Project name: c032f92f12fc27

Chain sequence(s)	A: VEESGGRLVTPGTPLTLTCTVSGFSLSNYAMSWVRQAPGKGLEWIGIVSISAGTYYASWAKGRFTISKTSTTVVLRVTSPTTEDTATYFCATGGYTGNVWGPGTLVTVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVGASGYSSSAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLACMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.146
• Maximal score value: 2.6259
• Average score: -0.5512
• Total score value: -241.4202

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	V	A	-0.9411
4	E	A	-2.1505
5	E	A	-1.5735
6	S	A	-1.3049
7	G	A	-1.4154
8	G	A	-1.0231
9	R	A	-0.1100
10	L	A	1.8141
11	V	A	1.3081
12	T	A	0.6645
13	P	A	-0.5305
14	G	A	-0.7198
15	T	A	-0.2653
16	P	A	-0.6897
17	L	A	0.0000
18	T	A	-1.1397
19	L	A	0.0000
20	T	A	-0.5284
21	C	A	0.0000
22	T	A	-0.6547
23	V	A	0.0000
24	S	A	-0.5157
25	G	A	-0.3243
26	F	A	-0.1149
27	S	A	-0.6783
28	L	A	0.0000
29	S	A	-1.1153
30	N	A	-1.1034
31	Y	A	-0.0691
32	A	A	0.3394
33	M	A	0.0000
34	S	A	1.0073
35	W	A	0.0000
36	V	A	0.0000
37	R	A	-0.5437
38	Q	A	-1.1483
39	A	A	0.0000
40	P	A	-1.3493
41	G	A	-1.4798
42	K	A	-2.2384
43	G	A	-1.0690
44	L	A	0.2427
45	E	A	-0.2202
46	W	A	0.8958
47	I	A	0.0000
48	G	A	0.8775
49	I	A	1.4569
50	V	A	0.0000
51	S	A	0.2967
52	I	A	0.0000
53	S	A	-0.8317
54	A	A	-0.1585
55	G	A	-0.1545
56	T	A	0.7767
57	Y	A	1.7207
58	Y	A	2.0759
59	A	A	0.9654
60	S	A	0.3853
61	W	A	0.2791
62	A	A	-0.6674
63	K	A	-1.3787
64	G	A	0.0000
65	R	A	-2.2969
66	F	A	0.0000
67	T	A	-0.5729
68	I	A	-0.2605
69	S	A	-0.8728
70	K	A	-1.8722
71	T	A	-0.9917
72	S	A	-0.7658
73	T	A	-0.6879
74	T	A	-0.6085
75	V	A	0.0000
76	V	A	-0.4146
77	L	A	0.0000
78	R	A	-2.4062
79	V	A	0.0000
80	T	A	-1.1293
81	S	A	-0.6894
82	P	A	0.0000
83	T	A	-0.9951
84	T	A	-1.1216
85	E	A	-2.0177
86	D	A	-1.2864
87	T	A	-0.7477
88	A	A	0.0000
89	T	A	-0.7666
90	Y	A	0.0000
91	F	A	-0.5679
92	C	A	0.0000
93	A	A	0.0000
94	T	A	0.0000
95	G	A	0.8699
96	G	A	0.9182
97	Y	A	1.3901
98	T	A	0.7385
99	G	A	0.3329
100	N	A	-0.2264
101	V	A	1.5544
102	W	A	1.4985
103	G	A	0.3699
104	P	A	0.0894
105	G	A	0.3528
106	T	A	0.8812
107	L	A	1.3793
108	V	A	2.0231
109	T	A	1.1323
110	V	A	1.0596
111	S	A	0.5081
112	S	A	-0.1382
113	G	A	-0.7127
114	Q	A	0.0000
115	P	A	-1.3212
116	K	A	-1.9816
117	A	A	0.0000
118	P	A	-0.8478
119	S	A	0.0349
120	V	A	1.5898
121	F	A	2.5124
122	P	A	0.6954
123	L	A	0.9108
124	A	A	0.0532
125	P	A	0.0000
126	C	A	0.7610
127	C	A	0.0634
128	G	A	0.0109
129	D	A	-0.3037
130	T	A	-0.0650
131	P	A	-0.1550
132	S	A	0.2341
133	S	A	0.2600
134	T	A	0.7139
135	V	A	1.8545
136	T	A	1.1321
137	L	A	0.0000
138	G	A	0.0000
139	C	A	0.0981
140	L	A	0.7084
141	V	A	0.4806
142	K	A	-0.3486
143	G	A	-0.2893
144	Y	A	0.0000
145	L	A	0.0000
146	P	A	0.0000
147	E	A	-0.2737
148	P	A	-0.5048
149	V	A	-0.1543
150	T	A	-0.1446
151	V	A	-0.0673
152	T	A	-0.2525
153	W	A	0.0000
154	N	A	-0.7231
155	S	A	-0.6796
156	G	A	-0.5507
157	T	A	-0.4509
158	L	A	-0.2472
159	T	A	-0.9200
160	N	A	-1.4799
161	G	A	-0.8712
162	V	A	-0.7189
163	R	A	-1.3124
164	T	A	0.1496
165	F	A	1.5427
166	P	A	0.7801
167	S	A	0.4858
168	V	A	0.7465
169	R	A	-1.3787
170	Q	A	-1.6740
171	S	A	-1.0451
172	S	A	-0.9813
173	G	A	-0.6900
174	L	A	-0.3902
175	Y	A	-0.5912
176	S	A	-0.0517
177	L	A	0.2398
178	S	A	0.0000
179	S	A	0.3103
180	V	A	1.5067
181	V	A	2.6259
182	S	A	2.0863
183	V	A	2.2271
184	T	A	0.9117
185	S	A	0.6851
186	S	A	-0.2076
187	S	A	-0.6100
188	Q	A	-1.1584
189	P	A	-0.9611
190	V	A	0.0000
191	T	A	-0.6621
192	C	A	0.0000
193	N	A	-0.9024
194	V	A	0.0000
195	A	A	-0.8375
196	H	A	0.0000
197	P	A	-1.0946
198	A	A	-0.2702
199	T	A	-0.8379
200	N	A	-1.7037
201	T	A	-1.0461
202	K	A	-1.8167
203	V	A	-0.4395
204	D	A	-1.4945
205	K	A	-0.9269
206	T	A	-0.8181
207	V	A	0.0000
208	G	A	-0.6426
209	A	A	-0.1543
210	S	A	0.1272
211	G	A	0.1434
212	Y	A	1.0089
213	S	A	0.1379
214	S	A	0.0817
215	S	A	-0.2848
216	A	A	-0.3172
217	P	A	-0.3456
218	S	A	-0.2240
219	T	A	-0.0981
220	C	A	0.1119
221	S	A	-0.7821
222	K	A	-1.7680
223	P	A	-0.8914
224	T	A	-0.4973
225	C	A	-0.4195
226	P	A	-0.4033
227	P	A	-0.1860
228	P	A	-0.2637
229	E	A	-0.4177
230	L	A	1.3129
231	L	A	1.5797
232	G	A	0.0081
233	G	A	-0.5470
234	P	A	0.0328
235	S	A	-0.0021
236	V	A	0.0000
237	F	A	1.6333
238	I	A	0.0000
239	F	A	0.8104
240	P	A	-0.4312
241	P	A	0.0000
242	K	A	-2.2170
243	P	A	-1.2765
244	K	A	-0.9356
245	D	A	-1.0941
246	T	A	0.0000
247	L	A	-0.0795
248	M	A	0.7582
249	I	A	1.6480
250	S	A	0.3031
251	R	A	-0.9639
252	T	A	-0.8004
253	P	A	0.0000
254	E	A	-1.3503
255	V	A	0.0000
256	T	A	0.1118
257	C	A	0.0000
258	V	A	0.0000
259	V	A	0.0000
260	V	A	-1.0792
261	D	A	-2.4635
262	V	A	0.0000
263	S	A	-2.5362
264	Q	A	-2.9679
265	D	A	-3.1460
266	D	A	-2.8688
267	P	A	-2.8382
268	E	A	-2.9673
269	V	A	-1.6952
270	Q	A	-1.7343
271	F	A	-1.0002
272	T	A	-1.0362
273	W	A	0.0000
274	Y	A	-1.9899
275	I	A	-1.8890
276	N	A	-2.8141
277	N	A	-3.0252
278	E	A	-2.9832
279	Q	A	-2.4042
280	V	A	-1.4978
281	R	A	-2.1298
282	T	A	-1.4457
283	A	A	-1.5774
284	R	A	-2.0876
285	P	A	-0.9834
286	P	A	-0.4500
287	L	A	0.2274
288	R	A	-1.6453
289	E	A	-2.5200
290	Q	A	-2.3727
291	Q	A	-1.3994
292	F	A	0.6449
293	N	A	-0.9312
294	S	A	-1.0853
295	T	A	-2.1823
296	I	A	0.0000
297	R	A	-2.3106
298	V	A	0.0000
299	V	A	-0.2359
300	S	A	0.0000
301	T	A	-0.8151
302	L	A	0.0000
303	P	A	-0.8194
304	I	A	0.0000
305	A	A	-0.9284
306	H	A	-0.9313
307	Q	A	-1.9251
308	D	A	-1.7642
309	W	A	0.0000
310	L	A	-1.3959
311	R	A	-2.7613
312	G	A	-2.2438
313	K	A	-2.2360
314	E	A	-2.2119
315	F	A	0.0000
316	K	A	-2.0767
317	C	A	0.0000
318	K	A	-1.4964
319	V	A	0.0000
320	H	A	-1.3922
321	N	A	0.0000
322	K	A	-2.4740
323	A	A	-1.3035
324	L	A	-0.3593
325	P	A	-0.6340
326	A	A	-0.5643
327	P	A	-0.7931
328	I	A	-0.7753
329	E	A	-2.0150
330	K	A	-1.1529
331	T	A	-0.8886
332	I	A	-0.2859
333	S	A	-1.1722
334	K	A	-1.3541
335	A	A	-1.2526
336	R	A	-2.5674
337	G	A	-1.8782
338	Q	A	-1.8663
339	P	A	-1.2894
340	L	A	-0.9860
341	E	A	-2.3933
342	P	A	0.0000
343	K	A	-1.9817
344	V	A	0.0000
345	Y	A	0.2738
346	T	A	0.2829
347	M	A	0.4306
348	G	A	-0.4944
349	P	A	0.0000
350	P	A	-1.5890
351	R	A	-2.7888
352	E	A	-2.8354
353	E	A	-2.0074
354	L	A	-1.5554
355	S	A	-1.3875
356	S	A	-1.3884
357	R	A	-2.0389
358	S	A	-1.2341
359	V	A	0.0000
360	S	A	-0.5006
361	L	A	0.0000
362	A	A	-0.1283
363	C	A	0.0000
364	M	A	0.4468
365	I	A	0.0000
366	N	A	-0.3194
367	G	A	-1.1140
368	F	A	0.0000
369	Y	A	-0.6009
370	P	A	0.0000
371	S	A	0.1161
372	D	A	-1.1714
373	I	A	-0.5723
374	S	A	0.0000
375	V	A	-0.2377
376	E	A	-1.2016
377	W	A	0.0000
378	E	A	-2.2163
379	K	A	-1.9042
380	N	A	-2.2051
381	G	A	-2.2867
382	K	A	-2.9775
383	A	A	-2.2864
384	E	A	-2.5947
385	D	A	-3.0914
386	N	A	-2.7798
387	Y	A	-2.4197
388	K	A	-2.5795
389	T	A	-1.1340
390	T	A	-0.4200
391	P	A	0.0618
392	A	A	0.7347
393	V	A	1.5836
394	L	A	1.2578
395	D	A	-0.6116
396	S	A	-1.2021
397	D	A	-2.0891
398	G	A	-0.9457
399	S	A	0.0000
400	Y	A	0.5889
401	F	A	0.7423
402	L	A	0.0000
403	Y	A	0.4363
404	S	A	0.0000
405	K	A	-2.1540
406	L	A	0.0000
407	S	A	-1.4174
408	V	A	0.0000
409	P	A	-1.1159
410	T	A	-1.5484
411	S	A	-1.7884
412	E	A	-1.7088
413	W	A	0.0000
414	Q	A	-2.7613
415	R	A	-2.8994
416	G	A	-1.9501
417	D	A	-1.0871
418	V	A	0.3072
419	F	A	0.0000
420	T	A	-1.0891
421	C	A	0.0000
422	S	A	0.0000
423	V	A	0.0000
424	M	A	-0.3095
425	H	A	0.0000
426	E	A	-1.0705
427	A	A	-1.3164
428	L	A	0.0000
429	H	A	-1.9284
430	N	A	-1.7810
431	H	A	-1.2976
432	Y	A	-0.3229
433	T	A	-1.1061
434	Q	A	-1.6237
435	K	A	-1.8283
436	S	A	-0.6796
437	I	A	0.0000
438	S	A	-0.8320
439	R	A	-2.0553
440	S	A	-1.1196