Project name: Full TAU 5

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.3822
• Maximal score value: 2.0926
• Average score: -0.4004
• Total score value: -176.5843

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	1.0548
2	A	A	-0.1323
3	E	A	-1.8586
4	P	A	-0.8772
5	R	A	-2.0954
6	Q	A	-1.5866
7	E	A	-0.6067
8	F	A	0.0000
9	E	A	0.0000
10	V	A	0.0000
11	M	A	-0.1841
12	E	A	-2.1297
13	D	A	-2.1387
14	H	A	-0.4464
15	A	A	-0.0097
16	G	A	-0.3885
17	T	A	-0.1579
18	Y	A	0.2996
19	G	A	0.0000
20	L	A	0.7959
21	G	A	-0.4762
22	D	A	-1.9702
23	R	A	-1.1983
24	K	A	-1.2301
25	D	A	-0.7004
26	Q	A	-0.2053
27	G	A	0.0000
28	G	A	-0.1234
29	Y	A	1.2257
30	T	A	0.4074
31	M	A	0.9745
32	H	A	-0.1349
33	Q	A	-1.4860
34	D	A	-1.7037
35	Q	A	0.0000
36	E	A	-0.4131
37	G	A	-0.4774
38	D	A	-1.8237
39	T	A	-0.7301
40	D	A	-1.8218
41	A	A	-0.3956
42	G	A	-0.1445
43	L	A	1.2240
44	K	A	-1.3774
45	E	A	-2.0725
46	S	A	-0.4274
47	P	A	0.0569
48	L	A	1.5112
49	Q	A	0.0000
50	T	A	0.0000
51	P	A	0.0000
52	T	A	-0.3424
53	E	A	-1.8677
54	D	A	-0.6005
55	G	A	-0.1669
56	S	A	-0.5720
57	E	A	-1.9744
58	E	A	-0.9831
59	P	A	-0.3415
60	G	A	-0.5015
61	S	A	-0.6233
62	E	A	-1.8648
63	T	A	-0.4212
64	S	A	-0.5536
65	D	A	-1.8184
66	A	A	-0.4951
67	K	A	-1.3331
68	S	A	-0.2903
69	T	A	-0.0876
70	P	A	-0.2671
71	T	A	0.0000
72	A	A	0.0000
73	E	A	-0.7839
74	D	A	-0.8964
75	V	A	0.2394
76	T	A	0.0348
77	A	A	0.0467
78	P	A	0.0298
79	L	A	1.7208
80	V	A	1.1604
81	D	A	-1.8948
82	E	A	-2.2273
83	G	A	-0.7828
84	A	A	-0.0708
85	P	A	-0.3275
86	G	A	-0.8126
87	K	A	-1.9981
88	Q	A	-1.4935
89	A	A	-0.1473
90	A	A	0.0797
91	A	A	-0.1484
92	Q	A	-1.2028
93	P	A	-0.4800
94	H	A	-1.0154
95	T	A	-0.5585
96	E	A	-1.7209
97	I	A	0.2481
98	P	A	-0.3942
99	E	A	-1.8659
100	G	A	-0.4237
101	T	A	-0.0980
102	T	A	-0.0796
103	A	A	-0.3488
104	E	A	-2.1785
105	E	A	-2.1374
106	A	A	-0.3490
107	G	A	-0.0286
108	I	A	0.7428
109	G	A	-0.7522
110	D	A	-1.8500
111	T	A	-0.3841
112	P	A	-0.2940
113	S	A	-0.2176
114	L	A	-0.0140
115	E	A	-1.3311
116	D	A	-1.5425
117	E	A	-0.4988
118	A	A	0.0000
119	A	A	-0.0313
120	G	A	-0.6654
121	H	A	-0.7611
122	V	A	1.5974
123	T	A	0.0973
124	Q	A	-1.1948
125	A	A	-0.2259
126	R	A	0.0000
127	M	A	1.0659
128	V	A	1.2354
129	S	A	-0.3243
130	K	A	-1.7522
131	S	A	-0.5765
132	K	A	-1.4080
133	D	A	-1.8876
134	G	A	-0.7706
135	T	A	-0.2045
136	G	A	-0.2887
137	S	A	-0.4194
138	D	A	-2.1394
139	D	A	-2.1852
140	K	A	-0.6144
141	K	A	0.0000
142	A	A	-0.0258
143	K	A	-0.1821
144	G	A	-0.4997
145	A	A	-0.3846
146	D	A	-1.8682
147	G	A	-1.0854
148	K	A	-1.7850
149	T	A	-0.6337
150	K	A	-1.4355
151	I	A	1.1464
152	A	A	0.3056
153	T	A	-0.0726
154	P	A	-0.4233
155	R	A	-1.9363
156	G	A	-0.7852
157	A	A	-0.0199
158	A	A	-0.2214
159	P	A	-0.2972
160	P	A	-0.3219
161	G	A	-0.3673
162	Q	A	-1.4555
163	K	A	-0.8863
164	G	A	-0.7956
165	Q	A	-1.4138
166	A	A	-0.4120
167	N	A	-1.2600
168	A	A	-0.1937
169	T	A	-0.3505
170	R	A	-1.2282
171	I	A	1.6656
172	P	A	0.1594
173	A	A	-0.2547
174	K	A	-1.4655
175	T	A	-0.1291
176	P	A	-0.3064
177	P	A	-0.2891
178	A	A	-0.0334
179	P	A	-0.5394
180	K	A	-1.7573
181	T	A	-0.4173
182	P	A	-0.2048
183	P	A	-0.1257
184	S	A	0.0000
185	S	A	-0.2682
186	G	A	-0.4266
187	E	A	-0.5143
188	P	A	-0.3838
189	P	A	-0.5746
190	K	A	-1.7923
191	S	A	-0.5393
192	G	A	-0.2135
193	D	A	-0.7065
194	R	A	-1.5955
195	S	A	0.0000
196	G	A	-0.1125
197	Y	A	0.0000
198	S	A	-0.0563
199	S	A	0.0000
200	P	A	-0.2446
201	G	A	-0.5985
202	S	A	-0.3201
203	P	A	-0.2151
204	G	A	-0.3565
205	T	A	-0.1799
206	P	A	-0.3281
207	G	A	-0.1595
208	S	A	0.0000
209	R	A	-0.3243
210	S	A	-0.4142
211	R	A	-1.4490
212	T	A	-0.2974
213	P	A	-0.1373
214	S	A	-0.0095
215	L	A	0.2951
216	P	A	0.0000
217	T	A	-0.2506
218	P	A	-0.6341
219	P	A	-0.3072
220	T	A	-0.2199
221	R	A	-1.0392
222	E	A	-1.6873
223	P	A	0.0000
224	K	A	-1.9304
225	K	A	-1.4960
226	V	A	0.1556
227	A	A	0.4325
228	V	A	2.0926
229	V	A	1.7565
230	R	A	-1.5408
231	T	A	-0.4361
232	P	A	-0.2250
233	P	A	-0.4318
234	K	A	-1.7163
235	S	A	0.0000
236	P	A	0.0000
237	S	A	0.0107
238	S	A	0.0126
239	A	A	-0.0049
240	K	A	-0.2236
241	S	A	-0.5779
242	R	A	-1.6454
243	L	A	0.7606
244	Q	A	-0.9745
245	T	A	-0.2789
246	A	A	-0.0361
247	P	A	-0.2069
248	V	A	0.2005
249	P	A	0.0000
250	M	A	0.0000
251	P	A	-0.4218
252	D	A	-1.5999
253	L	A	0.7533
254	K	A	-0.4277
255	N	A	-1.2854
256	V	A	-0.2297
257	K	A	-1.6672
258	S	A	-0.7672
259	K	A	-1.3511
260	I	A	1.6806
261	G	A	0.2453
262	S	A	-0.2397
263	T	A	-0.4448
264	E	A	-2.0695
265	N	A	-1.3342
266	L	A	1.0205
267	K	A	-1.6026
268	H	A	-1.5076
269	Q	A	-1.4223
270	P	A	-0.5556
271	G	A	-0.5756
272	G	A	-0.4515
273	G	A	-0.2822
274	K	A	0.0826
275	V	A	1.5184
276	Q	A	-0.7197
277	I	A	0.6546
278	I	A	0.0000
279	N	A	-1.4648
280	K	A	-2.0376
281	K	A	-0.9676
282	L	A	0.1633
283	D	A	0.0000
284	L	A	0.0107
285	S	A	-0.4668
286	N	A	-1.2001
287	V	A	0.0186
288	Q	A	-0.7743
289	S	A	-0.3885
290	K	A	-0.5452
291	C	A	0.0069
292	G	A	0.0000
293	S	A	-0.4257
294	K	A	-1.9441
295	D	A	-1.0177
296	N	A	-0.1447
297	I	A	0.5232
298	K	A	-0.3404
299	H	A	0.0000
300	V	A	0.0000
301	P	A	0.0076
302	G	A	-0.5566
303	G	A	-0.6341
304	G	A	-0.5600
305	S	A	0.1762
306	V	A	1.5320
307	Q	A	-0.4812
308	I	A	0.0000
309	V	A	0.9040
310	Y	A	1.1912
311	K	A	-0.9622
312	P	A	-0.1328
313	V	A	1.5788
314	D	A	-0.2398
315	L	A	1.3624
316	S	A	-0.2408
317	K	A	-1.6572
318	V	A	0.1485
319	T	A	0.0000
320	S	A	-0.5137
321	K	A	-1.7156
322	C	A	-0.1952
323	G	A	-0.0277
324	S	A	0.0000
325	L	A	0.1672
326	G	A	-0.5547
327	N	A	-0.5165
328	I	A	1.2029
329	H	A	-0.8988
330	H	A	-1.2111
331	K	A	-0.4290
332	P	A	-0.1564
333	G	A	-0.5572
334	G	A	-0.5806
335	G	A	-0.3973
336	Q	A	-1.0081
337	V	A	0.0574
338	E	A	-0.1471
339	V	A	1.3769
340	K	A	-1.3949
341	S	A	-0.7072
342	E	A	-1.8669
343	K	A	-0.2576
344	L	A	1.4031
345	D	A	0.0131
346	F	A	1.7118
347	K	A	-0.3386
348	D	A	-0.8588
349	R	A	-1.6057
350	V	A	1.2418
351	Q	A	-0.9306
352	S	A	-0.7191
353	K	A	-1.3724
354	I	A	1.6613
355	G	A	0.0845
356	S	A	0.0224
357	L	A	1.3209
358	D	A	-0.9912
359	N	A	-1.1102
360	I	A	1.7745
361	T	A	0.1166
362	H	A	-0.6817
363	V	A	1.5476
364	P	A	-0.0211
365	G	A	-0.5972
366	G	A	-0.5914
367	G	A	-0.5366
368	N	A	-1.4413
369	K	A	-1.2410
370	K	A	-1.4740
371	I	A	1.3826
372	E	A	-1.4651
373	T	A	-0.5803
374	H	A	-1.3104
375	K	A	-1.5947
376	L	A	1.2230
377	T	A	0.5533
378	F	A	1.5934
379	R	A	-1.8204
380	E	A	-2.3822
381	N	A	-1.5904
382	A	A	-0.3757
383	K	A	-1.1412
384	A	A	-0.3583
385	K	A	-1.1617
386	T	A	-0.3735
387	D	A	-1.4241
388	H	A	-1.3639
389	G	A	-0.5124
390	A	A	-0.3616
391	E	A	-1.4483
392	I	A	1.5515
393	V	A	1.1655
394	Y	A	0.7788
395	K	A	-1.5547
396	S	A	-0.5591
397	P	A	-0.0455
398	V	A	1.4887
399	V	A	1.9518
400	S	A	0.0233
401	G	A	-0.5846
402	D	A	-0.5223
403	T	A	-0.1631
404	S	A	-0.1181
405	P	A	-0.3894
406	R	A	-1.7710
407	H	A	-0.9933
408	L	A	1.3288
409	S	A	-0.1493
410	N	A	-1.2243
411	V	A	0.2399
412	S	A	0.0333
413	S	A	-0.0673
414	T	A	-0.0233
415	G	A	0.0000
416	S	A	0.4323
417	I	A	1.6888
418	D	A	-1.2471
419	M	A	0.8880
420	V	A	0.7684
421	D	A	-1.2058
422	S	A	0.0000
423	P	A	-0.4490
424	Q	A	-1.2395
425	L	A	0.0000
426	A	A	0.0455
427	T	A	0.1678
428	L	A	1.1933
429	A	A	-0.0977
430	D	A	-2.1090
431	E	A	-1.8164
432	V	A	1.4078
433	S	A	0.1089
434	A	A	-0.0178
435	S	A	-0.1549
436	L	A	0.2375
437	A	A	-0.2016
438	K	A	-1.7251
439	Q	A	-0.5244
440	G	A	-0.0307
441	L	A	0.4434