| Chain sequence(s) |
A: SSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACDWAGIKQEDGIPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNSLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD B: DSSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTGATVRAACDWAGIKQVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNKKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRNSLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 56 | S | A | -0.3741 | |
| 57 | S | A | -0.1625 | |
| 58 | P | A | -0.1971 | |
| 59 | G | A | 0.0000 | |
| 60 | I | A | -0.1346 | |
| 61 | W | A | 0.0000 | |
| 62 | Q | A | -0.5521 | |
| 63 | L | A | 0.0000 | |
| 64 | D | A | -1.1106 | |
| 65 | C | A | -0.9152 | |
| 66 | T | A | 0.0000 | |
| 67 | H | A | -1.9020 | |
| 68 | L | A | -1.6773 | |
| 69 | E | A | -2.4056 | |
| 70 | G | A | -2.0476 | |
| 71 | K | A | -2.2899 | |
| 72 | V | A | -1.5582 | |
| 73 | I | A | 0.0000 | |
| 74 | L | A | 0.0000 | |
| 75 | V | A | 0.0000 | |
| 76 | A | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | H | A | 0.0000 | |
| 79 | V | A | 0.6019 | |
| 80 | A | A | 0.2534 | |
| 81 | S | A | 0.0000 | |
| 82 | G | A | 0.0565 | |
| 83 | Y | A | 0.0000 | |
| 84 | I | A | 0.0000 | |
| 85 | E | A | 0.0000 | |
| 86 | A | A | 0.0000 | |
| 87 | E | A | -0.3756 | |
| 88 | V | A | -0.7021 | |
| 89 | I | A | 0.0000 | |
| 90 | P | A | -0.8865 | |
| 91 | A | A | -1.3988 | |
| 92 | E | A | -2.4011 | |
| 93 | T | A | -1.5777 | |
| 94 | G | A | -1.5205 | |
| 95 | Q | A | -1.6529 | |
| 96 | E | A | -1.2057 | |
| 97 | T | A | 0.0000 | |
| 98 | A | A | -0.6844 | |
| 99 | Y | A | -0.1697 | |
| 100 | F | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | L | A | 0.3247 | |
| 103 | K | A | 0.0000 | |
| 104 | L | A | 0.0000 | |
| 105 | A | A | 0.0000 | |
| 106 | G | A | 0.0000 | |
| 107 | R | A | 0.0000 | |
| 108 | W | A | 0.0000 | |
| 109 | P | A | -0.2837 | |
| 110 | V | A | -0.4303 | |
| 111 | K | A | -1.2641 | |
| 112 | T | A | -1.5307 | |
| 113 | I | A | 0.0000 | |
| 114 | H | A | -1.9664 | |
| 115 | T | A | -2.2015 | |
| 116 | D | A | -2.7352 | |
| 117 | N | A | -2.5103 | |
| 118 | G | A | -1.7539 | |
| 119 | S | A | -1.2111 | |
| 120 | N | A | -1.5315 | |
| 121 | F | A | 0.0000 | |
| 122 | T | A | -1.2492 | |
| 123 | G | A | -1.0397 | |
| 124 | A | A | -0.8159 | |
| 125 | T | A | -0.8635 | |
| 126 | V | A | 0.0000 | |
| 127 | R | A | -2.5117 | |
| 128 | A | A | -1.3192 | |
| 129 | A | A | -1.0584 | |
| 130 | C | A | 0.0000 | |
| 131 | D | A | -2.4632 | |
| 132 | W | A | -0.8934 | |
| 133 | A | A | -0.8073 | |
| 134 | G | A | -1.5168 | |
| 135 | I | A | 0.0000 | |
| 136 | K | A | -3.0874 | |
| 137 | Q | A | -2.9527 | |
| 138 | E | A | -3.2412 | |
| 139 | D | A | -2.9411 | |
| 140 | G | A | -1.5601 | |
| 141 | I | A | 0.6215 | |
| 145 | P | A | -0.8794 | |
| 146 | Q | A | -1.5816 | |
| 147 | S | A | -0.9013 | |
| 148 | Q | A | -1.4070 | |
| 149 | G | A | -1.3194 | |
| 150 | V | A | -0.4475 | |
| 151 | V | A | 0.0000 | |
| 152 | E | A | -1.8431 | |
| 153 | S | A | -1.4112 | |
| 154 | M | A | -1.5000 | |
| 155 | N | A | -1.9501 | |
| 156 | K | A | -2.7958 | |
| 157 | E | A | -2.5439 | |
| 158 | L | A | 0.0000 | |
| 159 | K | A | -2.4633 | |
| 160 | K | A | -3.0029 | |
| 161 | I | A | 0.0000 | |
| 162 | I | A | 0.0000 | |
| 163 | G | A | -2.5447 | |
| 164 | Q | A | -2.7260 | |
| 165 | V | A | -2.5500 | |
| 166 | R | A | -3.6358 | |
| 167 | D | A | -3.7287 | |
| 168 | Q | A | -3.2723 | |
| 169 | A | A | -2.9462 | |
| 170 | E | A | -3.2019 | |
| 171 | H | A | -2.6483 | |
| 172 | L | A | -1.9706 | |
| 173 | K | A | -1.5282 | |
| 174 | T | A | -1.4250 | |
| 175 | A | A | 0.0000 | |
| 176 | V | A | 0.0000 | |
| 177 | Q | A | 0.0000 | |
| 178 | M | A | 0.0000 | |
| 179 | A | A | 0.0000 | |
| 180 | V | A | 0.0000 | |
| 181 | F | A | -0.0086 | |
| 182 | I | A | -0.3210 | |
| 183 | H | A | -0.9705 | |
| 184 | N | A | 0.0000 | |
| 185 | K | A | -1.7348 | |
| 186 | K | A | -3.0868 | |
| 187 | R | A | -3.7245 | |
| 188 | K | A | -3.2813 | |
| 189 | G | A | -2.0898 | |
| 190 | G | A | -0.9257 | |
| 191 | I | A | -0.2666 | |
| 192 | G | A | -0.9025 | |
| 193 | G | A | -1.7311 | |
| 194 | Y | A | -1.7401 | |
| 195 | S | A | 0.0000 | |
| 196 | A | A | 0.0000 | |
| 197 | G | A | -1.0348 | |
| 198 | E | A | -1.1444 | |
| 199 | R | A | -0.9970 | |
| 200 | I | A | 0.0000 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -1.2680 | |
| 203 | I | A | -0.4457 | |
| 204 | I | A | 0.0000 | |
| 205 | A | A | 0.0000 | |
| 206 | T | A | -0.9071 | |
| 207 | D | A | -1.4196 | |
| 208 | I | A | -1.0143 | |
| 209 | Q | A | -1.4936 | |
| 210 | T | A | -1.7938 | |
| 211 | K | A | -3.0560 | |
| 212 | E | A | -2.8793 | |
| 213 | L | A | -1.2880 | |
| 214 | Q | A | -2.4991 | |
| 215 | K | A | -2.9524 | |
| 216 | Q | A | -2.2450 | |
| 217 | I | A | -0.8014 | |
| 218 | T | A | -1.5149 | |
| 219 | K | A | -2.3656 | |
| 220 | I | A | 0.0000 | |
| 221 | Q | A | -1.2651 | |
| 222 | N | A | -2.2194 | |
| 223 | F | A | -1.4213 | |
| 224 | R | A | -1.5579 | |
| 225 | V | A | 0.0000 | |
| 226 | Y | A | -0.6843 | |
| 227 | Y | A | 0.0000 | |
| 228 | R | A | -1.5157 | |
| 229 | D | A | -1.4877 | |
| 230 | S | A | -2.0247 | |
| 231 | R | A | -2.6515 | |
| 232 | N | A | -2.1216 | |
| 233 | S | A | -0.7839 | |
| 234 | L | A | 0.7122 | |
| 235 | W | A | 0.4927 | |
| 236 | K | A | -0.6490 | |
| 237 | G | A | -1.0580 | |
| 238 | P | A | -0.9158 | |
| 239 | A | A | 0.0000 | |
| 240 | K | A | -1.1924 | |
| 241 | L | A | 0.0000 | |
| 242 | L | A | 0.3322 | |
| 243 | W | A | 0.5985 | |
| 244 | K | A | -1.5165 | |
| 245 | G | A | -1.9074 | |
| 246 | E | A | -2.7446 | |
| 247 | G | A | -2.3861 | |
| 248 | A | A | -1.5172 | |
| 249 | V | A | 0.0000 | |
| 250 | V | A | 0.8727 | |
| 251 | I | A | 0.0000 | |
| 252 | Q | A | -0.7985 | |
| 253 | D | A | -1.8581 | |
| 254 | N | A | -2.0716 | |
| 255 | S | A | -1.3890 | |
| 256 | D | A | -1.2695 | |
| 257 | I | A | 0.5000 | |
| 258 | K | A | 0.6308 | |
| 259 | V | A | 1.6182 | |
| 260 | V | A | 0.0000 | |
| 261 | P | A | -1.5858 | |
| 262 | R | A | -3.2847 | |
| 263 | R | A | -3.1717 | |
| 264 | K | A | -2.2340 | |
| 265 | A | A | -1.8907 | |
| 266 | K | A | -2.1320 | |
| 267 | I | A | -0.9893 | |
| 268 | I | A | -0.9350 | |
| 269 | R | A | -2.5071 | |
| 270 | D | A | -2.5872 | |
| 55 | D | B | -2.7348 | |
| 56 | S | B | -1.4745 | |
| 57 | S | B | -1.2317 | |
| 58 | P | B | -0.5733 | |
| 59 | G | B | 0.0000 | |
| 60 | I | B | -0.3955 | |
| 61 | W | B | 0.0000 | |
| 62 | Q | B | -0.3058 | |
| 63 | L | B | 0.0000 | |
| 64 | D | B | -1.1297 | |
| 65 | C | B | -0.7643 | |
| 66 | T | B | -1.1741 | |
| 67 | H | B | -1.4163 | |
| 68 | L | B | -1.0603 | |
| 69 | E | B | -1.4492 | |
| 70 | G | B | -1.3714 | |
| 71 | K | B | -1.5971 | |
| 72 | V | B | 0.0000 | |
| 73 | I | B | 0.0000 | |
| 74 | L | B | 0.0000 | |
| 75 | V | B | 0.0000 | |
| 76 | A | B | 0.0000 | |
| 77 | V | B | 0.0000 | |
| 78 | H | B | 0.0000 | |
| 79 | V | B | 1.2219 | |
| 80 | A | B | 0.4658 | |
| 81 | S | B | 0.0000 | |
| 82 | G | B | 0.3294 | |
| 83 | Y | B | 0.0000 | |
| 84 | I | B | 0.0000 | |
| 85 | E | B | 0.0000 | |
| 86 | A | B | 0.0000 | |
| 87 | E | B | -0.3592 | |
| 88 | V | B | 0.0000 | |
| 89 | I | B | 0.0000 | |
| 90 | P | B | -0.7044 | |
| 91 | A | B | -0.8914 | |
| 92 | E | B | -1.2836 | |
| 93 | T | B | -1.0665 | |
| 94 | G | B | -1.2416 | |
| 95 | Q | B | -1.5127 | |
| 96 | E | B | -1.1919 | |
| 97 | T | B | 0.0000 | |
| 98 | A | B | -0.7801 | |
| 99 | Y | B | -0.3469 | |
| 100 | F | B | 0.0000 | |
| 101 | L | B | 0.0000 | |
| 102 | L | B | 0.0000 | |
| 103 | K | B | -0.2512 | |
| 104 | L | B | 0.0000 | |
| 105 | A | B | 0.0000 | |
| 106 | G | B | 0.0000 | |
| 107 | R | B | 0.0000 | |
| 108 | W | B | 0.0000 | |
| 109 | P | B | -0.4908 | |
| 110 | V | B | 0.0000 | |
| 111 | K | B | -2.3500 | |
| 112 | T | B | 0.0000 | |
| 113 | I | B | 0.0000 | |
| 114 | H | B | -1.6772 | |
| 115 | T | B | -1.8258 | |
| 116 | D | B | -2.6644 | |
| 117 | N | B | -2.3846 | |
| 118 | G | B | -1.5893 | |
| 119 | S | B | -1.0073 | |
| 120 | N | B | 0.0000 | |
| 121 | F | B | 0.0000 | |
| 122 | T | B | -1.3531 | |
| 123 | G | B | -0.9253 | |
| 124 | A | B | -0.9021 | |
| 125 | T | B | -1.0204 | |
| 126 | V | B | 0.0000 | |
| 127 | R | B | -2.6900 | |
| 128 | A | B | -1.4663 | |
| 129 | A | B | -1.1400 | |
| 130 | C | B | 0.0000 | |
| 131 | D | B | -2.7297 | |
| 132 | W | B | -0.8422 | |
| 133 | A | B | -1.1349 | |
| 134 | G | B | -1.9202 | |
| 135 | I | B | 0.0000 | |
| 136 | K | B | -3.7682 | |
| 137 | Q | B | -3.1600 | |
| 150 | V | B | 1.3031 | |
| 151 | V | B | -0.1608 | |
| 152 | E | B | -1.6593 | |
| 153 | S | B | -1.0121 | |
| 154 | M | B | -1.3092 | |
| 155 | N | B | -2.1624 | |
| 156 | K | B | -3.3825 | |
| 157 | E | B | -2.9358 | |
| 158 | L | B | 0.0000 | |
| 159 | K | B | -3.2086 | |
| 160 | K | B | -3.4225 | |
| 161 | I | B | 0.0000 | |
| 162 | I | B | 0.0000 | |
| 163 | G | B | -2.4495 | |
| 164 | Q | B | -2.6532 | |
| 165 | V | B | 0.0000 | |
| 166 | R | B | -2.7810 | |
| 167 | D | B | -3.2467 | |
| 168 | Q | B | -2.9198 | |
| 169 | A | B | -2.4381 | |
| 170 | E | B | -2.9869 | |
| 171 | H | B | -2.2739 | |
| 172 | L | B | 0.0000 | |
| 173 | K | B | -1.2348 | |
| 174 | T | B | -1.1958 | |
| 175 | A | B | 0.0000 | |
| 176 | V | B | 0.0000 | |
| 177 | Q | B | 0.0000 | |
| 178 | M | B | 0.0000 | |
| 179 | A | B | 0.0000 | |
| 180 | V | B | 0.0000 | |
| 181 | F | B | 0.3141 | |
| 182 | I | B | 0.2123 | |
| 183 | H | B | 0.0000 | |
| 184 | N | B | 0.0000 | |
| 185 | K | B | -1.3528 | |
| 186 | K | B | -2.0423 | |
| 187 | R | B | -3.0616 | |
| 188 | K | B | -2.7129 | |
| 189 | G | B | -1.6456 | |
| 190 | G | B | -0.4894 | |
| 191 | I | B | 1.2199 | |
| 192 | G | B | -0.0292 | |
| 193 | G | B | -0.7456 | |
| 194 | Y | B | -1.0816 | |
| 195 | S | B | 0.0000 | |
| 196 | A | B | 0.0000 | |
| 197 | G | B | -0.8504 | |
| 198 | E | B | -0.8476 | |
| 199 | R | B | -0.5853 | |
| 200 | I | B | 0.0000 | |
| 201 | V | B | 0.0000 | |
| 202 | D | B | -0.7436 | |
| 203 | I | B | -0.2078 | |
| 204 | I | B | 0.0000 | |
| 205 | A | B | -0.9553 | |
| 206 | T | B | -1.1055 | |
| 207 | D | B | -1.3254 | |
| 208 | I | B | 0.0000 | |
| 209 | Q | B | -1.7669 | |
| 210 | T | B | -1.5381 | |
| 211 | K | B | -2.0622 | |
| 212 | E | B | -1.3805 | |
| 213 | L | B | -0.4179 | |
| 214 | Q | B | -1.6654 | |
| 215 | K | B | -1.4432 | |
| 216 | Q | B | -0.9809 | |
| 217 | I | B | -0.3915 | |
| 218 | T | B | -0.9513 | |
| 219 | K | B | -1.1048 | |
| 220 | I | B | -0.9146 | |
| 221 | Q | B | -1.3562 | |
| 222 | N | B | -2.1175 | |
| 223 | F | B | -1.6766 | |
| 224 | R | B | -1.4143 | |
| 225 | V | B | 0.0000 | |
| 226 | Y | B | -0.5803 | |
| 227 | Y | B | 0.0000 | |
| 228 | R | B | -2.0885 | |
| 229 | D | B | -2.9292 | |
| 230 | S | B | -2.3892 | |
| 231 | R | B | -2.8695 | |
| 232 | N | B | -2.3070 | |
| 233 | S | B | -1.3238 | |
| 234 | L | B | 0.2843 | |
| 235 | W | B | -0.5713 | |
| 236 | K | B | -1.2013 | |
| 237 | G | B | -1.4333 | |
| 238 | P | B | -1.1852 | |
| 239 | A | B | 0.0000 | |
| 240 | K | B | -0.8003 | |
| 241 | L | B | 0.0000 | |
| 242 | L | B | 0.5552 | |
| 243 | W | B | 0.4614 | |
| 244 | K | B | -1.6420 | |
| 245 | G | B | -2.2047 | |
| 246 | E | B | -2.6772 | |
| 247 | G | B | -2.5076 | |
| 248 | A | B | -1.6430 | |
| 249 | V | B | 0.0000 | |
| 250 | V | B | 0.8522 | |
| 251 | I | B | 0.0000 | |
| 252 | Q | B | -0.7049 | |
| 253 | D | B | -1.8406 | |
| 254 | N | B | -2.1298 | |
| 255 | S | B | -1.5301 | |
| 256 | D | B | -1.5571 | |
| 257 | I | B | 0.7266 | |
| 258 | K | B | 0.4287 | |
| 259 | V | B | 1.5487 | |
| 260 | V | B | 0.0000 | |
| 261 | P | B | -1.7834 | |
| 262 | R | B | -3.1038 | |
| 263 | R | B | -3.3740 | |
| 264 | K | B | -2.9333 | |
| 265 | A | B | 0.0000 | |
| 266 | K | B | -1.8227 | |
| 267 | I | B | -0.7157 | |
| 268 | I | B | -0.5503 | |
| 269 | R | B | -2.3139 | |
| 270 | D | B | -2.7354 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine