Project name: c61fdf0f7a89182

Chain sequence(s)	A: QSVEESGGRLVTPGTPLTLTCTVSGFSLSNYAMSWVRQAPGKGLEWIGIVSISAGTYYASWAKGRFTISKTSTTVVLRVTSPTTEDTATYFCATGGYTGNVWGPGTLVTVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVGAAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLACMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGKGDYKDDDDKGDYKDDDDKGDYKDDDDK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.8856
• Maximal score value: 2.8102
• Average score: -0.784
• Total score value: -363.7828

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.3311
2	S	A	-1.3913
3	V	A	0.0000
4	E	A	-2.2746
5	E	A	-1.4428
6	S	A	-1.1521
7	G	A	-1.1578
8	G	A	-0.8406
9	R	A	-0.0727
10	L	A	1.8271
11	V	A	1.1509
12	T	A	0.5350
13	P	A	-0.5735
14	G	A	-0.7383
15	T	A	-0.2866
16	P	A	-0.6471
17	L	A	0.0000
18	T	A	-1.0346
19	L	A	0.0000
20	T	A	-0.5179
21	C	A	0.0000
22	T	A	-0.7578
23	V	A	0.0000
24	S	A	-1.0177
25	G	A	-0.8311
26	F	A	-0.6239
27	S	A	-0.8248
28	L	A	-0.8711
29	S	A	-1.0767
30	N	A	-1.1345
31	Y	A	0.0000
32	A	A	0.2970
33	M	A	0.0000
34	S	A	0.0000
35	W	A	0.0000
36	V	A	0.0000
37	R	A	-0.7122
38	Q	A	-1.2461
39	A	A	-1.6606
40	P	A	-1.4049
41	G	A	-1.5274
42	K	A	-2.3903
43	G	A	-1.4063
44	L	A	-0.4791
45	E	A	-0.6342
46	W	A	0.7464
47	I	A	0.0000
48	G	A	0.0000
49	I	A	1.4992
50	V	A	0.0000
51	S	A	0.2649
52	I	A	0.0000
53	S	A	-0.8061
54	A	A	-0.1631
55	G	A	-0.1625
56	T	A	0.7555
57	Y	A	1.7007
58	Y	A	2.0620
59	A	A	0.9140
60	S	A	0.3848
61	W	A	-0.0814
62	A	A	-0.7104
63	K	A	-1.2525
64	G	A	0.0000
65	R	A	-2.1408
66	F	A	0.0000
67	T	A	-0.5403
68	I	A	-0.4197
69	S	A	-0.8278
70	K	A	-1.6900
71	T	A	-0.9145
72	S	A	-0.7354
73	T	A	-0.6702
74	T	A	-0.5988
75	V	A	0.0000
76	V	A	-0.3913
77	L	A	0.0000
78	R	A	-2.0638
79	V	A	0.0000
80	T	A	-1.0455
81	S	A	-0.6632
82	P	A	0.0000
83	T	A	-0.9993
84	T	A	-1.1260
85	E	A	-2.0116
86	D	A	-1.2689
87	T	A	-0.7359
88	A	A	0.0000
89	T	A	-0.6379
90	Y	A	0.0000
91	F	A	-0.4974
92	C	A	0.0000
93	A	A	0.0000
94	T	A	0.0000
95	G	A	0.7936
96	G	A	0.9548
97	Y	A	1.4105
98	T	A	0.7504
99	G	A	0.4404
100	N	A	-0.1846
101	V	A	1.5820
102	W	A	1.5365
103	G	A	0.5285
104	P	A	0.0742
105	G	A	0.2319
106	T	A	0.8832
107	L	A	1.4302
108	V	A	1.9433
109	T	A	1.0513
110	V	A	0.8821
111	S	A	0.3615
112	S	A	-0.4363
113	G	A	-0.8963
114	Q	A	0.0000
115	P	A	-1.1185
116	K	A	-1.4271
117	A	A	0.0000
118	P	A	-0.6172
119	S	A	0.3709
120	V	A	1.7383
121	F	A	2.8102
122	P	A	1.9845
123	L	A	1.7974
124	A	A	0.3348
125	P	A	0.0000
126	C	A	0.2527
127	C	A	-0.5959
128	G	A	-0.8207
129	D	A	-0.9603
130	T	A	-0.1933
131	P	A	-0.2586
132	S	A	0.0000
133	S	A	0.2600
134	T	A	0.8143
135	V	A	1.8848
136	T	A	1.1144
137	L	A	0.0000
138	G	A	0.0000
139	C	A	0.0000
140	L	A	-0.1641
141	V	A	0.0000
142	K	A	-1.1538
143	G	A	-0.7497
144	Y	A	0.0000
145	L	A	0.8639
146	P	A	0.0000
147	E	A	-0.3191
148	P	A	-0.4295
149	V	A	-0.2799
150	T	A	-0.2893
151	V	A	-0.3892
152	T	A	-0.4059
153	W	A	0.0000
154	N	A	-0.7730
155	S	A	-0.7584
156	G	A	-0.5541
157	T	A	-0.4502
158	L	A	-0.3091
159	T	A	-0.9456
160	N	A	-1.5562
161	G	A	-1.0384
162	V	A	-0.8255
163	R	A	-1.3901
164	T	A	-0.1207
165	F	A	0.7922
166	P	A	0.1155
167	S	A	-0.2369
168	V	A	-0.2068
169	R	A	-2.0736
170	Q	A	-1.9479
171	S	A	-1.3618
172	S	A	-1.3436
173	G	A	-0.6762
174	L	A	0.0000
175	Y	A	0.2911
176	S	A	0.0000
177	L	A	0.0694
178	S	A	0.0000
179	S	A	0.2582
180	V	A	1.4603
181	V	A	2.5818
182	S	A	1.8664
183	V	A	1.9250
184	T	A	0.9810
185	S	A	0.5569
186	S	A	-0.2925
187	S	A	-0.3430
188	Q	A	-0.6552
189	P	A	-0.7501
190	V	A	0.0000
191	T	A	-1.0570
192	C	A	0.0000
193	N	A	-1.3337
194	V	A	0.0000
195	A	A	-1.0942
196	H	A	0.0000
197	P	A	-1.1363
198	A	A	0.0951
199	T	A	-0.3452
200	N	A	-1.6223
201	T	A	-1.0348
202	K	A	-2.0563
203	V	A	-0.9816
204	D	A	-2.3444
205	K	A	-1.8273
206	T	A	-1.2120
207	V	A	0.0000
208	G	A	-0.8390
209	A	A	-0.1869
210	A	A	-0.2433
211	P	A	-0.2186
212	S	A	-0.1398
213	T	A	0.0689
214	C	A	0.0783
215	S	A	-0.6273
216	K	A	-1.5334
217	P	A	-0.9021
218	T	A	-0.4278
219	C	A	0.1980
220	P	A	-0.5881
221	P	A	-0.6233
222	P	A	-0.7476
223	E	A	-1.1229
224	L	A	0.8085
225	L	A	0.9108
226	G	A	0.1002
227	G	A	-0.1738
228	P	A	0.0000
229	S	A	-0.0413
230	V	A	0.0000
231	F	A	1.2087
232	I	A	0.8429
233	F	A	0.9670
234	P	A	-0.3574
235	P	A	0.0000
236	K	A	-2.2768
237	P	A	-1.3864
238	K	A	-1.2281
239	D	A	0.0000
240	T	A	0.0000
241	L	A	-0.4488
242	M	A	0.4623
243	I	A	1.4060
244	S	A	-0.0187
245	R	A	-1.6398
246	T	A	-1.1022
247	P	A	0.0000
248	E	A	-1.3686
249	V	A	0.0000
250	T	A	0.3158
251	C	A	0.0000
252	V	A	0.0000
253	V	A	0.0000
254	V	A	-0.6037
255	D	A	-1.6248
256	V	A	0.0000
257	S	A	-2.3044
258	Q	A	-2.8478
259	D	A	-3.1377
260	D	A	-2.8255
261	P	A	-2.8047
262	E	A	-3.0748
263	V	A	-1.8568
264	Q	A	-1.8468
265	F	A	-1.0783
266	T	A	-1.1251
267	W	A	0.0000
268	Y	A	-2.1684
269	I	A	-2.0843
270	N	A	-3.0320
271	N	A	-3.1757
272	E	A	-3.2196
273	Q	A	-2.7483
274	V	A	-1.6016
275	R	A	-2.1549
276	T	A	-1.4008
277	A	A	-1.4954
278	R	A	-2.0627
279	P	A	-1.0714
280	P	A	-0.6306
281	L	A	-0.0785
282	R	A	-2.2316
283	E	A	-2.7926
284	Q	A	-2.5143
285	Q	A	-1.4381
286	F	A	0.5712
287	N	A	-0.8639
288	S	A	-1.0603
289	T	A	-1.9537
290	I	A	0.0000
291	R	A	-2.0915
292	V	A	0.0000
293	V	A	-0.3562
294	S	A	0.0000
295	T	A	-0.7558
296	L	A	0.0000
297	P	A	-0.7634
298	I	A	0.0000
299	A	A	-1.0139
300	H	A	-1.1000
301	Q	A	-2.0424
302	D	A	-2.1227
303	W	A	0.0000
304	L	A	-1.6300
305	R	A	-2.8247
306	G	A	-2.2896
307	K	A	-2.2912
308	E	A	-2.1191
309	F	A	0.0000
310	K	A	-2.0704
311	C	A	0.0000
312	K	A	-1.5729
313	V	A	0.0000
314	H	A	-1.7652
315	N	A	0.0000
316	K	A	-2.6434
317	A	A	-1.4385
318	L	A	0.0000
319	P	A	-0.4860
320	A	A	-0.6307
321	P	A	-0.9614
322	I	A	-0.8363
323	E	A	-1.9847
324	K	A	-1.3679
325	T	A	-0.9133
326	I	A	-0.1376
327	S	A	-1.0646
328	K	A	-1.4132
329	A	A	-1.2910
330	R	A	-2.4989
331	G	A	-1.7093
332	Q	A	-1.8409
333	P	A	-1.3586
334	L	A	-0.8688
335	E	A	-2.3551
336	P	A	0.0000
337	K	A	-1.6608
338	V	A	0.0000
339	Y	A	0.1043
340	T	A	0.2946
341	M	A	0.2398
342	G	A	-0.7412
343	P	A	0.0000
344	P	A	-1.8900
345	R	A	-2.9982
346	E	A	-3.1031
347	E	A	-2.5485
348	L	A	-1.7751
349	S	A	-1.5906
350	S	A	-1.6191
351	R	A	-2.1710
352	S	A	-1.4576
353	V	A	0.0000
354	S	A	-0.4785
355	L	A	0.0000
356	A	A	0.0069
357	C	A	0.0000
358	M	A	0.4235
359	I	A	0.0000
360	N	A	-0.1172
361	G	A	-0.8428
362	F	A	0.0000
363	Y	A	-0.5982
364	P	A	0.0000
365	S	A	0.1253
366	D	A	-1.1433
367	I	A	-0.6613
368	S	A	-0.4931
369	V	A	-0.3543
370	E	A	-1.1199
371	W	A	0.0000
372	E	A	-1.8536
373	K	A	-1.5424
374	N	A	-2.0648
375	G	A	-2.1299
376	K	A	-2.8133
377	A	A	-2.1663
378	E	A	-2.4367
379	D	A	-3.0357
380	N	A	-2.6060
381	Y	A	-2.0431
382	K	A	-2.3156
383	T	A	-0.9808
384	T	A	-0.3499
385	P	A	0.0397
386	A	A	0.7202
387	V	A	1.5620
388	L	A	1.2501
389	D	A	-0.6363
390	S	A	-1.1867
391	D	A	-2.0546
392	G	A	-0.8883
393	S	A	0.0000
394	Y	A	0.6229
395	F	A	0.7792
396	L	A	0.0000
397	Y	A	0.2623
398	S	A	0.0000
399	K	A	-1.3053
400	L	A	0.0000
401	S	A	-1.2319
402	V	A	0.0000
403	P	A	-1.3245
404	T	A	-1.7436
405	S	A	-1.9363
406	E	A	-1.9792
407	W	A	0.0000
408	Q	A	-2.8626
409	R	A	-2.9772
410	G	A	-2.0257
411	D	A	-1.1278
412	V	A	0.2536
413	F	A	0.0000
414	T	A	-0.6023
415	C	A	0.0000
416	S	A	0.0000
417	V	A	0.0000
418	M	A	0.0000
419	H	A	0.0000
420	E	A	-1.3267
421	A	A	-1.4847
422	L	A	0.0000
423	H	A	-2.4664
424	N	A	-2.2028
425	H	A	-1.6620
426	Y	A	-0.9779
427	T	A	0.0000
428	Q	A	-1.2946
429	K	A	-1.0608
430	S	A	-0.1575
431	I	A	0.0000
432	S	A	-1.0610
433	R	A	-2.3709
434	S	A	-1.6246
435	P	A	-1.2996
436	G	A	-1.8195
437	K	A	-2.4544
438	G	A	-2.1426
439	D	A	-2.1085
440	Y	A	-1.4416
441	K	A	-2.9353
442	D	A	-2.4005
443	D	A	-3.4091
444	D	A	-4.0780
445	D	A	-3.9151
446	K	A	-3.8710
447	G	A	-2.8795
448	D	A	-3.1098
449	Y	A	-1.3513
450	K	A	-3.3712
451	D	A	-4.5665
452	D	A	-4.7221
453	D	A	-4.8777
454	D	A	-4.4623
455	K	A	-3.6204
456	G	A	-2.6592
457	D	A	-2.5452
458	Y	A	-1.5528
459	K	A	-3.5103
460	D	A	-4.8546
461	D	A	-4.6911
462	D	A	-4.8856
463	D	A	-4.8063
464	K	A	-3.6840