| Chain sequence(s) |
A: QVQLQESGPGLVKPSETLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVGISVDTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGEGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMDQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHRPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6589 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1906 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -2.1008 | |
| 6 | E | A | -1.3816 | |
| 7 | S | A | -0.8770 | |
| 8 | G | A | -0.6618 | |
| 9 | P | A | -0.6459 | |
| 10 | G | A | -0.5228 | |
| 11 | L | A | -0.4958 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.1549 | |
| 14 | P | A | -1.4476 | |
| 15 | S | A | -1.2312 | |
| 16 | E | A | -1.5752 | |
| 17 | T | A | -1.2912 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -1.0546 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.7827 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -1.1876 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3045 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1558 | |
| 28 | S | A | -0.8555 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.2072 | |
| 31 | S | A | 0.0139 | |
| 32 | G | A | 0.1250 | |
| 33 | Y | A | 0.1725 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8128 | |
| 40 | P | A | -0.9910 | |
| 41 | P | A | -1.1109 | |
| 42 | G | A | -1.4999 | |
| 43 | K | A | -2.3383 | |
| 44 | G | A | -1.4693 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6537 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | -0.0368 | |
| 53 | Y | A | 0.5842 | |
| 54 | S | A | -0.4386 | |
| 55 | G | A | -0.9455 | |
| 56 | D | A | -1.6510 | |
| 57 | T | A | -0.5896 | |
| 58 | Y | A | -0.1397 | |
| 59 | Y | A | -0.1082 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -1.2666 | |
| 62 | S | A | -1.1199 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0150 | |
| 65 | S | A | -1.2964 | |
| 66 | R | A | -1.4568 | |
| 67 | V | A | 0.0000 | |
| 68 | G | A | -0.8460 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.7048 | |
| 71 | V | A | -0.2991 | |
| 72 | D | A | -1.1913 | |
| 73 | T | A | -1.1495 | |
| 74 | S | A | -1.3402 | |
| 75 | K | A | -2.1414 | |
| 76 | N | A | -1.4584 | |
| 77 | Q | A | -1.2843 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.6260 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.9362 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -1.0949 | |
| 84 | S | A | -0.9045 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.5510 | |
| 87 | A | A | -0.2071 | |
| 88 | A | A | 0.0286 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0314 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.0112 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6544 | |
| 98 | Y | A | -0.0574 | |
| 99 | G | A | -0.0786 | |
| 100 | S | A | -0.0759 | |
| 101 | Y | A | 0.2760 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4326 | |
| 105 | Y | A | -0.8613 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | E | A | -2.5556 | |
| 109 | G | A | -1.4055 | |
| 110 | T | A | -0.7459 | |
| 111 | T | A | -0.3202 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2903 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.8334 | |
| 116 | S | A | -0.9407 | |
| 117 | A | A | -0.5494 | |
| 118 | S | A | -0.6645 | |
| 119 | T | A | -0.7513 | |
| 120 | K | A | -1.1887 | |
| 121 | G | A | -1.3197 | |
| 122 | P | A | -0.6147 | |
| 123 | S | A | -0.4736 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3407 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8951 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4474 | |
| 131 | S | A | -0.5270 | |
| 132 | R | A | -0.8887 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.9003 | |
| 135 | S | A | -1.3782 | |
| 136 | E | A | -2.0794 | |
| 137 | S | A | -1.3123 | |
| 138 | T | A | -0.9408 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2974 | |
| 147 | D | A | -0.3621 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.5157 | |
| 152 | P | A | -0.6676 | |
| 153 | V | A | -0.6082 | |
| 154 | T | A | -0.5243 | |
| 155 | V | A | -0.3232 | |
| 156 | S | A | -0.4541 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0268 | |
| 159 | S | A | -0.7679 | |
| 160 | G | A | -0.5953 | |
| 161 | A | A | -0.2865 | |
| 162 | L | A | -0.1410 | |
| 163 | T | A | -0.2502 | |
| 164 | S | A | -0.2763 | |
| 165 | G | A | -0.3956 | |
| 166 | V | A | 0.0649 | |
| 167 | H | A | -0.2465 | |
| 168 | T | A | -0.0004 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3102 | |
| 171 | A | A | 0.2971 | |
| 172 | V | A | 0.6785 | |
| 173 | L | A | 1.3839 | |
| 174 | Q | A | 0.3656 | |
| 175 | S | A | -0.0005 | |
| 176 | S | A | -0.1575 | |
| 177 | G | A | 0.1264 | |
| 178 | L | A | 0.2348 | |
| 179 | Y | A | 0.5208 | |
| 180 | S | A | 0.3014 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1899 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6409 | |
| 189 | S | A | -0.6897 | |
| 190 | S | A | -0.5503 | |
| 191 | S | A | -0.6636 | |
| 192 | L | A | -0.8239 | |
| 193 | G | A | -1.1740 | |
| 194 | T | A | -0.9002 | |
| 195 | K | A | -1.6329 | |
| 196 | T | A | -1.4990 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.7307 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.8052 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.6921 | |
| 205 | P | A | -1.6484 | |
| 206 | S | A | -1.8336 | |
| 207 | N | A | -2.5187 | |
| 208 | T | A | -2.0496 | |
| 209 | K | A | -2.6486 | |
| 210 | V | A | -2.0052 | |
| 211 | D | A | -2.9374 | |
| 212 | K | A | -2.7145 | |
| 213 | R | A | -3.1217 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6270 | |
| 216 | S | A | -1.1034 | |
| 217 | D | B | -1.8321 | |
| 218 | I | B | -0.8038 | |
| 219 | V | B | 0.4663 | |
| 220 | M | B | 0.0000 | |
| 221 | D | B | -1.6545 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.5936 | |
| 224 | P | B | -0.3494 | |
| 225 | L | B | -0.0482 | |
| 226 | S | B | -0.5073 | |
| 227 | L | B | -0.6398 | |
| 228 | S | B | -0.9876 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.6678 | |
| 231 | P | B | -2.0346 | |
| 232 | G | B | -1.9067 | |
| 233 | Q | B | -2.3101 | |
| 234 | P | B | -2.1025 | |
| 235 | A | B | -1.2572 | |
| 236 | S | B | -0.7612 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -1.0666 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.5096 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -1.0469 | |
| 243 | Q | B | -1.3731 | |
| 244 | S | B | -0.7142 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5214 | |
| 247 | H | B | -0.6037 | |
| 248 | S | B | -0.9348 | |
| 249 | N | B | -1.6460 | |
| 250 | G | B | -1.1393 | |
| 251 | N | B | -0.9764 | |
| 252 | T | B | -0.2744 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1509 | |
| 260 | K | B | -1.7687 | |
| 261 | P | B | -1.4334 | |
| 262 | G | B | -1.7117 | |
| 263 | Q | B | -2.1957 | |
| 264 | S | B | -1.6282 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.3427 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4901 | |
| 271 | K | B | -0.9043 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9374 | |
| 274 | N | B | -1.2343 | |
| 275 | R | B | -1.7379 | |
| 276 | F | B | -0.6647 | |
| 277 | S | B | -0.5829 | |
| 278 | G | B | -0.8118 | |
| 279 | V | B | -0.8928 | |
| 280 | P | B | -1.2708 | |
| 281 | D | B | -2.2252 | |
| 282 | R | B | -2.0436 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3081 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7740 | |
| 287 | G | B | -0.9603 | |
| 288 | S | B | -0.6359 | |
| 289 | G | B | -0.6052 | |
| 290 | T | B | -1.3406 | |
| 291 | D | B | -2.0781 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9771 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5596 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2786 | |
| 298 | R | B | -3.0462 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6276 | |
| 301 | A | B | -2.2760 | |
| 302 | E | B | -2.3988 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7118 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -1.5920 | |
| 315 | R | B | -2.2783 | |
| 316 | P | B | 0.0000 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | -0.3854 | |
| 319 | F | B | -0.0057 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.3257 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7451 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.6405 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5683 | |
| 329 | R | B | -1.1104 | |
| 330 | T | B | -0.2022 | |
| 331 | V | B | 0.0511 | |
| 332 | A | B | -0.2161 | |
| 333 | A | B | -0.2338 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.2264 | |
| 336 | V | B | 0.0000 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6818 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.5330 | |
| 343 | D | B | -2.9920 | |
| 344 | E | B | -2.8215 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.2031 | |
| 347 | K | B | -2.7411 | |
| 348 | S | B | -1.7641 | |
| 349 | G | B | -1.0997 | |
| 350 | T | B | -1.1200 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0910 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.8657 | |
| 363 | R | B | -3.2010 | |
| 364 | E | B | -3.2853 | |
| 365 | A | B | -2.4040 | |
| 366 | K | B | -2.5228 | |
| 367 | V | B | -1.1485 | |
| 368 | Q | B | -0.7458 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.8138 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1422 | |
| 373 | N | B | -1.6658 | |
| 374 | A | B | -0.3863 | |
| 375 | L | B | 0.6778 | |
| 376 | Q | B | -0.2224 | |
| 377 | S | B | -0.4850 | |
| 378 | G | B | -0.8926 | |
| 379 | N | B | -0.7950 | |
| 380 | S | B | -1.0527 | |
| 381 | Q | B | -1.2239 | |
| 382 | E | B | -1.4987 | |
| 383 | S | B | -0.6632 | |
| 384 | V | B | -0.7352 | |
| 385 | T | B | 0.0000 | |
| 386 | E | B | -2.3482 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2186 | |
| 389 | S | B | -2.3861 | |
| 390 | K | B | -2.6764 | |
| 391 | D | B | -1.8809 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5495 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4555 | |
| 402 | L | B | -0.8216 | |
| 403 | S | B | -1.4342 | |
| 404 | K | B | -2.2678 | |
| 405 | A | B | -2.2114 | |
| 406 | D | B | -3.0463 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.8252 | |
| 409 | K | B | -3.8727 | |
| 410 | H | B | -3.3128 | |
| 411 | K | B | -3.4100 | |
| 412 | V | B | -2.1438 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.8865 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -0.9849 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.2598 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.8272 | |
| 421 | G | B | -0.5652 | |
| 422 | L | B | -0.3188 | |
| 423 | S | B | -0.4458 | |
| 424 | S | B | -0.4376 | |
| 425 | P | B | -0.5761 | |
| 426 | V | B | 0.0379 | |
| 427 | T | B | -0.4841 | |
| 428 | K | B | -0.7997 | |
| 429 | S | B | -0.9976 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.4906 | |
| 432 | R | B | -2.8489 | |
| 433 | G | B | -2.2598 | |
| 434 | E | B | -2.2125 | |
| 435 | C | B | -0.7034 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine