| Chain sequence(s) |
A: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF C: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF B: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF E: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF D: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF G: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF F: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF I: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF H: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF J: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
| Mutated residues | IB308K, IJ308K |
| Energy difference between WT (input) and mutated protein (by FoldX) | 2.25465 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 306 | V | A | 1.9555 | |
| 307 | Q | A | 0.5729 | |
| 308 | I | A | 1.4469 | |
| 309 | V | A | 1.2523 | |
| 310 | Y | A | 0.3177 | |
| 311 | K | A | -1.2222 | |
| 312 | P | A | -0.2959 | |
| 313 | V | A | 0.8863 | |
| 314 | D | A | -0.1897 | |
| 315 | L | A | 0.8683 | |
| 316 | S | A | -0.6312 | |
| 317 | K | A | -1.5368 | |
| 318 | V | A | -1.0620 | |
| 319 | T | A | -1.3472 | |
| 320 | S | A | -1.5811 | |
| 321 | K | A | -2.4652 | |
| 322 | C | A | -1.1728 | |
| 323 | G | A | -1.0682 | |
| 324 | S | A | -0.6347 | |
| 325 | L | A | -0.0103 | |
| 326 | G | A | -0.7593 | |
| 327 | N | A | -1.5296 | |
| 328 | I | A | -0.5645 | |
| 329 | H | A | -1.1920 | |
| 330 | H | A | -0.6559 | |
| 331 | K | A | -1.3700 | |
| 332 | P | A | -0.9067 | |
| 333 | G | A | -1.0342 | |
| 334 | G | A | -0.9889 | |
| 335 | G | A | -1.0608 | |
| 336 | Q | A | -1.6851 | |
| 337 | V | A | -1.0918 | |
| 338 | E | A | -2.2889 | |
| 339 | V | A | -1.6314 | |
| 340 | K | A | -2.9803 | |
| 341 | S | A | -2.6608 | |
| 342 | E | A | -3.6299 | |
| 343 | K | A | -3.4456 | |
| 344 | L | A | -1.9004 | |
| 345 | D | A | -2.7221 | |
| 346 | F | A | -2.8432 | |
| 347 | K | A | -4.0059 | |
| 348 | D | A | -3.8525 | |
| 349 | R | A | -4.0962 | |
| 350 | V | A | -2.6595 | |
| 351 | Q | A | -2.7479 | |
| 352 | S | A | -1.6016 | |
| 353 | K | A | -2.1089 | |
| 354 | I | A | -1.0215 | |
| 355 | G | A | -1.0103 | |
| 356 | S | A | -0.8215 | |
| 357 | L | A | -0.1840 | |
| 358 | D | A | -0.2067 | |
| 359 | N | A | 0.1145 | |
| 360 | I | A | 1.2390 | |
| 361 | T | A | 0.0000 | |
| 362 | H | A | -0.4624 | |
| 363 | V | A | -0.0392 | |
| 364 | P | A | -0.3790 | |
| 365 | G | A | 0.0000 | |
| 366 | G | A | -1.1997 | |
| 367 | G | A | -1.1121 | |
| 368 | N | A | -1.5581 | |
| 369 | K | A | -2.2977 | |
| 370 | K | A | -1.2958 | |
| 371 | I | A | 0.1014 | |
| 372 | E | A | -0.5217 | |
| 373 | T | A | -0.6509 | |
| 374 | H | A | -1.1901 | |
| 375 | K | A | -2.0630 | |
| 376 | L | A | -0.3171 | |
| 377 | T | A | 0.5385 | |
| 378 | F | A | 1.8382 | |
| 306 | V | B | 1.7639 | |
| 307 | Q | B | 0.1804 | |
| 308 | K | B | 0.7784 | mutated: IB308K |
| 309 | V | B | 0.9289 | |
| 310 | Y | B | 0.1918 | |
| 311 | K | B | -1.1596 | |
| 312 | P | B | -0.2267 | |
| 313 | V | B | 1.0235 | |
| 314 | D | B | 0.1162 | |
| 315 | L | B | 0.9888 | |
| 316 | S | B | -0.5794 | |
| 317 | K | B | -1.6450 | |
| 318 | V | B | -0.9195 | |
| 319 | T | B | -1.2676 | |
| 320 | S | B | -1.4086 | |
| 321 | K | B | -2.2905 | |
| 322 | C | B | -1.0166 | |
| 323 | G | B | -0.9552 | |
| 324 | S | B | -0.5324 | |
| 325 | L | B | 0.1962 | |
| 326 | G | B | -0.6403 | |
| 327 | N | B | -1.4709 | |
| 328 | I | B | -0.6374 | |
| 329 | H | B | -1.1965 | |
| 330 | H | B | -0.7919 | |
| 331 | K | B | -1.1862 | |
| 332 | P | B | -0.9391 | |
| 333 | G | B | -0.9257 | |
| 334 | G | B | -0.7148 | |
| 335 | G | B | -0.6219 | |
| 336 | Q | B | -0.8842 | |
| 337 | V | B | -0.7793 | |
| 338 | E | B | -2.1937 | |
| 339 | V | B | -1.5788 | |
| 340 | K | B | -2.9810 | |
| 341 | S | B | -2.6389 | |
| 342 | E | B | -3.6809 | |
| 343 | K | B | -3.5900 | |
| 344 | L | B | -2.0101 | |
| 345 | D | B | -2.8552 | |
| 346 | F | B | -2.8400 | |
| 347 | K | B | -3.9838 | |
| 348 | D | B | -3.7106 | |
| 349 | R | B | -4.0010 | |
| 350 | V | B | -2.6116 | |
| 351 | Q | B | -2.7570 | |
| 352 | S | B | -1.5863 | |
| 353 | K | B | -2.1014 | |
| 354 | I | B | -0.9878 | |
| 355 | G | B | -0.9416 | |
| 356 | S | B | -0.8102 | |
| 357 | L | B | -0.0874 | |
| 358 | D | B | -0.4131 | |
| 359 | N | B | -0.0764 | |
| 360 | I | B | 1.1311 | |
| 361 | T | B | 0.0000 | |
| 362 | H | B | -0.4408 | |
| 363 | V | B | -0.0252 | |
| 364 | P | B | -0.3525 | |
| 365 | G | B | 0.0000 | |
| 366 | G | B | -1.0888 | |
| 367 | G | B | -1.0724 | |
| 368 | N | B | -1.3587 | |
| 369 | K | B | -1.9272 | |
| 370 | K | B | -0.6543 | |
| 371 | I | B | 0.4403 | |
| 372 | E | B | -0.3717 | |
| 373 | T | B | -0.6430 | |
| 374 | H | B | -1.1878 | |
| 375 | K | B | -2.1054 | |
| 376 | L | B | -0.2475 | |
| 377 | T | B | 0.7595 | |
| 378 | F | B | 2.3203 | |
| 306 | V | C | 2.5280 | |
| 307 | Q | C | 1.0562 | |
| 308 | I | C | 0.0000 | |
| 309 | V | C | 0.1753 | |
| 310 | Y | C | 0.0000 | |
| 311 | K | C | -1.0155 | |
| 312 | P | C | 0.0000 | |
| 313 | V | C | 0.5495 | |
| 314 | D | C | 0.6361 | |
| 315 | L | C | 0.8217 | |
| 316 | S | C | 0.0000 | |
| 317 | K | C | -1.1264 | |
| 318 | V | C | 0.0000 | |
| 319 | T | C | -1.6135 | |
| 320 | S | C | 0.0000 | |
| 321 | K | C | -2.9870 | |
| 322 | C | C | 0.0000 | |
| 323 | G | C | -1.2801 | |
| 324 | S | C | -0.6836 | |
| 325 | L | C | 0.0000 | |
| 326 | G | C | -0.9327 | |
| 327 | N | C | -1.5326 | |
| 328 | I | C | 0.0000 | |
| 329 | H | C | -0.9911 | |
| 330 | H | C | 0.0000 | |
| 331 | K | C | 0.0000 | |
| 332 | P | C | 0.0000 | |
| 333 | G | C | 0.0000 | |
| 334 | G | C | 0.0000 | |
| 335 | G | C | 0.0000 | |
| 336 | Q | C | 0.0000 | |
| 337 | V | C | 0.0000 | |
| 338 | E | C | -1.5657 | |
| 339 | V | C | 0.0000 | |
| 340 | K | C | -2.7175 | |
| 341 | S | C | -2.8478 | |
| 342 | E | C | -3.3942 | |
| 343 | K | C | -3.4050 | |
| 344 | L | C | 0.0000 | |
| 345 | D | C | -2.7845 | |
| 346 | F | C | 0.0000 | |
| 347 | K | C | -4.1398 | |
| 348 | D | C | -4.4412 | |
| 349 | R | C | -5.1444 | |
| 350 | V | C | 0.0000 | |
| 351 | Q | C | -2.8963 | |
| 352 | S | C | -1.5141 | |
| 353 | K | C | -1.3964 | |
| 354 | I | C | 0.0000 | |
| 355 | G | C | 0.0000 | |
| 356 | S | C | 0.0000 | |
| 357 | L | C | 0.0000 | |
| 358 | D | C | 0.0000 | |
| 359 | N | C | 0.0000 | |
| 360 | I | C | 0.5651 | |
| 361 | T | C | 0.0000 | |
| 362 | H | C | -0.2718 | |
| 363 | V | C | 0.0000 | |
| 364 | P | C | 0.0000 | |
| 365 | G | C | 0.0000 | |
| 366 | G | C | 0.0000 | |
| 367 | G | C | -0.9949 | |
| 368 | N | C | 0.0000 | |
| 369 | K | C | -1.8905 | |
| 370 | K | C | 0.0000 | |
| 371 | I | C | 0.0362 | |
| 372 | E | C | 0.0000 | |
| 373 | T | C | -0.4902 | |
| 374 | H | C | 0.0000 | |
| 375 | K | C | -1.6355 | |
| 376 | L | C | 0.0000 | |
| 377 | T | C | 0.5927 | |
| 378 | F | C | 1.9239 | |
| 306 | V | D | 2.3200 | |
| 307 | Q | D | 0.8717 | |
| 308 | I | D | 0.0000 | |
| 309 | V | D | 0.0349 | |
| 310 | Y | D | 0.0000 | |
| 311 | K | D | -0.8598 | |
| 312 | P | D | 0.0000 | |
| 313 | V | D | 0.5292 | |
| 314 | D | D | 0.0000 | |
| 315 | L | D | 0.9218 | |
| 316 | S | D | 0.0000 | |
| 317 | K | D | -1.5734 | |
| 318 | V | D | 0.0000 | |
| 319 | T | D | -1.5972 | |
| 320 | S | D | 0.0000 | |
| 321 | K | D | -2.5082 | |
| 322 | C | D | 0.0000 | |
| 323 | G | D | -1.1693 | |
| 324 | S | D | -0.5799 | |
| 325 | L | D | 0.0000 | |
| 326 | G | D | -0.8287 | |
| 327 | N | D | -1.4241 | |
| 328 | I | D | 0.0000 | |
| 329 | H | D | -0.9996 | |
| 330 | H | D | 0.0000 | |
| 331 | K | D | 0.0000 | |
| 332 | P | D | 0.0000 | |
| 333 | G | D | 0.0000 | |
| 334 | G | D | 0.0000 | |
| 335 | G | D | 0.0000 | |
| 336 | Q | D | 0.0000 | |
| 337 | V | D | 0.0000 | |
| 338 | E | D | -1.5715 | |
| 339 | V | D | 0.0000 | |
| 340 | K | D | -2.8343 | |
| 341 | S | D | 0.0000 | |
| 342 | E | D | -3.5506 | |
| 343 | K | D | -3.6478 | |
| 344 | L | D | 0.0000 | |
| 345 | D | D | -3.1275 | |
| 346 | F | D | 0.0000 | |
| 347 | K | D | -4.3728 | |
| 348 | D | D | -4.3070 | |
| 349 | R | D | -5.1034 | |
| 350 | V | D | 0.0000 | |
| 351 | Q | D | -2.9402 | |
| 352 | S | D | 0.0000 | |
| 353 | K | D | -1.3757 | |
| 354 | I | D | 0.0000 | |
| 355 | G | D | 0.0000 | |
| 356 | S | D | 0.0000 | |
| 357 | L | D | 0.0000 | |
| 358 | D | D | 0.0000 | |
| 359 | N | D | 0.0000 | |
| 360 | I | D | 0.5032 | |
| 361 | T | D | 0.0000 | |
| 362 | H | D | -0.3050 | |
| 363 | V | D | 0.0000 | |
| 364 | P | D | 0.0000 | |
| 365 | G | D | 0.0000 | |
| 366 | G | D | 0.0000 | |
| 367 | G | D | -0.9492 | |
| 368 | N | D | 0.0000 | |
| 369 | K | D | -1.5603 | |
| 370 | K | D | 0.0000 | |
| 371 | I | D | 0.1924 | |
| 372 | E | D | 0.0000 | |
| 373 | T | D | -0.5327 | |
| 374 | H | D | 0.0000 | |
| 375 | K | D | -1.7762 | |
| 376 | L | D | 0.0000 | |
| 377 | T | D | 0.6516 | |
| 378 | F | D | 1.9867 | |
| 306 | V | E | 2.6839 | |
| 307 | Q | E | 0.7531 | |
| 308 | I | E | 0.0000 | |
| 309 | V | E | -0.0904 | |
| 310 | Y | E | 0.0000 | |
| 311 | K | E | -1.4675 | |
| 312 | P | E | 0.0000 | |
| 313 | V | E | 0.6980 | |
| 314 | D | E | 0.0000 | |
| 315 | L | E | 1.1723 | |
| 316 | S | E | 0.0000 | |
| 317 | K | E | -1.3218 | |
| 318 | V | E | 0.0000 | |
| 319 | T | E | 0.0000 | |
| 320 | S | E | 0.0000 | |
| 321 | K | E | -2.6477 | |
| 322 | C | E | 0.0000 | |
| 323 | G | E | -1.3096 | |
| 324 | S | E | -0.6646 | |
| 325 | L | E | 0.0000 | |
| 326 | G | E | -1.0332 | |
| 327 | N | E | -1.5697 | |
| 328 | I | E | 0.0000 | |
| 329 | H | E | -0.7283 | |
| 330 | H | E | 0.0000 | |
| 331 | K | E | 0.0000 | |
| 332 | P | E | 0.0000 | |
| 333 | G | E | 0.0000 | |
| 334 | G | E | 0.0000 | |
| 335 | G | E | 0.0000 | |
| 336 | Q | E | 0.0000 | |
| 337 | V | E | 0.0000 | |
| 338 | E | E | -0.9824 | |
| 339 | V | E | 0.0000 | |
| 340 | K | E | -2.0122 | |
| 341 | S | E | -2.5601 | |
| 342 | E | E | -3.0916 | |
| 343 | K | E | -2.9997 | |
| 344 | L | E | 0.0000 | |
| 345 | D | E | -2.6394 | |
| 346 | F | E | 0.0000 | |
| 347 | K | E | -3.8893 | |
| 348 | D | E | -4.2934 | |
| 349 | R | E | -5.0429 | |
| 350 | V | E | 0.0000 | |
| 351 | Q | E | -2.5643 | |
| 352 | S | E | 0.0000 | |
| 353 | K | E | -1.1230 | |
| 354 | I | E | 0.0000 | |
| 355 | G | E | 0.0000 | |
| 356 | S | E | 0.0000 | |
| 357 | L | E | 0.0000 | |
| 358 | D | E | 0.0000 | |
| 359 | N | E | 0.0000 | |
| 360 | I | E | 0.5110 | |
| 361 | T | E | 0.0000 | |
| 362 | H | E | -0.4770 | |
| 363 | V | E | 0.0000 | |
| 364 | P | E | 0.0000 | |
| 365 | G | E | 0.0000 | |
| 366 | G | E | 0.0000 | |
| 367 | G | E | -0.6861 | |
| 368 | N | E | 0.0000 | |
| 369 | K | E | -1.8195 | |
| 370 | K | E | 0.0000 | |
| 371 | I | E | 0.2812 | |
| 372 | E | E | 0.0000 | |
| 373 | T | E | -0.3120 | |
| 374 | H | E | 0.0000 | |
| 375 | K | E | -1.4171 | |
| 376 | L | E | 0.0000 | |
| 377 | T | E | 0.5607 | |
| 378 | F | E | 1.7546 | |
| 306 | V | F | 2.6771 | |
| 307 | Q | F | 0.7383 | |
| 308 | I | F | 0.0000 | |
| 309 | V | F | 0.0558 | |
| 310 | Y | F | 0.0000 | |
| 311 | K | F | -1.2690 | |
| 312 | P | F | 0.0000 | |
| 313 | V | F | 0.6998 | |
| 314 | D | F | 0.0000 | |
| 315 | L | F | 1.1552 | |
| 316 | S | F | 0.0000 | |
| 317 | K | F | -1.5844 | |
| 318 | V | F | 0.0000 | |
| 319 | T | F | 0.0000 | |
| 320 | S | F | 0.0000 | |
| 321 | K | F | -2.5083 | |
| 322 | C | F | 0.0000 | |
| 323 | G | F | -1.2654 | |
| 324 | S | F | -0.6929 | |
| 325 | L | F | 0.0000 | |
| 326 | G | F | -1.0493 | |
| 327 | N | F | -1.5852 | |
| 328 | I | F | 0.0000 | |
| 329 | H | F | -0.7492 | |
| 330 | H | F | 0.0000 | |
| 331 | K | F | 0.0000 | |
| 332 | P | F | 0.0000 | |
| 333 | G | F | 0.0000 | |
| 334 | G | F | 0.0000 | |
| 335 | G | F | 0.0000 | |
| 336 | Q | F | 0.0000 | |
| 337 | V | F | 0.0000 | |
| 338 | E | F | -1.0151 | |
| 339 | V | F | 0.0000 | |
| 340 | K | F | -2.4593 | |
| 341 | S | F | -2.8538 | |
| 342 | E | F | -3.4041 | |
| 343 | K | F | -3.1571 | |
| 344 | L | F | 0.0000 | |
| 345 | D | F | -2.9674 | |
| 346 | F | F | 0.0000 | |
| 347 | K | F | -4.5765 | |
| 348 | D | F | -4.8816 | |
| 349 | R | F | -5.3105 | |
| 350 | V | F | 0.0000 | |
| 351 | Q | F | -2.5888 | |
| 352 | S | F | 0.0000 | |
| 353 | K | F | -1.0396 | |
| 354 | I | F | 0.0000 | |
| 355 | G | F | 0.0000 | |
| 356 | S | F | 0.0000 | |
| 357 | L | F | 0.0000 | |
| 358 | D | F | 0.0000 | |
| 359 | N | F | 0.0000 | |
| 360 | I | F | 0.5145 | |
| 361 | T | F | 0.0000 | |
| 362 | H | F | -0.4676 | |
| 363 | V | F | 0.0000 | |
| 364 | P | F | 0.0000 | |
| 365 | G | F | 0.0000 | |
| 366 | G | F | 0.0000 | |
| 367 | G | F | -0.6744 | |
| 368 | N | F | 0.0000 | |
| 369 | K | F | -1.7844 | |
| 370 | K | F | 0.0000 | |
| 371 | I | F | 0.3217 | |
| 372 | E | F | 0.0000 | |
| 373 | T | F | -0.3496 | |
| 374 | H | F | 0.0000 | |
| 375 | K | F | -1.6657 | |
| 376 | L | F | 0.0000 | |
| 377 | T | F | 0.5327 | |
| 378 | F | F | 1.9976 | |
| 306 | V | G | 2.6306 | |
| 307 | Q | G | 1.0053 | |
| 308 | I | G | 0.0000 | |
| 309 | V | G | -0.2812 | |
| 310 | Y | G | 0.0000 | |
| 311 | K | G | -1.5176 | |
| 312 | P | G | 0.0000 | |
| 313 | V | G | 0.3040 | |
| 314 | D | G | 0.0000 | |
| 315 | L | G | 0.6326 | |
| 316 | S | G | 0.0000 | |
| 317 | K | G | -1.1349 | |
| 318 | V | G | 0.0000 | |
| 319 | T | G | -1.3341 | |
| 320 | S | G | 0.0000 | |
| 321 | K | G | -2.6217 | |
| 322 | C | G | 0.0000 | |
| 323 | G | G | -1.1688 | |
| 324 | S | G | -0.7201 | |
| 325 | L | G | 0.0000 | |
| 326 | G | G | -1.0554 | |
| 327 | N | G | -1.4101 | |
| 328 | I | G | 0.0000 | |
| 329 | H | G | -0.8264 | |
| 330 | H | G | 0.0000 | |
| 331 | K | G | 0.0000 | |
| 332 | P | G | 0.0000 | |
| 333 | G | G | 0.0000 | |
| 334 | G | G | 0.0000 | |
| 335 | G | G | 0.0000 | |
| 336 | Q | G | 0.0000 | |
| 337 | V | G | 0.0000 | |
| 338 | E | G | -1.1426 | |
| 339 | V | G | 0.0000 | |
| 340 | K | G | -2.5615 | |
| 341 | S | G | -3.0093 | |
| 342 | E | G | -3.9077 | |
| 343 | K | G | -3.6679 | |
| 344 | L | G | 0.0000 | |
| 345 | D | G | -2.5951 | |
| 346 | F | G | 0.0000 | |
| 347 | K | G | -3.9642 | |
| 348 | D | G | -4.2127 | |
| 349 | R | G | -5.2040 | |
| 350 | V | G | 0.0000 | |
| 351 | Q | G | -2.7712 | |
| 352 | S | G | 0.0000 | |
| 353 | K | G | -1.1519 | |
| 354 | I | G | 0.0000 | |
| 355 | G | G | 0.0000 | |
| 356 | S | G | 0.0000 | |
| 357 | L | G | 0.0000 | |
| 358 | D | G | -0.6511 | |
| 359 | N | G | 0.0000 | |
| 360 | I | G | -0.1232 | |
| 361 | T | G | 0.0000 | |
| 362 | H | G | -0.4481 | |
| 363 | V | G | 0.0000 | |
| 364 | P | G | 0.0000 | |
| 365 | G | G | 0.0000 | |
| 366 | G | G | 0.0000 | |
| 367 | G | G | -0.9363 | |
| 368 | N | G | 0.0000 | |
| 369 | K | G | -2.2777 | |
| 370 | K | G | 0.0000 | |
| 371 | I | G | -0.5706 | |
| 372 | E | G | 0.0000 | |
| 373 | T | G | -0.8395 | |
| 374 | H | G | 0.0000 | |
| 375 | K | G | -1.7370 | |
| 376 | L | G | 0.0000 | |
| 377 | T | G | 0.8274 | |
| 378 | F | G | 2.1088 | |
| 306 | V | H | 2.2332 | |
| 307 | Q | H | 0.6435 | |
| 308 | I | H | 0.0000 | |
| 309 | V | H | -0.4022 | |
| 310 | Y | H | 0.0000 | |
| 311 | K | H | -0.9456 | |
| 312 | P | H | 0.0000 | |
| 313 | V | H | 0.6869 | |
| 314 | D | H | 0.0000 | |
| 315 | L | H | 0.8751 | |
| 316 | S | H | 0.0000 | |
| 317 | K | H | -1.2270 | |
| 318 | V | H | 0.0000 | |
| 319 | T | H | -1.4099 | |
| 320 | S | H | 0.0000 | |
| 321 | K | H | -2.6816 | |
| 322 | C | H | 0.0000 | |
| 323 | G | H | -1.3105 | |
| 324 | S | H | -0.7790 | |
| 325 | L | H | 0.0000 | |
| 326 | G | H | -1.1769 | |
| 327 | N | H | -1.6232 | |
| 328 | I | H | 0.0000 | |
| 329 | H | H | -1.0400 | |
| 330 | H | H | 0.0000 | |
| 331 | K | H | -1.0473 | |
| 332 | P | H | 0.0000 | |
| 333 | G | H | 0.0000 | |
| 334 | G | H | 0.0000 | |
| 335 | G | H | 0.0000 | |
| 336 | Q | H | 0.0000 | |
| 337 | V | H | 0.0000 | |
| 338 | E | H | -0.8795 | |
| 339 | V | H | 0.0000 | |
| 340 | K | H | -2.6370 | |
| 341 | S | H | 0.0000 | |
| 342 | E | H | -3.7803 | |
| 343 | K | H | -3.4755 | |
| 344 | L | H | 0.0000 | |
| 345 | D | H | -2.6236 | |
| 346 | F | H | 0.0000 | |
| 347 | K | H | -4.5742 | |
| 348 | D | H | -4.8199 | |
| 349 | R | H | -5.5212 | |
| 350 | V | H | 0.0000 | |
| 351 | Q | H | -2.7250 | |
| 352 | S | H | -1.1314 | |
| 353 | K | H | -0.8095 | |
| 354 | I | H | 0.0000 | |
| 355 | G | H | 0.0000 | |
| 356 | S | H | 0.0000 | |
| 357 | L | H | 0.0000 | |
| 358 | D | H | 0.0000 | |
| 359 | N | H | 0.0000 | |
| 360 | I | H | -0.1178 | |
| 361 | T | H | 0.0000 | |
| 362 | H | H | -0.3941 | |
| 363 | V | H | 0.0000 | |
| 364 | P | H | 0.0000 | |
| 365 | G | H | 0.0000 | |
| 366 | G | H | 0.0000 | |
| 367 | G | H | -0.9627 | |
| 368 | N | H | 0.0000 | |
| 369 | K | H | -2.3103 | |
| 370 | K | H | 0.0000 | |
| 371 | I | H | -0.5267 | |
| 372 | E | H | 0.0000 | |
| 373 | T | H | -0.6856 | |
| 374 | H | H | 0.0000 | |
| 375 | K | H | -1.7898 | |
| 376 | L | H | 0.0000 | |
| 377 | T | H | 0.7702 | |
| 378 | F | H | 2.0594 | |
| 306 | V | I | 2.0460 | |
| 307 | Q | I | 0.3516 | |
| 308 | I | I | 1.1172 | |
| 309 | V | I | -0.0752 | |
| 310 | Y | I | -0.1356 | |
| 311 | K | I | -1.6449 | |
| 312 | P | I | -0.9719 | |
| 313 | V | I | 0.4180 | |
| 314 | D | I | -0.4232 | |
| 315 | L | I | 0.6534 | |
| 316 | S | I | -0.8112 | |
| 317 | K | I | -1.5582 | |
| 318 | V | I | -1.4460 | |
| 319 | T | I | -1.2163 | |
| 320 | S | I | -1.3702 | |
| 321 | K | I | -2.0308 | |
| 322 | C | I | -1.2590 | |
| 323 | G | I | -1.1128 | |
| 324 | S | I | -0.8158 | |
| 325 | L | I | -0.4854 | |
| 326 | G | I | -1.2448 | |
| 327 | N | I | -1.6445 | |
| 328 | I | I | -0.7508 | |
| 329 | H | I | -0.9098 | |
| 330 | H | I | -0.5130 | |
| 331 | K | I | -0.8810 | |
| 332 | P | I | -0.5902 | |
| 333 | G | I | 0.0000 | |
| 334 | G | I | -0.6132 | |
| 335 | G | I | 0.0000 | |
| 336 | Q | I | -0.6536 | |
| 337 | V | I | -0.4066 | |
| 338 | E | I | -1.4646 | |
| 339 | V | I | -1.3369 | |
| 340 | K | I | -2.9412 | |
| 341 | S | I | -3.2277 | |
| 342 | E | I | -3.8477 | |
| 343 | K | I | -3.6946 | |
| 344 | L | I | -2.4765 | |
| 345 | D | I | -2.4798 | |
| 346 | F | I | -1.9232 | |
| 347 | K | I | -3.7309 | |
| 348 | D | I | -4.2771 | |
| 349 | R | I | -4.3992 | |
| 350 | V | I | -3.0291 | |
| 351 | Q | I | -2.6542 | |
| 352 | S | I | -1.4095 | |
| 353 | K | I | -1.7218 | |
| 354 | I | I | -0.2006 | |
| 355 | G | I | -0.6319 | |
| 356 | S | I | -0.7534 | |
| 357 | L | I | -0.4352 | |
| 358 | D | I | -1.6361 | |
| 359 | N | I | -1.0556 | |
| 360 | I | I | -0.1178 | |
| 361 | T | I | -0.2113 | |
| 362 | H | I | -0.8004 | |
| 363 | V | I | -0.1398 | |
| 364 | P | I | -0.4919 | |
| 365 | G | I | -0.7770 | |
| 366 | G | I | -0.7882 | |
| 367 | G | I | -1.0254 | |
| 368 | N | I | -2.0956 | |
| 369 | K | I | -2.9437 | |
| 370 | K | I | -2.7363 | |
| 371 | I | I | -1.2120 | |
| 372 | E | I | -1.3175 | |
| 373 | T | I | -1.1779 | |
| 374 | H | I | -1.9910 | |
| 375 | K | I | -2.1650 | |
| 376 | L | I | -0.0349 | |
| 377 | T | I | 1.0000 | |
| 378 | F | I | 2.4994 | |
| 306 | V | J | 1.7303 | |
| 307 | Q | J | -0.2095 | |
| 308 | K | J | 0.1110 | mutated: IJ308K |
| 309 | V | J | -0.4360 | |
| 310 | Y | J | -0.1653 | |
| 311 | K | J | -1.2123 | |
| 312 | P | J | -0.3875 | |
| 313 | V | J | 1.1210 | |
| 314 | D | J | 0.2549 | |
| 315 | L | J | 1.1501 | |
| 316 | S | J | -0.5255 | |
| 317 | K | J | -1.2713 | |
| 318 | V | J | -1.3261 | |
| 319 | T | J | -1.2701 | |
| 320 | S | J | -1.5707 | |
| 321 | K | J | -2.5373 | |
| 322 | C | J | -1.5220 | |
| 323 | G | J | -1.2553 | |
| 324 | S | J | -0.9296 | |
| 325 | L | J | -0.6045 | |
| 326 | G | J | -1.3483 | |
| 327 | N | J | -1.7380 | |
| 328 | I | J | -0.7897 | |
| 329 | H | J | -1.1640 | |
| 330 | H | J | -0.9868 | |
| 331 | K | J | -1.8404 | |
| 332 | P | J | -1.1730 | |
| 333 | G | J | -0.8078 | |
| 334 | G | J | -0.8844 | |
| 335 | G | J | -0.3383 | |
| 336 | Q | J | -0.4267 | |
| 337 | V | J | -0.0010 | |
| 338 | E | J | -0.6527 | |
| 339 | V | J | -0.8699 | |
| 340 | K | J | -2.7040 | |
| 341 | S | J | -3.0029 | |
| 342 | E | J | -3.6090 | |
| 343 | K | J | -3.2385 | |
| 344 | L | J | -2.2970 | |
| 345 | D | J | -2.5245 | |
| 346 | F | J | -2.2289 | |
| 347 | K | J | -4.0593 | |
| 348 | D | J | -4.5920 | |
| 349 | R | J | -4.6131 | |
| 350 | V | J | -3.2121 | |
| 351 | Q | J | -2.5407 | |
| 352 | S | J | -1.0277 | |
| 353 | K | J | -0.8224 | |
| 354 | I | J | 0.3354 | |
| 355 | G | J | -0.0285 | |
| 356 | S | J | -0.1355 | |
| 357 | L | J | 0.0615 | |
| 358 | D | J | -1.3908 | |
| 359 | N | J | -1.1120 | |
| 360 | I | J | -0.1279 | |
| 361 | T | J | -0.2181 | |
| 362 | H | J | -0.7546 | |
| 363 | V | J | -0.0204 | |
| 364 | P | J | -0.4344 | |
| 365 | G | J | -0.8330 | |
| 366 | G | J | -0.8856 | |
| 367 | G | J | -1.0313 | |
| 368 | N | J | -2.1744 | |
| 369 | K | J | -2.9983 | |
| 370 | K | J | -2.7428 | |
| 371 | I | J | -1.1219 | |
| 372 | E | J | -1.0065 | |
| 373 | T | J | -0.8705 | |
| 374 | H | J | -1.4569 | |
| 375 | K | J | -2.1467 | |
| 376 | L | J | -0.2803 | |
| 377 | T | J | 0.8357 | |
| 378 | F | J | 2.3746 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine