| 573 | A | A | 0.0000 | |
| 574 | L | A | 0.0000 | |
| 575 | W | A | -1.9027 | |
| 576 | E | A | -2.4488 | |
| 577 | A | A | 0.0000 | |
| 578 | L | A | 0.0000 | |
| 579 | Q | A | -2.1426 | |
| 580 | V | A | -1.0963 | |
| 581 | S | A | -1.8052 | |
| 582 | A | A | -1.4860 | |
| 583 | N | A | -2.6554 | |
| 584 | K | A | -2.5247 | |
| 585 | V | A | 0.0000 | |
| 586 | P | A | -1.4085 | |
| 587 | T | A | -1.4994 | |
| 588 | C | A | 0.0000 | |
| 589 | E | A | -2.2883 | |
| 590 | E | A | -2.3089 | |
| 591 | V | A | 0.0000 | |
| 592 | I | A | -0.2968 | |
| 593 | F | A | 0.6920 | |
| 594 | P | A | 0.1501 | |
| 780 | N | A | -2.4144 | |
| 781 | R | A | -3.1349 | |
| 782 | P | A | -2.1806 | |
| 783 | K | A | -2.6731 | |
| 784 | R | A | -1.9931 | |
| 785 | T | A | -1.4326 | |
| 786 | G | A | -1.1809 | |
| 787 | S | A | -0.7911 | |
| 788 | L | A | 0.0000 | |
| 789 | A | A | -0.5703 | |
| 790 | L | A | -0.2124 | |
| 791 | F | A | 0.0000 | |
| 792 | Y | A | 0.0000 | |
| 793 | R | A | -0.9922 | |
| 794 | K | A | -0.7456 | |
| 795 | V | A | 0.0000 | |
| 796 | Y | A | 0.0000 | |
| 797 | H | A | -0.4378 | |
| 798 | L | A | 0.0283 | |
| 799 | A | A | 0.0000 | |
| 800 | S | A | 0.0000 | |
| 801 | V | A | 0.6369 | |
| 802 | R | A | 0.0000 | |
| 803 | L | A | 0.0000 | |
| 804 | R | A | -1.4508 | |
| 805 | D | A | -1.0169 | |
| 806 | L | A | 0.0000 | |
| 807 | C | A | 0.0000 | |
| 808 | L | A | -0.6725 | |
| 809 | K | A | -2.1592 | |
| 810 | L | A | 0.0000 | |
| 811 | D | A | -2.0053 | |
| 812 | V | A | -1.6926 | |
| 813 | S | A | -1.7478 | |
| 814 | N | A | -2.8433 | |
| 815 | E | A | -2.9919 | |
| 816 | L | A | 0.0000 | |
| 817 | R | A | -2.2103 | |
| 818 | R | A | -2.2958 | |
| 819 | K | A | -1.5507 | |
| 820 | I | A | 0.0000 | |
| 821 | W | A | 0.0000 | |
| 822 | T | A | 0.0000 | |
| 823 | C | A | 0.0000 | |
| 824 | F | A | 0.0000 | |
| 825 | E | A | 0.0000 | |
| 826 | F | A | 0.0647 | |
| 827 | T | A | 0.0000 | |
| 828 | L | A | 0.0000 | |
| 829 | V | A | -0.8298 | |
| 830 | H | A | -1.4561 | |
| 831 | C | A | 0.0000 | |
| 832 | P | A | -1.2529 | |
| 833 | D | A | -1.7288 | |
| 834 | L | A | 0.0000 | |
| 835 | M | A | 0.0000 | |
| 836 | K | A | -2.0131 | |
| 837 | D | A | -1.7854 | |
| 838 | R | A | -0.9455 | |
| 839 | H | A | 0.0000 | |
| 840 | L | A | 0.0000 | |
| 841 | D | A | 0.0000 | |
| 842 | Q | A | 0.0000 | |
| 843 | L | A | 0.0000 | |
| 844 | L | A | 0.0000 | |
| 845 | L | A | 0.0000 | |
| 846 | C | A | 0.0000 | |
| 847 | A | A | 0.0000 | |
| 848 | F | A | 0.0000 | |
| 849 | Y | A | 0.0000 | |
| 850 | I | A | 0.0000 | |
| 851 | M | A | 0.0000 | |
| 852 | A | A | 0.0000 | |
| 853 | K | A | -1.4118 | |
| 854 | V | A | 0.0000 | |
| 855 | T | A | -1.1020 | |
| 856 | K | A | -2.4644 | |
| 857 | E | A | -1.9740 | |
| 858 | E | A | -2.2086 | |
| 859 | R | A | -1.4745 | |
| 860 | T | A | -0.7655 | |
| 861 | F | A | 0.0000 | |
| 862 | Q | A | -1.6619 | |
| 863 | E | A | -1.7600 | |
| 864 | I | A | 0.0000 | |
| 865 | M | A | 0.0000 | |
| 866 | K | A | -2.9295 | |
| 867 | S | A | -2.2082 | |
| 868 | Y | A | 0.0000 | |
| 869 | R | A | -3.4087 | |
| 870 | N | A | -2.9645 | |
| 871 | Q | A | 0.0000 | |
| 872 | P | A | -1.1627 | |
| 873 | Q | A | -1.2717 | |
| 874 | A | A | -1.8745 | |
| 875 | N | A | -2.5572 | |
| 876 | S | A | -2.2126 | |
| 877 | H | A | -2.2368 | |
| 878 | V | A | 0.0000 | |
| 879 | Y | A | -1.7736 | |
| 880 | R | A | -3.0662 | |
| 881 | S | A | -2.1720 | |
| 882 | V | A | 0.0000 | |
| 883 | L | A | -1.7822 | |
| 884 | L | A | 0.0000 | |
| 885 | K | A | -2.5001 | |
| 926 | E | A | -3.1804 | |
| 927 | R | A | -3.4787 | |
| 928 | G | A | -2.5134 | |
| 929 | D | A | -2.2791 | |
| 930 | L | A | 0.0000 | |
| 931 | I | A | 0.0000 | |
| 932 | K | A | -1.6692 | |
| 933 | F | A | 0.0000 | |
| 934 | Y | A | 0.0000 | |
| 935 | N | A | -0.1441 | |
| 936 | T | A | -0.4024 | |
| 937 | I | A | -0.5259 | |
| 938 | Y | A | 0.0000 | |
| 939 | V | A | 0.0000 | |
| 940 | G | A | -0.9847 | |
| 941 | R | A | -1.3332 | |
| 942 | V | A | 0.0000 | |
| 943 | K | A | -0.8898 | |
| 944 | S | A | -0.5460 | |
| 945 | F | A | -0.1705 | |
| 946 | A | A | 0.0000 | |
| 947 | L | A | 0.5515 | |
| 948 | K | A | -0.8761 | |
| 949 | Y | A | -0.0821 | |
| 962 | P | A | 0.0066 | |
| 963 | L | A | -0.0618 | |
| 964 | S | A | -0.3957 | |
| 965 | P | A | -0.5045 | |
| 966 | F | A | -0.7027 | |
| 967 | P | A | -0.4792 | |
| 21 | D | B | -1.3374 | |
| 22 | L | B | 0.0000 | |
| 23 | Y | B | 0.4204 | |
| 24 | C | B | 0.0000 | |
| 25 | Y | B | 0.8029 | |
| 26 | E | B | -0.3429 | |
| 27 | Q | B | -1.3659 | |
| 28 | L | B | -1.3320 | |
| 29 | N | B | -1.6763 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine