Project name: c7b223364bbf06f

Chain sequence(s)	B: DQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2632
• Maximal score value: 3.354
• Average score: -0.578
• Total score value: -319.0653

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
130	D	B	-2.0316
131	Q	B	-1.3341
132	V	B	0.4958
133	N	B	-0.5252
134	N	B	-0.8808
135	K	B	-0.1357
136	V	B	1.1401
137	L	B	0.0000
138	M	B	0.0000
139	W	B	0.2344
140	R	B	-1.0445
141	L	B	0.0000
142	L	B	-0.7850
143	K	B	-2.1435
144	L	B	-1.3949
145	S	B	-1.3829
146	R	B	-1.8703
147	P	B	-1.0733
148	D	B	-0.0978
149	L	B	1.1172
150	P	B	0.9841
151	L	B	1.5784
152	L	B	1.8514
153	V	B	2.9049
154	A	B	2.1436
155	A	B	0.0000
156	F	B	2.8213
157	F	B	3.0960
158	F	B	2.5230
159	L	B	0.0000
160	V	B	1.8212
161	L	B	2.0210
162	A	B	0.0000
163	V	B	0.0000
164	L	B	0.8419
165	G	B	0.3172
166	E	B	-1.0316
167	T	B	0.0000
168	L	B	0.2149
169	I	B	0.4502
170	P	B	0.0142
171	H	B	-0.2910
172	Y	B	0.5106
173	S	B	0.3650
174	G	B	0.0000
175	R	B	-0.9302
176	V	B	0.0000
177	I	B	1.3969
178	D	B	-0.4222
179	I	B	0.0166
180	L	B	0.7411
181	G	B	-0.2371
182	G	B	-0.7918
183	D	B	-1.1400
184	F	B	0.7790
185	D	B	-0.4366
186	P	B	-0.3266
187	H	B	-0.8046
188	A	B	-0.1707
189	F	B	0.7613
190	A	B	0.8714
191	S	B	1.0463
192	A	B	0.0000
193	I	B	2.2656
194	F	B	3.3540
195	F	B	3.1700
196	M	B	2.4082
197	C	B	2.8364
198	L	B	2.8725
199	F	B	2.1934
200	S	B	1.6928
201	F	B	2.6147
202	G	B	1.5173
203	S	B	0.0000
204	S	B	0.9157
205	L	B	1.8655
206	S	B	0.0000
207	A	B	0.4080
208	G	B	-0.0420
209	C	B	0.1740
210	R	B	0.5792
211	G	B	-0.3731
212	G	B	-0.3534
213	C	B	0.3658
214	F	B	0.0000
215	T	B	0.2544
216	Y	B	0.6521
217	T	B	0.0000
218	M	B	0.2872
219	S	B	-0.0478
220	R	B	-0.7942
221	I	B	0.0000
222	N	B	-0.6474
223	L	B	-0.3921
224	R	B	-2.2618
225	I	B	0.0000
226	R	B	-1.3431
227	E	B	-2.2537
228	Q	B	-1.8760
229	L	B	0.0000
230	F	B	0.9292
231	S	B	-0.0750
232	S	B	-0.6486
233	L	B	0.0000
234	L	B	1.0735
235	R	B	-1.1291
236	Q	B	-0.7125
237	D	B	-0.1086
238	L	B	0.3624
239	G	B	-0.2441
240	F	B	-0.3770
241	F	B	-0.0510
242	Q	B	-1.6786
243	E	B	-2.2622
244	T	B	-1.7128
245	K	B	-2.6267
246	T	B	-1.7604
247	G	B	-1.7962
248	E	B	-1.9381
249	L	B	-1.2598
250	N	B	-1.9683
251	S	B	-1.4991
252	R	B	-1.3741
253	L	B	-0.5593
254	S	B	-0.8232
255	S	B	-0.6473
256	D	B	-1.1069
257	T	B	0.0000
258	T	B	-0.0789
259	L	B	0.0639
260	M	B	0.0000
261	S	B	0.0000
262	N	B	0.0763
263	W	B	0.0000
264	L	B	0.5950
265	P	B	0.0000
266	L	B	1.3588
267	N	B	0.8388
268	A	B	0.6294
269	N	B	0.4674
270	V	B	0.7217
271	L	B	0.8672
272	L	B	0.4597
273	R	B	-0.2910
274	S	B	0.0000
275	L	B	1.1567
276	V	B	1.2956
277	K	B	0.0000
278	V	B	0.0000
279	V	B	2.0199
280	G	B	1.1866
281	L	B	0.0000
282	Y	B	1.2329
283	G	B	0.8907
284	F	B	0.9181
285	M	B	0.0000
286	L	B	1.0868
287	S	B	0.5291
288	I	B	0.3771
289	S	B	0.0000
290	P	B	-0.3442
291	R	B	-1.3597
292	L	B	0.0000
293	T	B	0.0000
294	L	B	2.1049
295	L	B	1.6849
296	S	B	0.0000
297	L	B	2.5002
298	L	B	2.7343
299	H	B	1.7588
300	M	B	0.0000
301	P	B	1.3980
302	F	B	2.3355
303	T	B	0.9421
304	I	B	0.8954
305	A	B	0.6438
306	A	B	0.4643
307	E	B	0.0000
308	K	B	-1.2899
309	V	B	-0.1520
310	Y	B	0.0000
311	N	B	-1.7259
312	T	B	-1.9102
313	R	B	-2.8491
314	H	B	-3.2127
315	Q	B	-3.1133
316	E	B	-3.9602
317	V	B	0.0000
318	L	B	-2.4072
319	R	B	-3.8878
320	E	B	-3.6674
321	I	B	-2.7546
322	Q	B	-2.9232
323	D	B	-3.0750
324	A	B	-2.3831
325	V	B	-1.0088
326	A	B	-1.6792
327	R	B	-2.2614
328	A	B	-1.6467
329	G	B	-1.1387
330	Q	B	-1.9296
331	V	B	-1.3862
332	V	B	-0.2864
333	R	B	-2.1757
334	E	B	-2.0838
335	A	B	-0.9042
336	V	B	0.5961
337	G	B	-0.6842
338	G	B	-0.7699
339	L	B	-0.6023
340	Q	B	-1.2009
341	T	B	-0.4146
342	V	B	-1.0085
343	R	B	-1.9909
344	S	B	-0.4886
345	F	B	0.7511
346	G	B	-1.2546
347	A	B	-1.7479
348	E	B	-3.1931
349	E	B	-3.2012
350	H	B	-2.9081
351	E	B	-2.4762
352	V	B	-1.5303
353	C	B	-2.1243
354	R	B	-3.2716
355	Y	B	-1.9721
356	K	B	-2.8839
357	E	B	-3.7475
358	A	B	-2.6753
359	L	B	-2.8175
360	E	B	-4.2632
361	Q	B	-3.4319
362	C	B	0.0000
363	R	B	-3.0727
364	Q	B	-2.8327
365	L	B	-1.8775
366	Y	B	-1.1669
367	W	B	-1.0172
368	R	B	-2.4710
369	R	B	-2.6772
370	D	B	-2.4439
371	L	B	-0.9305
372	E	B	-1.6898
373	R	B	-1.6960
374	A	B	-0.2107
375	L	B	0.9762
376	Y	B	0.6504
377	L	B	1.0775
378	L	B	1.8107
379	V	B	1.6212
380	R	B	0.0003
381	R	B	-0.2958
382	V	B	1.5232
383	L	B	0.9284
384	H	B	-0.3606
385	L	B	0.7597
386	G	B	0.7721
387	V	B	1.0125
388	Q	B	0.6126
389	M	B	1.5217
390	L	B	1.6978
391	M	B	0.0000
392	L	B	1.4104
393	S	B	0.8343
394	C	B	0.2109
395	G	B	0.0000
396	L	B	0.1919
397	Q	B	-1.4824
398	Q	B	-1.7638
399	M	B	-1.5882
400	Q	B	-2.5132
401	D	B	-3.0747
402	G	B	-2.5750
403	E	B	-2.7823
404	L	B	-1.4026
405	T	B	-1.1229
406	Q	B	-1.0376
407	G	B	0.0000
408	S	B	0.0674
409	L	B	0.8173
410	L	B	1.0629
411	S	B	0.0000
412	F	B	0.0000
413	M	B	0.4994
414	I	B	0.6827
415	Y	B	0.0000
416	Q	B	0.0000
417	E	B	-1.5300
418	S	B	-0.7163
419	V	B	0.0000
420	G	B	-0.3960
421	S	B	-0.5204
422	Y	B	-0.0722
423	V	B	0.0000
424	Q	B	0.2015
425	T	B	0.5749
426	L	B	0.9203
427	V	B	0.5174
428	Y	B	0.4799
429	I	B	0.8979
430	Y	B	1.2672
431	G	B	-0.2014
432	D	B	-0.6896
433	M	B	0.0361
434	L	B	-0.3919
435	S	B	-0.8585
436	N	B	-0.9800
437	V	B	0.0000
438	G	B	-1.2773
439	A	B	-1.1201
440	A	B	0.0000
441	E	B	-2.0809
442	K	B	-2.2012
443	V	B	0.0000
444	F	B	-1.3378
445	S	B	-1.4942
446	Y	B	0.0000
447	M	B	-1.2345
448	D	B	-2.3279
449	R	B	-2.2280
450	Q	B	-2.4542
451	P	B	-1.5204
452	N	B	-1.3853
453	L	B	-0.0752
454	P	B	-0.4178
455	S	B	-0.5906
456	P	B	-0.8007
457	G	B	-1.0681
458	T	B	-0.6338
459	L	B	-0.3272
460	A	B	0.0346
461	P	B	0.1533
462	T	B	0.0756
463	T	B	0.1948
464	L	B	0.4806
465	Q	B	-0.6177
466	G	B	-0.3650
467	V	B	-0.1669
468	V	B	0.0000
469	K	B	-0.9478
470	F	B	0.0000
471	Q	B	-2.4482
472	D	B	-3.0427
473	V	B	0.0000
474	S	B	0.0000
475	F	B	0.0000
476	A	B	-1.0290
477	Y	B	-0.4286
478	P	B	-1.0344
479	N	B	-1.7203
480	R	B	-2.8684
481	P	B	-2.4587
482	D	B	-3.2595
483	R	B	-3.1384
484	P	B	-2.0701
485	V	B	-1.2323
486	L	B	0.0000
487	K	B	-2.6930
488	G	B	-2.1059
489	L	B	0.0000
490	T	B	-1.5123
491	F	B	0.0036
492	T	B	0.1981
493	L	B	1.3491
494	R	B	0.0194
495	P	B	-0.6467
496	G	B	-1.4737
497	E	B	-2.7706
498	V	B	-1.4568
499	T	B	0.0000
500	A	B	0.0000
501	L	B	0.0000
502	V	B	0.5858
503	G	B	-0.8904
504	P	B	-1.4479
505	N	B	-1.6973
506	G	B	-1.4643
507	S	B	-1.6282
508	G	B	-0.9671
509	K	B	-0.7219
510	S	B	-0.6111
511	T	B	-0.0322
512	V	B	0.0000
513	A	B	0.0000
514	A	B	-0.2275
515	L	B	0.0000
516	L	B	0.0000
517	Q	B	-0.4095
518	N	B	-0.5343
519	L	B	0.3811
520	Y	B	0.2126
521	Q	B	-0.8798
522	P	B	-0.6632
523	T	B	-0.6369
524	G	B	-1.4518
525	G	B	-2.0935
526	Q	B	-1.9665
527	V	B	0.0000
528	L	B	-1.5087
529	L	B	0.0000
530	D	B	-1.7216
531	E	B	-2.5597
532	K	B	-2.2151
533	P	B	-1.4230
534	I	B	0.0000
535	S	B	-1.1391
536	Q	B	-1.7280
537	Y	B	0.0000
538	E	B	-0.8473
539	H	B	-1.1603
540	C	B	-0.0085
541	Y	B	0.1351
542	L	B	0.0000
543	H	B	-1.1630
544	S	B	-0.7992
545	Q	B	0.0000
546	V	B	0.0000
547	V	B	-0.5021
548	S	B	-0.3465
549	V	B	0.0000
550	G	B	-1.1195
551	Q	B	-1.8090
552	E	B	-1.8872
553	P	B	-0.4986
554	V	B	1.1501
555	L	B	0.0245
556	F	B	-0.2302
557	S	B	-1.4673
558	G	B	-0.9861
559	S	B	-1.1582
560	V	B	0.0000
561	R	B	-1.5954
562	N	B	-1.1444
563	N	B	0.0000
564	I	B	0.0000
565	A	B	-0.9579
566	Y	B	0.3336
567	G	B	-0.2908
568	L	B	-0.4810
569	Q	B	-1.1975
570	S	B	-1.2961
571	C	B	-2.0816
572	E	B	-3.4934
573	D	B	-3.8364
574	D	B	-3.3998
575	K	B	-2.7974
576	V	B	0.0000
577	M	B	-1.9291
578	A	B	-1.5591
579	A	B	0.0000
580	A	B	0.0000
581	Q	B	-1.8941
582	A	B	-0.7241
583	A	B	0.0000
584	H	B	-1.7591
585	A	B	0.0000
586	D	B	-2.5406
587	D	B	-3.1628
588	F	B	0.0000
589	I	B	0.0000
590	Q	B	-3.3571
591	E	B	-3.4438
592	M	B	-2.7466
593	E	B	-2.9256
594	H	B	-2.1272
595	G	B	-1.9232
596	I	B	0.0000
597	Y	B	-0.3500
598	T	B	0.0000
599	D	B	-2.6008
600	V	B	0.0000
601	G	B	-2.2677
602	E	B	-2.9817
603	K	B	-2.2890
604	G	B	-1.5141
605	S	B	-1.7404
606	Q	B	-2.1608
607	L	B	0.0000
608	A	B	-0.5464
609	A	B	-0.5351
610	G	B	-0.5805
611	Q	B	-0.8847
612	K	B	-0.7188
613	Q	B	0.0000
614	R	B	-0.9355
615	L	B	0.0000
616	A	B	-0.3740
617	I	B	0.0000
618	A	B	0.0000
619	R	B	-0.4438
620	A	B	0.0000
621	L	B	-0.7923
622	V	B	0.0000
623	R	B	-1.3737
624	D	B	-1.7932
625	P	B	0.0000
626	R	B	-0.7626
627	V	B	0.0000
628	L	B	0.0000
629	I	B	0.0000
630	L	B	0.0000
631	D	B	-1.3601
632	E	B	-2.0022
633	A	B	0.0000
634	T	B	-0.8519
635	S	B	-0.8660
636	A	B	-0.4656
637	L	B	0.0000
638	D	B	-0.2456
639	V	B	0.6801
640	Q	B	-0.8862
641	C	B	0.0000
642	E	B	-0.8867
643	Q	B	-1.5219
644	A	B	-0.9572
645	L	B	-1.0418
646	Q	B	-1.3382
647	D	B	-1.6392
648	W	B	-0.4299
649	N	B	-1.4241
650	S	B	-1.4242
651	R	B	-2.1296
652	G	B	-1.5808
653	D	B	-1.2881
654	R	B	0.0000
655	T	B	0.0000
656	V	B	0.0000
657	L	B	0.0000
658	V	B	0.0000
659	I	B	0.0000
660	A	B	-1.1485
661	H	B	-1.6843
662	R	B	-1.9543
663	L	B	-0.5390
664	Q	B	-1.9483
665	T	B	-1.5551
666	V	B	-1.1746
667	Q	B	-2.2867
668	R	B	-2.8828
669	A	B	0.0000
670	H	B	-2.0401
671	Q	B	-0.7835
672	I	B	0.7982
673	L	B	0.0000
674	V	B	0.4335
675	L	B	0.0000
676	Q	B	-2.3270
677	E	B	-3.1337
678	G	B	0.0000
679	K	B	-2.7637
680	L	B	-1.2940
681	Q	B	-1.5381