| Chain sequence(s) |
A: QVQLQESGPGLVKPSFTLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVFTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTWGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEFHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6589 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1246 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8504 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.6722 | |
| 8 | G | A | -0.4246 | |
| 9 | P | A | -0.5428 | |
| 10 | G | A | -0.4711 | |
| 11 | L | A | -0.2360 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -1.3153 | |
| 14 | P | A | -0.6255 | |
| 15 | S | A | -0.0571 | |
| 16 | F | A | 0.8509 | |
| 17 | T | A | -0.0330 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -0.6171 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.4059 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -0.9081 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.3029 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8540 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | 0.0114 | |
| 31 | S | A | 0.0164 | |
| 32 | G | A | 0.1273 | |
| 33 | Y | A | 0.1794 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8043 | |
| 40 | P | A | -0.9999 | |
| 41 | P | A | -1.1161 | |
| 42 | G | A | -1.5020 | |
| 43 | K | A | -2.3799 | |
| 44 | G | A | -1.5454 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6490 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0350 | |
| 53 | Y | A | 0.5894 | |
| 54 | S | A | -0.4323 | |
| 55 | G | A | -0.7333 | |
| 56 | D | A | -1.5341 | |
| 57 | T | A | -0.3278 | |
| 58 | Y | A | 0.7971 | |
| 59 | Y | A | 0.5168 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8735 | |
| 62 | S | A | -1.1280 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0159 | |
| 65 | S | A | -1.2751 | |
| 66 | R | A | -1.3678 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.5688 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.2009 | |
| 71 | V | A | 0.6309 | |
| 72 | F | A | 0.8622 | |
| 73 | T | A | -0.1450 | |
| 74 | S | A | -0.6931 | |
| 75 | K | A | -1.4922 | |
| 76 | N | A | -0.8810 | |
| 77 | Q | A | -0.5610 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | 0.0000 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6097 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -0.4256 | |
| 84 | S | A | -0.1795 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.2144 | |
| 87 | A | A | -0.2085 | |
| 88 | A | A | 0.0271 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0293 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1100 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6559 | |
| 98 | Y | A | -0.0559 | |
| 99 | G | A | -0.0745 | |
| 100 | S | A | -0.0627 | |
| 101 | Y | A | 0.2817 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4276 | |
| 105 | Y | A | -0.7959 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8500 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.4672 | |
| 111 | T | A | -0.1973 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.3014 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.5919 | |
| 116 | S | A | -0.8803 | |
| 117 | A | A | -0.3843 | |
| 118 | S | A | -0.3102 | |
| 119 | T | A | -0.1051 | |
| 120 | W | A | 0.0414 | |
| 121 | G | A | -0.8923 | |
| 122 | P | A | -0.4653 | |
| 123 | S | A | -0.3879 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | 0.0000 | |
| 126 | P | A | -1.3334 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8952 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4511 | |
| 131 | S | A | -0.5321 | |
| 132 | R | A | -0.8709 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8821 | |
| 135 | S | A | -1.3554 | |
| 136 | E | A | -2.0794 | |
| 137 | S | A | -1.3123 | |
| 138 | T | A | -0.9408 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | 0.0000 | |
| 147 | D | A | -0.4062 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.4423 | |
| 152 | P | A | -0.7222 | |
| 153 | V | A | -0.7211 | |
| 154 | T | A | -0.6489 | |
| 155 | V | A | -0.4243 | |
| 156 | S | A | -0.5345 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0453 | |
| 159 | S | A | -0.7951 | |
| 160 | G | A | -0.6095 | |
| 161 | A | A | -0.2851 | |
| 162 | L | A | -0.1378 | |
| 163 | T | A | -0.2482 | |
| 164 | S | A | -0.2749 | |
| 165 | G | A | -0.3945 | |
| 166 | V | A | 0.0674 | |
| 167 | H | A | -0.2209 | |
| 168 | T | A | 0.0397 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.2394 | |
| 171 | A | A | 0.3362 | |
| 172 | V | A | 0.7296 | |
| 173 | L | A | 1.3277 | |
| 174 | Q | A | 0.3255 | |
| 175 | S | A | 0.0024 | |
| 176 | S | A | -0.2074 | |
| 177 | G | A | 0.0887 | |
| 178 | L | A | 0.2867 | |
| 179 | Y | A | 0.5790 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1893 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6409 | |
| 189 | S | A | -0.6897 | |
| 190 | S | A | -0.5403 | |
| 191 | S | A | -0.6374 | |
| 192 | L | A | -0.7981 | |
| 193 | G | A | -1.1457 | |
| 194 | T | A | -0.8571 | |
| 195 | K | A | -1.5450 | |
| 196 | T | A | -1.4483 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.8981 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -2.1296 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7892 | |
| 205 | P | A | -1.4583 | |
| 206 | S | A | -1.5421 | |
| 207 | N | A | -2.4396 | |
| 208 | T | A | -1.9997 | |
| 209 | K | A | -2.7968 | |
| 210 | V | A | -2.0716 | |
| 211 | D | A | -2.9902 | |
| 212 | K | A | -2.6963 | |
| 213 | R | A | -3.1133 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6114 | |
| 216 | S | A | -1.1030 | |
| 217 | D | B | -1.2338 | |
| 218 | I | B | -0.2035 | |
| 219 | V | B | 0.7408 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.5005 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3428 | |
| 224 | P | B | -0.2019 | |
| 225 | L | B | 0.1125 | |
| 226 | S | B | -0.4538 | |
| 227 | L | B | -0.5745 | |
| 228 | S | B | -0.8694 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.5941 | |
| 231 | P | B | -1.9883 | |
| 232 | G | B | -1.9030 | |
| 233 | Q | B | -2.3054 | |
| 234 | P | B | -2.1000 | |
| 235 | A | B | -1.2500 | |
| 236 | S | B | -0.7628 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8800 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1257 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8607 | |
| 243 | Q | B | -1.3834 | |
| 244 | S | B | -0.7236 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.5174 | |
| 247 | H | B | -0.6083 | |
| 248 | S | B | -0.9374 | |
| 249 | N | B | -1.6499 | |
| 250 | G | B | -1.1457 | |
| 251 | N | B | -0.9821 | |
| 252 | T | B | -0.2726 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1563 | |
| 260 | K | B | -1.7659 | |
| 261 | P | B | -1.4206 | |
| 262 | G | B | -1.6430 | |
| 263 | Q | B | -2.0408 | |
| 264 | S | B | -1.4121 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.3407 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4898 | |
| 271 | K | B | -0.8892 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9546 | |
| 274 | N | B | -1.2759 | |
| 275 | R | B | -1.7525 | |
| 276 | F | B | -0.6706 | |
| 277 | S | B | -0.5850 | |
| 278 | G | B | -0.8100 | |
| 279 | V | B | -0.8965 | |
| 280 | P | B | -1.2712 | |
| 281 | D | B | -2.2266 | |
| 282 | R | B | -2.0461 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3175 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7818 | |
| 287 | G | B | -0.9747 | |
| 288 | S | B | -0.6489 | |
| 289 | G | B | -0.6187 | |
| 290 | T | B | -1.3675 | |
| 291 | D | B | -1.9938 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9894 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5602 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.2768 | |
| 298 | R | B | -3.0424 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.6194 | |
| 301 | A | B | -2.2592 | |
| 302 | E | B | -2.4182 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7454 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0788 | |
| 315 | V | B | 0.8688 | |
| 316 | P | B | 0.3401 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1179 | |
| 319 | F | B | 0.1202 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2908 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.7423 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.5271 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.3563 | |
| 329 | R | B | -0.9493 | |
| 330 | T | B | -0.0239 | |
| 331 | V | B | 0.3985 | |
| 332 | A | B | -0.0301 | |
| 333 | A | B | -0.1500 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1309 | |
| 336 | V | B | -0.1424 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6886 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.5311 | |
| 343 | D | B | -2.9871 | |
| 344 | E | B | -2.8319 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -2.1249 | |
| 347 | K | B | -2.7054 | |
| 348 | S | B | -1.7249 | |
| 349 | G | B | -1.0506 | |
| 350 | T | B | -0.9952 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.0029 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.5271 | |
| 363 | R | B | -2.6357 | |
| 364 | E | B | -3.0485 | |
| 365 | A | B | -2.2938 | |
| 366 | K | B | -2.5700 | |
| 367 | V | B | 0.0000 | |
| 368 | Q | B | -0.8647 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.8481 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -1.8371 | |
| 373 | N | B | -1.7058 | |
| 374 | A | B | -0.4202 | |
| 375 | L | B | 0.6742 | |
| 376 | Q | B | -0.2211 | |
| 377 | S | B | -0.4923 | |
| 378 | G | B | -0.9091 | |
| 379 | N | B | -0.8345 | |
| 380 | S | B | -1.0884 | |
| 381 | Q | B | -1.2273 | |
| 382 | E | B | -1.4234 | |
| 383 | S | B | -0.4970 | |
| 384 | V | B | -0.3681 | |
| 385 | T | B | 0.0000 | |
| 386 | E | B | -2.1987 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.1721 | |
| 389 | S | B | -2.3728 | |
| 390 | K | B | -2.7008 | |
| 391 | D | B | -1.9460 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | -0.4202 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5511 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.3969 | |
| 402 | L | B | -0.6510 | |
| 403 | S | B | -0.7968 | |
| 404 | K | B | -1.4210 | |
| 405 | A | B | -0.9616 | |
| 406 | D | B | -1.1770 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -1.8084 | |
| 409 | F | B | -0.0874 | |
| 410 | H | B | -1.6550 | |
| 411 | K | B | -2.7540 | |
| 412 | V | B | -1.8513 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.9027 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -1.0595 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.3042 | |
| 419 | H | B | 0.0000 | |
| 420 | Q | B | -1.7285 | |
| 421 | G | B | -0.4900 | |
| 422 | L | B | -0.2772 | |
| 423 | S | B | -0.4362 | |
| 424 | S | B | -0.4210 | |
| 425 | P | B | -0.5799 | |
| 426 | V | B | 0.1057 | |
| 427 | T | B | -0.4605 | |
| 428 | K | B | -0.7306 | |
| 429 | S | B | -0.9984 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5396 | |
| 432 | R | B | -2.5073 | |
| 433 | G | B | -2.2633 | |
| 434 | E | B | -2.2207 | |
| 435 | C | B | -0.7089 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine