Project name: 20190218h8C12woDyn

Chain sequence(s)	H: QVQLQESGPGLVKPSETLSLTCTVSGFSLNSFGWSWIRQPPGKGLEWIGYIWAGKNTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARAGYGNSLDYWGQGTTLTVSSDIVMTQSPDSLAVSLGERATINCKSSQSLLNSGNQRNYLTWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQNNYYFPLTFGTGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.2447
• Maximal score value: 1.8098
• Average score: -0.259
• Total score value: -59.5697

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.1983
2	V	H	0.0000
3	Q	H	-1.1983
4	L	H	0.0000
5	Q	H	-0.7117
6	E	H	0.0000
7	S	H	-0.2528
8	G	H	-0.5247
9	P	H	-0.3780
10	G	H	-0.1353
11	L	H	1.4788
12	V	H	0.0000
13	K	H	-1.7282
14	P	H	-0.5037
15	S	H	-0.4181
16	E	H	-0.8285
17	T	H	-0.2128
18	L	H	0.0000
19	S	H	-0.2923
20	L	H	0.0000
21	T	H	-0.0231
22	C	H	0.0000
23	T	H	-0.0481
24	V	H	0.0000
25	S	H	-0.2830
26	G	H	-0.4513
27	F	H	0.1771
28	S	H	-0.0290
29	L	H	0.0000
30	N	H	-1.0599
31	S	H	-0.2236
32	F	H	0.7440
33	G	H	0.0000
34	W	H	0.0000
35	S	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	0.0000
39	Q	H	-0.1313
40	P	H	-0.1010
41	P	H	-0.3468
42	G	H	-0.8280
43	K	H	-1.7979
44	G	H	-0.3865
45	L	H	0.0000
46	E	H	-0.5548
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	Y	H	0.1554
51	I	H	0.0000
52	W	H	0.5117
53	A	H	-0.0589
54	G	H	-0.7676
55	K	H	-2.0205
56	N	H	-1.5913
57	T	H	-0.3597
58	N	H	-0.5200
59	Y	H	0.1537
60	N	H	-0.1070
61	P	H	-0.2549
62	S	H	-0.2482
63	L	H	0.0000
64	K	H	-1.7391
65	S	H	-0.5939
66	R	H	-0.4194
67	V	H	0.0000
68	T	H	-0.0263
69	I	H	0.0000
70	S	H	-0.1050
71	V	H	0.1232
72	D	H	-0.5165
73	T	H	-0.2345
74	S	H	-0.5367
75	K	H	-1.7874
76	N	H	-0.6229
77	Q	H	-0.2736
78	F	H	0.0000
79	S	H	-0.0594
80	L	H	0.0000
81	K	H	-0.8909
82	L	H	0.0000
83	S	H	-0.1453
84	S	H	-0.2586
85	V	H	0.0000
86	T	H	-0.0421
87	A	H	0.0593
88	A	H	0.0691
89	D	H	0.0000
90	T	H	-0.0186
91	A	H	0.0000
92	V	H	0.4334
93	Y	H	0.0000
94	Y	H	0.0000
95	C	H	0.0000
96	A	H	0.0000
97	R	H	0.0000
98	A	H	0.0000
99	G	H	0.1672
100	Y	H	1.2183
101	G	H	-0.2291
102	N	H	0.0000
103	S	H	-0.0295
104	L	H	0.0000
105	D	H	-1.4202
106	Y	H	0.1220
107	W	H	0.2328
108	G	H	0.0000
109	Q	H	-1.1983
110	G	H	0.0000
111	T	H	-0.0239
112	T	H	-0.0105
113	L	H	0.0000
114	T	H	-0.0312
115	V	H	0.0000
116	S	H	-0.1535
117	S	H	-0.2341
118	D	H	-1.7522
119	I	H	0.1977
120	V	H	1.8098
121	M	H	0.0000
122	T	H	-0.0750
123	Q	H	-0.1599
124	S	H	-0.1784
125	P	H	-0.4504
126	D	H	-1.8445
127	S	H	-0.6070
128	L	H	0.2872
129	A	H	-0.2964
130	V	H	0.0000
131	S	H	-0.0006
132	L	H	1.3693
133	G	H	-0.5344
134	E	H	-2.2447
135	R	H	-2.1932
136	A	H	0.0000
137	T	H	-0.0437
138	I	H	0.0000
139	N	H	-0.4977
140	C	H	0.0000
141	K	H	-1.0324
142	S	H	0.0000
143	S	H	-0.3927
144	Q	H	-1.2542
145	S	H	-0.3632
146	L	H	0.0000
147	L	H	0.3746
148	N	H	-0.1824
149	S	H	-0.4781
150	G	H	-0.7014
151	N	H	-1.3889
152	Q	H	-1.5948
153	R	H	-1.1736
154	N	H	-0.2031
155	Y	H	0.1629
156	L	H	0.0000
157	T	H	0.0000
158	W	H	0.0000
159	Y	H	0.0000
160	Q	H	0.0000
161	Q	H	0.0000
162	K	H	-0.7808
163	P	H	-0.4736
164	G	H	-0.7263
165	Q	H	-1.2589
166	P	H	-0.2772
167	P	H	0.0000
168	K	H	-1.5877
169	L	H	-0.1097
170	L	H	0.0000
171	I	H	0.0000
172	Y	H	0.2407
173	W	H	0.4144
174	A	H	0.0000
175	S	H	-0.2173
176	T	H	-0.1959
177	R	H	-0.8307
178	E	H	-0.7209
179	S	H	-0.3985
180	G	H	-0.5053
181	V	H	0.0000
182	P	H	-0.4182
183	D	H	-1.8615
184	R	H	-0.6407
185	F	H	0.0000
186	S	H	-0.0901
187	G	H	0.0000
188	S	H	-0.2715
189	G	H	-0.3959
190	S	H	-0.2860
191	G	H	-0.1384
192	T	H	-0.3767
193	D	H	-1.8883
194	F	H	0.0000
195	T	H	-0.0799
196	L	H	0.0000
197	T	H	-0.0238
198	I	H	0.0000
199	S	H	-0.3814
200	S	H	-0.5578
201	L	H	0.0000
202	Q	H	-0.4658
203	A	H	-0.3619
204	E	H	-1.8092
205	D	H	0.0000
206	V	H	0.4998
207	A	H	0.0000
208	V	H	0.0471
209	Y	H	0.0000
210	Y	H	0.0000
211	C	H	0.0000
212	Q	H	0.0000
213	N	H	0.0000
214	N	H	-0.0895
215	Y	H	0.4361
216	Y	H	1.4977
217	F	H	1.0003
218	P	H	0.1617
219	L	H	0.0000
220	T	H	0.0230
221	F	H	0.1977
222	G	H	0.0000
223	T	H	-0.0876
224	G	H	-0.0691
225	T	H	0.0000
226	K	H	-1.0641
227	L	H	0.0000
228	E	H	-1.5641
229	I	H	0.4011
230	K	H	-1.5140