Project name: 4hix:H

Chain sequence(s)	H: VQLLESGGGLVQPGGSLRLSCAASGFTFSNYGMSWVRQAPGKGLEWVASIRSGGGRTYYSDNVKGRFTISRDNAKNSLYLQMNSLRAEDTALYYCVRYDHYSGSSDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8738
• Maximal score value: 2.475
• Average score: -0.6003
• Total score value: -131.4585

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	V	H	1.0487
3	Q	H	-0.2736
4	L	H	0.0000
5	L	H	0.1885
6	E	H	0.0000
7	S	H	-0.5152
8	G	H	-0.8378
9	G	H	-0.4266
10	G	H	-0.4421
11	L	H	-0.1006
12	V	H	0.0000
13	Q	H	-1.6350
14	P	H	-1.7161
15	G	H	-1.4068
16	G	H	0.0000
17	S	H	-1.2746
18	L	H	-1.1603
19	R	H	-2.0353
20	L	H	0.0000
21	S	H	-0.4267
22	C	H	0.0000
23	A	H	-0.4337
24	A	H	0.0000
25	S	H	-0.2735
26	G	H	-0.0266
27	F	H	-0.0228
28	T	H	-0.4350
29	F	H	0.0000
30	S	H	-1.3593
31	N	H	-1.6465
32	Y	H	-0.7902
33	G	H	-1.2504
34	M	H	0.0000
35	S	H	0.1589
36	W	H	0.0000
37	V	H	0.4746
38	R	H	0.0000
39	Q	H	-0.5303
40	A	H	-1.0960
41	P	H	-0.9522
42	G	H	-1.5712
43	K	H	-2.1342
44	G	H	-1.0484
45	L	H	0.4511
46	E	H	-0.5028
47	W	H	0.3031
48	V	H	0.0000
49	A	H	0.0000
50	S	H	-0.2683
51	I	H	0.0000
52	R	H	-2.6074
52A	S	H	-2.0017
53	G	H	-1.8467
54	G	H	-1.7972
55	G	H	-2.2124
56	R	H	-2.7080
57	T	H	-1.1815
58	Y	H	-0.2422
59	Y	H	-0.4775
60	S	H	-1.2424
61	D	H	-2.4860
62	N	H	-2.0404
63	V	H	0.0000
64	K	H	-2.5549
65	G	H	-1.7930
66	R	H	-1.4121
67	F	H	0.0000
68	T	H	-0.6850
69	I	H	0.0000
70	S	H	-0.8563
71	R	H	-1.2623
72	D	H	-1.5892
73	N	H	-1.9625
74	A	H	-1.4828
75	K	H	-2.3611
76	N	H	-1.8740
77	S	H	-1.1559
78	L	H	0.0000
79	Y	H	-0.3484
80	L	H	0.0000
81	Q	H	-1.1060
82	M	H	0.0000
82A	N	H	-1.5194
82B	S	H	-1.2915
82C	L	H	0.0000
83	R	H	-2.3407
84	A	H	-1.7378
85	E	H	-2.2932
86	D	H	0.0000
87	T	H	-0.7750
88	A	H	0.0000
89	L	H	0.3031
90	Y	H	0.0000
91	Y	H	0.4814
92	C	H	0.0000
93	V	H	0.0000
94	R	H	0.0000
95	Y	H	-0.1239
96	D	H	-0.2628
97	H	H	-0.3211
98	Y	H	0.8133
99	S	H	-0.1294
100	G	H	-0.5267
100A	S	H	-0.4807
100B	S	H	-0.2867
101	D	H	-0.4292
102	Y	H	0.6817
103	W	H	0.6351
104	G	H	0.0212
105	Q	H	-0.8880
106	G	H	0.0000
107	T	H	-0.1069
108	L	H	-0.0024
109	V	H	0.0000
110	T	H	-0.4739
111	V	H	0.0000
112	S	H	-0.9852
113	S	H	-0.6739
114	A	H	-0.4546
115	S	H	-0.5818
116	T	H	-0.5575
117	K	H	-1.1177
118	G	H	-1.4382
119	P	H	-0.6066
120	S	H	-0.0618
121	V	H	0.0000
122	F	H	0.9548
123	P	H	0.1247
124	L	H	0.4352
125	A	H	-0.8425
126	P	H	0.0000
127	S	H	-1.4592
128	S	H	-1.7425
129	K	H	-2.2166
130	S	H	-1.5819
131	T	H	-1.1482
132	S	H	-0.9930
133	G	H	-1.0848
134	G	H	-1.1906
135	T	H	-0.9311
136	A	H	0.0000
137	A	H	-0.1752
138	L	H	0.0000
139	G	H	0.0000
140	C	H	0.0000
141	L	H	0.7708
142	V	H	0.0000
143	K	H	-0.1269
144	D	H	-0.3591
145	Y	H	0.0000
146	F	H	0.0000
147	P	H	0.0000
148	Q	H	-0.3277
149	P	H	-0.6888
150	V	H	-0.7914
151	T	H	-0.7151
152	V	H	-0.1792
153	S	H	-0.3769
154	W	H	0.0000
155	N	H	-0.7229
156	S	H	-0.6094
157	G	H	-0.5765
158	A	H	-0.2463
159	L	H	-0.0198
160	T	H	-0.2939
161	S	H	-0.3601
162	G	H	-0.4544
163	V	H	0.0472
164	H	H	-0.3547
165	T	H	0.2840
166	F	H	1.0290
167	P	H	0.7704
168	A	H	1.3314
169	V	H	2.4750
170	L	H	2.1455
171	Q	H	0.7413
172	S	H	0.0736
173	S	H	-0.2246
174	G	H	0.1886
175	L	H	0.3323
176	Y	H	0.8483
177	S	H	0.0000
178	L	H	0.0000
179	S	H	0.7097
180	S	H	0.0000
181	V	H	0.5006
182	V	H	0.0000
183	T	H	-0.2043
184	V	H	0.0000
185	P	H	-0.6135
186	S	H	-0.8924
187	S	H	-0.6192
188	S	H	-0.6633
189	L	H	-0.8281
190	G	H	-0.9774
191	T	H	-0.8010
192	Q	H	-1.4391
193	T	H	-1.1942
194	Y	H	0.0000
195	I	H	-1.1545
196	C	H	0.0000
197	N	H	-1.3969
198	V	H	0.0000
199	N	H	-2.2691
200	H	H	0.0000
201	K	H	-2.8738
202	P	H	-1.5773
203	S	H	-1.8376
204	N	H	-2.6022
205	T	H	-2.2328
206	K	H	-2.7793
207	V	H	-1.6045
208	D	H	-2.0541
209	K	H	-1.9142
210	K	H	-2.3943
211	V	H	0.0000
212	E	H	-2.7681
213	P	H	-1.7843
214	K	H	-2.1672